Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02939:Or10g9'

365929

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or10g9

Ensembl Gene

ENSMUSG00000059473

Gene Name

olfactory receptor family 10 subfamily G member 9

Synonyms

MOR223-1, Olfr979, GA_x6K02T2PVTD-33699706-33698771

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.072) question?

Stock #

IGL02939

Quality Score

Status

Chromosome

Chromosomal Location

39911502-39912546 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 39912194 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Lysine at position 110 (E110K)

Ref Sequence

ENSEMBL: ENSMUSP00000148903 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080835] [ENSMUST00000215523] [ENSMUST00000216463]

AlphaFold

Q8VH10

Predicted Effect

probably benign
Transcript: ENSMUST00000080835
AA Change: E110K

PolyPhen 2 Score 0.259 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000079648
Gene: ENSMUSG00000059473
AA Change: E110K

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	304	7.9e-58	PFAM
Pfam:7tm_1	39	287	5.2e-22	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000215523
AA Change: E110K

PolyPhen 2 Score 0.259 (Sensitivity: 0.91; Specificity: 0.88)

Predicted Effect

probably benign
Transcript: ENSMUST00000216463

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Atp6ap1	A	G	X: 73,340,924 (GRCm39)	D47G	probably benign	Het
Atr	T	C	9: 95,747,314 (GRCm39)	F199L	probably benign	Het
Bivm	C	A	1: 44,182,120 (GRCm39)	H443N	probably benign	Het
Btnl2	A	T	17: 34,580,043 (GRCm39)	H192L	probably benign	Het
Ccdc178	A	T	18: 22,253,775 (GRCm39)	C155S	probably benign	Het
Celsr1	C	A	15: 85,785,673 (GRCm39)	V2934L	probably benign	Het
Celsr3	T	C	9: 108,726,652 (GRCm39)	S3294P	probably damaging	Het
Ddx10	T	A	9: 53,115,579 (GRCm39)	E585V	possibly damaging	Het
Elapor2	T	C	5: 9,511,478 (GRCm39)	Y947H	probably damaging	Het
Eps15l1	A	T	8: 73,138,606 (GRCm39)		probably benign	Het
Erlin1	G	T	19: 44,051,491 (GRCm39)	T70K	probably damaging	Het
Ext2	A	T	2: 93,534,964 (GRCm39)		probably null	Het
Fam124a	G	A	14: 62,793,368 (GRCm39)		probably null	Het
Fam53a	T	C	5: 33,765,103 (GRCm39)	D201G	probably damaging	Het
Fgf14	C	T	14: 124,369,891 (GRCm39)	G136D	possibly damaging	Het
Gdi2	A	T	13: 3,614,623 (GRCm39)	T323S	probably benign	Het
Gemin5	A	T	11: 58,047,556 (GRCm39)	N339K	probably damaging	Het
Golga4	A	G	9: 118,364,522 (GRCm39)	E286G	probably benign	Het
Golga4	A	C	9: 118,363,700 (GRCm39)	K233T	probably damaging	Het
Gosr1	A	G	11: 76,641,732 (GRCm39)		probably benign	Het
Haus8	A	G	8: 71,708,361 (GRCm39)		probably benign	Het
Itgb3bp	T	C	4: 99,690,373 (GRCm39)	T49A	probably null	Het
Ldlrad4	A	G	18: 68,387,585 (GRCm39)	D299G	probably damaging	Het
Lpo	A	G	11: 87,706,004 (GRCm39)	M273T	possibly damaging	Het
Map3k4	T	A	17: 12,491,036 (GRCm39)	S132C	probably damaging	Het
Mycbp2	T	G	14: 103,414,715 (GRCm39)	T2566P	probably benign	Het
Nalcn	T	C	14: 123,536,284 (GRCm39)	E1255G	probably null	Het
Nop56	A	T	2: 130,120,117 (GRCm39)	K157N	probably damaging	Het
Or6c1	A	T	10: 129,517,857 (GRCm39)	Y250*	probably null	Het
Pcdh15	A	G	10: 74,340,648 (GRCm39)		probably benign	Het
Pi4ka	T	C	16: 17,172,074 (GRCm39)	H557R	probably damaging	Het
Plekha4	C	T	7: 45,181,787 (GRCm39)	Q64*	probably null	Het
Ppp2r3c	G	A	12: 55,345,192 (GRCm39)		probably benign	Het
Rgmb	C	T	17: 16,027,755 (GRCm39)	M321I	probably benign	Het
Rnf31	T	C	14: 55,833,131 (GRCm39)	S363P	probably benign	Het
Sap18b	T	A	8: 96,552,329 (GRCm39)	M113K	probably benign	Het
Scara3	T	A	14: 66,169,105 (GRCm39)	M171L	probably benign	Het
Slc9a2	T	G	1: 40,781,863 (GRCm39)	M364R	probably damaging	Het
Sorcs1	C	T	19: 50,666,368 (GRCm39)	W180*	probably null	Het
Stat6	T	A	10: 127,482,809 (GRCm39)	M10K	probably benign	Het
Sun1	T	C	5: 139,221,243 (GRCm39)		probably benign	Het
Tead2	T	C	7: 44,869,858 (GRCm39)		probably benign	Het
Tjp1	T	G	7: 64,964,638 (GRCm39)	E844D	probably damaging	Het
Tmtc2	A	G	10: 105,206,411 (GRCm39)	S295P	probably damaging	Het
Ttn	G	A	2: 76,612,756 (GRCm39)	R17108C	probably damaging	Het
Ubr1	T	C	2: 120,711,664 (GRCm39)		probably null	Het
Vmn2r108	T	A	17: 20,691,545 (GRCm39)	H326L	probably benign	Het
Xdh	A	G	17: 74,250,840 (GRCm39)		probably null	Het
Zfp385b	A	G	2: 77,242,403 (GRCm39)	S439P	probably benign	Het
Zfp597	G	A	16: 3,683,805 (GRCm39)	S317L	probably benign	Het
Zfp638	A	G	6: 83,946,214 (GRCm39)	D1081G	probably damaging	Het
Zfp93	C	T	7: 23,974,509 (GRCm39)	H165Y	possibly damaging	Het

