Incidental Mutation 'IGL02964:Or5w1'
ID 365475
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5w1
Ensembl Gene ENSMUSG00000111747
Gene Name olfactory receptor family 5 subfamily W member 1
Synonyms MOR176-1, Olfr1134, GA_x6K02T2Q125-49162076-49161138
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # IGL02964
Quality Score
Status
Chromosome 2
Chromosomal Location 87486269-87488801 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 87487058 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Phenylalanine at position 69 (C69F)
Ref Sequence ENSEMBL: ENSMUSP00000150358 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099857] [ENSMUST00000135875] [ENSMUST00000213939]
AlphaFold Q7TR43
Predicted Effect probably damaging
Transcript: ENSMUST00000099854
AA Change: C69F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097440
Gene: ENSMUSG00000075154
AA Change: C69F

DomainStartEndE-ValueType
GHB 123 190 1.21e0 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000099857
AA Change: C69F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097443
Gene: ENSMUSG00000111747
AA Change: C69F

DomainStartEndE-ValueType
GHB 123 190 1.21e0 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000135875
AA Change: C69F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000213939
AA Change: C69F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc3 T C 11: 94,242,636 (GRCm39) I1364V possibly damaging Het
Adamts19 T A 18: 59,122,037 (GRCm39) I813K probably damaging Het
Adamtsl1 G T 4: 86,342,594 (GRCm39) C1703F probably damaging Het
Atp2b4 T A 1: 133,658,303 (GRCm39) T536S probably damaging Het
Capg T A 6: 72,539,827 (GRCm39) I340N probably damaging Het
Casc3 T A 11: 98,719,749 (GRCm39) M567K probably damaging Het
Chmp1a T C 8: 123,934,806 (GRCm39) E50G probably damaging Het
Cryba1 T C 11: 77,610,207 (GRCm39) probably benign Het
Dnah8 T A 17: 30,965,735 (GRCm39) Y2356N probably damaging Het
Ercc6 T G 14: 32,292,060 (GRCm39) S1141R probably benign Het
Exd2 T A 12: 80,527,302 (GRCm39) V165D probably damaging Het
Fbln1 A T 15: 85,115,663 (GRCm39) E233V probably damaging Het
Ftsj3 T C 11: 106,143,163 (GRCm39) K384E probably damaging Het
Ggt5 A G 10: 75,439,962 (GRCm39) I188V probably benign Het
Gm42742 A T 7: 126,616,018 (GRCm39) S26T probably damaging Het
Gucy1a2 T A 9: 3,759,542 (GRCm39) D449E probably damaging Het
Igfbp7 C T 5: 77,499,188 (GRCm39) S239N possibly damaging Het
Klf11 C T 12: 24,705,626 (GRCm39) A360V probably damaging Het
Kmt2e T A 5: 23,672,098 (GRCm39) probably benign Het
Magea8 A T X: 153,769,678 (GRCm39) C144S probably damaging Het
Med4 A G 14: 73,755,361 (GRCm39) Q223R probably damaging Het
Mmd2 G T 5: 142,555,232 (GRCm39) F153L probably damaging Het
Nav3 C A 10: 109,572,814 (GRCm39) R1615L probably damaging Het
Nisch A G 14: 30,902,769 (GRCm39) probably benign Het
Nr1i3 A T 1: 171,041,964 (GRCm39) Y16F probably benign Het
Or7e169 G A 9: 19,757,550 (GRCm39) R122* probably null Het
Or7g16 A G 9: 18,727,024 (GRCm39) C189R probably damaging Het
Or8g34 A G 9: 39,373,077 (GRCm39) T117A possibly damaging Het
Ppil6 C A 10: 41,383,479 (GRCm39) H252N probably benign Het
Ppp6r2 C T 15: 89,143,378 (GRCm39) P175L probably damaging Het
Psme4 T A 11: 30,741,095 (GRCm39) Y90* probably null Het
Rbm20 C A 19: 53,802,133 (GRCm39) L214I probably benign Het
Rhox2f T C X: 36,753,334 (GRCm39) V24A probably benign Het
Scnm1 T C 3: 95,040,348 (GRCm39) K96E probably benign Het
Sec16a A C 2: 26,309,735 (GRCm39) D2090E probably benign Het
Smg6 T C 11: 74,821,576 (GRCm39) probably null Het
Snx2 T C 18: 53,327,630 (GRCm39) S119P probably benign Het
Stam A G 2: 14,120,779 (GRCm39) probably benign Het
Sult2b1 T A 7: 45,384,698 (GRCm39) E126V probably benign Het
Tor1aip1 T C 1: 155,911,590 (GRCm39) E131G probably damaging Het
Ttn C T 2: 76,619,040 (GRCm39) C14367Y probably damaging Het
Ubr4 T C 4: 139,135,131 (GRCm39) F821S possibly damaging Het
Vmn1r32 T C 6: 66,529,922 (GRCm39) N285D probably benign Het
Vmn2r23 T C 6: 123,718,741 (GRCm39) L698P possibly damaging Het
Wnt8a T A 18: 34,675,474 (GRCm39) L18Q possibly damaging Het
Zfp747 T C 7: 126,973,666 (GRCm39) E168G probably benign Het
Other mutations in Or5w1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00164:Or5w1 APN 2 87,486,582 (GRCm39) missense probably benign 0.01
IGL01397:Or5w1 APN 2 87,487,249 (GRCm39) missense probably damaging 0.99
IGL01583:Or5w1 APN 2 87,486,757 (GRCm39) nonsense probably null
IGL01655:Or5w1 APN 2 87,486,773 (GRCm39) missense probably damaging 1.00
IGL02184:Or5w1 APN 2 87,487,136 (GRCm39) missense probably damaging 0.99
IGL02263:Or5w1 APN 2 87,486,543 (GRCm39) missense probably damaging 1.00
IGL03391:Or5w1 APN 2 87,487,032 (GRCm39) missense possibly damaging 0.93
R5171:Or5w1 UTSW 2 87,486,888 (GRCm39) missense possibly damaging 0.95
R6434:Or5w1 UTSW 2 87,486,558 (GRCm39) nonsense probably null
R7466:Or5w1 UTSW 2 87,486,740 (GRCm39) missense possibly damaging 0.73
R7770:Or5w1 UTSW 2 87,486,813 (GRCm39) missense not run
R8810:Or5w1 UTSW 2 87,486,591 (GRCm39) missense possibly damaging 0.54
R9249:Or5w1 UTSW 2 87,486,660 (GRCm39) missense probably benign 0.10
R9572:Or5w1 UTSW 2 87,486,914 (GRCm39) missense probably benign 0.08
Posted On 2015-12-18