Incidental Mutation 'R4766:Fut9'
ID 366128
Institutional Source Beutler Lab
Gene Symbol Fut9
Ensembl Gene ENSMUSG00000055373
Gene Name fucosyltransferase 9
Synonyms mFuc-TIX, mFUT9
MMRRC Submission 042407-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4766 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 25609332-25800244 bp(-) (GRCm38)
Type of Mutation intron
DNA Base Change (assembly) A to G at 25799191 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000103834 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084770] [ENSMUST00000108199]
AlphaFold O88819
Predicted Effect probably benign
Transcript: ENSMUST00000084770
SMART Domains Protein: ENSMUSP00000081826
Gene: ENSMUSG00000055373

DomainStartEndE-ValueType
Pfam:Glyco_transf_10 6 358 2.9e-140 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000108199
SMART Domains Protein: ENSMUSP00000103834
Gene: ENSMUSG00000055373

DomainStartEndE-ValueType
transmembrane domain 7 29 N/A INTRINSIC
Pfam:Glyco_tran_10_N 61 169 1.4e-43 PFAM
Pfam:Glyco_transf_10 185 357 4.8e-69 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149875
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.9%
Validation Efficiency 97% (87/90)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the glycosyltransferase family. It is localized to the golgi, and catalyzes the last step in the biosynthesis of Lewis X (LeX) antigen, the addition of a fucose to precursor polysaccharides. This protein is one of the few fucosyltransferases that synthesizes the LeX oligosaccharide (CD15) expressed in the organ buds progressing in mesenchyma during embryogenesis. It is also responsible for the expression of CD15 in mature granulocytes. A common haplotype of this gene has also been associated with susceptibility to placental malaria infection. [provided by RefSeq, Nov 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased number of neuronal stem cells with increased self-renewal capacity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2900026A02Rik C T 5: 113,097,636 (GRCm38) V1584I probably benign Het
Adamts12 A G 15: 11,285,901 (GRCm38) D732G probably benign Het
Agpat4 A G 17: 12,151,750 (GRCm38) probably benign Het
AI182371 T C 2: 35,095,817 (GRCm38) D140G possibly damaging Het
Apol11b T A 15: 77,634,933 (GRCm38) T316S probably benign Het
Arsi G A 18: 60,916,651 (GRCm38) G202E probably benign Het
Bard1 T C 1: 71,075,174 (GRCm38) E216G probably benign Het
Bdp1 C A 13: 100,049,868 (GRCm38) R1692L probably damaging Het
Capn10 T C 1: 92,943,419 (GRCm38) I101T probably damaging Het
Ccdc175 C T 12: 72,112,205 (GRCm38) M653I probably benign Het
Ccdc9b C A 2: 118,759,577 (GRCm38) R262L probably damaging Het
Ccr8 G A 9: 120,094,464 (GRCm38) C215Y probably damaging Het
Cct3 T A 3: 88,311,785 (GRCm38) L241* probably null Het
Cd2ap A T 17: 42,852,459 (GRCm38) I25N probably damaging Het
Cdh19 T C 1: 110,893,260 (GRCm38) K583E probably benign Het
Cela3a A G 4: 137,402,675 (GRCm38) S212P unknown Het
Cfap44 T A 16: 44,415,883 (GRCm38) probably null Het
Clca3a1 A T 3: 144,749,712 (GRCm38) L440Q probably damaging Het
Crybg2 A G 4: 134,089,352 (GRCm38) Y1676C probably damaging Het
Dscam T C 16: 96,643,988 (GRCm38) D1501G probably benign Het
