Incidental Mutation 'IGL02971:Vmn2r121'
ID 365791
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r121
Ensembl Gene ENSMUSG00000072049
Gene Name vomeronasal 2, receptor 121
Synonyms EG625699
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # IGL02971
Quality Score
Status
Chromosome X
Chromosomal Location 123037036-123045607 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 123037591 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 810 (I810L)
Ref Sequence ENSEMBL: ENSMUSP00000092067 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094491]
AlphaFold A2BE32
Predicted Effect probably damaging
Transcript: ENSMUST00000094491
AA Change: I810L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000092067
Gene: ENSMUSG00000072049
AA Change: I810L

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 75 448 3.2e-26 PFAM
Pfam:NCD3G 506 560 2.1e-19 PFAM
Pfam:7tm_3 593 828 3.8e-56 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930018P22Rik C T 2: 103,953,564 (GRCm39) T130I probably benign Het
Ahi1 T C 10: 20,876,450 (GRCm39) L787P possibly damaging Het
Atf3 A G 1: 190,909,640 (GRCm39) S10P probably benign Het
Cdr2l A G 11: 115,281,726 (GRCm39) N77S probably damaging Het
Cnp A G 11: 100,467,525 (GRCm39) D156G probably benign Het
Cntn3 A T 6: 102,145,894 (GRCm39) D982E probably damaging Het
Col22a1 A G 15: 71,878,587 (GRCm39) L190S probably damaging Het
Csmd3 C T 15: 47,777,325 (GRCm39) probably benign Het
Dnah5 A G 15: 28,384,607 (GRCm39) D3117G probably damaging Het
Dock5 T C 14: 67,994,558 (GRCm39) E1834G probably null Het
Eea1 A G 10: 95,877,389 (GRCm39) T1368A probably benign Het
Fam83f T C 15: 80,556,350 (GRCm39) V78A probably benign Het
Fcgbp G A 7: 27,800,898 (GRCm39) V1315I probably damaging Het
Fsd2 A T 7: 81,198,671 (GRCm39) Y364* probably null Het
Gm21976 G A 13: 98,439,057 (GRCm39) G16R probably null Het
Guca2b A G 4: 119,514,885 (GRCm39) S59P probably damaging Het
Hars2 A G 18: 36,919,231 (GRCm39) E123G probably damaging Het
Hdac2 A T 10: 36,876,370 (GRCm39) K462* probably null Het
Huwe1 T A X: 150,710,622 (GRCm39) probably benign Het
Iqgap3 T A 3: 87,997,611 (GRCm39) N262K probably benign Het
Kat6b A G 14: 21,719,826 (GRCm39) S1502G probably damaging Het
Mapkapk3 A T 9: 107,134,279 (GRCm39) D328E probably benign Het
Naca C T 10: 127,877,437 (GRCm39) probably benign Het
Npffr1 T C 10: 61,449,918 (GRCm39) V64A probably damaging Het
Oga A G 19: 45,750,682 (GRCm39) F671S probably damaging Het
Or2t49 A G 11: 58,393,211 (GRCm39) L57P probably damaging Het
Or8b3b T A 9: 38,584,564 (GRCm39) M72L probably damaging Het
Pcca A G 14: 123,126,945 (GRCm39) D718G probably damaging Het
Pde6a A C 18: 61,397,326 (GRCm39) D670A probably damaging Het
Pramel7 T A 2: 87,320,417 (GRCm39) E292V probably benign Het
Prmt9 A C 8: 78,291,698 (GRCm39) M357L probably benign Het
Ptgfr A T 3: 151,540,963 (GRCm39) S182T probably benign Het
Rtraf A T 14: 19,866,260 (GRCm39) M152K possibly damaging Het
Satb1 T C 17: 52,049,717 (GRCm39) D579G possibly damaging Het
Serpinb6a A G 13: 34,115,453 (GRCm39) probably null Het
Slc5a9 T C 4: 111,747,497 (GRCm39) I297V possibly damaging Het
Slf1 T A 13: 77,195,223 (GRCm39) probably benign Het
St8sia2 C T 7: 73,616,559 (GRCm39) V139M probably damaging Het
Tas2r114 T C 6: 131,666,243 (GRCm39) M262V probably benign Het
Tmem147 A G 7: 30,428,847 (GRCm39) probably benign Het
Tmem220 A G 11: 66,924,933 (GRCm39) probably null Het
Uspl1 A G 5: 149,125,156 (GRCm39) N35S possibly damaging Het
Vmn1r170 A T 7: 23,305,759 (GRCm39) I54F possibly damaging Het
Wbp2nl A T 15: 82,189,945 (GRCm39) T46S possibly damaging Het
Zfp955b T A 17: 33,519,940 (GRCm39) M57K probably benign Het
Other mutations in Vmn2r121
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00990:Vmn2r121 APN X 123,037,480 (GRCm39) missense possibly damaging 0.95
IGL00990:Vmn2r121 APN X 123,037,499 (GRCm39) missense probably benign 0.04
IGL00990:Vmn2r121 APN X 123,043,413 (GRCm39) missense probably benign 0.00
IGL01125:Vmn2r121 APN X 123,042,504 (GRCm39) missense probably damaging 0.99
IGL01450:Vmn2r121 APN X 123,040,888 (GRCm39) missense possibly damaging 0.57
IGL01619:Vmn2r121 APN X 123,041,997 (GRCm39) missense probably benign
IGL01797:Vmn2r121 APN X 123,041,048 (GRCm39) splice site probably benign
IGL02227:Vmn2r121 APN X 123,042,378 (GRCm39) missense probably benign 0.44
IGL03058:Vmn2r121 APN X 123,042,618 (GRCm39) missense probably benign 0.00
IGL03142:Vmn2r121 APN X 123,042,635 (GRCm39) missense possibly damaging 0.94
IGL03183:Vmn2r121 APN X 123,042,023 (GRCm39) missense probably benign 0.03
E0370:Vmn2r121 UTSW X 123,037,617 (GRCm39) missense probably benign 0.01
R0196:Vmn2r121 UTSW X 123,041,879 (GRCm39) missense probably benign 0.03
R1381:Vmn2r121 UTSW X 123,037,837 (GRCm39) missense probably damaging 1.00
R1399:Vmn2r121 UTSW X 123,039,545 (GRCm39) missense possibly damaging 0.94
R1423:Vmn2r121 UTSW X 123,039,602 (GRCm39) missense possibly damaging 0.52
R1687:Vmn2r121 UTSW X 123,042,488 (GRCm39) missense probably benign 0.39
R2121:Vmn2r121 UTSW X 123,043,439 (GRCm39) splice site probably null
R2124:Vmn2r121 UTSW X 123,043,439 (GRCm39) splice site probably null
R3151:Vmn2r121 UTSW X 123,040,849 (GRCm39) missense probably benign 0.20
R4460:Vmn2r121 UTSW X 123,038,281 (GRCm39) missense probably benign 0.01
R4735:Vmn2r121 UTSW X 123,038,335 (GRCm39) missense probably benign
R5332:Vmn2r121 UTSW X 123,043,272 (GRCm39) missense probably benign
R6102:Vmn2r121 UTSW X 123,043,272 (GRCm39) missense probably benign
X0023:Vmn2r121 UTSW X 123,045,354 (GRCm39) missense possibly damaging 0.64
Posted On 2015-12-18