Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02971:Vmn1r170'

365808

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r170

Ensembl Gene

ENSMUSG00000094187

Gene Name

vomeronasal 1 receptor 170

Synonyms

Gm5999

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

IGL02971

Quality Score

Status

Chromosome

Chromosomal Location

23606175-23607089 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 23606334 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 54 (I54F)

Ref Sequence

ENSEMBL: ENSMUSP00000127655 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170166]

AlphaFold

K7N6W9

Predicted Effect

possibly damaging
Transcript: ENSMUST00000170166
AA Change: I54F

PolyPhen 2 Score 0.810 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000127655
Gene: ENSMUSG00000094187
AA Change: I54F

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	296	1.8e-13	PFAM
Pfam:7tm_1	30	287	3.6e-6	PFAM
Pfam:V1R	42	295	1.4e-20	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A930018P22Rik	C	T	2: 104,123,219	T130I	probably benign	Het
Ahi1	T	C	10: 21,000,551	L787P	possibly damaging	Het
Atf3	A	G	1: 191,177,443	S10P	probably benign	Het
Cdr2l	A	G	11: 115,390,900	N77S	probably damaging	Het
Cnp	A	G	11: 100,576,699	D156G	probably benign	Het
Cntn3	A	T	6: 102,168,933	D982E	probably damaging	Het
Col22a1	A	G	15: 72,006,738	L190S	probably damaging	Het
Csmd3	C	T	15: 47,913,929		probably benign	Het
Dnah5	A	G	15: 28,384,461	D3117G	probably damaging	Het
Dock5	T	C	14: 67,757,109	E1834G	probably null	Het
Eea1	A	G	10: 96,041,527	T1368A	probably benign	Het
Fam83f	T	C	15: 80,672,149	V78A	probably benign	Het
Fcgbp	G	A	7: 28,101,473	V1315I	probably damaging	Het
Fsd2	A	T	7: 81,548,923	Y364*	probably null	Het
Gm21976	G	A	13: 98,302,549	G16R	probably null	Het
Guca2b	A	G	4: 119,657,688	S59P	probably damaging	Het
Hars2	A	G	18: 36,786,178	E123G	probably damaging	Het
Hdac2	A	T	10: 37,000,374	K462*	probably null	Het
Huwe1	T	A	X: 151,927,626		probably benign	Het
Iqgap3	T	A	3: 88,090,304	N262K	probably benign	Het
Kat6b	A	G	14: 21,669,758	S1502G	probably damaging	Het
Mapkapk3	A	T	9: 107,257,080	D328E	probably benign	Het
Mgea5	A	G	19: 45,762,243	F671S	probably damaging	Het
Naca	C	T	10: 128,041,568		probably benign	Het
Npffr1	T	C	10: 61,614,139	V64A	probably damaging	Het
Olfr331	A	G	11: 58,502,385	L57P	probably damaging	Het
Olfr918	T	A	9: 38,673,268	M72L	probably damaging	Het
Pcca	A	G	14: 122,889,533	D718G	probably damaging	Het
Pde6a	A	C	18: 61,264,255	D670A	probably damaging	Het
Pramel7	T	A	2: 87,490,073	E292V	probably benign	Het
Prmt9	A	C	8: 77,565,069	M357L	probably benign	Het
Ptgfr	A	T	3: 151,835,326	S182T	probably benign	Het
Rtraf	A	T	14: 19,816,192	M152K	possibly damaging	Het
Satb1	T	C	17: 51,742,689	D579G	possibly damaging	Het
Serpinb6a	A	G	13: 33,931,470		probably null	Het
Slc5a9	T	C	4: 111,890,300	I297V	possibly damaging	Het
Slf1	T	A	13: 77,047,104		probably benign	Het
St8sia2	C	T	7: 73,966,811	V139M	probably damaging	Het
Tas2r114	T	C	6: 131,689,280	M262V	probably benign	Het
Tmem147	A	G	7: 30,729,422		probably benign	Het
Tmem220	A	G	11: 67,034,107		probably null	Het
Uspl1	A	G	5: 149,188,346	N35S	possibly damaging	Het
Vmn2r121	T	G	X: 124,127,894	I810L	probably damaging	Het
Wbp2nl	A	T	15: 82,305,744	T46S	possibly damaging	Het
Zfp955b	T	A	17: 33,300,966	M57K	probably benign	Het

Other mutations in Vmn1r170

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02005:Vmn1r170	APN	7	23606913	missense	probably damaging	1.00
IGL02150:Vmn1r170	APN	7	23607040	nonsense	probably null
IGL02216:Vmn1r170	APN	7	23606490	missense	probably damaging	1.00
IGL02749:Vmn1r170	APN	7	23606291	missense	probably benign	0.00
IGL02807:Vmn1r170	APN	7	23606335	missense	probably damaging	1.00
IGL02828:Vmn1r170	APN	7	23606518	missense	probably damaging	0.99
IGL03073:Vmn1r170	APN	7	23606848	missense	probably damaging	1.00
IGL03151:Vmn1r170	APN	7	23606577	missense	probably benign	0.35
R0079:Vmn1r170	UTSW	7	23606310	missense	possibly damaging	0.95
R0266:Vmn1r170	UTSW	7	23606481	missense	probably benign	0.00
R0980:Vmn1r170	UTSW	7	23606334	missense	possibly damaging	0.81
R1345:Vmn1r170	UTSW	7	23606362	missense	probably benign	0.00
R1620:Vmn1r170	UTSW	7	23606329	missense	probably benign	0.30
R1713:Vmn1r170	UTSW	7	23606863	missense	probably benign	0.30
R1745:Vmn1r170	UTSW	7	23606334	missense	probably damaging	0.98
R1974:Vmn1r170	UTSW	7	23606481	missense	probably benign	0.00
R2163:Vmn1r170	UTSW	7	23607037	missense	probably damaging	1.00
R3812:Vmn1r170	UTSW	7	23606292	missense	probably damaging	1.00
R4583:Vmn1r170	UTSW	7	23606662	missense	probably benign	0.25
R5309:Vmn1r170	UTSW	7	23606455	missense	probably damaging	0.97
R5378:Vmn1r170	UTSW	7	23606538	missense	probably benign	0.00
R5379:Vmn1r170	UTSW	7	23606629	missense	possibly damaging	0.81
R5661:Vmn1r170	UTSW	7	23606806	missense	possibly damaging	0.82
R5673:Vmn1r170	UTSW	7	23606205	missense	possibly damaging	0.58
R6181:Vmn1r170	UTSW	7	23606267	missense	probably damaging	0.98
R6192:Vmn1r170	UTSW	7	23606509	missense	probably damaging	1.00
R7467:Vmn1r170	UTSW	7	23606895	missense	not run
R7667:Vmn1r170	UTSW	7	23607048	missense	probably damaging	1.00
R8458:Vmn1r170	UTSW	7	23606896	missense	possibly damaging	0.90
R8699:Vmn1r170	UTSW	7	23606655	nonsense	probably null
R8927:Vmn1r170	UTSW	7	23606389	missense	possibly damaging	0.82
R8928:Vmn1r170	UTSW	7	23606389	missense	possibly damaging	0.82
R9269:Vmn1r170	UTSW	7	23606838	missense	probably benign	0.02
R9569:Vmn1r170	UTSW	7	23606869	missense	probably benign	0.19
X0060:Vmn1r170	UTSW	7	23606943	missense	possibly damaging	0.50
Z1176:Vmn1r170	UTSW	7	23606410	missense	possibly damaging	0.89

Posted On

2015-12-18