Incidental Mutation 'IGL02951:Fus'
ID366022
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fus
Ensembl Gene ENSMUSG00000030795
Gene Namefused in sarcoma
SynonymsD430004D17Rik, hnRNP P2, pigpen, D930039C12Rik, translocated in liposarcoma, Tls
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #IGL02951
Quality Score
Status
Chromosome7
Chromosomal Location127967457-127985701 bp(+) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) T to C at 127981837 bp
ZygosityHeterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000077609] [ENSMUST00000079045] [ENSMUST00000106251] [ENSMUST00000121616]
Predicted Effect probably benign
Transcript: ENSMUST00000077609
SMART Domains Protein: ENSMUSP00000076801
Gene: ENSMUSG00000030795

DomainStartEndE-ValueType
low complexity region 20 44 N/A INTRINSIC
low complexity region 48 67 N/A INTRINSIC
low complexity region 72 104 N/A INTRINSIC
low complexity region 110 179 N/A INTRINSIC
low complexity region 185 253 N/A INTRINSIC
RRM 278 359 3.85e-16 SMART
ZnF_RBZ 416 442 9e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000079045
SMART Domains Protein: ENSMUSP00000078054
Gene: ENSMUSG00000030795

DomainStartEndE-ValueType
transmembrane domain 89 111 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000106251
SMART Domains Protein: ENSMUSP00000101858
Gene: ENSMUSG00000030795

DomainStartEndE-ValueType
low complexity region 20 44 N/A INTRINSIC
low complexity region 47 63 N/A INTRINSIC
low complexity region 73 105 N/A INTRINSIC
low complexity region 111 180 N/A INTRINSIC
low complexity region 186 254 N/A INTRINSIC
RRM 279 360 3.85e-16 SMART
ZnF_RBZ 417 443 9e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000121616
SMART Domains Protein: ENSMUSP00000112721
Gene: ENSMUSG00000030795

DomainStartEndE-ValueType
low complexity region 20 44 N/A INTRINSIC
low complexity region 47 63 N/A INTRINSIC
low complexity region 73 105 N/A INTRINSIC
low complexity region 111 176 N/A INTRINSIC
ZnF_RBZ 179 205 9e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128851
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136289
Predicted Effect probably benign
Transcript: ENSMUST00000141997
SMART Domains Protein: ENSMUSP00000134447
Gene: ENSMUSG00000030795

DomainStartEndE-ValueType
ZnF_RBZ 15 41 9e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154843
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155941
Predicted Effect noncoding transcript
Transcript: ENSMUST00000172755
Predicted Effect probably benign
Transcript: ENSMUST00000174632
SMART Domains Protein: ENSMUSP00000133820
Gene: ENSMUSG00000030795

