Incidental Mutation 'IGL02964:Zfp747'
ID365471
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp747
Ensembl Gene ENSMUSG00000054381
Gene Namezinc finger protein 747
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.095) question?
Stock #IGL02964
Quality Score
Status
Chromosome7
Chromosomal Location127372537-127376050 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 127374494 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Glycine at position 168 (E168G)
Ref Sequence ENSEMBL: ENSMUSP00000070685 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067425] [ENSMUST00000205832]
Predicted Effect probably benign
Transcript: ENSMUST00000067425
AA Change: E168G

PolyPhen 2 Score 0.208 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000070685
Gene: ENSMUSG00000054381
AA Change: E168G

DomainStartEndE-ValueType
KRAB 22 82 3.64e-26 SMART
low complexity region 102 115 N/A INTRINSIC
ZnF_C2H2 152 174 3.63e-3 SMART
ZnF_C2H2 180 202 1.47e-3 SMART
ZnF_C2H2 208 230 6.42e-4 SMART
ZnF_C2H2 236 258 3.63e-3 SMART
ZnF_C2H2 264 286 1.13e-4 SMART
ZnF_C2H2 292 314 1.45e-2 SMART
ZnF_C2H2 320 342 1.5e-4 SMART
ZnF_C2H2 348 371 2.49e-1 SMART
ZnF_C2H2 377 399 3.69e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000205832
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206942
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc3 T C 11: 94,351,810 I1364V possibly damaging Het
Adamts19 T A 18: 58,988,965 I813K probably damaging Het
Adamtsl1 G T 4: 86,424,357 C1703F probably damaging Het
Atp2b4 T A 1: 133,730,565 T536S probably damaging Het
Capg T A 6: 72,562,844 I340N probably damaging Het
Casc3 T A 11: 98,828,923 M567K probably damaging Het
Chmp1a T C 8: 123,208,067 E50G probably damaging Het
Cryba1 T C 11: 77,719,381 probably benign Het
Dnah8 T A 17: 30,746,761 Y2356N probably damaging Het
Ercc6 T G 14: 32,570,103 S1141R probably benign Het
Exd2 T A 12: 80,480,528 V165D probably damaging Het
Fbln1 A T 15: 85,231,462 E233V probably damaging Het
Ftsj3 T C 11: 106,252,337 K384E probably damaging Het
Ggt5 A G 10: 75,604,128 I188V probably benign Het
Gm42742 A T 7: 127,016,846 S26T probably damaging Het
Gucy1a2 T A 9: 3,759,542 D449E probably damaging Het
Igfbp7 C T 5: 77,351,341 S239N possibly damaging Het
Klf11 C T 12: 24,655,627 A360V probably damaging Het
Kmt2e T A 5: 23,467,100 probably benign Het
Magea8 A T X: 154,986,682 C144S probably damaging Het
Med4 A G 14: 73,517,921 Q223R probably damaging Het
Mmd2 G T 5: 142,569,477 F153L probably damaging Het
Nav3 C A 10: 109,736,953 R1615L probably damaging Het
Nisch A G 14: 31,180,812 probably benign Het
Nr1i3 A T 1: 171,214,395 Y16F probably benign Het
Olfr1134 C A 2: 87,656,714 C69F probably damaging Het
Olfr828 A G 9: 18,815,728 C189R probably damaging Het
Olfr860 G A 9: 19,846,254 R122* probably null Het
Olfr954 A G 9: 39,461,781 T117A possibly damaging Het
Ppil6 C A 10: 41,507,483 H252N probably benign Het
Ppp6r2 C T 15: 89,259,175 P175L probably damaging Het
Psme4 T A 11: 30,791,095 Y90* probably null Het
Rbm20 C A 19: 53,813,702 L214I probably benign Het
Rhox2f T C X: 37,571,681 V24A probably benign Het
Scnm1 T C 3: 95,133,037 K96E probably benign Het
Sec16a A C 2: 26,419,723 D2090E probably benign Het
Smg6 T C 11: 74,930,750 probably null Het
Snx2 T C 18: 53,194,558 S119P probably benign Het
Stam A G 2: 14,115,968 probably benign Het
Sult2b1 T A 7: 45,735,274 E126V probably benign Het
Tor1aip1 T C 1: 156,035,844 E131G probably damaging Het
Ttn C T 2: 76,788,696 C14367Y probably damaging Het
Ubr4 T C 4: 139,407,820 F821S possibly damaging Het
Vmn1r32 T C 6: 66,552,938 N285D probably benign Het
Vmn2r23 T C 6: 123,741,782 L698P possibly damaging Het
Wnt8a T A 18: 34,542,421 L18Q possibly damaging Het
Other mutations in Zfp747
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03201:Zfp747 APN 7 127374008 missense probably damaging 0.99
R0066:Zfp747 UTSW 7 127374600 missense probably benign 0.00
R1056:Zfp747 UTSW 7 127374588 missense probably benign
R1190:Zfp747 UTSW 7 127374554 missense probably damaging 0.99
R1457:Zfp747 UTSW 7 127374504 missense probably benign 0.37
R1727:Zfp747 UTSW 7 127374077 missense probably damaging 0.99
R2072:Zfp747 UTSW 7 127373970 missense possibly damaging 0.48
R2157:Zfp747 UTSW 7 127375757 missense possibly damaging 0.92
R3724:Zfp747 UTSW 7 127374590 missense probably benign 0.06
R4762:Zfp747 UTSW 7 127374326 missense possibly damaging 0.92
R4770:Zfp747 UTSW 7 127375799 missense probably damaging 0.99
R5135:Zfp747 UTSW 7 127374394 missense probably damaging 0.98
R5355:Zfp747 UTSW 7 127374597 missense possibly damaging 0.85
R6232:Zfp747 UTSW 7 127374134 missense probably damaging 1.00
R6263:Zfp747 UTSW 7 127375966 start gained probably benign
R6835:Zfp747 UTSW 7 127374047 missense possibly damaging 0.56
R7638:Zfp747 UTSW 7 127374647 missense probably benign 0.09
R7735:Zfp747 UTSW 7 127374500 missense probably damaging 0.99
R8043:Zfp747 UTSW 7 127374053 missense probably benign 0.00
Z1176:Zfp747 UTSW 7 127375459 nonsense probably null
Posted On2015-12-18