Incidental Mutation 'IGL02971:Olfr331'
ID365792
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr331
Ensembl Gene ENSMUSG00000058807
Gene Nameolfactory receptor 331
SynonymsGA_x6K02T2NKPP-912840-913784, MOR275-4
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.056) question?
Stock #IGL02971
Quality Score
Status
Chromosome11
Chromosomal Location58501598-58502572 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 58502385 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Proline at position 57 (L57P)
Ref Sequence ENSEMBL: ENSMUSP00000132693 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081743] [ENSMUST00000170501]
Predicted Effect probably damaging
Transcript: ENSMUST00000081743
AA Change: L63P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000080440
Gene: ENSMUSG00000058807
AA Change: L63P

DomainStartEndE-ValueType
Pfam:7tm_4 35 315 1e-42 PFAM
Pfam:7tm_1 45 299 1.8e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000170501
AA Change: L57P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000132693
Gene: ENSMUSG00000058807
AA Change: L57P

DomainStartEndE-ValueType
low complexity region 23 37 N/A INTRINSIC
Pfam:7tm_1 39 292 4.9e-28 PFAM
Pfam:7tm_4 141 285 3.6e-42 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Feb 2012]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930018P22Rik C T 2: 104,123,219 T130I probably benign Het
Ahi1 T C 10: 21,000,551 L787P possibly damaging Het
Atf3 A G 1: 191,177,443 S10P probably benign Het
Cdr2l A G 11: 115,390,900 N77S probably damaging Het
Cnp A G 11: 100,576,699 D156G probably benign Het
Cntn3 A T 6: 102,168,933 D982E probably damaging Het
Col22a1 A G 15: 72,006,738 L190S probably damaging Het
Csmd3 C T 15: 47,913,929 probably benign Het
Dnah5 A G 15: 28,384,461 D3117G probably damaging Het
Dock5 T C 14: 67,757,109 E1834G probably null Het
Eea1 A G 10: 96,041,527 T1368A probably benign Het
Fam83f T C 15: 80,672,149 V78A probably benign Het
Fcgbp G A 7: 28,101,473 V1315I probably damaging Het
Fsd2 A T 7: 81,548,923 Y364* probably null Het
Gm21976 G A 13: 98,302,549 G16R probably null Het
Guca2b A G 4: 119,657,688 S59P probably damaging Het
Hars2 A G 18: 36,786,178 E123G probably damaging Het
Hdac2 A T 10: 37,000,374 K462* probably null Het
Huwe1 T A X: 151,927,626 probably benign Het
Iqgap3 T A 3: 88,090,304 N262K probably benign Het
Kat6b A G 14: 21,669,758 S1502G probably damaging Het
Mapkapk3 A T 9: 107,257,080 D328E probably benign Het
Mgea5 A G 19: 45,762,243 F671S probably damaging Het
Naca C T 10: 128,041,568 probably benign Het
Npffr1 T C 10: 61,614,139 V64A probably damaging Het
Olfr918 T A 9: 38,673,268 M72L probably damaging Het
Pcca A G 14: 122,889,533 D718G probably damaging Het
Pde6a A C 18: 61,264,255 D670A probably damaging Het
Pramel7 T A 2: 87,490,073 E292V probably benign Het
Prmt9 A C 8: 77,565,069 M357L probably benign Het
Ptgfr A T 3: 151,835,326 S182T probably benign Het
Rtraf A T 14: 19,816,192 M152K possibly damaging Het
Satb1 T C 17: 51,742,689 D579G possibly damaging Het
Serpinb6a A G 13: 33,931,470 probably null Het
Slc5a9 T C 4: 111,890,300 I297V possibly damaging Het
Slf1 T A 13: 77,047,104 probably benign Het
St8sia2 C T 7: 73,966,811 V139M probably damaging Het
Tas2r114 T C 6: 131,689,280 M262V probably benign Het
Tmem147 A G 7: 30,729,422 probably benign Het
Tmem220 A G 11: 67,034,107 probably null Het
Uspl1 A G 5: 149,188,346 N35S possibly damaging Het
Vmn1r170 A T 7: 23,606,334 I54F possibly damaging Het
Vmn2r121 T G X: 124,127,894 I810L probably damaging Het
Wbp2nl A T 15: 82,305,744 T46S possibly damaging Het
