Incidental Mutation 'IGL02962:Prkra'
ID |
365398 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Prkra
|
Ensembl Gene |
ENSMUSG00000002731 |
Gene Name |
protein kinase, interferon inducible double stranded RNA dependent activator |
Synonyms |
Pact, RAX, PRK, lear |
Accession Numbers |
|
Essential gene? |
Possibly essential
(E-score: 0.548)
|
Stock # |
IGL02962
|
Quality Score |
|
Status
|
|
Chromosome |
2 |
Chromosomal Location |
76460242-76478359 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to A
at 76463891 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Threonine to Methionine
at position 257
(T257M)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000002808
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000002808]
|
AlphaFold |
Q9WTX2 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000002808
AA Change: T257M
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000002808 Gene: ENSMUSG00000002731 AA Change: T257M
Domain | Start | End | E-Value | Type |
DSRM
|
35 |
100 |
4.63e-24 |
SMART |
DSRM
|
127 |
193 |
2.23e-17 |
SMART |
DSRM
|
241 |
307 |
1.16e-6 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000140493
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008] PHENOTYPE: Mice homozygous for a deletion of the entire gene show embryonic lethality prior to implantation. Mice homozygous for a deletion in the last exon are viable but exhibit small size, turbinate hypoplasia, short snout, severe microtia, outer and middle ear defects, and impaired hearing. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 39 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1700017N19Rik |
T |
A |
10: 100,446,455 (GRCm39) |
|
probably null |
Het |
9530068E07Rik |
T |
C |
11: 52,294,362 (GRCm39) |
V209A |
possibly damaging |
Het |
Abca3 |
T |
A |
17: 24,619,383 (GRCm39) |
V907E |
probably damaging |
Het |
Acvrl1 |
T |
C |
15: 101,033,382 (GRCm39) |
Y90H |
probably benign |
Het |
Aff3 |
T |
C |
1: 38,574,737 (GRCm39) |
D81G |
probably damaging |
Het |
Amn |
G |
T |
12: 111,240,951 (GRCm39) |
V152L |
probably damaging |
Het |
Arhgap44 |
A |
G |
11: 64,957,987 (GRCm39) |
|
probably benign |
Het |
Atad5 |
T |
A |
11: 79,999,405 (GRCm39) |
V895D |
possibly damaging |
Het |
Card9 |
T |
G |
2: 26,248,029 (GRCm39) |
|
probably null |
Het |
Ccer1 |
T |
C |
10: 97,529,702 (GRCm39) |
S122P |
unknown |
Het |
Ccr2 |
A |
G |
9: 123,905,712 (GRCm39) |
|
probably benign |
Het |
Dsg1a |
T |
A |
18: 20,473,381 (GRCm39) |
I818N |
possibly damaging |
Het |
Ear10 |
G |
T |
14: 44,160,774 (GRCm39) |
L18I |
probably damaging |
Het |
Mertk |
A |
G |
2: 128,619,374 (GRCm39) |
Y544C |
probably damaging |
Het |
Miga1 |
A |
T |
3: 151,990,978 (GRCm39) |
|
probably benign |
Het |
Myo18a |
T |
C |
11: 77,669,061 (GRCm39) |
V307A |
probably damaging |
Het |
Or5p64 |
A |
T |
7: 107,854,910 (GRCm39) |
I145N |
possibly damaging |
Het |
Or7a38 |
T |
A |
10: 78,752,773 (GRCm39) |
L33H |
probably damaging |
Het |
Pou2f3 |
T |
C |
9: 43,036,384 (GRCm39) |
|
probably benign |
Het |
Pramel23 |
T |
A |
4: 143,423,910 (GRCm39) |
E293V |
probably benign |
Het |
Prickle2 |
A |
C |
6: 92,353,403 (GRCm39) |
S744A |
probably benign |
Het |
Prkcb |
T |
A |
7: 122,024,270 (GRCm39) |
|
probably null |
Het |
Prkd2 |
A |
G |
7: 16,603,757 (GRCm39) |
T813A |
probably benign |
Het |
