Incidental Mutation 'R0410:Vmn2r13'
| ID |
36575 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r13
|
| Ensembl Gene |
ENSMUSG00000091635 |
| Gene Name |
vomeronasal 2, receptor 13 |
| Synonyms |
Gm4867 |
| MMRRC Submission |
038612-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.081)
|
| Stock # |
R0410 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
109303889-109339973 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 109321679 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Asparagine
at position 339
(K339N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000052977
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000053253]
|
| AlphaFold |
L7N1X2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000053253
AA Change: K339N
PolyPhen 2
Score 0.350 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000052977
Gene: ENSMUSG00000091635
AA Change: K339N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
76 |
463 |
2.8e-29 |
PFAM |
|
Pfam:NCD3G
|
506 |
560 |
1.3e-18 |
PFAM |
|
Pfam:7tm_3
|
593 |
828 |
1.8e-54 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.1%
- 20x: 95.1%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 70 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4833420G17Rik |
A |
G |
13: 119,606,268 (GRCm39) |
D170G |
probably benign |
Het |
| Actrt3 |
C |
T |
3: 30,652,273 (GRCm39) |
G274S |
probably benign |
Het |
| Adamts18 |
G |
T |
8: 114,440,990 (GRCm39) |
C889* |
probably null |
Het |
| Alkbh6 |
C |
T |
7: 30,012,031 (GRCm39) |
P104S |
probably damaging |
Het |
| Alms1 |
A |
T |
6: 85,564,785 (GRCm39) |
E53V |
unknown |
Het |
| Ap3s1 |
T |
C |
18: 46,912,279 (GRCm39) |
C100R |
probably benign |
Het |
| Apbb2 |
G |
T |
5: 66,609,149 (GRCm39) |
A166E |
possibly damaging |
Het |
| Asph |
A |
G |
4: 9,595,415 (GRCm39) |
V174A |
probably damaging |
Het |
| Cacna2d2 |
T |
C |
9: 107,401,819 (GRCm39) |
L758P |
probably damaging |
Het |
| Cacng5 |
A |
G |
11: 107,768,195 (GRCm39) |
S271P |
possibly damaging |
Het |
| Camta1 |
C |
A |
4: 151,159,597 (GRCm39) |
R1614L |
probably damaging |
Het |
| Chn1 |
A |
T |
2: 73,462,094 (GRCm39) |
C236* |
probably null |
Het |
| Coro1b |
T |
C |
19: 4,199,362 (GRCm39) |
V7A |
probably damaging |
Het |
| Dhx16 |
A |
G |
17: 36,201,859 (GRCm39) |
Y962C |
probably damaging |
Het |
| Dixdc1 |
T |
C |
9: 50,596,153 (GRCm39) |
D152G |
probably damaging |
Het |
| Dmrt1 |
T |
C |
19: 25,483,467 (GRCm39) |
S84P |
probably damaging |
Het |
| Dnah10 |
A |
G |
5: 124,832,799 (GRCm39) |
D844G |
probably benign |
Het |
| Edn3 |
C |
T |
2: 174,603,482 (GRCm39) |
P77S |
possibly damaging |
Het |
| Efcab7 |
T |
C |
4: 99,735,487 (GRCm39) |
|
probably null |
Het |
| Fam83g |
A |
G |
11: 61,594,218 (GRCm39) |
D584G |
probably damaging |
Het |
| Fbxo7 |
T |
A |
10: 85,865,102 (GRCm39) |
|
probably null |
Het |
| Ffar1 |
T |
C |
7: 30,560,055 (GRCm39) |
T281A |
probably benign |
Het |
| Fntb |
T |
C |
12: 76,934,826 (GRCm39) |
V201A |
probably benign |
Het |
| Gart |
C |
A |
16: 91,438,215 (GRCm39) |
A101S |
probably damaging |
Het |
| Gbp9 |
T |
C |
5: 105,232,939 (GRCm39) |
T238A |
probably benign |
Het |
| Hectd4 |
T |
C |
5: 121,424,329 (GRCm39) |
L663S |
possibly damaging |
Het |
| Helz2 |
A |
T |
2: 180,872,386 (GRCm39) |
V2512E |
probably damaging |
Het |
| Hip1 |
A |
C |
5: 135,487,009 (GRCm39) |
L66R |
probably damaging |
Het |
| Iigp1 |
T |
A |
18: 60,523,375 (GRCm39) |
D164E |
probably benign |
Het |
| Kcnip3 |
A |
G |
2: 127,301,986 (GRCm39) |
S193P |
probably damaging |
Het |
| Klra9 |
T |
A |
6: 130,165,707 (GRCm39) |
T103S |
probably benign |
Het |
| Meis2 |
T |
C |
2: 115,694,709 (GRCm39) |
*471W |
probably null |
Het |
| Minar1 |
T |
G |
9: 89,484,256 (GRCm39) |
E380D |
probably damaging |
Het |
| Mrpl21 |
T |
C |
19: 3,334,792 (GRCm39) |
S45P |
possibly damaging |
Het |
| Mterf1b |
A |
G |
5: 4,246,488 (GRCm39) |
E43G |
probably benign |
Het |
| Mycbp2 |
G |
T |
14: 103,372,569 (GRCm39) |
S4092R |
probably damaging |
Het |
| Nfatc3 |
A |
T |
8: 106,822,828 (GRCm39) |
N538I |
probably damaging |
Het |
| Nphp4 |
T |
C |
4: 152,641,503 (GRCm39) |
C1095R |
probably benign |
Het |
| Npm2 |
T |
A |
14: 70,889,993 (GRCm39) |
T13S |
probably benign |
Het |
| Or1m1 |
C |
A |
9: 18,666,137 (GRCm39) |
V265F |
probably damaging |
Het |
| Or7e176 |
T |
A |
9: 20,171,797 (GRCm39) |
F220L |
probably benign |
Het |