Eml6 C A 11: 29,805,757 (GRCm38) L832F probably benign Het
Enpp3 A G 10: 24,773,927 (GRCm38) L867P probably damaging Het
Erbb3 A G 10: 128,586,238 (GRCm38) Y46H possibly damaging Het
Fads3 T C 19: 10,056,020 (GRCm38) I342T possibly damaging Het
Flvcr1 A T 1: 191,021,106 (GRCm38) S290T probably benign Het
Gad2 C T 2: 22,622,667 (GRCm38) A2V probably damaging Het
Gkn3 C T 6: 87,383,525 (GRCm38) A163T probably damaging Het
Gm10715 T G 9: 3,038,073 (GRCm38) probably benign Het
Herc1 T G 9: 66,441,929 (GRCm38) D2023E probably benign Het
Hsd3b3 A G 3: 98,742,485 (GRCm38) L174P probably damaging Het
Impg2 TACCACCACCACCACCACCACCACCA TACCACCACCACCACCACCACCA 16: 56,257,939 (GRCm38) probably benign Het
Iqcf3 A G 9: 106,560,949 (GRCm38) probably null Het
Kcna4 G A 2: 107,296,543 (GRCm38) V541M probably damaging Het
Kcnj11 T C 7: 46,099,816 (GRCm38) T28A probably benign Het
Kcnmb2 T A 3: 32,181,867 (GRCm38) N88K probably damaging Het
Kdm2a TTCCTCCTCCTCCTCCTCTTCCTCCTCCTC TTCCTCCTCCTCCTCTTCCTCCTCCTC 19: 4,324,507 (GRCm38) probably benign Het
Krt2 T C 15: 101,813,960 (GRCm38) E430G probably damaging Het
Lins1 C T 7: 66,710,641 (GRCm38) L384F possibly damaging Het
Man1c1 G C 4: 134,703,438 (GRCm38) P11R probably damaging Het
Mfge8 T C 7: 79,134,525 (GRCm38) N389D probably damaging Het
Mug1 C T 6: 121,884,254 (GRCm38) T1278I probably benign Het
Myh9 T C 15: 77,807,877 (GRCm38) M161V probably damaging Het
Myl7 T A 11: 5,898,171 (GRCm38) Y61F probably benign Het
Nlrp4d A T 7: 10,362,779 (GRCm38) unknown Het
Nol3 A G 8: 105,281,933 (GRCm38) probably null Het
Nup85 T A 11: 115,577,925 (GRCm38) probably null Het
Obscn T A 11: 59,012,742 (GRCm38) T7619S probably damaging Het
Or2t49 T A 11: 58,501,668 (GRCm38) N296I probably damaging Het
Or4k48 T C 2: 111,645,881 (GRCm38) M39V probably benign Het
Or52a24 C T 7: 103,732,250 (GRCm38) T108I possibly damaging Het
Or7g26 G A 9: 19,318,845 (GRCm38) V104I probably benign Het
Pax5 T A 4: 44,679,494 (GRCm38) I184F probably damaging Het
Pcdha7 T A 18: 36,974,507 (GRCm38) V195D probably damaging Het
Phf3 A T 1: 30,813,939 (GRCm38) probably benign Het
Pla2g15 G T 8: 106,163,071 (GRCm38) G325V probably damaging Het
Ppp1r21 T C 17: 88,572,615 (GRCm38) F487L probably benign Het
Ppp1r9a A G 6: 5,157,016 (GRCm38) I965V probably benign Het
Ptpru A G 4: 131,820,964 (GRCm38) V74A probably damaging Het
Rif1 T A 2: 52,098,934 (GRCm38) Y780N probably damaging Het
Rps25 T A 9: 44,408,749 (GRCm38) Y23N possibly damaging Het
Ryr1 T C 7: 29,085,833 (GRCm38) D1811G probably damaging Het
Scamp5 T G 9: 57,452,036 (GRCm38) probably null Het
Senp1 T C 15: 98,045,896 (GRCm38) D602G probably damaging Het
Sh2b2 T G 5: 136,231,957 (GRCm38) D135A probably damaging Het
Slc26a8 G A 17: 28,638,661 (GRCm38) T836M probably benign Het
Slfn4 T G 11: 83,186,821 (GRCm38) I145S possibly damaging Het
Spag6l G A 16: 16,777,390 (GRCm38) T377I probably benign Het
Spdye4b T C 5: 143,196,334 (GRCm38) F129S probably damaging Het
Sspo G A 6: 48,470,580 (GRCm38) G2360E probably benign Het
Taar2 A T 10: 23,940,771 (GRCm38) I70F probably damaging Het
Taar7e A G 10: 24,038,566 (GRCm38) N318S probably damaging Het
Tor1a C A 2: 30,967,730 (GRCm38) R42L probably benign Het
