Incidental Mutation 'R4766:Pcdha7'
| ID |
366190 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pcdha7
|
| Ensembl Gene |
ENSMUSG00000104318 |
| Gene Name |
protocadherin alpha 7 |
| Synonyms |
Crnr4, Cnr4 |
| MMRRC Submission |
042407-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.099)
|
| Stock # |
R4766 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
18 |
| Chromosomal Location |
37106864-37320716 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 37107560 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Aspartic acid
at position 195
(V195D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000142156
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000070797]
[ENSMUST00000115661]
[ENSMUST00000115662]
[ENSMUST00000192168]
[ENSMUST00000192295]
[ENSMUST00000192503]
[ENSMUST00000192512]
[ENSMUST00000192631]
[ENSMUST00000193839]
[ENSMUST00000195590]
[ENSMUST00000193777]
[ENSMUST00000193389]
[ENSMUST00000194544]
[ENSMUST00000194751]
|
| AlphaFold |
Q91Y13 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000070797
|
| SMART Domains |
Protein: ENSMUSP00000068828
Gene: ENSMUSG00000103442
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
22 |
132 |
3.09e-2 |
SMART |
|
CA
|
156 |
241 |
6.14e-20 |
SMART |
|
CA
|
265 |
349 |
3.92e-27 |
SMART |
|
CA
|
373 |
454 |
4.94e-24 |
SMART |
|
CA
|
478 |
564 |
1e-24 |
SMART |
|
CA
|
592 |
672 |
4.55e-14 |
SMART |
|
transmembrane domain
|
694 |
716 |
N/A |
INTRINSIC |
|
Pfam:Cadherin_tail
|
797 |
931 |
5.3e-58 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115661
|
| SMART Domains |
Protein: ENSMUSP00000111325
Gene: ENSMUSG00000103458
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
20 |
131 |
5.3e-2 |
SMART |
|
CA
|
155 |
240 |
1.51e-19 |
SMART |
|
CA
|
264 |
348 |
7.6e-25 |
SMART |
|
CA
|
372 |
453 |
1.42e-24 |
SMART |
|
CA
|
477 |
563 |
1.42e-24 |
SMART |
|
CA
|
594 |
674 |
4.12e-12 |
SMART |
|
low complexity region
|
706 |
721 |
N/A |
INTRINSIC |
|
Pfam:Cadherin_tail
|
796 |
930 |
3.9e-58 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115662
|
| SMART Domains |
Protein: ENSMUSP00000111326
Gene: ENSMUSG00000104148
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
45 |
131 |
6.34e-2 |
SMART |
|
CA
|
155 |
240 |
2.98e-18 |
SMART |
|
CA
|
264 |
348 |
2.17e-29 |
SMART |
|
CA
|
372 |
453 |
2.84e-24 |
SMART |
|
CA
|
477 |
563 |
5.02e-25 |
SMART |
|
CA
|
594 |
675 |
8.16e-16 |
SMART |
|
transmembrane domain
|
695 |
717 |
N/A |
INTRINSIC |
|
low complexity region
|
916 |
940 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000192168
|
| SMART Domains |
Protein: ENSMUSP00000142293
Gene: ENSMUSG00000103092
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
21 |
131 |
2.2e-2 |
SMART |
|
CA
|
155 |
240 |
2.05e-21 |
SMART |
|
CA
|
264 |
348 |
8.81e-21 |
SMART |
|
CA
|
372 |
453 |
2.01e-24 |
SMART |
|
CA
|
477 |
563 |
1.42e-24 |
SMART |
|
CA
|
591 |
673 |
1.63e-15 |
SMART |
|
transmembrane domain
|
693 |
715 |
N/A |
INTRINSIC |
|
low complexity region
|
902 |
926 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000192295
|
| SMART Domains |
Protein: ENSMUSP00000142103
Gene: ENSMUSG00000104252
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
20 |
131 |
5.3e-2 |
SMART |
|
CA
|
155 |
240 |
1.51e-19 |
SMART |
|
CA
|
264 |
348 |
7.6e-25 |
SMART |
|
CA
|
372 |