| Plcg2 |
A |
T |
8: 118,342,112 (GRCm39) |
I1158F |
probably damaging |
Het |
| Popdc3 |
T |
C |
10: 45,193,829 (GRCm39) |
V210A |
possibly damaging |
Het |
| Postn |
T |
C |
3: 54,292,698 (GRCm39) |
L755S |
possibly damaging |
Het |
| Prdx6b |
T |
C |
2: 80,123,373 (GRCm39) |
F61L |
probably damaging |
Het |
| Rars1 |
C |
T |
11: 35,716,847 (GRCm39) |
R223H |
probably damaging |
Het |
| Robo1 |
G |
A |
16: 72,768,872 (GRCm39) |
G479D |
possibly damaging |
Het |
| Scaf4 |
A |
G |
16: 90,057,058 (GRCm39) |
Y98H |
unknown |
Het |
| Scn4a |
A |
G |
11: 106,214,775 (GRCm39) |
I1274T |
probably damaging |
Het |
| Senp2 |
G |
T |
16: 21,828,444 (GRCm39) |
R18L |
probably damaging |
Het |
| Six5 |
T |
A |
7: 18,830,381 (GRCm39) |
V336D |
probably damaging |
Het |
| Slc31a2 |
G |
A |
4: 62,210,890 (GRCm39) |
E8K |
probably benign |
Het |
| Slc4a7 |
A |
T |
14: 14,738,299 (GRCm38) |
T184S |
probably damaging |
Het |
| Slco2a1 |
T |
A |
9: 102,950,513 (GRCm39) |
|
probably null |
Het |
| Smr3a |
T |
G |
5: 88,156,070 (GRCm39) |
|
probably benign |
Het |
| Sqor |
T |
C |
2: 122,629,442 (GRCm39) |
V100A |
probably benign |
Het |
| Srarp |
T |
C |
4: 141,160,459 (GRCm39) |
N125D |
possibly damaging |
Het |
| Stam |
T |
C |
2: 14,143,802 (GRCm39) |
V364A |
probably benign |
Het |
| Tgm5 |
T |
C |
2: 120,908,039 (GRCm39) |
I46V |
possibly damaging |
Het |
| Tie1 |
A |
T |
4: 118,337,766 (GRCm39) |
V443E |
probably damaging |
Het |
| Tipin |
T |
C |
9: 64,195,397 (GRCm39) |
M1T |
probably null |
Het |
| Tnc |
T |
C |
4: 63,925,931 (GRCm39) |
T950A |
probably benign |
Het |
| Tns3 |
T |
C |
11: 8,385,852 (GRCm39) |
D1382G |
probably benign |
Het |
| Tor1aip1 |
A |
G |
1: 155,911,686 (GRCm39) |
V99A |
possibly damaging |
Het |
| Trim16 |
C |
T |
11: 62,711,297 (GRCm39) |
|
probably benign |
Het |
| Ttn |
G |
T |
2: 76,618,701 (GRCm39) |
N14448K |
possibly damaging |
Het |
| Ttn |
C |
T |
2: 76,717,204 (GRCm39) |
|
probably benign |
Het |
| Tut4 |
A |
G |
4: 108,343,752 (GRCm39) |
R255G |
probably benign |
Het |
| Vmn1r23 |
A |
G |
6: 57,903,175 (GRCm39) |
I201T |
probably benign |
Het |
| Yap1 |
A |
G |
9: 8,001,468 (GRCm39) |
Y173H |
probably damaging |
Het |
|
| Other mutations in Vmn2r13 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00965:Vmn2r13
|
APN |
5 |
109,303,964 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01373:Vmn2r13
|
APN |
5 |
109,304,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01946:Vmn2r13
|
APN |
5 |
109,322,085 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01971:Vmn2r13
|
APN |
5 |
109,321,981 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02636:Vmn2r13
|
APN |
5 |
109,339,883 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03062:Vmn2r13
|
APN |
5 |
109,304,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03173:Vmn2r13
|
APN |
5 |
109,319,645 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03301:Vmn2r13
|
APN |
5 |
109,305,955 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03383:Vmn2r13
|
APN |
5 |
109,304,398 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03048:Vmn2r13
|
UTSW |
5 |
109,304,151 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0123:Vmn2r13
|
UTSW |
5 |
109,322,915 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0134:Vmn2r13
|
UTSW |
5 |
109,322,915 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0220:Vmn2r13
|
UTSW |
5 |
109,304,332 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0225:Vmn2r13
|
UTSW |
5 |
109,322,915 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0393:Vmn2r13
|
UTSW |
5 |
109,304,395 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0787:Vmn2r13
|
UTSW |
5 |
109,304,713 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1200:Vmn2r13
|
UTSW |
5 |
109,322,068 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1448:Vmn2r13
|
UTSW |
5 |
109,322,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1782:Vmn2r13
|
UTSW |
5 |
109,306,040 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1939:Vmn2r13
|
UTSW |
5 |
109,339,852 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R2029:Vmn2r13
|
UTSW |
5 |
109,339,943 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2125:Vmn2r13
|
UTSW |
5 |
109,306,058 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2126:Vmn2r13
|
UTSW |
5 |
109,306,058 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2379:Vmn2r13
|
UTSW |
5 |
