Incidental Mutation 'IGL02966:Lrrc40'
ID 365619
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lrrc40
Ensembl Gene ENSMUSG00000063052
Gene Name leucine rich repeat containing 40
Synonyms 2610040E16Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.141) question?
Stock # IGL02966
Quality Score
Status
Chromosome 3
Chromosomal Location 157742319-157772727 bp(+) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) G to A at 157747302 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000143518 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072080] [ENSMUST00000150525] [ENSMUST00000156597] [ENSMUST00000200540]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000072080
SMART Domains Protein: ENSMUSP00000071956
Gene: ENSMUSG00000063052

DomainStartEndE-ValueType
LRR 81 100 7.11e1 SMART
LRR 104 126 6.13e-1 SMART
LRR 127 149 1.51e0 SMART
LRR_TYP 150 172 8.47e-4 SMART
LRR 173 195 3.52e-1 SMART
LRR_TYP 196 219 2.91e-2 SMART
LRR 242 261 9.15e0 SMART
LRR 265 287 1.01e2 SMART
LRR 288 310 1.86e1 SMART
LRR 311 334 2.32e-1 SMART
LRR 335 356 2.21e2 SMART
LRR 471 493 1.86e0 SMART
LRR 494 517 8.97e0 SMART
LRR 541 564 1.53e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000123028
SMART Domains Protein: ENSMUSP00000121905
Gene: ENSMUSG00000063052

DomainStartEndE-ValueType
SCOP:d1fqva2 37 68 3e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000131518
SMART Domains Protein: ENSMUSP00000121417
Gene: ENSMUSG00000063052

DomainStartEndE-ValueType
SCOP:d1fqva2 80 110 2e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000150525
SMART Domains Protein: ENSMUSP00000116475
Gene: ENSMUSG00000063052

