Incidental Mutation 'IGL02951:Nadk'
ID 366012
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Nadk
Ensembl Gene ENSMUSG00000029063
Gene Name NAD kinase
Synonyms 4432404C02Rik
Accession Numbers
Essential gene? Probably essential (E-score: 0.937) question?
Stock # IGL02951
Quality Score
Status
Chromosome 4
Chromosomal Location 155646838-155675458 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 155671933 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamine at position 271 (K271Q)
Ref Sequence ENSEMBL: ENSMUSP00000101238 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030939] [ENSMUST00000105612] [ENSMUST00000105613]
AlphaFold P58058
Predicted Effect probably benign
Transcript: ENSMUST00000030939
AA Change: K271Q

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000030939
Gene: ENSMUSG00000029063
AA Change: K271Q

DomainStartEndE-ValueType
Pfam:NAD_kinase 106 406 2.5e-64 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000105612
AA Change: K195Q

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000101237
Gene: ENSMUSG00000029063
AA Change: K195Q

DomainStartEndE-ValueType
Pfam:NAD_kinase 30 330 7.6e-66 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000105613
AA Change: K271Q

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000101238
Gene: ENSMUSG00000029063
AA Change: K271Q

DomainStartEndE-ValueType
Pfam:NAD_kinase 106 406 1.4e-67 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152297
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] NADK catalyzes the transfer of a phosphate group from ATP to NAD to generate NADP, which in its reduced form acts as an electron donor for biosynthetic reactions (Lerner et al., 2001 [PubMed 11594753]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610028H24Rik C A 10: 76,290,536 (GRCm39) probably benign Het
Acot10 G A 15: 20,665,868 (GRCm39) T291I probably benign Het
Adam34l T G 8: 44,080,125 (GRCm39) H33P possibly damaging Het
Atp13a3 A G 16: 30,157,439 (GRCm39) probably null Het
Atp2a1 C T 7: 126,049,399 (GRCm39) V548M possibly damaging Het
Bsn G A 9: 107,992,812 (GRCm39) S980L probably damaging Het
Ccdc158 A G 5: 92,797,865 (GRCm39) M425T probably damaging Het
Cdh23 A G 10: 60,147,143 (GRCm39) L2733S probably damaging Het
Chd3 C T 11: 69,251,874 (GRCm39) probably null Het
Cimap1d T C 10: 79,475,811 (GRCm39) N251S probably benign Het
Dock2 T C 11: 34,260,448 (GRCm39) probably benign Het
Elfn2 T C 15: 78,556,082 (GRCm39) K822E probably damaging Het
Eps15l1 G A 8: 73,112,240 (GRCm39) S764L probably benign Het
Etl4 C A 2: 20,806,348 (GRCm39) probably benign Het
Faap24 C A 7: 35,092,376 (GRCm39) K180N probably damaging Het
Fhod1 G A 8: 106,057,862 (GRCm39) R888W probably damaging Het
Fus T C 7: 127,581,009 (GRCm39) probably benign Het
Gm3453 T C 14: 5,976,168 (GRCm38) E201G possibly damaging Het
Gnpat G T 8: 125,597,644 (GRCm39) D69Y probably benign Het
Gpaa1 T A 15: 76,217,019 (GRCm39) probably benign Het
Gsta1 A T 9: 78,149,819 (GRCm39) K211* probably null Het
Lct G T 1: 128,227,948 (GRCm39) Q1182K probably damaging Het
Mroh1 T C 15: 76,311,836 (GRCm39) L523P probably damaging Het
Mrpl46 A G 7: 78,425,200 (GRCm39) probably benign Het
Mst1r G T 9: 107,785,403 (GRCm39) V354F possibly damaging Het
Myo15b A G 11: 115,772,127 (GRCm39) D299G probably damaging Het
Myo6 G A 9: 80,171,516 (GRCm39) V506I possibly damaging Het
Nbas A G 12: 13,412,542 (GRCm39) R954G probably benign Het
Nbr1 T A 11: 101,462,805 (GRCm39) probably null Het
Nup88 T C 11: 70,835,698 (GRCm39) D587G possibly damaging Het
Oas1a A T 5: 121,043,727 (GRCm39) F135Y probably damaging Het
Obscn A G 11: 58,885,339 (GRCm39) probably benign Het
Or4k42 T G 2: 111,320,465 (GRCm39) I13L probably benign Het
Parp14 G A 16: 35,678,903 (GRCm39) T355I probably benign Het
Pdgfd G T 9: 6,288,494 (GRCm39) L43F probably damaging Het
