Incidental Mutation 'IGL02968:Olfr670'
ID365698
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr670
Ensembl Gene ENSMUSG00000044705
Gene Nameolfactory receptor 670
SynonymsMOR32-8, GA_x6K02T2PBJ9-7589577-7588639
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.061) question?
Stock #IGL02968
Quality Score
Status
Chromosome7
Chromosomal Location104957114-104962620 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 104960244 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 163 (F163I)
Ref Sequence ENSEMBL: ENSMUSP00000151138 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050482] [ENSMUST00000214216]
Predicted Effect possibly damaging
Transcript: ENSMUST00000050482
AA Change: F163I

PolyPhen 2 Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000060289
Gene: ENSMUSG00000044705
AA Change: F163I

DomainStartEndE-ValueType
Pfam:7tm_4 33 311 3.7e-121 PFAM
Pfam:7TM_GPCR_Srsx 37 211 4.5e-7 PFAM
Pfam:7tm_1 43 293 3.9e-17 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214216
AA Change: F163I

PolyPhen 2 Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930590J08Rik A T 6: 91,923,473 D441V probably damaging Het
Abcd1 T C X: 73,717,058 S10P possibly damaging Het
Acad12 T C 5: 121,610,038 S106G probably benign Het
C1s1 T C 6: 124,540,351 T127A probably damaging Het
Cela3a A G 4: 137,403,821 V202A probably damaging Het
Cenpu T C 8: 46,556,195 probably null Het
Dusp9 T C X: 73,641,433 S222P probably benign Het
Exoc5 A G 14: 49,033,269 probably null Het
Foxp1 G T 6: 99,075,861 A90D probably damaging Het
Krt12 G T 11: 99,418,017 A398E probably damaging Het
Mtss1 G T 15: 58,956,515 T183K possibly damaging Het
Napa T C 7: 16,113,341 probably benign Het
Nlrp2 T C 7: 5,301,025 E167G possibly damaging Het
Nos2 T C 11: 78,937,637 Y148H probably damaging Het
Olfr224 T C 11: 58,567,195 D50G possibly damaging Het
Olfr611 C T 7: 103,518,259 V42M probably damaging Het
Pde7a G A 3: 19,243,121 R122* probably null Het
Pkdrej A T 15: 85,816,181 Y1851* probably null Het
Rbl1 C T 2: 157,177,274 R517H probably damaging Het
Rnf10 A T 5: 115,245,888 S661T probably benign Het
Ryr1 T C 7: 29,043,893 D3886G probably damaging Het
Samd9l A G 6: 3,376,026 Y412H probably damaging Het
Scarf1 T C 11: 75,524,089 S530P probably damaging Het
Spam1 A G 6: 24,796,443 E131G possibly damaging Het
Tmem185b C A 1: 119,527,121 A204E possibly damaging Het
Tshz3 A G 7: 36,769,824 K413E probably damaging Het
Vps13d A G 4: 145,122,498 S2448P probably benign Het
Xkr5 T C 8: 18,933,625 S634G probably benign Het
Zic1 G A 9: 91,362,490 T372M probably damaging Het
Other mutations in Olfr670
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00978:Olfr670 APN 7 104960716 missense probably damaging 0.96
IGL01100:Olfr670 APN 7 104959995 missense probably benign 0.07
IGL01351:Olfr670 APN 7 104960739 start gained probably benign
IGL01478:Olfr670 APN 7 104960348 missense probably damaging 0.97
IGL01835:Olfr670 APN 7 104960462 missense probably benign 0.01
IGL02326:Olfr670 APN 7 104960646 missense probably benign 0.12
IGL02434:Olfr670 APN 7 104960072 missense probably benign 0.05
IGL02434:Olfr670 APN 7 104960074 nonsense probably null
R0055:Olfr670 UTSW 7 104960496 missense possibly damaging 0.46
R0055:Olfr670 UTSW 7 104960496 missense possibly damaging 0.46
R0345:Olfr670 UTSW 7 104960181 missense probably damaging 1.00
R0401:Olfr670 UTSW 7 104959943 missense probably damaging 1.00
R0646:Olfr670 UTSW 7 104959811 missense probably benign 0.02
R1493:Olfr670 UTSW 7 104960502 missense probably damaging 0.97
R1532:Olfr670 UTSW 7 104960265 missense probably benign
R1557:Olfr670 UTSW 7 104960540 missense probably damaging 0.99
R4072:Olfr670 UTSW 7 104960716 missense probably damaging 0.96
R4074:Olfr670 UTSW 7 104960716 missense probably damaging 0.96
R4075:Olfr670 UTSW 7 104960716 missense probably damaging 0.96
R4076:Olfr670 UTSW 7 104960716 missense probably damaging 0.96
R4229:Olfr670 UTSW 7 104960594 missense probably benign 0.18
R4230:Olfr670 UTSW 7 104960594 missense probably benign 0.18
R5374:Olfr670 UTSW 7 104959996 missense probably damaging 1.00
R6006:Olfr670 UTSW 7 104960663 missense probably damaging 0.99
R6891:Olfr670 UTSW 7 104959985 missense probably damaging 1.00
R7465:Olfr670 UTSW 7 104959917 missense probably benign 0.23
Posted On2015-12-18