109,319,644 (GRCm39) |
missense |
probably benign |
0.05 |
|
R2680:Vmn2r13
|
UTSW |
5 |
109,322,178 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R2888:Vmn2r13
|
UTSW |
5 |
109,339,840 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R2889:Vmn2r13
|
UTSW |
5 |
109,339,840 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R2890:Vmn2r13
|
UTSW |
5 |
109,339,840 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R3014:Vmn2r13
|
UTSW |
5 |
109,319,627 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R3683:Vmn2r13
|
UTSW |
5 |
109,304,721 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4074:Vmn2r13
|
UTSW |
5 |
109,304,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4599:Vmn2r13
|
UTSW |
5 |
109,304,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4614:Vmn2r13
|
UTSW |
5 |
109,323,065 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4805:Vmn2r13
|
UTSW |
5 |
109,304,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4822:Vmn2r13
|
UTSW |
5 |
109,321,938 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4943:Vmn2r13
|
UTSW |
5 |
109,322,915 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5263:Vmn2r13
|
UTSW |
5 |
109,321,841 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5297:Vmn2r13
|
UTSW |
5 |
109,339,805 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5502:Vmn2r13
|
UTSW |
5 |
109,321,580 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5554:Vmn2r13
|
UTSW |
5 |
109,339,860 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R5563:Vmn2r13
|
UTSW |
5 |
109,321,846 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5819:Vmn2r13
|
UTSW |
5 |
109,321,966 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R6074:Vmn2r13
|
UTSW |
5 |
109,322,167 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6416:Vmn2r13
|
UTSW |
5 |
109,321,982 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6419:Vmn2r13
|
UTSW |
5 |
109,323,085 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6484:Vmn2r13
|
UTSW |
5 |
109,304,540 (GRCm39) |
nonsense |
probably null |
|
|
R6486:Vmn2r13
|
UTSW |
5 |
109,304,425 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6545:Vmn2r13
|
UTSW |
5 |
109,304,806 (GRCm39) |
splice site |
probably null |
|
|
R6700:Vmn2r13
|
UTSW |
5 |
109,322,938 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6897:Vmn2r13
|
UTSW |
5 |
109,306,015 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6957:Vmn2r13
|
UTSW |
5 |
109,304,753 (GRCm39) |
nonsense |
probably null |
|
|
R7276:Vmn2r13
|
UTSW |
5 |
109,321,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7363:Vmn2r13
|
UTSW |
5 |
109,339,909 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7443:Vmn2r13
|
UTSW |
5 |
109,339,909 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7555:Vmn2r13
|
UTSW |
5 |
109,319,557 (GRCm39) |
splice site |
probably null |
|
|
R7607:Vmn2r13
|
UTSW |
5 |
109,321,506 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7719:Vmn2r13
|
UTSW |
5 |
109,319,618 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8116:Vmn2r13
|
UTSW |
5 |
109,322,926 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8242:Vmn2r13
|
UTSW |
5 |
109,322,872 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R8294:Vmn2r13
|
UTSW |
5 |
109,322,978 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8340:Vmn2r13
|
UTSW |
5 |
109,322,006 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8692:Vmn2r13
|
UTSW |
5 |
109,319,514 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8742:Vmn2r13
|
UTSW |
5 |
109,304,263 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9022:Vmn2r13
|
UTSW |
5 |
109,304,242 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9281:Vmn2r13
|
UTSW |
5 |
109,303,953 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9529:Vmn2r13
|
UTSW |
5 |
109,304,064 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9708:Vmn2r13
|
UTSW |
5 |
109,322,007 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9746:Vmn2r13
|
UTSW |
5 |
109,339,773 (GRCm39) |
critical splice donor site |
probably null |
|
|
X0066:Vmn2r13
|
UTSW |
5 |
109,304,085 (GRCm39) |
missense |
probably benign |
0.44 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGGTGTGGGCCACAGCATATACAG -3'
(R):5'- GCTGAGTGACCATGACCAGTTTCC -3'
Sequencing Primer
(F):5'- CAGCATTATACAGATTGTAACCTTCC -3'
(R):5'- TCATCTCAGATGATGACCAAGG -3'
|
| Posted On |
2013-05-09 |
Incidental Mutation