Other mutations in Or10g9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02718:Or10g9	APN	9	39,912,182 (GRCm39)	missense	probably damaging	1.00
IGL02991:Or10g9	UTSW	9	39,911,698 (GRCm39)	missense	probably damaging	1.00
R1388:Or10g9	UTSW	9	39,911,948 (GRCm39)	missense	probably damaging	0.99
R1572:Or10g9	UTSW	9	39,912,490 (GRCm39)	missense	probably benign	0.35
R2089:Or10g9	UTSW	9	39,912,500 (GRCm39)	missense	probably benign	0.01
R2091:Or10g9	UTSW	9	39,912,500 (GRCm39)	missense	probably benign	0.01
R2091:Or10g9	UTSW	9	39,912,500 (GRCm39)	missense	probably benign	0.01
R2179:Or10g9	UTSW	9	39,912,220 (GRCm39)	missense	probably benign	0.44
R3424:Or10g9	UTSW	9	39,911,830 (GRCm39)	missense	probably damaging	0.97
R3964:Or10g9	UTSW	9	39,911,767 (GRCm39)	missense	possibly damaging	0.95
R3965:Or10g9	UTSW	9	39,911,767 (GRCm39)	missense	possibly damaging	0.95
R4111:Or10g9	UTSW	9	39,912,194 (GRCm39)	nonsense	probably null
R4537:Or10g9	UTSW	9	39,911,616 (GRCm39)	missense	probably benign	0.01
R4737:Or10g9	UTSW	9	39,911,718 (GRCm39)	missense	probably damaging	0.96
R4926:Or10g9	UTSW	9	39,912,319 (GRCm39)	splice site	probably null
R5303:Or10g9	UTSW	9	39,911,884 (GRCm39)	missense	probably damaging	1.00
R5587:Or10g9	UTSW	9	39,911,917 (GRCm39)	missense	possibly damaging	0.90
R6387:Or10g9	UTSW	9	39,912,148 (GRCm39)	missense	probably damaging	0.99
R6394:Or10g9	UTSW	9	39,912,001 (GRCm39)	missense	probably benign	0.04
R6765:Or10g9	UTSW	9	39,912,493 (GRCm39)	missense	probably damaging	1.00
R7312:Or10g9	UTSW	9	39,912,106 (GRCm39)	missense	probably benign	0.22
R7463:Or10g9	UTSW	9	39,911,860 (GRCm39)	missense	probably benign	0.07
R7486:Or10g9	UTSW	9	39,912,181 (GRCm39)	missense	probably benign	0.39
R7581:Or10g9	UTSW	9	39,911,718 (GRCm39)	missense	probably damaging	0.96
R8364:Or10g9	UTSW	9	39,911,660 (GRCm39)	missense	probably benign	0.22
R8414:Or10g9	UTSW	9	39,912,241 (GRCm39)	missense	probably benign	0.19
R9049:Or10g9	UTSW	9	39,911,919 (GRCm39)	missense	possibly damaging	0.56
R9567:Or10g9	UTSW	9	39,912,367 (GRCm39)	missense	possibly damaging	0.95
R9632:Or10g9	UTSW	9	39,912,172 (GRCm39)	missense	probably damaging	1.00
R9710:Or10g9	UTSW	9	39,912,172 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-12-18