DomainStartEndE-ValueType
Pfam:RRM_1 6 56 6.6e-9 PFAM
ZnF_RBZ 77 103 9e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181457
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205351
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygotes for targeted null mutations exhibit impaired lymphocyte development, chromosomal instability, increased cellular radiation sensitivity, high neonatal mortality, and male sterility associated with lack of chromosomal pairing. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610028H24Rik C A 10: 76,454,702 probably benign Het
Acot10 G A 15: 20,665,782 T291I probably benign Het
Atp13a3 A G 16: 30,338,621 probably null Het
Atp2a1 C T 7: 126,450,227 V548M possibly damaging Het
Bsn G A 9: 108,115,613 S980L probably damaging Het
Ccdc158 A G 5: 92,650,006 M425T probably damaging Het
Cdh23 A G 10: 60,311,364 L2733S probably damaging Het
Chd3 C T 11: 69,361,048 probably null Het
Dock2 T C 11: 34,310,448 probably benign Het
Elfn2 T C 15: 78,671,882 K822E probably damaging Het
Eps15l1 G A 8: 72,358,396 S764L probably benign Het
Etl4 C A 2: 20,801,537 probably benign Het
Faap24 C A 7: 35,392,951 K180N probably damaging Het
Fam205a1 C T 4: 42,850,696 E487K probably benign Het
Fhod1 G A 8: 105,331,230 R888W probably damaging Het
Gm3453 T C 14: 5,976,168 E201G possibly damaging Het
Gm5346 T G 8: 43,627,088 H33P possibly damaging Het
Gnpat G T 8: 124,870,905 D69Y probably benign Het
Gpaa1 T A 15: 76,332,819 probably benign Het
Gsta1 A T 9: 78,242,537 K211* probably null Het
Lct G T 1: 128,300,211 Q1182K probably damaging Het
Mroh1 T C 15: 76,427,636 L523P probably damaging Het
Mrpl46 A G 7: 78,775,452 probably benign Het
Mst1r G T 9: 107,908,204 V354F possibly damaging Het
Myo15b A G 11: 115,881,301 D299G probably damaging Het
Myo6 G A 9: 80,264,234 V506I possibly damaging Het
Nadk A C 4: 155,587,476 K271Q probably benign Het
Nbas A G 12: 13,362,541 R954G probably benign Het
Nbr1 T A 11: 101,571,979 probably null Het
Nup88 T C 11: 70,944,872 D587G possibly damaging Het
Oas1a A T 5: 120,905,664 F135Y probably damaging Het
Obscn A G 11: 58,994,513 probably benign Het
Odf3l2 T C 10: 79,639,977 N251S probably benign Het
Olfr1290 T G 2: 111,490,120 I13L probably benign Het
Parp14 G A 16: 35,858,533 T355I probably benign Het
Pdgfd G T 9: 6,288,494 L43F probably damaging Het
Pou5f2 T C 13: 78,025,118 S60P probably benign Het
Prp2 A G 6: 132,599,825 N25S unknown Het
Ptprq A T 10: 107,667,460 F779Y probably benign Het
Rims2 C T 15: 39,534,938 R1078C probably damaging Het
Rnf38 G T 4: 44,129,619 S425* probably null Het
Rps21 T A 2: 180,258,047 I59N probably damaging Het
Scn5a A T 9: 119,495,685 F1359Y probably damaging Het
Slc35b2 A G 17: 45,564,768 E67G probably damaging Het
Slc37a2 A G 9: 37,255,315 F15L probably benign Het
Snapc4 A C 2: 26,370,835 N465K probably benign Het
Stxbp2 A T 8: 3,641,971 I538F probably benign Het
Taco1 A G 11: 106,069,527 N98S probably benign Het
Tcea3 T C 4: 136,257,988 probably null Het
Thada T C 17: 84,444,028 S507G probably benign Het
Tmem132b T A 5: 125,787,547 C906S probably damaging Het
Trpm2 A T 10: 77,929,278 I963N possibly damaging Het
Usp10 A G 8: 119,947,086 T397A probably benign Het
Usp3 G A 9: 66,542,550 R160* probably null Het
Utp15 T C 13: 98,257,952 Y144C probably damaging Het
Xpc G A 6: 91,506,849 R172W probably damaging Het
Other mutations in Fus
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02505:Fus APN 7 127981507 missense possibly damaging 0.53
IGL02622:Fus APN 7 127985622 missense probably damaging 0.99
IGL03029:Fus APN 7 127985540 unclassified probably benign
R0588:Fus UTSW 7 127985574 missense probably damaging 0.99
R0674:Fus UTSW 7 127972776 unclassified probably benign
R0686:Fus UTSW 7 127972763 unclassified probably benign
R0746:Fus UTSW 7 127985424 unclassified probably benign
R1562:Fus UTSW 7 127979922 missense probably damaging 1.00
R1733:Fus UTSW 7 127981545 missense probably benign 0.01
R2186:Fus UTSW 7 127985534 unclassified probably benign
R2200:Fus UTSW 7 127977228 missense probably damaging 0.99
R4537:Fus UTSW 7 127975915 missense probably damaging 0.99
R4981:Fus UTSW 7 127967555 start gained probably benign
R5206:Fus UTSW 7 127969797 missense unknown
R5283:Fus UTSW 7 127985547 unclassified probably benign
R5614:Fus UTSW 7 127974371 unclassified probably benign
R6182:Fus UTSW 7 127977293 missense probably damaging 0.97
R6239:Fus UTSW 7 127981434 missense possibly damaging 0.91
R6939:Fus UTSW 7 127972569 unclassified probably benign
R7130:Fus UTSW 7 127974413 missense unknown
R7340:Fus UTSW 7 127981951 splice site probably null
R8293:Fus UTSW 7 127972577 missense unknown
R8440:Fus UTSW 7 127969826 missense unknown
X0061:Fus UTSW 7 127985433 unclassified probably benign
Posted On2015-12-18