Zfp955b T A 17: 33,300,966 M57K probably benign Het
Other mutations in Olfr331
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01124:Olfr331 APN 11 58502194 missense possibly damaging 0.89
IGL02458:Olfr331 APN 11 58502247 missense probably benign 0.20
IGL03346:Olfr331 APN 11 58501755 missense possibly damaging 0.76
R0416:Olfr331 UTSW 11 58502396 missense unknown
R1547:Olfr331 UTSW 11 58501825 missense probably damaging 1.00
R1697:Olfr331 UTSW 11 58501676 missense probably damaging 1.00
R1717:Olfr331 UTSW 11 58502059 missense probably benign 0.09
R1721:Olfr331 UTSW 11 58501939 missense probably damaging 1.00
R2194:Olfr331 UTSW 11 58501642 missense probably damaging 0.97
R3606:Olfr331 UTSW 11 58502131 missense possibly damaging 0.49
R4457:Olfr331 UTSW 11 58502118 missense probably damaging 1.00
R4766:Olfr331 UTSW 11 58501668 missense probably damaging 1.00
R4858:Olfr331 UTSW 11 58501909 missense probably damaging 1.00
R5475:Olfr331 UTSW 11 58501605 missense probably benign 0.10
R5822:Olfr331 UTSW 11 58501638 missense possibly damaging 0.61
R6337:Olfr331 UTSW 11 58502012 nonsense probably null
R6416:Olfr331 UTSW 11 58502340 missense probably damaging 1.00
R7101:Olfr331 UTSW 11 58502553 missense probably benign 0.00
R7108:Olfr331 UTSW 11 58502554 missense probably benign
R8327:Olfr331 UTSW 11 58502116 missense probably benign
RF035:Olfr331 UTSW 11 58502382 small deletion probably benign
Z1186:Olfr331 UTSW 11 58502384 small deletion probably benign
Z1186:Olfr331 UTSW 11 58502386 small deletion probably benign
Z1186:Olfr331 UTSW 11 58502461 missense probably benign 0.00
Z1186:Olfr331 UTSW 11 58502570 start codon destroyed probably null 0.96
Z1187:Olfr331 UTSW 11 58501648 missense probably benign
Z1187:Olfr331 UTSW 11 58502101 missense probably benign
Z1187:Olfr331 UTSW 11 58502110 missense probably benign 0.06
Z1187:Olfr331 UTSW 11 58502386 small deletion probably benign
Z1187:Olfr331 UTSW 11 58502461 missense probably benign 0.00
Z1187:Olfr331 UTSW 11 58502570 start codon destroyed probably null 0.96
Z1188:Olfr331 UTSW 11 58501648 missense probably benign
Z1188:Olfr331 UTSW 11 58502101 missense probably benign
Z1188:Olfr331 UTSW 11 58502110 missense probably benign 0.06
Z1188:Olfr331 UTSW 11 58502386 small deletion probably benign
Z1188:Olfr331 UTSW 11 58502461 missense probably benign 0.00
Z1188:Olfr331 UTSW 11 58502570 start codon destroyed probably null 0.96
Z1189:Olfr331 UTSW 11 58502386 small deletion probably benign
Z1189:Olfr331 UTSW 11 58502461 missense probably benign 0.00
Z1189:Olfr331 UTSW 11 58502570 start codon destroyed probably null 0.96
Z1190:Olfr331 UTSW 11 58501648 missense probably benign
Z1190:Olfr331 UTSW 11 58502101 missense probably benign
Z1190:Olfr331 UTSW 11 58502110 missense probably benign 0.06
Z1190:Olfr331 UTSW 11 58502386 small deletion probably benign
Z1190:Olfr331 UTSW 11 58502461 missense probably benign 0.00
Z1190:Olfr331 UTSW 11 58502570 start codon destroyed probably null 0.96
Z1191:Olfr331 UTSW 11 58501648 missense probably benign
Z1191:Olfr331 UTSW 11 58502101 missense probably benign
Z1191:Olfr331 UTSW 11 58502110 missense probably benign 0.06
Z1191:Olfr331 UTSW 11 58502386 small deletion probably benign
Z1191:Olfr331 UTSW 11 58502461 missense probably benign 0.00
Z1191:Olfr331 UTSW 11 58502570 start codon destroyed probably null 0.96
Z1192:Olfr331 UTSW 11 58502384 small deletion probably benign
Z1192:Olfr331 UTSW 11 58502386 small deletion probably benign
Z1192:Olfr331 UTSW 11 58502461 missense probably benign 0.00
Z1192:Olfr331 UTSW 11 58502570 start codon destroyed probably null 0.96
Posted On2015-12-18