Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02971:Vmn2r121'

365791

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r121

Ensembl Gene

ENSMUSG00000072049

Gene Name

vomeronasal 2, receptor 121

Synonyms

EG625699

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

IGL02971

Quality Score

Status

Chromosome

Chromosomal Location

124127339-124135910 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 124127894 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Leucine at position 810 (I810L)

Ref Sequence

ENSEMBL: ENSMUSP00000092067 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094491]

AlphaFold

A2BE32

Predicted Effect

probably damaging
Transcript: ENSMUST00000094491
AA Change: I810L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000092067
Gene: ENSMUSG00000072049
AA Change: I810L

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:ANF_receptor	75	448	3.2e-26	PFAM
Pfam:NCD3G	506	560	2.1e-19	PFAM
Pfam:7tm_3	593	828	3.8e-56	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A930018P22Rik	C	T	2: 104,123,219	T130I	probably benign	Het
Ahi1	T	C	10: 21,000,551	L787P	possibly damaging	Het
Atf3	A	G	1: 191,177,443	S10P	probably benign	Het
Cdr2l	A	G	11: 115,390,900	N77S	probably damaging	Het
Cnp	A	G	11: 100,576,699	D156G	probably benign	Het
Cntn3	A	T	6: 102,168,933	D982E	probably damaging	Het
Col22a1	A	G	15: 72,006,738	L190S	probably damaging	Het
Csmd3	C	T	15: 47,913,929		probably benign	Het
Dnah5	A	G	15: 28,384,461	D3117G	probably damaging	Het
Dock5	T	C	14: 67,757,109	E1834G	probably null	Het
Eea1	A	G	10: 96,041,527	T1368A	probably benign	Het
Fam83f	T	C	15: 80,672,149	V78A	probably benign	Het
Fcgbp	G	A	7: 28,101,473	V1315I	probably damaging	Het
Fsd2	A	T	7: 81,548,923	Y364*	probably null	Het
Gm21976	G	A	13: 98,302,549	G16R	probably null	Het
Guca2b	A	G	4: 119,657,688	S59P	probably damaging	Het
Hars2	A	G	18: 36,786,178	E123G	probably damaging	Het
Hdac2	A	T	10: 37,000,374	K462*	probably null	Het
Huwe1	T	A	X: 151,927,626		probably benign	Het
Iqgap3	T	A	3: 88,090,304	N262K	probably benign	Het
Kat6b	A	G	14: 21,669,758	S1502G	probably damaging	Het
Mapkapk3	A	T	9: 107,257,080	D328E	probably benign	Het
Mgea5	A	G	19: 45,762,243	F671S	probably damaging	Het
Naca	C	T	10: 128,041,568		probably benign	Het
Npffr1	T	C	10: 61,614,139	V64A	probably damaging	Het
Olfr331	A	G	11: 58,502,385	L57P	probably damaging	Het
Olfr918	T	A	9: 38,673,268	M72L	probably damaging	Het
Pcca	A	G	14: 122,889,533	D718G	probably damaging	Het
Pde6a	A	C	18: 61,264,255	D670A	probably damaging	Het
Pramel7	T	A	2: 87,490,073	E292V	probably benign	Het
Prmt9	A	C	8: 77,565,069	M357L	probably benign	Het
Ptgfr	A	T	3: 151,835,326	S182T	probably benign	Het
Rtraf	A	T	14: 19,816,192	M152K	possibly damaging	Het
Satb1	T	C	17: 51,742,689	D579G	possibly damaging	Het
Serpinb6a	A	G	13: 33,931,470		probably null	Het
Slc5a9	T	C	4: 111,890,300	I297V	possibly damaging	Het
Slf1	T	A	13: 77,047,104		probably benign	Het
St8sia2	C	T	7: 73,966,811	V139M	probably damaging	Het
Tas2r114	T	C	6: 131,689,280	M262V	probably benign	Het
Tmem147	A	G	7: 30,729,422		probably benign	Het
Tmem220	A	G	11: 67,034,107		probably null	Het
Uspl1	A	G	5: 149,188,346	N35S	possibly damaging	Het
Vmn1r170	A	T	7: 23,606,334	I54F	possibly damaging	Het
Wbp2nl	A	T	15: 82,305,744	T46S	possibly damaging	Het
Zfp955b	T	A	17: 33,300,966	M57K	probably benign	Het

Other mutations in Vmn2r121

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Vmn2r121	APN	X	124127802	missense	probably benign	0.04
IGL00990:Vmn2r121	APN	X	124127783	missense	possibly damaging	0.95
IGL00990:Vmn2r121	APN	X	124133716	missense	probably benign	0.00
IGL01125:Vmn2r121	APN	X	124132807	missense	probably damaging	0.99
IGL01450:Vmn2r121	APN	X	124131191	missense	possibly damaging	0.57
IGL01619:Vmn2r121	APN	X	124132300	missense	probably benign
IGL01797:Vmn2r121	APN	X	124131351	splice site	probably benign
IGL02227:Vmn2r121	APN	X	124132681	missense	probably benign	0.44
IGL03058:Vmn2r121	APN	X	124132921	missense	probably benign	0.00
IGL03142:Vmn2r121	APN	X	124132938	missense	possibly damaging	0.94
IGL03183:Vmn2r121	APN	X	124132326	missense	probably benign	0.03
E0370:Vmn2r121	UTSW	X	124127920	missense	probably benign	0.01
R0196:Vmn2r121	UTSW	X	124132182	missense	probably benign	0.03
R1381:Vmn2r121	UTSW	X	124128140	missense	probably damaging	1.00
R1399:Vmn2r121	UTSW	X	124129848	missense	possibly damaging	0.94
R1423:Vmn2r121	UTSW	X	124129905	missense	possibly damaging	0.52
R1687:Vmn2r121	UTSW	X	124132791	missense	probably benign	0.39
R2121:Vmn2r121	UTSW	X	124133742	splice site	probably null
R2124:Vmn2r121	UTSW	X	124133742	splice site	probably null
R3151:Vmn2r121	UTSW	X	124131152	missense	probably benign	0.20
R4460:Vmn2r121	UTSW	X	124128584	missense	probably benign	0.01
R4735:Vmn2r121	UTSW	X	124128638	missense	probably benign
R5332:Vmn2r121	UTSW	X	124133575	missense	probably benign
R6102:Vmn2r121	UTSW	X	124133575	missense	probably benign
X0023:Vmn2r121	UTSW	X	124135657	missense	possibly damaging	0.64

Posted On

2015-12-18