453 |
1.42e-24 |
SMART |
|
CA
|
477 |
568 |
5.38e-1 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000192503
|
| SMART Domains |
Protein: ENSMUSP00000141989
Gene: ENSMUSG00000102312
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
11 |
17 |
N/A |
INTRINSIC |
|
CA
|
42 |
128 |
3.78e-2 |
SMART |
|
CA
|
152 |
237 |
8.94e-22 |
SMART |
|
CA
|
261 |
345 |
3.74e-24 |
SMART |
|
CA
|
369 |
450 |
1.09e-25 |
SMART |
|
CA
|
474 |
560 |
1.42e-24 |
SMART |
|
CA
|
588 |
670 |
2.96e-13 |
SMART |
|
transmembrane domain
|
692 |
714 |
N/A |
INTRINSIC |
|
low complexity region
|
910 |
934 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000192512
|
| SMART Domains |
Protein: ENSMUSP00000141408
Gene: ENSMUSG00000104252
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
20 |
131 |
5.3e-2 |
SMART |
|
CA
|
155 |
240 |
1.51e-19 |
SMART |
|
CA
|
264 |
348 |
7.6e-25 |
SMART |
|
CA
|
372 |
453 |
1.42e-24 |
SMART |
|
CA
|
477 |
563 |
1.42e-24 |
SMART |
|
CA
|
594 |
674 |
4.12e-12 |
SMART |
|
low complexity region
|
706 |
721 |
N/A |
INTRINSIC |
|
low complexity region
|
915 |
939 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000192631
AA Change: V195D
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000142156
Gene: ENSMUSG00000104318
AA Change: V195D
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
21 |
131 |
2.58e-2 |
SMART |
|
CA
|
155 |
240 |
4.27e-19 |
SMART |
|
CA
|
264 |
348 |
1.42e-24 |
SMART |
|
CA
|
372 |
453 |
9.36e-25 |
SMART |
|
CA
|
477 |
563 |
1.42e-24 |
SMART |
|
CA
|
594 |
671 |
4.03e-6 |
SMART |
|
transmembrane domain
|
696 |
718 |
N/A |
INTRINSIC |
|
low complexity region
|
905 |
929 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193839
|
| SMART Domains |
Protein: ENSMUSP00000142308
Gene: ENSMUSG00000103442
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
22 |
132 |
3.09e-2 |
SMART |
|
CA
|
156 |
241 |
6.14e-20 |
SMART |
|
CA
|
265 |
349 |
3.92e-27 |
SMART |
|
CA
|
373 |
454 |
4.94e-24 |
SMART |
|
CA
|
478 |
564 |
1e-24 |
SMART |
|
CA
|
592 |
672 |
4.55e-14 |
SMART |
|
transmembrane domain
|
694 |
716 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000195590
|
| SMART Domains |
Protein: ENSMUSP00000141355
Gene: ENSMUSG00000104148
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
45 |
131 |
6.34e-2 |
SMART |
|
CA
|
155 |
240 |
2.98e-18 |
SMART |
|
CA
|
264 |
348 |
2.17e-29 |
SMART |
|
CA
|
372 |
453 |
2.84e-24 |
SMART |
|
CA
|
477 |
563 |
5.02e-25 |
SMART |
|
CA
|
594 |
675 |
8.16e-16 |
SMART |
|
transmembrane domain
|
695 |
717 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193777
|
| SMART Domains |
Protein: ENSMUSP00000141587
Gene: ENSMUSG00000103707
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
21 |
131 |
5.67e-2 |
SMART |
|
CA
|
155 |
240 |
4.72e-21 |
SMART |
|
CA
|
264 |
348 |
1.9e-25 |
SMART |
|
CA
|
372 |
453 |
3.31e-25 |
SMART |
|
CA
|
477 |
563 |
1.42e-24 |
SMART |
|
CA
|
594 |
676 |
5.91e-13 |
SMART |
|
low complexity region
|
914 |
938 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193389
|
| SMART Domains |
Protein: ENSMUSP00000141459
Gene: ENSMUSG00000103707
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
21 |
131 |
5.67e-2 |
SMART |
|
CA
|
155 |
240 |
4.72e-21 |
SMART |
|
CA
|
264 |
348 |
1.9e-25 |
SMART |
|
CA
|
372 |
453 |
3.31e-25 |
SMART |
|
CA
|
477 |
563 |
