Incidental Mutation 'IGL02973:Zc3h6'
ID 365897
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zc3h6
Ensembl Gene ENSMUSG00000042851
Gene Name zinc finger CCCH type containing 6
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.185) question?
Stock # IGL02973
Quality Score
Status
Chromosome 2
Chromosomal Location 128967402-129018563 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to A at 128997795 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Arginine to Glutamine at position 176 (R176Q)
Ref Sequence ENSEMBL: ENSMUSP00000105949 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000110319] [ENSMUST00000110320]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000110319
SMART Domains Protein: ENSMUSP00000105948
Gene: ENSMUSG00000042851

DomainStartEndE-ValueType
low complexity region 8 25 N/A INTRINSIC
coiled coil region 30 71 N/A INTRINSIC
low complexity region 74 88 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000110320
AA Change: R176Q

PolyPhen 2 Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000105949
Gene: ENSMUSG00000042851
AA Change: R176Q

DomainStartEndE-ValueType
low complexity region 8 25 N/A INTRINSIC
coiled coil region 30 71 N/A INTRINSIC
low complexity region 74 88 N/A INTRINSIC
low complexity region 177 192 N/A INTRINSIC
ZnF_C3H1 271 296 1.72e-4 SMART
ZnF_C3H1 300 325 2.51e-6 SMART
ZnF_C3H1 326 349 5.24e0 SMART
coiled coil region 351 383 N/A INTRINSIC
low complexity region 385 400 N/A INTRINSIC
low complexity region 493 509 N/A INTRINSIC
low complexity region 698 707 N/A INTRINSIC
low complexity region 784 798 N/A INTRINSIC
low complexity region 815 829 N/A INTRINSIC
low complexity region 876 890 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ada A G 2: 163,731,133 (GRCm38) L193P probably benign Het
Ago2 A T 15: 73,123,465 (GRCm38) probably benign Het
Ankrd26 A G 6: 118,523,550 (GRCm38) S987P probably damaging Het
Ap2a2 T C 7: 141,631,364 (GRCm38) F938L possibly damaging Het
Arhgap35 A G 7: 16,562,878 (GRCm38) V754A possibly damaging Het
Atp10b A T 11: 43,197,509 (GRCm38) N314I probably damaging Het
Atp5a1 T C 18: 77,780,149 (GRCm38) V291A probably damaging Het
Ccm2 C A 11: 6,584,544 (GRCm38) P19T probably damaging Het
Cdc5l C A 17: 45,404,647 (GRCm38) A680S probably benign Het
Cds1 A G 5: 101,812,510 (GRCm38) T276A probably damaging Het
Cit A G 5: 116,005,999 (GRCm38) R1976G possibly damaging Het
Col6a5 T C 9: 105,925,821 (GRCm38) D1315G unknown Het
Emilin1 T G 5: 30,920,663 (GRCm38) L922R probably damaging Het
Fank1 T C 7: 133,876,849 (GRCm38) L213P probably damaging Het
Foxc2 T C 8: 121,118,049 (GRCm38) S479P probably benign Het
Gm14548 T C 7: 3,897,240 (GRCm38) Y121C probably damaging Het
Golgb1 G A 16: 36,912,080 (GRCm38) R563H possibly damaging Het
Hoxb13 A G 11: 96,194,843 (GRCm38) Y134C probably damaging Het
Krtap4-16 A T 11: 99,851,341 (GRCm38) C78S possibly damaging Het
Lars C T 18: 42,214,759 (GRCm38) probably null Het
Lipe T C 7: 25,383,632 (GRCm38) N740S probably damaging Het
Mbd1 C T 18: 74,275,427 (GRCm38) probably benign Het
Mbd5 A G 2: 49,313,709 (GRCm38) D1700G probably damaging Het
Mpp7 A G 18: 7,403,297 (GRCm38) Y338H probably damaging Het
Pdgfrl A G 8: 40,985,594 (GRCm38) D189G probably damaging Het
Plxnc1 T C 10: 94,810,684 (GRCm38) N1293S probably damaging Het
Ppm1e C A 11: 87,240,662 (GRCm38) A302S probably damaging Het
Rassf8 A G 6: 145,817,190 (GRCm38) probably benign Het
Rttn T C 18: 88,972,494 (GRCm38) W52R probably damaging Het
Skint8 T C 4: 111,939,593 (GRCm38) V298A probably benign Het
Tulp1 A T 17: 28,358,542 (GRCm38) probably benign Het
Unc5c T A 3: 141,788,890 (GRCm38) D321E probably benign Het
Usp16 G A 16: 87,479,739 (GRCm38) C654Y probably damaging Het
Vwce G A 19: 10,655,400 (GRCm38) W575* probably null Het
Wdr89 T G 12: 75,633,099 (GRCm38) D127A probably damaging Het
Zfp942 A G 17: 21,932,991 (GRCm38) probably null Het
