Incidental Mutation 'IGL02951:Fus'
ID 366022
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fus
Ensembl Gene ENSMUSG00000030795
Gene Name fused in sarcoma
Synonyms D930039C12Rik, translocated in liposarcoma, pigpen, hnRNP P2, Tls, D430004D17Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL02951
Quality Score
Status
Chromosome 7
Chromosomal Location 127565276-127581204 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to C at 127581009 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000077609] [ENSMUST00000079045] [ENSMUST00000106251] [ENSMUST00000121616]
AlphaFold P56959
Predicted Effect probably benign
Transcript: ENSMUST00000077609
SMART Domains Protein: ENSMUSP00000076801
Gene: ENSMUSG00000030795

DomainStartEndE-ValueType
low complexity region 20 44 N/A INTRINSIC
low complexity region 48 67 N/A INTRINSIC
low complexity region 72 104 N/A INTRINSIC
low complexity region 110 179 N/A INTRINSIC
low complexity region 185 253 N/A INTRINSIC
RRM 278 359 3.85e-16 SMART
ZnF_RBZ 416 442 9e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000079045
SMART Domains Protein: ENSMUSP00000078054
Gene: ENSMUSG00000030795

DomainStartEndE-ValueType
transmembrane domain 89 111 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000106251
SMART Domains Protein: ENSMUSP00000101858
Gene: ENSMUSG00000030795

DomainStartEndE-ValueType
low complexity region 20 44 N/A INTRINSIC
low complexity region 47 63 N/A INTRINSIC
low complexity region 73 105 N/A INTRINSIC
low complexity region 111 180 N/A INTRINSIC
low complexity region 186 254 N/A INTRINSIC
RRM 279 360 3.85e-16 SMART
ZnF_RBZ 417 443 9e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000121616
SMART Domains Protein: ENSMUSP00000112721
Gene: ENSMUSG00000030795

DomainStartEndE-ValueType
low complexity region 20 44 N/A INTRINSIC
low complexity region 47 63 N/A INTRINSIC
low complexity region 73 105 N/A INTRINSIC
low complexity region 111 176 N/A INTRINSIC
ZnF_RBZ 179 205 9e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128851
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136289
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155941
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205351
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181457
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154843
Predicted Effect noncoding transcript
Transcript: ENSMUST00000172755
Predicted Effect probably benign
Transcript: ENSMUST00000141997
SMART Domains Protein: ENSMUSP00000134447
Gene: ENSMUSG00000030795

DomainStartEndE-ValueType
ZnF_RBZ 15 41 9e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000174632
SMART Domains Protein: ENSMUSP00000133820
Gene: ENSMUSG00000030795