1.42e-24 |
SMART |
|
CA
|
594 |
676 |
5.91e-13 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000194544
|
| SMART Domains |
Protein: ENSMUSP00000141847
Gene: ENSMUSG00000102836
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:CA
|
18 |
66 |
5e-20 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000194751
|
| SMART Domains |
Protein: ENSMUSP00000142285
Gene: ENSMUSG00000103707
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
15 |
21 |
N/A |
INTRINSIC |
|
Pfam:Cadherin_2
|
29 |
112 |
4.5e-32 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193984
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.1%
- 20x: 94.9%
|
| Validation Efficiency |
97% (87/90) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 80 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2900026A02Rik |
C |
T |
5: 113,245,502 (GRCm39) |
V1584I |
probably benign |
Het |
| Adamts12 |
A |
G |
15: 11,285,987 (GRCm39) |
D732G |
probably benign |
Het |
| Agpat4 |
A |
G |
17: 12,370,637 (GRCm39) |
|
probably benign |
Het |
| AI182371 |
T |
C |
2: 34,985,829 (GRCm39) |
D140G |
possibly damaging |
Het |
| Apol11b |
T |
A |
15: 77,519,133 (GRCm39) |
T316S |
probably benign |
Het |
| Arsi |
G |
A |
18: 61,049,723 (GRCm39) |
G202E |
probably benign |
Het |
| Bard1 |
T |
C |
1: 71,114,333 (GRCm39) |
E216G |
probably benign |
Het |
| Bdp1 |
C |
A |
13: 100,186,376 (GRCm39) |
R1692L |
probably damaging |
Het |
| Capn10 |
T |
C |
1: 92,871,141 (GRCm39) |
I101T |
probably damaging |
Het |
| Ccdc175 |
C |
T |
12: 72,158,979 (GRCm39) |
M653I |
probably benign |
Het |
| Ccdc9b |
C |
A |
2: 118,590,058 (GRCm39) |
R262L |
probably damaging |
Het |
| Ccr8 |
G |
A |
9: 119,923,530 (GRCm39) |
C215Y |
probably damaging |
Het |
| Cct3 |
T |
A |
3: 88,219,092 (GRCm39) |
L241* |
probably null |
Het |
| Cd2ap |
A |
T |
17: 43,163,350 (GRCm39) |
I25N |
probably damaging |
Het |
| Cdh19 |
T |
C |
1: 110,820,990 (GRCm39) |
K583E |
probably benign |
Het |
| Cela3a |
A |
G |
4: 137,129,986 (GRCm39) |
S212P |
unknown |
Het |
| Cfap44 |
T |
A |
16: 44,236,246 (GRCm39) |
|
probably null |
Het |
| Clca3a1 |
A |
T |
3: 144,455,473 (GRCm39) |
L440Q |
probably damaging |
Het |
| Crybg2 |
A |
G |
4: 133,816,663 (GRCm39) |
Y1676C |
probably damaging |
Het |
| Dscam |
T |
C |
16: 96,445,188 (GRCm39) |
D1501G |
probably benign |
Het |
| Eml6 |
C |
A |
11: 29,755,757 (GRCm39) |
L832F |
probably benign |
Het |
| Enpp3 |
A |
G |
10: 24,649,825 (GRCm39) |
L867P |
probably damaging |
Het |
| Erbb3 |
A |
G |
10: 128,422,107 (GRCm39) |
Y46H |
possibly damaging |
Het |
| Fads3 |
T |
C |
19: 10,033,384 (GRCm39) |
I342T |
possibly damaging |
Het |
| Flvcr1 |
A |
T |
1: 190,753,303 (GRCm39) |
S290T |
probably benign |
Het |
| Fut9 |
A |
G |
4: 25,799,191 (GRCm39) |
|
probably benign |
Het |
| Gad2 |
C |
T |
2: 22,512,679 (GRCm39) |
A2V |
probably damaging |
Het |
| Gkn3 |
C |
T |
6: 87,360,507 (GRCm39) |
A163T |
probably damaging |
Het |
| Gm10715 |
T |
G |
9: 3,038,073 (GRCm39) |
|
probably benign |
Het |
| Herc1 |
T |
G |
9: 66,349,211 (GRCm39) |
D2023E |
probably benign |
Het |
| Hsd3b3 |
A |
G |
3: 98,649,801 (GRCm39) |
L174P |
probably damaging |
Het |
| Impg2 |
TACCACCACCACCACCACCACCACCA |
TACCACCACCACCACCACCACCA |
16: 56,078,302 (GRCm39) |
|
probably benign |
Het |
| Iqcf3 |
A |
G |
9: 106,438,148 (GRCm39) |