DomainStartEndE-ValueType
SCOP:d1fqva2 81 111 3e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000156597
Predicted Effect probably benign
Transcript: ENSMUST00000200540
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930595M18Rik A T X: 80,463,317 (GRCm39) Y797N possibly damaging Het
Actbl2 G A 13: 111,392,106 (GRCm39) G147E probably damaging Het
Adam18 A T 8: 25,101,165 (GRCm39) probably benign Het
Ahcyl2 G A 6: 29,880,556 (GRCm39) V175I probably benign Het
Alox12 T A 11: 70,140,911 (GRCm39) T375S probably damaging Het
Batf2 C A 19: 6,221,819 (GRCm39) Q210K probably damaging Het
Bicd1 T C 6: 149,385,494 (GRCm39) S76P probably damaging Het
Bphl A T 13: 34,247,980 (GRCm39) H251L probably damaging Het
C130074G19Rik C A 1: 184,614,943 (GRCm39) E82D probably damaging Het
Calu A T 6: 29,356,584 (GRCm39) K39* probably null Het
Capns1 T C 7: 29,891,618 (GRCm39) D142G probably damaging Het
Ccr8 T C 9: 119,923,206 (GRCm39) V107A probably damaging Het
Cep170b G A 12: 112,702,878 (GRCm39) G447D possibly damaging Het
Chat C T 14: 32,170,903 (GRCm39) V199M probably damaging Het
Cntnap1 G T 11: 101,075,575 (GRCm39) V918L probably damaging Het
Cyp27a1 A G 1: 74,771,249 (GRCm39) T145A probably benign Het
Dgkq T A 5: 108,804,287 (GRCm39) probably null Het
Dnhd1 A G 7: 105,369,948 (GRCm39) I4458V probably benign Het
Enpp1 T A 10: 24,536,172 (GRCm39) E409D probably damaging Het
Fam78b G T 1: 166,906,457 (GRCm39) L205F probably damaging Het
Foxr2 C A X: 151,913,677 (GRCm39) R183S probably damaging Het
Ganc T C 2: 120,264,129 (GRCm39) S361P probably damaging Het
Gfra4 C A 2: 130,884,560 (GRCm39) A15S possibly damaging Het
Gm8011 A T 14: 42,287,957 (GRCm39) D145V unknown Het
Gnb4 A G 3: 32,639,372 (GRCm39) V307A probably benign Het
Hdac4 A T 1: 91,982,667 (GRCm39) V17E possibly damaging Het
Herc6 G A 6: 57,560,318 (GRCm39) probably null Het
Hivep3 A G 4: 119,989,383 (GRCm39) T1945A probably benign Het
Ica1l A T 1: 60,049,298 (GRCm39) N218K probably damaging Het
Kmt2b A T 7: 30,274,887 (GRCm39) L1939Q probably benign Het
Marchf8 C T 6: 116,380,499 (GRCm39) R117C probably damaging Het
Megf6 T C 4: 154,338,234 (GRCm39) S327P probably damaging Het
Mocos T G 18: 24,809,668 (GRCm39) C424G probably damaging Het
Mrpl50 A G 4: 49,521,014 (GRCm39) W14R probably benign Het
Mysm1 A T 4: 94,863,523 (GRCm39) D23E probably benign Het
Naa35 T A 13: 59,734,085 (GRCm39) D34E probably benign Het
Nid1 A G 13: 13,656,806 (GRCm39) I646V probably benign Het
Nupr1 T C 7: 126,224,073 (GRCm39) probably benign Het
Or2aj6 G T 16: 19,443,051 (GRCm39) H266Q probably damaging Het
Or5b24 A T 19: 12,912,164 (GRCm39) I21F probably benign Het
Or8b12b T G 9: 37,684,882 (GRCm39) L309R probably benign Het
Pcbp2 A C 15: 102,392,684 (GRCm39) probably benign Het
Pde8b T C 13: 95,232,156 (GRCm39) Q158R probably damaging Het
Pdzd8 T C 19: 59,289,291 (GRCm39) Y703C probably damaging Het
Plxnb3 T C X: 72,808,889 (GRCm39) S885P probably benign Het
Poc1b T A 10: 98,980,176 (GRCm39) C136S probably damaging Het
Pole2 T C 12: 69,256,649 (GRCm39) D292G probably damaging Het
Prpf39 T C 12: 65,089,553 (GRCm39) V97A probably benign Het
Rbbp8 T A 18: 11,838,869 (GRCm39) H183Q possibly damaging Het
Scn2a C T 2: 65,532,188 (GRCm39) T600M possibly damaging Het
Spata32 T C 11: 103,099,629 (GRCm39) Q292R possibly damaging Het
Sugp1 T C 8: 70,523,758 (GRCm39) probably benign Het
Sult3a1 A C 10: 33,753,269 (GRCm39) probably benign Het
Tpm3-rs7 C T 14: 113,552,810 (GRCm39) Q235* probably null Het
Trbv2 A T 6: 41,024,685 (GRCm39) T34S possibly damaging Het
Tssk6 A G 8: 70,355,535 (GRCm39) Y193C probably benign Het
Ttn T C 2: 76,538,802 (GRCm39) K34676R possibly damaging Het
Ugt3a1 T C 15: 9,370,154 (GRCm39) Y433H probably damaging Het
Wdhd1 T C 14: 47,479,101 (GRCm39) K1072E possibly damaging Het
Other mutations in Lrrc40
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00432:Lrrc40 APN 3 157,754,087 (GRCm39) missense probably damaging 1.00
IGL00501:Lrrc40 APN 3 157,766,919 (GRCm39) missense probably damaging 0.96
IGL00727:Lrrc40 APN 3 157,769,508 (GRCm39) critical splice donor site probably null
IGL01349:Lrrc40 APN 3 157,764,302 (GRCm39) splice site probably benign
IGL02377:Lrrc40 APN 3 157,742,365 (GRCm39) start codon destroyed probably null 1.00
IGL02490:Lrrc40 APN 3 157,768,336 (GRCm39) missense probably damaging 1.00
IGL02657:Lrrc40 APN 3 157,742,410 (GRCm39) missense probably damaging 1.00
IGL02879:Lrrc40 APN 3 157,747,302 (GRCm39) intron probably benign
IGL02944:Lrrc40 APN 3 157,747,302 (GRCm39) intron probably benign
IGL02954:Lrrc40 APN 3 157,747,302 (GRCm39) intron probably benign
IGL03004:Lrrc40 APN 3 157,747,302 (GRCm39) intron probably benign
IGL03032:Lrrc40 APN 3 157,747,302 (GRCm39) intron probably benign
IGL03112:Lrrc40 APN 3 157,747,302 (GRCm39) intron probably benign
IGL03163:Lrrc40 APN 3 157,747,224 (GRCm39) missense possibly damaging 0.82
I2288:Lrrc40 UTSW 3 157,758,426 (GRCm39) missense probably damaging 1.00
R0266:Lrrc40 UTSW 3 157,747,298 (GRCm39) critical splice donor site probably null
R0355:Lrrc40 UTSW 3 157,746,108 (GRCm39) missense probably damaging 0.99
R0457:Lrrc40 UTSW 3 157,760,201 (GRCm39) splice site probably null
R0968:Lrrc40 UTSW 3 157,742,426 (GRCm39) missense probably damaging 1.00
R1799:Lrrc40 UTSW 3 157,742,441 (GRCm39) missense probably benign 0.38
R1962:Lrrc40 UTSW 3 157,746,086 (GRCm39) missense probably benign 0.01
R4614:Lrrc40 UTSW 3 157,760,271 (GRCm39) missense probably damaging 1.00
R4825:Lrrc40 UTSW 3 157,766,967 (GRCm39) nonsense probably null
R4857:Lrrc40 UTSW 3 157,771,866 (GRCm39) utr 3 prime probably benign
R4947:Lrrc40 UTSW 3 157,769,472 (GRCm39) missense probably benign 0.00
R5148:Lrrc40 UTSW 3 157,760,206 (GRCm39) splice site probably null
R5673:Lrrc40 UTSW 3 157,754,035 (GRCm39) splice site probably null
R6354:Lrrc40 UTSW 3 157,766,901 (GRCm39) nonsense probably null
R6382:Lrrc40 UTSW 3 157,764,333 (GRCm39) missense probably damaging 0.98
R6713:Lrrc40 UTSW 3 157,769,350 (GRCm39) missense probably benign 0.00
R7081:Lrrc40 UTSW 3 157,742,442 (GRCm39) missense probably damaging 0.98
R7098:Lrrc40 UTSW 3 157,747,276 (GRCm39) missense probably benign 0.29
R7484:Lrrc40 UTSW 3 157,746,194 (GRCm39) missense probably benign 0.14
R8043:Lrrc40 UTSW 3 157,769,397 (GRCm39) missense possibly damaging 0.81
R8093:Lrrc40 UTSW 3 157,757,419 (GRCm39) nonsense probably null
R8461:Lrrc40 UTSW 3 157,764,371 (GRCm39) missense possibly damaging 0.66
R9564:Lrrc40 UTSW 3 157,746,078 (GRCm39) missense probably benign 0.27
V1662:Lrrc40 UTSW 3 157,758,426 (GRCm39) missense probably damaging 1.00
Posted On 2015-12-18