Pou5f2 T C 13: 78,173,237 (GRCm39) S60P probably benign Het
Prp2 A G 6: 132,576,788 (GRCm39) N25S unknown Het
Ptprq A T 10: 107,503,321 (GRCm39) F779Y probably benign Het
Rims2 C T 15: 39,398,334 (GRCm39) R1078C probably damaging Het
Rnf38 G T 4: 44,129,619 (GRCm39) S425* probably null Het
Rps21 T A 2: 179,899,840 (GRCm39) I59N probably damaging Het
Scn5a A T 9: 119,324,751 (GRCm39) F1359Y probably damaging Het
Slc35b2 A G 17: 45,875,694 (GRCm39) E67G probably damaging Het
Slc37a2 A G 9: 37,166,611 (GRCm39) F15L probably benign Het
Snapc4 A C 2: 26,260,847 (GRCm39) N465K probably benign Het
Spata31f1a C T 4: 42,850,696 (GRCm39) E487K probably benign Het
Stxbp2 A T 8: 3,691,971 (GRCm39) I538F probably benign Het
Taco1 A G 11: 105,960,353 (GRCm39) N98S probably benign Het
Tcea3 T C 4: 135,985,299 (GRCm39) probably null Het
Thada T C 17: 84,751,456 (GRCm39) S507G probably benign Het
Tmem132b T A 5: 125,864,611 (GRCm39) C906S probably damaging Het
Trpm2 A T 10: 77,765,112 (GRCm39) I963N possibly damaging Het
Usp10 A G 8: 120,673,825 (GRCm39) T397A probably benign Het
Usp3 G A 9: 66,449,832 (GRCm39) R160* probably null Het
Utp15 T C 13: 98,394,460 (GRCm39) Y144C probably damaging Het
Xpc G A 6: 91,483,831 (GRCm39) R172W probably damaging Het
Other mutations in Nadk
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01551:Nadk APN 4 155,673,157 (GRCm39) splice site probably benign
IGL02078:Nadk APN 4 155,663,860 (GRCm39) unclassified probably benign
IGL02116:Nadk APN 4 155,663,763 (GRCm39) splice site probably benign
IGL03059:Nadk APN 4 155,671,253 (GRCm39) missense probably benign 0.02
IGL03203:Nadk APN 4 155,669,708 (GRCm39) missense probably damaging 0.99
R0416:Nadk UTSW 4 155,672,256 (GRCm39) splice site probably benign
R1633:Nadk UTSW 4 155,661,642 (GRCm39) missense probably damaging 1.00
R2044:Nadk UTSW 4 155,669,898 (GRCm39) missense probably damaging 1.00
R2891:Nadk UTSW 4 155,671,817 (GRCm39) missense possibly damaging 0.46
R2892:Nadk UTSW 4 155,671,817 (GRCm39) missense possibly damaging 0.46
R2894:Nadk UTSW 4 155,671,817 (GRCm39) missense possibly damaging 0.46
R4275:Nadk UTSW 4 155,668,712 (GRCm39) missense probably benign 0.44
R4386:Nadk UTSW 4 155,667,032 (GRCm39) unclassified probably benign
R4416:Nadk UTSW 4 155,672,183 (GRCm39) nonsense probably null
R4703:Nadk UTSW 4 155,669,684 (GRCm39) missense probably benign 0.00
R4704:Nadk UTSW 4 155,669,684 (GRCm39) missense probably benign 0.00
R4705:Nadk UTSW 4 155,669,684 (GRCm39) missense probably benign 0.00
R5219:Nadk UTSW 4 155,668,711 (GRCm39) missense probably benign 0.00
R5610:Nadk UTSW 4 155,668,628 (GRCm39) missense probably damaging 1.00
R5673:Nadk UTSW 4 155,669,642 (GRCm39) missense possibly damaging 0.48
R6393:Nadk UTSW 4 155,673,808 (GRCm39) missense possibly damaging 0.60
R7091:Nadk UTSW 4 155,672,215 (GRCm39) missense probably benign 0.00
R7144:Nadk UTSW 4 155,673,793 (GRCm39) missense probably damaging 0.99
R7811:Nadk UTSW 4 155,661,332 (GRCm39) intron probably benign
R7951:Nadk UTSW 4 155,661,524 (GRCm39) missense probably benign 0.06
R7952:Nadk UTSW 4 155,661,524 (GRCm39) missense probably benign 0.06
R8002:Nadk UTSW 4 155,661,655 (GRCm39) critical splice donor site probably null
R8039:Nadk UTSW 4 155,661,524 (GRCm39) missense probably benign 0.06
R8041:Nadk UTSW 4 155,661,524 (GRCm39) missense probably benign 0.06
R8042:Nadk UTSW 4 155,661,524 (GRCm39) missense probably benign 0.06
R8066:Nadk UTSW 4 155,661,524 (GRCm39) missense probably benign 0.06
R8113:Nadk UTSW 4 155,655,127 (GRCm39) splice site probably null
R8558:Nadk UTSW 4 155,669,844 (GRCm39) missense probably benign 0.40
R9122:Nadk UTSW 4 155,671,275 (GRCm39) missense probably benign 0.00
Z1177:Nadk UTSW 4 155,672,157 (GRCm39) missense probably damaging 1.00
Posted On 2015-12-18