Rbm18 |
C |
T |
2: 36,012,886 (GRCm39) |
R102Q |
probably damaging |
Het |
Rbsn |
A |
G |
6: 92,167,307 (GRCm39) |
S446P |
probably benign |
Het |
Rpgrip1l |
A |
T |
8: 91,996,990 (GRCm39) |
V28D |
possibly damaging |
Het |
Sdccag8 |
A |
T |
1: 176,775,928 (GRCm39) |
K613I |
probably damaging |
Het |
Serbp1 |
G |
A |
6: 67,244,103 (GRCm39) |
G8D |
probably damaging |
Het |
Slc6a2 |
T |
A |
8: 93,699,390 (GRCm39) |
Y139* |
probably null |
Het |
Slc7a2 |
T |
A |
8: 41,358,621 (GRCm39) |
F321L |
probably damaging |
Het |
Slco1b2 |
G |
A |
6: 141,594,279 (GRCm39) |
S48N |
probably damaging |
Het |
Ssbp2 |
G |
T |
13: 91,790,490 (GRCm39) |
V118L |
possibly damaging |
Het |
Sugp1 |
T |
A |
8: 70,512,512 (GRCm39) |
|
probably benign |
Het |
Taar5 |
C |
A |
10: 23,846,883 (GRCm39) |
R94S |
possibly damaging |
Het |
Tgs1 |
G |
T |
4: 3,586,181 (GRCm39) |
A353S |
probably benign |
Het |
Trav1 |
A |
G |
14: 52,666,099 (GRCm39) |
E32G |
probably damaging |
Het |
Trp53bp2 |
T |
C |
1: 182,259,160 (GRCm39) |
V71A |
probably benign |
Het |
Vmn2r50 |
T |
C |
7: 9,784,252 (GRCm39) |
Y74C |
probably damaging |
Het |
Wars1 |
A |
T |
12: 108,841,706 (GRCm39) |
M147K |
probably damaging |
Het |
|
Other mutations in Prkra |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01459:Prkra
|
APN |
2 |
76,460,780 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02016:Prkra
|
APN |
2 |
76,473,653 (GRCm39) |
splice site |
probably null |
|
IGL02823:Prkra
|
APN |
2 |
76,460,768 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03265:Prkra
|
APN |
2 |
76,470,614 (GRCm39) |
missense |
probably benign |
0.06 |
smallear
|
UTSW |
2 |
76,460,879 (GRCm39) |
missense |
probably damaging |
1.00 |
R1520:Prkra
|
UTSW |
2 |
76,469,622 (GRCm39) |
missense |
possibly damaging |
0.62 |
R1609:Prkra
|
UTSW |
2 |
76,463,936 (GRCm39) |
missense |
probably benign |
0.06 |
R1751:Prkra
|
UTSW |
2 |
76,477,584 (GRCm39) |
missense |
possibly damaging |
0.63 |
R1767:Prkra
|
UTSW |
2 |
76,477,584 (GRCm39) |
missense |
possibly damaging |
0.63 |
R2131:Prkra
|
UTSW |
2 |
76,477,480 (GRCm39) |
missense |
probably damaging |
1.00 |
R5288:Prkra
|
UTSW |
2 |
76,469,622 (GRCm39) |
missense |
probably damaging |
0.99 |
R5385:Prkra
|
UTSW |
2 |
76,469,622 (GRCm39) |
missense |
probably damaging |
0.99 |
R5386:Prkra
|
UTSW |
2 |
76,469,622 (GRCm39) |
missense |
probably damaging |
0.99 |
R6802:Prkra
|
UTSW |
2 |
76,463,881 (GRCm39) |
missense |
probably damaging |
1.00 |
R6918:Prkra
|
UTSW |
2 |
76,460,797 (GRCm39) |
missense |
probably damaging |
1.00 |
R7445:Prkra
|
UTSW |
2 |
76,463,942 (GRCm39) |
missense |
probably benign |
0.25 |
R7471:Prkra
|
UTSW |
2 |
76,477,545 (GRCm39) |
missense |
probably benign |
0.01 |
R8181:Prkra
|
UTSW |
2 |
76,469,634 (GRCm39) |
missense |
probably damaging |
1.00 |
R8290:Prkra
|
UTSW |
2 |
76,463,982 (GRCm39) |
missense |
probably damaging |
0.98 |
R8749:Prkra
|
UTSW |
2 |
76,460,879 (GRCm39) |
missense |
probably damaging |
1.00 |
R9035:Prkra
|
UTSW |
2 |
76,460,856 (GRCm39) |
missense |
probably benign |
0.00 |
R9101:Prkra
|
UTSW |
2 |
76,478,184 (GRCm39) |
missense |
probably benign |
0.04 |
R9115:Prkra
|
UTSW |
2 |
76,478,193 (GRCm39) |
missense |
probably benign |
|
R9290:Prkra
|
UTSW |
2 |
76,478,147 (GRCm39) |
missense |
probably benign |
0.00 |
|
Posted On |
2015-12-18 |