Incidental Mutation 'IGL02964:Wnt8a'
ID 365472
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Wnt8a
Ensembl Gene ENSMUSG00000012282
Gene Name wingless-type MMTV integration site family, member 8A
Synonyms Stra11
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02964
Quality Score
Status
Chromosome 18
Chromosomal Location 34675380-34681114 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 34675474 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 18 (L18Q)
Ref Sequence ENSEMBL: ENSMUSP00000012426 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000012426]
AlphaFold Q64527
Predicted Effect possibly damaging
Transcript: ENSMUST00000012426
AA Change: L18Q

PolyPhen 2 Score 0.864 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000012426
Gene: ENSMUSG00000012282
AA Change: L18Q

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
WNT1 21 337 2.26e-155 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc3 T C 11: 94,242,636 (GRCm39) I1364V possibly damaging Het
Adamts19 T A 18: 59,122,037 (GRCm39) I813K probably damaging Het
Adamtsl1 G T 4: 86,342,594 (GRCm39) C1703F probably damaging Het
Atp2b4 T A 1: 133,658,303 (GRCm39) T536S probably damaging Het
Capg T A 6: 72,539,827 (GRCm39) I340N probably damaging Het
Casc3 T A 11: 98,719,749 (GRCm39) M567K probably damaging Het
Chmp1a T C 8: 123,934,806 (GRCm39) E50G probably damaging Het
Cryba1 T C 11: 77,610,207 (GRCm39) probably benign Het
Dnah8 T A 17: 30,965,735 (GRCm39) Y2356N probably damaging Het
Ercc6 T G 14: 32,292,060 (GRCm39) S1141R probably benign Het
Exd2 T A 12: 80,527,302 (GRCm39) V165D probably damaging Het
Fbln1 A T 15: 85,115,663 (GRCm39) E233V probably damaging Het
Ftsj3 T C 11: 106,143,163 (GRCm39) K384E probably damaging Het
Ggt5 A G 10: 75,439,962 (GRCm39) I188V probably benign Het
Gm42742 A T 7: 126,616,018 (GRCm39) S26T probably damaging Het
Gucy1a2 T A 9: 3,759,542 (GRCm39) D449E probably damaging Het
Igfbp7 C T 5: 77,499,188 (GRCm39) S239N possibly damaging Het
Klf11 C T 12: 24,705,626 (GRCm39) A360V probably damaging Het
Kmt2e T A 5: 23,672,098 (GRCm39) probably benign Het
Magea8 A T X: 153,769,678 (GRCm39) C144S probably damaging Het
Med4 A G 14: 73,755,361 (GRCm39) Q223R probably damaging Het
Mmd2 G T 5: 142,555,232 (GRCm39) F153L probably damaging Het
Nav3 C A 10: 109,572,814 (GRCm39) R1615L probably damaging Het
Nisch A G 14: 30,902,769 (GRCm39) probably benign Het
Nr1i3 A T 1: 171,041,964 (GRCm39) Y16F probably benign Het
Or5w1 C A 2: 87,487,058 (GRCm39) C69F probably damaging Het
Or7e169 G A 9: 19,757,550 (GRCm39) R122* probably null Het
Or7g16 A G 9: 18,727,024 (GRCm39) C189R probably damaging Het
Or8g34 A G 9: 39,373,077 (GRCm39) T117A possibly damaging Het
Ppil6 C A 10: 41,383,479 (GRCm39) H252N probably benign Het
Ppp6r2 C T 15: 89,143,378 (GRCm39) P175L probably damaging Het
Psme4 T A 11: 30,741,095 (GRCm39) Y90* probably null Het
Rbm20 C A 19: 53,802,133 (GRCm39) L214I probably benign Het
Rhox2f T C X: 36,753,334 (GRCm39) V24A probably benign Het
Scnm1 T C 3: 95,040,348 (GRCm39) K96E probably benign Het
Sec16a A C 2: 26,309,735 (GRCm39) D2090E probably benign Het
Smg6 T C 11: 74,821,576 (GRCm39) probably null Het
Snx2 T C 18: 53,327,630 (GRCm39) S119P probably benign Het
Stam A G 2: 14,120,779 (GRCm39) probably benign Het
Sult2b1 T A 7: 45,384,698 (GRCm39) E126V probably benign Het
Tor1aip1 T C 1: 155,911,590 (GRCm39) E131G probably damaging Het
Ttn C T 2: 76,619,040 (GRCm39) C14367Y probably damaging Het
Ubr4 T C 4: 139,135,131 (GRCm39) F821S possibly damaging Het
Vmn1r32 T C 6: 66,529,922 (GRCm39) N285D probably benign Het
Vmn2r23 T C 6: 123,718,741 (GRCm39) L698P possibly damaging Het
Zfp747 T C 7: 126,973,666 (GRCm39) E168G probably benign Het
Other mutations in Wnt8a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01592:Wnt8a APN 18 34,677,846 (GRCm39) missense probably damaging 0.98
IGL01823:Wnt8a APN 18 34,677,846 (GRCm39) missense possibly damaging 0.85
PIT4486001:Wnt8a UTSW 18 34,680,636 (GRCm39) missense probably damaging 1.00
R0496:Wnt8a UTSW 18 34,677,900 (GRCm39) missense probably damaging 1.00
R0646:Wnt8a UTSW 18 34,680,618 (GRCm39) missense probably benign 0.02
R1813:Wnt8a UTSW 18 34,675,422 (GRCm39) start codon destroyed probably null 0.89
R1990:Wnt8a UTSW 18 34,677,937 (GRCm39) missense probably damaging 1.00
R1991:Wnt8a UTSW 18 34,677,937 (GRCm39) missense probably damaging 1.00
R1992:Wnt8a UTSW 18 34,677,937 (GRCm39) missense probably damaging 1.00
R4927:Wnt8a UTSW 18 34,680,525 (GRCm39) missense probably damaging 1.00
R5085:Wnt8a UTSW 18 34,678,656 (GRCm39) nonsense probably null
R6161:Wnt8a UTSW 18 34,678,599 (GRCm39) missense possibly damaging 0.86
R7719:Wnt8a UTSW 18 34,680,588 (GRCm39) missense probably damaging 1.00
R8001:Wnt8a UTSW 18 34,678,569 (GRCm39) missense probably damaging 0.98
R9022:Wnt8a UTSW 18 34,680,298 (GRCm39) missense probably damaging 1.00
R9617:Wnt8a UTSW 18 34,680,163 (GRCm39) missense probably benign 0.00
Posted On 2015-12-18