Other mutations in Zc3h6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01732:Zc3h6 APN 2 129,011,875 (GRCm38) missense probably damaging 1.00
IGL01880:Zc3h6 APN 2 129,017,378 (GRCm38) missense probably damaging 0.99
IGL02160:Zc3h6 APN 2 128,997,685 (GRCm38) missense probably benign 0.02
IGL02161:Zc3h6 APN 2 128,993,226 (GRCm38) missense possibly damaging 0.90
IGL02202:Zc3h6 APN 2 129,016,581 (GRCm38) missense probably damaging 1.00
IGL02547:Zc3h6 APN 2 129,015,611 (GRCm38) missense probably benign 0.00
BB001:Zc3h6 UTSW 2 129,015,480 (GRCm38) missense possibly damaging 0.52
BB011:Zc3h6 UTSW 2 129,015,480 (GRCm38) missense possibly damaging 0.52
R0336:Zc3h6 UTSW 2 129,015,412 (GRCm38) missense possibly damaging 0.81
R0420:Zc3h6 UTSW 2 129,014,827 (GRCm38) missense probably benign 0.00
R0538:Zc3h6 UTSW 2 129,017,223 (GRCm38) missense possibly damaging 0.75
R0944:Zc3h6 UTSW 2 129,006,816 (GRCm38) missense probably damaging 1.00
R1151:Zc3h6 UTSW 2 129,017,136 (GRCm38) missense probably benign 0.00
R1528:Zc3h6 UTSW 2 129,017,069 (GRCm38) missense probably benign 0.01
R1698:Zc3h6 UTSW 2 129,017,358 (GRCm38) missense probably benign
R1712:Zc3h6 UTSW 2 129,016,734 (GRCm38) missense probably damaging 1.00
R1913:Zc3h6 UTSW 2 129,016,620 (GRCm38) missense probably damaging 1.00
R1926:Zc3h6 UTSW 2 128,997,795 (GRCm38) missense probably damaging 0.98
R2030:Zc3h6 UTSW 2 129,006,086 (GRCm38) missense probably damaging 1.00
R2051:Zc3h6 UTSW 2 129,015,618 (GRCm38) missense possibly damaging 0.55
R2133:Zc3h6 UTSW 2 128,967,830 (GRCm38) missense possibly damaging 0.53
R2273:Zc3h6 UTSW 2 129,014,709 (GRCm38) missense probably benign 0.01
R2328:Zc3h6 UTSW 2 128,993,202 (GRCm38) missense possibly damaging 0.85
R2862:Zc3h6 UTSW 2 129,015,460 (GRCm38) missense probably benign 0.43
R2899:Zc3h6 UTSW 2 129,002,232 (GRCm38) missense probably benign 0.00
R3711:Zc3h6 UTSW 2 129,017,331 (GRCm38) missense probably benign 0.00
R3743:Zc3h6 UTSW 2 128,997,792 (GRCm38) missense probably damaging 1.00
R3893:Zc3h6 UTSW 2 129,016,140 (GRCm38) missense probably damaging 1.00
R4748:Zc3h6 UTSW 2 129,002,240 (GRCm38) missense probably damaging 1.00
R5025:Zc3h6 UTSW 2 129,010,433 (GRCm38) missense possibly damaging 0.87
R5026:Zc3h6 UTSW 2 129,017,309 (GRCm38) missense probably benign 0.00
R5125:Zc3h6 UTSW 2 129,014,479 (GRCm38) missense possibly damaging 0.93
R5373:Zc3h6 UTSW 2 129,002,156 (GRCm38) missense possibly damaging 0.75
R5374:Zc3h6 UTSW 2 129,002,156 (GRCm38) missense possibly damaging 0.75
R5703:Zc3h6 UTSW 2 128,993,452 (GRCm38) intron probably benign
R5802:Zc3h6 UTSW 2 129,015,559 (GRCm38) missense possibly damaging 0.56
R5876:Zc3h6 UTSW 2 128,993,277 (GRCm38) missense probably benign 0.29
R5879:Zc3h6 UTSW 2 128,997,776 (GRCm38) splice site probably null
R5950:Zc3h6 UTSW 2 128,997,790 (GRCm38) nonsense probably null
R6031:Zc3h6 UTSW 2 128,967,812 (GRCm38) missense possibly damaging 0.85
R6031:Zc3h6 UTSW 2 128,967,812 (GRCm38) missense possibly damaging 0.85
R6781:Zc3h6 UTSW 2 129,015,421 (GRCm38) missense probably damaging 0.99
R7323:Zc3h6 UTSW 2 128,993,411 (GRCm38) missense unknown
R7340:Zc3h6 UTSW 2 128,993,190 (GRCm38) missense possibly damaging 0.90
R7572:Zc3h6 UTSW 2 129,017,252 (GRCm38) missense probably benign 0.02
R7576:Zc3h6 UTSW 2 129,014,553 (GRCm38) missense probably damaging 1.00
R7797:Zc3h6 UTSW 2 129,015,635 (GRCm38) critical splice donor site probably null
R7924:Zc3h6 UTSW 2 129,015,480 (GRCm38) missense possibly damaging 0.52
R8048:Zc3h6 UTSW 2 129,017,014 (GRCm38) missense probably benign 0.30
R8877:Zc3h6 UTSW 2 129,014,399 (GRCm38) nonsense probably null
R9076:Zc3h6 UTSW 2 129,017,176 (GRCm38) nonsense probably null
R9577:Zc3h6 UTSW 2 129,016,182 (GRCm38) missense
R9687:Zc3h6 UTSW 2 129,017,361 (GRCm38) missense probably damaging 1.00
R9745:Zc3h6 UTSW 2 129,017,235 (GRCm38) missense probably benign 0.08
Z1176:Zc3h6 UTSW 2 129,016,221 (GRCm38) missense probably benign 0.01
Posted On 2015-12-18