DomainStartEndE-ValueType
Pfam:RRM_1 6 56 6.6e-9 PFAM
ZnF_RBZ 77 103 9e-4 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygotes for targeted null mutations exhibit impaired lymphocyte development, chromosomal instability, increased cellular radiation sensitivity, high neonatal mortality, and male sterility associated with lack of chromosomal pairing. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610028H24Rik C A 10: 76,290,536 (GRCm39) probably benign Het
Acot10 G A 15: 20,665,868 (GRCm39) T291I probably benign Het
Adam34l T G 8: 44,080,125 (GRCm39) H33P possibly damaging Het
Atp13a3 A G 16: 30,157,439 (GRCm39) probably null Het
Atp2a1 C T 7: 126,049,399 (GRCm39) V548M possibly damaging Het
Bsn G A 9: 107,992,812 (GRCm39) S980L probably damaging Het
Ccdc158 A G 5: 92,797,865 (GRCm39) M425T probably damaging Het
Cdh23 A G 10: 60,147,143 (GRCm39) L2733S probably damaging Het
Chd3 C T 11: 69,251,874 (GRCm39) probably null Het
Cimap1d T C 10: 79,475,811 (GRCm39) N251S probably benign Het
Dock2 T C 11: 34,260,448 (GRCm39) probably benign Het
Elfn2 T C 15: 78,556,082 (GRCm39) K822E probably damaging Het
Eps15l1 G A 8: 73,112,240 (GRCm39) S764L probably benign Het
Etl4 C A 2: 20,806,348 (GRCm39) probably benign Het
Faap24 C A 7: 35,092,376 (GRCm39) K180N probably damaging Het
Fhod1 G A 8: 106,057,862 (GRCm39) R888W probably damaging Het
Gm3453 T C 14: 5,976,168 (GRCm38) E201G possibly damaging Het
Gnpat G T 8: 125,597,644 (GRCm39) D69Y probably benign Het
Gpaa1 T A 15: 76,217,019 (GRCm39) probably benign Het
Gsta1 A T 9: 78,149,819 (GRCm39) K211* probably null Het
Lct G T 1: 128,227,948 (GRCm39) Q1182K probably damaging Het
Mroh1 T C 15: 76,311,836 (GRCm39) L523P probably damaging Het
Mrpl46 A G 7: 78,425,200 (GRCm39) probably benign Het
Mst1r G T 9: 107,785,403 (GRCm39) V354F possibly damaging Het
Myo15b A G 11: 115,772,127 (GRCm39) D299G probably damaging Het
Myo6 G A 9: 80,171,516 (GRCm39) V506I possibly damaging Het
Nadk A C 4: 155,671,933 (GRCm39) K271Q probably benign Het
Nbas A G 12: 13,412,542 (GRCm39) R954G probably benign Het
Nbr1 T A 11: 101,462,805 (GRCm39) probably null Het
Nup88 T C 11: 70,835,698 (GRCm39) D587G possibly damaging Het
Oas1a A T 5: 121,043,727 (GRCm39) F135Y probably damaging Het
Obscn A G 11: 58,885,339 (GRCm39) probably benign Het
Or4k42 T G 2: 111,320,465 (GRCm39) I13L probably benign Het
Parp14 G A 16: 35,678,903 (GRCm39) T355I probably benign Het
Pdgfd G T 9: 6,288,494 (GRCm39) L43F probably damaging Het
Pou5f2 T C 13: 78,173,237 (GRCm39) S60P probably benign Het
Prp2 A G 6: 132,576,788 (GRCm39) N25S unknown Het
Ptprq A T 10: 107,503,321 (GRCm39) F779Y probably benign Het
Rims2 C T 15: 39,398,334 (GRCm39) R1078C probably damaging Het
Rnf38 G T 4: 44,129,619 (GRCm39) S425* probably null Het
Rps21 T A 2: 179,899,840 (GRCm39) I59N probably damaging Het
Scn5a A T 9: 119,324,751 (GRCm39) F1359Y probably damaging Het
Slc35b2 A G 17: 45,875,694 (GRCm39) E67G probably damaging Het
Slc37a2 A G 9: 37,166,611 (GRCm39) F15L probably benign Het
Snapc4 A C 2: 26,260,847 (GRCm39) N465K probably benign Het
Spata31f1a C T 4: 42,850,696 (GRCm39) E487K probably benign Het
Stxbp2 A T 8: 3,691,971 (GRCm39) I538F probably benign Het
Taco1 A G 11: 105,960,353 (GRCm39) N98S probably benign Het
Tcea3 T C 4: 135,985,299 (GRCm39) probably null Het
Thada T C 17: 84,751,456 (GRCm39) S507G probably benign Het
Tmem132b T A 5: 125,864,611 (GRCm39) C906S probably damaging Het
Trpm2 A T 10: 77,765,112 (GRCm39) I963N possibly damaging Het
Usp10 A G 8: 120,673,825 (GRCm39) T397A probably benign Het
Usp3 G A 9: 66,449,832 (GRCm39) R160* probably null Het
Utp15 T C 13: 98,394,460 (GRCm39) Y144C probably damaging Het
Xpc G A 6: 91,483,831 (GRCm39) R172W probably damaging Het
Other mutations in Fus
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02505:Fus APN 7 127,580,679 (GRCm39) missense possibly damaging 0.53
IGL02622:Fus APN 7 127,584,794 (GRCm39) missense probably damaging 0.99
IGL03029:Fus APN 7 127,584,712 (GRCm39) unclassified probably benign
R0588:Fus UTSW 7 127,584,746 (GRCm39) missense probably damaging 0.99
R0674:Fus UTSW 7 127,571,948 (GRCm39) unclassified probably benign
R0686:Fus UTSW 7 127,571,935 (GRCm39) unclassified probably benign
R0746:Fus UTSW 7 127,584,596 (GRCm39) unclassified probably benign
R1562:Fus UTSW 7 127,579,094 (GRCm39) missense probably damaging 1.00
R1733:Fus UTSW 7 127,580,717 (GRCm39) missense probably benign 0.01
R2186:Fus UTSW 7 127,584,706 (GRCm39) unclassified probably benign
R2200:Fus UTSW 7 127,576,400 (GRCm39) missense probably damaging 0.99
R4537:Fus UTSW 7 127,575,087 (GRCm39) missense probably damaging 0.99
R4981:Fus UTSW 7 127,566,727 (GRCm39) start gained probably benign
R5206:Fus UTSW 7 127,568,969 (GRCm39) missense unknown
R5283:Fus UTSW 7 127,584,719 (GRCm39) unclassified probably benign
R5614:Fus UTSW 7 127,573,543 (GRCm39) unclassified probably benign
R6182:Fus UTSW 7 127,576,465 (GRCm39) missense probably damaging 0.97
R6239:Fus UTSW 7 127,580,606 (GRCm39) missense possibly damaging 0.91
R6939:Fus UTSW 7 127,571,741 (GRCm39) unclassified probably benign
R7130:Fus UTSW 7 127,573,585 (GRCm39) missense unknown
R7340:Fus UTSW 7 127,581,123 (GRCm39) splice site probably null
R8293:Fus UTSW 7 127,571,749 (GRCm39) missense unknown
R8440:Fus UTSW 7 127,568,998 (GRCm39) missense unknown
R9154:Fus UTSW 7 127,580,440 (GRCm39) missense unknown
X0061:Fus UTSW 7 127,584,605 (GRCm39) unclassified probably benign
Posted On 2015-12-18