Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02965:Kif18b'

365562

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Kif18b

Ensembl Gene

ENSMUSG00000051378

Gene Name

kinesin family member 18B

Synonyms

3000004C01Rik, N-8 kinesin

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL02965

Quality Score

Status

Chromosome

Chromosomal Location

102905529-102925124 bp(-) (GRCm38)

Type of Mutation

start gained

DNA Base Change (assembly)

A to G at 102916512 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000021311 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000021311]

AlphaFold

Q6PFD6

Predicted Effect

probably benign
Transcript: ENSMUST00000021311

SMART Domains

Protein: ENSMUSP00000021311
Gene: ENSMUSG00000051378

Domain	Start	End	E-Value	Type
KISc	7	361	1.47e-158	SMART
coiled coil region	368	404	N/A	INTRINSIC
low complexity region	510	522	N/A	INTRINSIC
low complexity region	676	682	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000132502

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000181125

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca6	T	C	11: 110,180,613	K1471R	probably benign	Het
Add1	A	G	5: 34,620,123	S77G	probably damaging	Het
Atm	G	T	9: 53,453,563	N2642K	probably damaging	Het
Atp6v0a2	T	A	5: 124,629,202	M10K	possibly damaging	Het
Btd	T	A	14: 31,667,236	S305T	probably damaging	Het
Cmya5	C	T	13: 93,092,557	V2008I	probably benign	Het
Cpd	T	G	11: 76,790,988		probably benign	Het
Dis3l	A	G	9: 64,310,484	F772L	probably damaging	Het
Dlg5	A	T	14: 24,172,023	I517N	probably damaging	Het
Fig4	G	A	10: 41,285,665	T34M	probably damaging	Het
Flna	C	T	X: 74,227,210	V2235I	probably damaging	Het
Flot2	T	C	11: 78,059,205	I371T	possibly damaging	Het
Fsip2	G	A	2: 82,983,054	S3239N	probably benign	Het
Gbp3	A	G	3: 142,567,582	I297V	probably benign	Het
Gcnt3	T	C	9: 70,034,953	E111G	probably benign	Het
Gdi1	G	T	X: 74,307,725	A148S	probably benign	Het
Heatr5b	G	A	17: 78,753,073	H2058Y	probably benign	Het
Hsp90aa1	A	G	12: 110,695,679	M1T	probably null	Het
Iltifb	A	G	10: 118,294,857	S45P	probably damaging	Het
Inppl1	C	A	7: 101,828,271	V715F	possibly damaging	Het
Kansl1	T	C	11: 104,335,165	Y975C	probably damaging	Het
Krt40	T	A	11: 99,541,666	R175W	probably damaging	Het
Map3k19	T	C	1: 127,824,066	D516G	probably damaging	Het
Mfsd3	A	G	15: 76,703,152	H345R	probably benign	Het
Mlkl	A	T	8: 111,331,837	I162N	probably benign	Het
Mtnr1a	A	T	8: 45,069,382	N58I	probably damaging	Het
Nsmf	T	C	2: 25,061,762	V499A	probably damaging	Het
Nudt6	A	G	3: 37,419,506	L22P	probably damaging	Het
Nxf7	T	G	X: 135,589,410	E35A	probably damaging	Het
Olfr748	A	C	14: 50,711,196	I289L	probably damaging	Het
Paf1	T	C	7: 28,396,204		probably null	Het
Pcdhb11	G	T	18: 37,423,968	V784L	probably benign	Het
Pglyrp2	T	C	17: 32,418,586	D156G	probably benign	Het
Pnpt1	A	G	11: 29,156,939	D670G	probably damaging	Het
Polr1b	T	A	2: 129,125,523	H945Q	probably benign	Het
Ptk6	C	T	2: 181,199,068		probably benign	Het
Rftn1	C	T	17: 50,055,252	E273K	probably benign	Het
Rnf125	A	G	18: 20,983,111	I117V	probably benign	Het
Robo4	A	G	9: 37,410,469	K742R	possibly damaging	Het
Sez6l	T	C	5: 112,475,574	E37G	probably damaging	Het
Skint4	A	T	4: 112,136,021	I306L	probably benign	Het
Sntb1	A	T	15: 55,642,685	Y497*	probably null	Het
Snx27	C	A	3: 94,582,426	V42L	probably damaging	Het
Sorbs1	T	A	19: 40,376,743	T199S	probably benign	Het
Sorcs2	A	G	5: 36,077,957	Y72H	probably benign	Het
Spef2	G	T	15: 9,725,106		probably benign	Het
Sucla2	G	T	14: 73,579,431	V204L	probably benign	Het
Tescl	C	A	7: 24,333,673	V76F	probably damaging	Het
Tnxb	T	A	17: 34,709,654	Y2681N	possibly damaging	Het
Usp42	T	C	5: 143,728,014	T2A	probably damaging	Het
Vdac3-ps1	T	A	13: 18,030,846		noncoding transcript	Het
Wapl	T	A	14: 34,739,224		probably benign	Het

Other mutations in Kif18b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00966:Kif18b	APN	11	102914675	missense	probably damaging	0.99
IGL01570:Kif18b	APN	11	102912391	missense	probably benign	0.04
IGL02997:Kif18b	APN	11	102909084	missense	probably damaging	1.00
IGL03135:Kif18b	APN	11	102914260	missense	probably damaging	1.00
IGL02988:Kif18b	UTSW	11	102908320	missense	probably damaging	1.00
R0541:Kif18b	UTSW	11	102915175	missense	probably damaging	0.98
R1446:Kif18b	UTSW	11	102914699	missense	probably damaging	0.99
R1674:Kif18b	UTSW	11	102913060	missense	probably benign	0.04
R1729:Kif18b	UTSW	11	102915541	critical splice donor site	probably null
R1784:Kif18b	UTSW	11	102915541	critical splice donor site	probably null
R2249:Kif18b	UTSW	11	102912388	missense	probably benign	0.01
R2291:Kif18b	UTSW	11	102908270	missense	probably damaging	1.00
R3723:Kif18b	UTSW	11	102916276	missense	probably damaging	1.00
R5496:Kif18b	UTSW	11	102913742	missense	possibly damaging	0.88
R5500:Kif18b	UTSW	11	102915700	missense	probably damaging	1.00
R5598:Kif18b	UTSW	11	102908189	missense	possibly damaging	0.89
R5820:Kif18b	UTSW	11	102913048	missense	probably benign	0.00
R5910:Kif18b	UTSW	11	102913544	missense	probably benign
R5912:Kif18b	UTSW	11	102912991	missense	probably benign
R6394:Kif18b	UTSW	11	102914410	missense	probably damaging	1.00
R6541:Kif18b	UTSW	11	102914266	missense	probably damaging	1.00
R6911:Kif18b	UTSW	11	102916380	missense	probably damaging	0.96
R7467:Kif18b	UTSW	11	102916408	missense	probably damaging	1.00
R7467:Kif18b	UTSW	11	102912348	splice site	probably null
R7526:Kif18b	UTSW	11	102914667	missense	probably damaging	1.00
R7581:Kif18b	UTSW	11	102914722	missense	probably damaging	1.00
R8314:Kif18b	UTSW	11	102913074	missense	probably benign
R8378:Kif18b	UTSW	11	102916473	missense	probably damaging	1.00
RF013:Kif18b	UTSW	11	102912366	missense	probably benign	0.00
Z1088:Kif18b	UTSW	11	102908157	missense	probably benign

Posted On

2015-12-18