|
probably null |
Het |
| Kcna4 |
G |
A |
2: 107,126,888 (GRCm39) |
V541M |
probably damaging |
Het |
| Kcnj11 |
T |
C |
7: 45,749,240 (GRCm39) |
T28A |
probably benign |
Het |
| Kcnmb2 |
T |
A |
3: 32,236,016 (GRCm39) |
N88K |
probably damaging |
Het |
| Kdm2a |
TTCCTCCTCCTCCTCCTCTTCCTCCTCCTC |
TTCCTCCTCCTCCTCTTCCTCCTCCTC |
19: 4,374,535 (GRCm39) |
|
probably benign |
Het |
| Krt1c |
T |
C |
15: 101,722,395 (GRCm39) |
E430G |
probably damaging |
Het |
| Lins1 |
C |
T |
7: 66,360,389 (GRCm39) |
L384F |
possibly damaging |
Het |
| Man1c1 |
G |
C |
4: 134,430,749 (GRCm39) |
P11R |
probably damaging |
Het |
| Mfge8 |
T |
C |
7: 78,784,273 (GRCm39) |
N389D |
probably damaging |
Het |
| Mug1 |
C |
T |
6: 121,861,213 (GRCm39) |
T1278I |
probably benign |
Het |
| Myh9 |
T |
C |
15: 77,692,077 (GRCm39) |
M161V |
probably damaging |
Het |
| Myl7 |
T |
A |
11: 5,848,171 (GRCm39) |
Y61F |
probably benign |
Het |
| Nlrp4d |
A |
T |
7: 10,096,706 (GRCm39) |
|
unknown |
Het |
| Nol3 |
A |
G |
8: 106,008,565 (GRCm39) |
|
probably null |
Het |
| Nup85 |
T |
A |
11: 115,468,751 (GRCm39) |
|
probably null |
Het |
| Obscn |
T |
A |
11: 58,903,568 (GRCm39) |
T7619S |
probably damaging |
Het |
| Or2t49 |
T |
A |
11: 58,392,494 (GRCm39) |
N296I |
probably damaging |
Het |
| Or4k48 |
T |
C |
2: 111,476,226 (GRCm39) |
M39V |
probably benign |
Het |
| Or52a24 |
C |
T |
7: 103,381,457 (GRCm39) |
T108I |
possibly damaging |
Het |
| Or7g26 |
G |
A |
9: 19,230,141 (GRCm39) |
V104I |
probably benign |
Het |
| Pax5 |
T |
A |
4: 44,679,494 (GRCm39) |
I184F |
probably damaging |
Het |
| Phf3 |
A |
T |
1: 30,853,020 (GRCm39) |
|
probably benign |
Het |
| Pla2g15 |
G |
T |
8: 106,889,703 (GRCm39) |
G325V |
probably damaging |
Het |
| Ppp1r21 |
T |
C |
17: 88,880,043 (GRCm39) |
F487L |
probably benign |
Het |
| Ppp1r9a |
A |
G |
6: 5,157,016 (GRCm39) |
I965V |
probably benign |
Het |
| Ptpru |
A |
G |
4: 131,548,275 (GRCm39) |
V74A |
probably damaging |
Het |
| Rif1 |
T |
A |
2: 51,988,946 (GRCm39) |
Y780N |
probably damaging |
Het |
| Rps25 |
T |
A |
9: 44,320,046 (GRCm39) |
Y23N |
possibly damaging |
Het |
| Ryr1 |
T |
C |
7: 28,785,258 (GRCm39) |
D1811G |
probably damaging |
Het |
| Scamp5 |
T |
G |
9: 57,359,319 (GRCm39) |
|
probably null |
Het |
| Senp1 |
T |
C |
15: 97,943,777 (GRCm39) |
D602G |
probably damaging |
Het |
| Sh2b2 |
T |
G |
5: 136,260,811 (GRCm39) |
D135A |
probably damaging |
Het |
| Slc26a8 |
G |
A |
17: 28,857,635 (GRCm39) |
T836M |
probably benign |
Het |
| Slfn4 |
T |
G |
11: 83,077,647 (GRCm39) |
I145S |
possibly damaging |
Het |
| Spag6l |
G |
A |
16: 16,595,254 (GRCm39) |
T377I |
probably benign |
Het |
| Spdye4b |
T |
C |
5: 143,182,089 (GRCm39) |
F129S |
probably damaging |
Het |
| Sspo |
G |
A |
6: 48,447,514 (GRCm39) |
G2360E |
probably benign |
Het |
| Taar2 |
A |
T |
10: 23,816,669 (GRCm39) |
I70F |
probably damaging |
Het |
| Taar7e |
A |
G |
10: 23,914,464 (GRCm39) |
N318S |
probably damaging |
Het |
| Tor1a |
C |
A |
2: 30,857,742 (GRCm39) |
R42L |
probably benign |
Het |
| Trdn |
A |
T |
10: 33,350,502 (GRCm39) |
Q690H |
probably benign |
Het |
| Trim56 |
C |
A |
5: 137,141,579 (GRCm39) |
V646L |
probably benign |
Het |
| Tspan15 |
T |
A |
10: 62,027,323 (GRCm39) |
K165I |
probably benign |
Het |
| Usp24 |
A |
G |
4: 106,273,245 (GRCm39) |
