Incidental Mutation 'IGL02971:Tas2r114'
ID 365828
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tas2r114
Ensembl Gene ENSMUSG00000063478
Gene Name taste receptor, type 2, member 114
Synonyms mt2r46, mGR14, T2R14, Tas2r14
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # IGL02971
Quality Score
Status
Chromosome 6
Chromosomal Location 131666097-131667026 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 131666243 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 262 (M262V)
Ref Sequence ENSEMBL: ENSMUSP00000079453 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053652] [ENSMUST00000072404] [ENSMUST00000080619]
AlphaFold Q7M722
Predicted Effect probably benign
Transcript: ENSMUST00000053652
SMART Domains Protein: ENSMUSP00000058006
Gene: ENSMUSG00000051153

DomainStartEndE-ValueType
Pfam:TAS2R 1 298 9.4e-109 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000072404
SMART Domains Protein: ENSMUSP00000072237
Gene: ENSMUSG00000061977

DomainStartEndE-ValueType
Pfam:TAS2R 1 298 8.3e-102 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000080619
AA Change: M262V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000079453
Gene: ENSMUSG00000063478
AA Change: M262V

DomainStartEndE-ValueType
Pfam:TAS2R 1 298 8.1e-104 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930018P22Rik C T 2: 103,953,564 (GRCm39) T130I probably benign Het
Ahi1 T C 10: 20,876,450 (GRCm39) L787P possibly damaging Het
Atf3 A G 1: 190,909,640 (GRCm39) S10P probably benign Het
Cdr2l A G 11: 115,281,726 (GRCm39) N77S probably damaging Het
Cnp A G 11: 100,467,525 (GRCm39) D156G probably benign Het
Cntn3 A T 6: 102,145,894 (GRCm39) D982E probably damaging Het
Col22a1 A G 15: 71,878,587 (GRCm39) L190S probably damaging Het
Csmd3 C T 15: 47,777,325 (GRCm39) probably benign Het
Dnah5 A G 15: 28,384,607 (GRCm39) D3117G probably damaging Het
Dock5 T C 14: 67,994,558 (GRCm39) E1834G probably null Het
Eea1 A G 10: 95,877,389 (GRCm39) T1368A probably benign Het
Fam83f T C 15: 80,556,350 (GRCm39) V78A probably benign Het
Fcgbp G A 7: 27,800,898 (GRCm39) V1315I probably damaging Het
Fsd2 A T 7: 81,198,671 (GRCm39) Y364* probably null Het
Gm21976 G A 13: 98,439,057 (GRCm39) G16R probably null Het
Guca2b A G 4: 119,514,885 (GRCm39) S59P probably damaging Het
Hars2 A G 18: 36,919,231 (GRCm39) E123G probably damaging Het
Hdac2 A T 10: 36,876,370 (GRCm39) K462* probably null Het
Huwe1 T A X: 150,710,622 (GRCm39) probably benign Het
Iqgap3 T A 3: 87,997,611 (GRCm39) N262K probably benign Het
Kat6b A G 14: 21,719,826 (GRCm39) S1502G probably damaging Het
Mapkapk3 A T 9: 107,134,279 (GRCm39) D328E probably benign Het
Naca C T 10: 127,877,437 (GRCm39) probably benign Het
Npffr1 T C 10: 61,449,918 (GRCm39) V64A probably damaging Het
Oga A G 19: 45,750,682 (GRCm39) F671S probably damaging Het
Or2t49 A G 11: 58,393,211 (GRCm39) L57P probably damaging Het
Or8b3b T A 9: 38,584,564 (GRCm39) M72L probably damaging Het
Pcca A G 14: 123,126,945 (GRCm39) D718G probably damaging Het
Pde6a A C 18: 61,397,326 (GRCm39) D670A probably damaging Het
Pramel7 T A 2: 87,320,417 (GRCm39) E292V probably benign Het
Prmt9 A C 8: 78,291,698 (GRCm39) M357L probably benign Het
Ptgfr A T 3: 151,540,963 (GRCm39) S182T probably benign Het
Rtraf A T 14: 19,866,260 (GRCm39) M152K possibly damaging Het
Satb1 T C 17: 52,049,717 (GRCm39) D579G possibly damaging Het
Serpinb6a A G 13: 34,115,453 (GRCm39) probably null Het
Slc5a9 T C 4: 111,747,497 (GRCm39) I297V possibly damaging Het
Slf1 T A 13: 77,195,223 (GRCm39) probably benign Het
St8sia2 C T 7: 73,616,559 (GRCm39) V139M probably damaging Het
Tmem147 A G 7: 30,428,847 (GRCm39) probably benign Het
Tmem220 A G 11: 66,924,933 (GRCm39) probably null Het
Uspl1 A G 5: 149,125,156 (GRCm39) N35S possibly damaging Het
Vmn1r170 A T 7: 23,305,759 (GRCm39) I54F possibly damaging Het
Vmn2r121 T G X: 123,037,591 (GRCm39) I810L probably damaging Het
Wbp2nl A T 15: 82,189,945 (GRCm39) T46S possibly damaging Het
Zfp955b T A 17: 33,519,940 (GRCm39) M57K probably benign Het
Other mutations in Tas2r114
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01777:Tas2r114 APN 6 131,666,664 (GRCm39) nonsense probably null
R0561:Tas2r114 UTSW 6 131,666,758 (GRCm39) missense probably benign 0.30
R3034:Tas2r114 UTSW 6 131,666,611 (GRCm39) missense probably benign 0.15
R3687:Tas2r114 UTSW 6 131,666,231 (GRCm39) missense probably benign 0.25
R4411:Tas2r114 UTSW 6 131,666,585 (GRCm39) missense probably benign 0.06
R4826:Tas2r114 UTSW 6 131,666,800 (GRCm39) missense probably damaging 0.99
R4889:Tas2r114 UTSW 6 131,666,758 (GRCm39) missense probably damaging 0.96
R5084:Tas2r114 UTSW 6 131,666,251 (GRCm39) nonsense probably null
R5258:Tas2r114 UTSW 6 131,666,504 (GRCm39) missense probably benign 0.03
R6038:Tas2r114 UTSW 6 131,666,444 (GRCm39) missense possibly damaging 0.89
R6038:Tas2r114 UTSW 6 131,666,444 (GRCm39) missense possibly damaging 0.89
R6499:Tas2r114 UTSW 6 131,666,099 (GRCm39) makesense probably null
R7164:Tas2r114 UTSW 6 131,666,728 (GRCm39) missense possibly damaging 0.74
R7276:Tas2r114 UTSW 6 131,666,310 (GRCm39) missense probably damaging 0.96
R7745:Tas2r114 UTSW 6 131,666,401 (GRCm39) missense probably damaging 1.00
R7851:Tas2r114 UTSW 6 131,666,888 (GRCm39) missense probably damaging 1.00
R8002:Tas2r114 UTSW 6 131,666,102 (GRCm39) missense probably damaging 1.00
R8901:Tas2r114 UTSW 6 131,666,914 (GRCm39) missense probably damaging 0.99
R9297:Tas2r114 UTSW 6 131,666,287 (GRCm39) missense probably damaging 0.96
R9380:Tas2r114 UTSW 6 131,666,381 (GRCm39) missense probably benign 0.00
R9402:Tas2r114 UTSW 6 131,666,894 (GRCm39) missense possibly damaging 0.49
R9473:Tas2r114 UTSW 6 131,666,104 (GRCm39) missense probably benign
R9513:Tas2r114 UTSW 6 131,666,746 (GRCm39) missense probably benign 0.01
Posted On 2015-12-18