Trdn A T 10: 33,474,506 (GRCm38) Q690H probably benign Het
Trim56 C A 5: 137,112,725 (GRCm38) V646L probably benign Het
Tspan15 T A 10: 62,191,544 (GRCm38) K165I probably benign Het
Usp24 A G 4: 106,416,048 (GRCm38) Y2210C probably damaging Het
Usp45 A G 4: 21,797,307 (GRCm38) T76A probably damaging Het
Vps13c T A 9: 67,878,224 (GRCm38) probably null Het
Zfp512b T C 2: 181,585,095 (GRCm38) probably benign Het
Zyx C A 6: 42,356,159 (GRCm38) probably null Het
Other mutations in Fut9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00919:Fut9 APN 4 25,620,316 (GRCm38) missense possibly damaging 0.71
IGL01134:Fut9 APN 4 25,620,446 (GRCm38) missense probably benign 0.13
IGL01330:Fut9 APN 4 25,619,791 (GRCm38) missense possibly damaging 0.95
IGL01732:Fut9 APN 4 25,619,867 (GRCm38) missense possibly damaging 0.58
IGL02824:Fut9 APN 4 25,620,037 (GRCm38) missense probably damaging 1.00
ANU74:Fut9 UTSW 4 25,620,802 (GRCm38) missense probably benign 0.25
R0280:Fut9 UTSW 4 25,619,852 (GRCm38) missense probably benign 0.00
R0408:Fut9 UTSW 4 25,620,319 (GRCm38) missense possibly damaging 0.69
R0594:Fut9 UTSW 4 25,620,526 (GRCm38) missense possibly damaging 0.94
R0609:Fut9 UTSW 4 25,620,811 (GRCm38) start codon destroyed probably null 0.98
R0709:Fut9 UTSW 4 25,620,359 (GRCm38) missense probably damaging 1.00
R1567:Fut9 UTSW 4 25,620,344 (GRCm38) missense probably damaging 0.99
R1719:Fut9 UTSW 4 25,619,744 (GRCm38) missense possibly damaging 0.62
R1856:Fut9 UTSW 4 25,620,352 (GRCm38) missense probably damaging 1.00
R2036:Fut9 UTSW 4 25,620,322 (GRCm38) missense probably damaging 1.00
R2165:Fut9 UTSW 4 25,619,734 (GRCm38) makesense probably null
R2165:Fut9 UTSW 4 25,619,733 (GRCm38) makesense probably null
R2332:Fut9 UTSW 4 25,619,823 (GRCm38) nonsense probably null
R4539:Fut9 UTSW 4 25,619,793 (GRCm38) missense probably damaging 1.00
R4722:Fut9 UTSW 4 25,799,734 (GRCm38) utr 5 prime probably benign
R4937:Fut9 UTSW 4 25,799,591 (GRCm38) splice site probably benign
R5025:Fut9 UTSW 4 25,620,502 (GRCm38) missense probably damaging 1.00
R5032:Fut9 UTSW 4 25,799,245 (GRCm38) intron probably benign
R5158:Fut9 UTSW 4 25,620,731 (GRCm38) missense probably benign 0.01
R5601:Fut9 UTSW 4 25,620,299 (GRCm38) missense probably benign 0.00
R5974:Fut9 UTSW 4 25,620,090 (GRCm38) nonsense probably null
R6315:Fut9 UTSW 4 25,619,774 (GRCm38) missense probably damaging 1.00
R6385:Fut9 UTSW 4 25,620,328 (GRCm38) missense probably damaging 1.00
R6652:Fut9 UTSW 4 25,620,619 (GRCm38) missense probably benign 0.44
R6809:Fut9 UTSW 4 25,620,647 (GRCm38) missense probably benign
R6825:Fut9 UTSW 4 25,619,925 (GRCm38) missense probably benign
R7145:Fut9 UTSW 4 25,620,507 (GRCm38) missense probably damaging 0.96
R7573:Fut9 UTSW 4 25,620,691 (GRCm38) missense probably benign 0.04
R8933:Fut9 UTSW 4 25,619,861 (GRCm38) missense probably damaging 1.00
R9715:Fut9 UTSW 4 25,620,679 (GRCm38) missense probably benign 0.00
X0057:Fut9 UTSW 4 25,799,686 (GRCm38) start gained probably benign
Predicted Primers PCR Primer
(F):5'- TGGGCACTTTGAAACAATGAC -3'
(R):5'- ACCAGCTTGGAACTTGAACC -3'

Sequencing Primer
(F):5'- GTCCCAAAAGATTTCCTGTTTTTG -3'
(R):5'- CCAGAGATAGCTGCTTGTACATC -3'
Posted On 2015-12-21