Y2210C |
probably damaging |
Het |
| Usp45 |
A |
G |
4: 21,797,307 (GRCm39) |
T76A |
probably damaging |
Het |
| Vps13c |
T |
A |
9: 67,785,506 (GRCm39) |
|
probably null |
Het |
| Zfp512b |
T |
C |
2: 181,226,888 (GRCm39) |
|
probably benign |
Het |
| Zyx |
C |
A |
6: 42,333,093 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Pcdha7 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R2511:Pcdha7
|
UTSW |
18 |
37,107,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3881:Pcdha7
|
UTSW |
18 |
37,108,432 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4212:Pcdha7
|
UTSW |
18 |
37,108,027 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4533:Pcdha7
|
UTSW |
18 |
37,108,460 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4608:Pcdha7
|
UTSW |
18 |
37,108,870 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4808:Pcdha7
|
UTSW |
18 |
37,107,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4897:Pcdha7
|
UTSW |
18 |
37,108,646 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5030:Pcdha7
|
UTSW |
18 |
37,108,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5173:Pcdha7
|
UTSW |
18 |
37,107,705 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5333:Pcdha7
|
UTSW |
18 |
37,107,619 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5342:Pcdha7
|
UTSW |
18 |
37,107,724 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R5463:Pcdha7
|
UTSW |
18 |
37,108,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5536:Pcdha7
|
UTSW |
18 |
37,108,303 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5848:Pcdha7
|
UTSW |
18 |
37,108,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5858:Pcdha7
|
UTSW |
18 |
37,109,279 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5887:Pcdha7
|
UTSW |
18 |
37,108,960 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6115:Pcdha7
|
UTSW |
18 |
37,107,788 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6496:Pcdha7
|
UTSW |
18 |
37,107,638 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6522:Pcdha7
|
UTSW |
18 |
37,106,995 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R6653:Pcdha7
|
UTSW |
18 |
37,107,539 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6815:Pcdha7
|
UTSW |
18 |
37,108,174 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7313:Pcdha7
|
UTSW |
18 |
37,107,471 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7519:Pcdha7
|
UTSW |
18 |
37,109,285 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7520:Pcdha7
|
UTSW |
18 |
37,108,366 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7857:Pcdha7
|
UTSW |
18 |
37,108,892 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7939:Pcdha7
|
UTSW |
18 |
37,109,063 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R8229:Pcdha7
|
UTSW |
18 |
37,107,776 (GRCm39) |
nonsense |
probably null |
|
|
R9592:Pcdha7
|
UTSW |
18 |
37,109,045 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9711:Pcdha7
|
UTSW |
18 |
37,107,409 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Pcdha7
|
UTSW |
18 |
37,108,893 (GRCm39) |
missense |
probably benign |
0.14 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAGGCTCTGTTTATCCTGGAGTC -3'
(R):5'- CGTCCAAATCTGAGGCATTG -3'
Sequencing Primer
(F):5'- AGTCCAGACTGCTTGACTCG -3'
(R):5'- GTCCAAATCTGAGGCATTGACTTTG -3'
|
| Posted On |
2015-12-21 |
Incidental Mutation