Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02971:Zfp955b'

365793

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp955b

Ensembl Gene

ENSMUSG00000096910

Gene Name

zinc finger protein 955B

Synonyms

A430003O12Rik, C430039G02Rik, Gm4455

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.078) question?

Stock #

IGL02971

Quality Score

Status

Chromosome

Chromosomal Location

33289649-33303196 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 33300966 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 57 (M57K)

Ref Sequence

ENSEMBL: ENSMUSP00000097011 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099414]

AlphaFold

L7N232

Predicted Effect

probably benign
Transcript: ENSMUST00000099414
AA Change: M57K

PolyPhen 2 Score 0.109 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000097011
Gene: ENSMUSG00000096910
AA Change: M57K

Domain	Start	End	E-Value	Type
KRAB	10	70	3.04e-14	SMART
ZnF_C2H2	230	252	7.68e0	SMART
ZnF_C2H2	258	280	5.72e-1	SMART
ZnF_C2H2	290	312	6.75e0	SMART
ZnF_C2H2	318	340	5.81e-2	SMART
ZnF_C2H2	346	368	3.16e-3	SMART
ZnF_C2H2	374	396	1.18e-2	SMART
ZnF_C2H2	402	424	7.78e-3	SMART
ZnF_C2H2	430	452	3.16e-3	SMART
ZnF_C2H2	458	480	1.1e-2	SMART
ZnF_C2H2	486	508	2.09e-3	SMART
ZnF_C2H2	514	536	6.67e-2	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000182230

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A930018P22Rik	C	T	2: 104,123,219	T130I	probably benign	Het
Ahi1	T	C	10: 21,000,551	L787P	possibly damaging	Het
Atf3	A	G	1: 191,177,443	S10P	probably benign	Het
Cdr2l	A	G	11: 115,390,900	N77S	probably damaging	Het
Cnp	A	G	11: 100,576,699	D156G	probably benign	Het
Cntn3	A	T	6: 102,168,933	D982E	probably damaging	Het
Col22a1	A	G	15: 72,006,738	L190S	probably damaging	Het
Csmd3	C	T	15: 47,913,929		probably benign	Het
Dnah5	A	G	15: 28,384,461	D3117G	probably damaging	Het
Dock5	T	C	14: 67,757,109	E1834G	probably null	Het
Eea1	A	G	10: 96,041,527	T1368A	probably benign	Het
Fam83f	T	C	15: 80,672,149	V78A	probably benign	Het
Fcgbp	G	A	7: 28,101,473	V1315I	probably damaging	Het
Fsd2	A	T	7: 81,548,923	Y364*	probably null	Het
Gm21976	G	A	13: 98,302,549	G16R	probably null	Het
Guca2b	A	G	4: 119,657,688	S59P	probably damaging	Het
Hars2	A	G	18: 36,786,178	E123G	probably damaging	Het
Hdac2	A	T	10: 37,000,374	K462*	probably null	Het
Huwe1	T	A	X: 151,927,626		probably benign	Het
Iqgap3	T	A	3: 88,090,304	N262K	probably benign	Het
Kat6b	A	G	14: 21,669,758	S1502G	probably damaging	Het
Mapkapk3	A	T	9: 107,257,080	D328E	probably benign	Het
Mgea5	A	G	19: 45,762,243	F671S	probably damaging	Het
Naca	C	T	10: 128,041,568		probably benign	Het
Npffr1	T	C	10: 61,614,139	V64A	probably damaging	Het
Olfr331	A	G	11: 58,502,385	L57P	probably damaging	Het
Olfr918	T	A	9: 38,673,268	M72L	probably damaging	Het
Pcca	A	G	14: 122,889,533	D718G	probably damaging	Het
Pde6a	A	C	18: 61,264,255	D670A	probably damaging	Het
Pramel7	T	A	2: 87,490,073	E292V	probably benign	Het
Prmt9	A	C	8: 77,565,069	M357L	probably benign	Het
Ptgfr	A	T	3: 151,835,326	S182T	probably benign	Het
Rtraf	A	T	14: 19,816,192	M152K	possibly damaging	Het
Satb1	T	C	17: 51,742,689	D579G	possibly damaging	Het
Serpinb6a	A	G	13: 33,931,470		probably null	Het
Slc5a9	T	C	4: 111,890,300	I297V	possibly damaging	Het
Slf1	T	A	13: 77,047,104		probably benign	Het
St8sia2	C	T	7: 73,966,811	V139M	probably damaging	Het
Tas2r114	T	C	6: 131,689,280	M262V	probably benign	Het
Tmem147	A	G	7: 30,729,422		probably benign	Het
Tmem220	A	G	11: 67,034,107		probably null	Het
Uspl1	A	G	5: 149,188,346	N35S	possibly damaging	Het
Vmn1r170	A	T	7: 23,606,334	I54F	possibly damaging	Het
Vmn2r121	T	G	X: 124,127,894	I810L	probably damaging	Het
Wbp2nl	A	T	15: 82,305,744	T46S	possibly damaging	Het

Other mutations in Zfp955b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00537:Zfp955b	APN	17	33302873	missense	probably damaging	1.00
IGL02073:Zfp955b	APN	17	33300590	missense	possibly damaging	0.69
IGL02126:Zfp955b	APN	17	33302264	nonsense	probably null
IGL02237:Zfp955b	APN	17	33301919	missense	probably damaging	1.00
IGL02587:Zfp955b	APN	17	33300650	missense	probably damaging	1.00
IGL03034:Zfp955b	APN	17	33302168	missense	probably benign	0.22
IGL03493:Zfp955b	APN	17	33302545	missense	probably benign	0.35
R0269:Zfp955b	UTSW	17	33305463	missense	probably damaging	1.00
R0373:Zfp955b	UTSW	17	33302522	missense	probably benign
R0617:Zfp955b	UTSW	17	33305463	missense	probably damaging	1.00
R0684:Zfp955b	UTSW	17	33302973	missense	probably benign	0.00
R1778:Zfp955b	UTSW	17	33302814	missense	probably benign	0.07
R1874:Zfp955b	UTSW	17	33305453	missense	probably benign	0.10
R3893:Zfp955b	UTSW	17	33302994	missense	probably benign	0.01
R3938:Zfp955b	UTSW	17	33305416	missense	probably damaging	1.00
R4082:Zfp955b	UTSW	17	33302155	missense	probably benign	0.08
R4672:Zfp955b	UTSW	17	33305259	unclassified	probably benign
R4956:Zfp955b	UTSW	17	33305235	unclassified	probably benign
R4998:Zfp955b	UTSW	17	33305151	unclassified	probably benign
R5276:Zfp955b	UTSW	17	33303057	missense	probably damaging	1.00
R5341:Zfp955b	UTSW	17	33305121	unclassified	probably benign
R5558:Zfp955b	UTSW	17	33302187	missense	possibly damaging	0.88
R6086:Zfp955b	UTSW	17	33302504	missense	probably benign
R6170:Zfp955b	UTSW	17	33302110	missense	probably benign	0.00
R6306:Zfp955b	UTSW	17	33303186	missense	probably benign	0.07
R6519:Zfp955b	UTSW	17	33302077	missense	possibly damaging	0.55
R9286:Zfp955b	UTSW	17	33302709	missense	probably benign	0.04

Posted On

2015-12-18