Incidental Mutation 'IGL02972:Or2y14'
ID 365843
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or2y14
Ensembl Gene ENSMUSG00000044170
Gene Name olfactory receptor family 2 subfamily Y member 14
Synonyms Olfr1384, MOR256-23, GA_x6K02T2QP88-5922712-5921756
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # IGL02972
Quality Score
Status
Chromosome 11
Chromosomal Location 49404445-49405478 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 49404918 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Aspartic acid at position 151 (G151D)
Ref Sequence ENSEMBL: ENSMUSP00000149183 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060434] [ENSMUST00000213776]
AlphaFold Q8VFA8
Predicted Effect probably damaging
Transcript: ENSMUST00000060434
AA Change: G151D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000051954
Gene: ENSMUSG00000044170
AA Change: G151D

DomainStartEndE-ValueType
Pfam:7tm_4 30 306 6.9e-48 PFAM
Pfam:7TM_GPCR_Srsx 34 161 4.3e-6 PFAM
Pfam:7tm_1 40 313 2.7e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213776
AA Change: G151D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410137M14Rik T A 17: 37,289,412 (GRCm39) I105F possibly damaging Het
Bmpr1b C T 3: 141,576,519 (GRCm39) D105N probably benign Het
Ces2e A T 8: 105,653,693 (GRCm39) S44C probably damaging Het
Chd7 T A 4: 8,855,174 (GRCm39) N2134K probably benign Het
Chst15 T C 7: 131,870,902 (GRCm39) D211G probably damaging Het
Dpp4 T C 2: 62,182,569 (GRCm39) S571G probably damaging Het
Gna11 T C 10: 81,369,225 (GRCm39) I113V probably benign Het
Grm3 T C 5: 9,562,410 (GRCm39) Y480C probably damaging Het
Mccc1 C T 3: 36,039,238 (GRCm39) V252I possibly damaging Het
Nol12 A G 15: 78,824,799 (GRCm39) T209A probably damaging Het
Or52a33 A G 7: 103,289,101 (GRCm39) M82T probably damaging Het
Or7e168 T C 9: 19,720,238 (GRCm39) F208S probably damaging Het
P3h1 C A 4: 119,105,157 (GRCm39) Q712K possibly damaging Het
Per2 T A 1: 91,351,703 (GRCm39) E934D possibly damaging Het
Pfkl T C 10: 77,824,108 (GRCm39) D760G probably benign Het
Piezo2 C A 18: 63,197,856 (GRCm39) probably benign Het
Pkd1l1 C T 11: 8,813,908 (GRCm39) R1481Q probably damaging Het
Plpp3 T C 4: 105,065,989 (GRCm39) V189A possibly damaging Het
Pnpla1 A G 17: 29,105,921 (GRCm39) E592G probably null Het
Prdm2 A T 4: 142,858,736 (GRCm39) M1518K probably benign Het
Rhbdl3 G A 11: 80,222,742 (GRCm39) probably benign Het
Rnf145 C T 11: 44,454,865 (GRCm39) S582F probably benign Het
Rsf1 A G 7: 97,310,533 (GRCm39) D421G probably benign Het
Serac1 A C 17: 6,121,039 (GRCm39) L85* probably null Het
Slc43a1 T G 2: 84,690,462 (GRCm39) V460G probably damaging Het
Slc7a6 G A 8: 106,906,059 (GRCm39) C97Y probably damaging Het
Slco5a1 A T 1: 13,060,379 (GRCm39) L114* probably null Het
Stxbp2 A T 8: 3,691,971 (GRCm39) I538F probably benign Het
Taok1 A G 11: 77,450,584 (GRCm39) V396A probably benign Het
Tmem232 T A 17: 65,783,668 (GRCm39) H233L probably benign Het
Tmprss11c C T 5: 86,385,692 (GRCm39) S247N possibly damaging Het
Tnc C T 4: 63,894,715 (GRCm39) S1557N probably benign Het
Txlng A G X: 161,590,551 (GRCm39) M94T probably damaging Het
Ube2b A T 11: 51,879,509 (GRCm39) I87K probably damaging Het
Ubr5 A T 15: 38,042,196 (GRCm39) S133R probably damaging Het
Ugt1a5 C T 1: 88,094,144 (GRCm39) T124I probably benign Het
Vamp1 G T 6: 125,196,610 (GRCm39) R117L probably benign Het
Vmn1r87 G T 7: 12,866,256 (GRCm39) Y10* probably null Het
Zan G A 5: 137,461,948 (GRCm39) T1077I unknown Het
Zc2hc1b C A 10: 13,047,025 (GRCm39) V29F probably damaging Het
Zfp597 T C 16: 3,684,387 (GRCm39) D123G probably benign Het
Other mutations in Or2y14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02212:Or2y14 APN 11 49,404,737 (GRCm39) missense probably damaging 0.98
R0157:Or2y14 UTSW 11 49,404,600 (GRCm39) missense probably damaging 1.00
R1106:Or2y14 UTSW 11 49,404,519 (GRCm39) missense probably damaging 1.00
R1213:Or2y14 UTSW 11 49,405,421 (GRCm39) makesense probably null
R3768:Or2y14 UTSW 11 49,404,600 (GRCm39) missense probably damaging 1.00
R4191:Or2y14 UTSW 11 49,404,639 (GRCm39) missense probably damaging 1.00
R4708:Or2y14 UTSW 11 49,405,216 (GRCm39) nonsense probably null
R5443:Or2y14 UTSW 11 49,405,262 (GRCm39) missense probably damaging 0.98
R5770:Or2y14 UTSW 11 49,405,419 (GRCm39) missense unknown
R6245:Or2y14 UTSW 11 49,404,992 (GRCm39) missense possibly damaging 0.94
R6336:Or2y14 UTSW 11 49,405,369 (GRCm39) missense probably damaging 0.99
R7652:Or2y14 UTSW 11 49,404,512 (GRCm39) missense probably damaging 1.00
R8070:Or2y14 UTSW 11 49,404,941 (GRCm39) missense probably damaging 1.00
R8147:Or2y14 UTSW 11 49,405,050 (GRCm39) missense probably benign 0.02
R9289:Or2y14 UTSW 11 49,404,635 (GRCm39) missense probably damaging 1.00
R9551:Or2y14 UTSW 11 49,404,942 (GRCm39) missense probably damaging 1.00
Posted On 2015-12-18