Incidental Mutation 'IGL02951:Prp2'
ID366008
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prp2
Ensembl Gene ENSMUSG00000058295
Gene Nameproline rich protein 2
SynonymsMP14
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL02951
Quality Score
Status
Chromosome6
Chromosomal Location132595913-132601236 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 132599825 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Serine at position 25 (N25S)
Ref Sequence ENSEMBL: ENSMUSP00000135942 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076061] [ENSMUST00000178961]
Predicted Effect unknown
Transcript: ENSMUST00000076061
AA Change: N25S
SMART Domains Protein: ENSMUSP00000075435
Gene: ENSMUSG00000058295
AA Change: N25S

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
low complexity region 24 44 N/A INTRINSIC
low complexity region 49 299 N/A INTRINSIC
low complexity region 302 316 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000178961
AA Change: N25S
SMART Domains Protein: ENSMUSP00000135942
Gene: ENSMUSG00000058295
AA Change: N25S

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
low complexity region 24 44 N/A INTRINSIC
low complexity region 49 299 N/A INTRINSIC
low complexity region 302 316 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The expression of this gene is dramatically induced in the parotid and submandibular glands of mice by beta-adrenergic stimulation. The encoded protein serves an important dental function by protecting mice against toxic dietary polyphenols such as tannins and influence the visco-elastic properties of the mucus. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 6. [provided by RefSeq, Nov 2015]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610028H24Rik C A 10: 76,454,702 probably benign Het
Acot10 G A 15: 20,665,782 T291I probably benign Het
Atp13a3 A G 16: 30,338,621 probably null Het
Atp2a1 C T 7: 126,450,227 V548M possibly damaging Het
Bsn G A 9: 108,115,613 S980L probably damaging Het
Ccdc158 A G 5: 92,650,006 M425T probably damaging Het
Cdh23 A G 10: 60,311,364 L2733S probably damaging Het
Chd3 C T 11: 69,361,048 probably null Het
Dock2 T C 11: 34,310,448 probably benign Het
Elfn2 T C 15: 78,671,882 K822E probably damaging Het
Eps15l1 G A 8: 72,358,396 S764L probably benign Het
Etl4 C A 2: 20,801,537 probably benign Het
Faap24 C A 7: 35,392,951 K180N probably damaging Het
Fam205a1 C T 4: 42,850,696 E487K probably benign Het
Fhod1 G A 8: 105,331,230 R888W probably damaging Het
Fus T C 7: 127,981,837 probably benign Het
Gm3453 T C 14: 5,976,168 E201G possibly damaging Het
Gm5346 T G 8: 43,627,088 H33P possibly damaging Het
Gnpat G T 8: 124,870,905 D69Y probably benign Het
Gpaa1 T A 15: 76,332,819 probably benign Het
Gsta1 A T 9: 78,242,537 K211* probably null Het
Lct G T 1: 128,300,211 Q1182K probably damaging Het
Mroh1 T C 15: 76,427,636 L523P probably damaging Het
Mrpl46 A G 7: 78,775,452 probably benign Het
Mst1r G T 9: 107,908,204 V354F possibly damaging Het
Myo15b A G 11: 115,881,301 D299G probably damaging Het
Myo6 G A 9: 80,264,234 V506I possibly damaging Het
Nadk A C 4: 155,587,476 K271Q probably benign Het
Nbas A G 12: 13,362,541 R954G probably benign Het
Nbr1 T A 11: 101,571,979 probably null Het
Nup88 T C 11: 70,944,872 D587G possibly damaging Het
Oas1a A T 5: 120,905,664 F135Y probably damaging Het
Obscn A G 11: 58,994,513 probably benign Het
Odf3l2 T C 10: 79,639,977 N251S probably benign Het
Olfr1290 T G 2: 111,490,120 I13L probably benign Het
Parp14 G A 16: 35,858,533 T355I probably benign Het
Pdgfd G T 9: 6,288,494 L43F probably damaging Het
Pou5f2 T C 13: 78,025,118 S60P probably benign Het
Ptprq A T 10: 107,667,460 F779Y probably benign Het
Rims2 C T 15: 39,534,938 R1078C probably damaging Het
Rnf38 G T 4: 44,129,619 S425* probably null Het
Rps21 T A 2: 180,258,047 I59N probably damaging Het
Scn5a A T 9: 119,495,685 F1359Y probably damaging Het
Slc35b2 A G 17: 45,564,768 E67G probably damaging Het
Slc37a2 A G 9: 37,255,315 F15L probably benign Het
Snapc4 A C 2: 26,370,835 N465K probably benign Het
Stxbp2 A T 8: 3,641,971 I538F probably benign Het
Taco1 A G 11: 106,069,527 N98S probably benign Het
Tcea3 T C 4: 136,257,988 probably null Het
Thada T C 17: 84,444,028 S507G probably benign Het
Tmem132b T A 5: 125,787,547 C906S probably damaging Het
Trpm2 A T 10: 77,929,278 I963N possibly damaging Het
Usp10 A G 8: 119,947,086 T397A probably benign Het
Usp3 G A 9: 66,542,550 R160* probably null Het
Utp15 T C 13: 98,257,952 Y144C probably damaging Het
Xpc G A 6: 91,506,849 R172W probably damaging Het
Other mutations in Prp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01383:Prp2 APN 6 132599878 missense unknown
PIT4458001:Prp2 UTSW 6 132600547 missense unknown
R2034:Prp2 UTSW 6 132595984 splice site probably null
R2432:Prp2 UTSW 6 132599911 missense unknown
R5283:Prp2 UTSW 6 132600643 missense unknown
R7761:Prp2 UTSW 6 132600343 nonsense probably null
R7877:Prp2 UTSW 6 132595965 missense unknown
R8033:Prp2 UTSW 6 132600428 missense unknown
R8062:Prp2 UTSW 6 132600688 missense unknown
R8695:Prp2 UTSW 6 132599969 missense unknown
R8696:Prp2 UTSW 6 132600359 missense unknown
R8938:Prp2 UTSW 6 132600618 missense unknown
RF005:Prp2 UTSW 6 132600501 small deletion probably benign
RF016:Prp2 UTSW 6 132600512 small deletion probably benign
RF039:Prp2 UTSW 6 132600501 small deletion probably benign
RF052:Prp2 UTSW 6 132600512 small deletion probably benign
RF054:Prp2 UTSW 6 132600521 frame shift probably null
RF057:Prp2 UTSW 6 132600530 frame shift probably null
X0053:Prp2 UTSW 6 132600596 missense unknown
Z1176:Prp2 UTSW 6 132600237 missense unknown
Z1177:Prp2 UTSW 6 132595970 missense unknown
Posted On2015-12-18