Incidental Mutation 'R4768:Fam13c'
| ID |
366286 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Fam13c
|
| Ensembl Gene |
ENSMUSG00000043259 |
| Gene Name |
family with sequence similarity 13, member C |
| Synonyms |
C030038O19Rik, 1200015N20Rik |
| MMRRC Submission |
042409-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.234)
|
| Stock # |
R4768 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
70276311-70394566 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 70387580 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Asparagine
at position 448
(I448N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000134648
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000062883]
[ENSMUST00000105436]
[ENSMUST00000173042]
|
| AlphaFold |
Q9DBR2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000062883
AA Change: I448N
PolyPhen 2
Score 0.965 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000051375
Gene: ENSMUSG00000043259
AA Change: I448N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
200 |
222 |
N/A |
INTRINSIC |
|
low complexity region
|
274 |
294 |
N/A |
INTRINSIC |
|
coiled coil region
|
304 |
372 |
N/A |
INTRINSIC |
|
coiled coil region
|
529 |
557 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000105436
AA Change: I366N
PolyPhen 2
Score 0.965 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000101076
Gene: ENSMUSG00000043259
AA Change: I366N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
118 |
140 |
N/A |
INTRINSIC |
|
low complexity region
|
192 |
212 |
N/A |
INTRINSIC |
|
coiled coil region
|
222 |
290 |
N/A |
INTRINSIC |
|
coiled coil region
|
447 |
475 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000173042
AA Change: I448N
PolyPhen 2
Score 0.965 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000134648
Gene: ENSMUSG00000043259
AA Change: I448N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
200 |
222 |
N/A |
INTRINSIC |
|
low complexity region
|
274 |
294 |
N/A |
INTRINSIC |
|
coiled coil region
|
304 |
372 |
N/A |
INTRINSIC |
|
coiled coil region
|
528 |
556 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000219514
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.7%
- 20x: 93.7%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 44 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acadm |
A |
G |
3: 153,628,579 (GRCm39) |
Y419H |
probably benign |
Het |
| Adam28 |
A |
G |
14: 68,872,264 (GRCm39) |
V326A |
possibly damaging |
Het |
| Amdhd1 |
T |
A |
10: 93,370,346 (GRCm39) |
E164V |
possibly damaging |
Het |
| Arhgap5 |
T |
C |
12: 52,604,275 (GRCm39) |
L29S |
probably damaging |
Het |
| Asb5 |
G |
A |
8: 55,038,031 (GRCm39) |
D185N |
probably benign |
Het |
| Ascc3 |
T |
C |
10: 50,576,595 (GRCm39) |
I850T |
probably damaging |
Het |
| Atxn1 |
A |
G |
13: 45,711,024 (GRCm39) |
V636A |
probably damaging |
Het |
| Bmp4 |
C |
T |
14: 46,623,381 (GRCm39) |
R55Q |
probably damaging |
Het |
| Brd8dc |
T |
C |
18: 34,714,005 (GRCm39) |
R207G |
probably damaging |
Het |
| Cmas |
T |
C |
6: 142,710,157 (GRCm39) |
|
probably null |
Het |
| Dchs1 |
T |
C |
7: 105,420,827 (GRCm39) |
D531G |
possibly damaging |
Het |
| Etv1 |
T |
C |
12: 38,877,792 (GRCm39) |
L44P |
probably damaging |
Het |
| Fcsk |
T |
C |
8: 111,618,766 (GRCm39) |
T331A |
probably benign |
Het |
| Fut8 |
A |
G |
12: 77,412,054 (GRCm39) |
K135E |
probably benign |
Het |
| Gabrg1 |
A |
G |
5: 70,911,516 (GRCm39) |
F370S |
probably damaging |
Het |
| Ighv1-5 |
A |
T |
12: 114,477,143 (GRCm39) |
M53K |
probably damaging |
Het |
| Igkv9-120 |
G |
T |
6: 68,027,351 (GRCm39) |
R88S |
possibly damaging |
Het |
| Kansl1l |
A |
G |
1: 66,840,292 (GRCm39) |
V336A |
probably damaging |
Het |
| Krt27 |
T |
A |
11: 99,240,351 (GRCm39) |
D189V |
probably damaging |
Het |
| Marf1 |
A |
T |
16: 13,949,461 (GRCm39) |
F1033I |
possibly damaging |
Het |
| Mdfi |
G |
A |
17: 48,135,475 (GRCm39) |
T85M |
probably damaging |
Het |
| Mrgpra3 |
C |
A |
7: 47,239,476 (GRCm39) |
R150L |
possibly damaging |
Het |
| Mst1r |
C |
A |
9: 107,788,849 (GRCm39) |
T456K |
probably damaging |
Het |
| Myh14 |
A |
T |
7: 44,263,099 (GRCm39) |
M1734K |
probably benign |
Het |
| Myo1e |
T |
C |
9: 70,277,751 (GRCm39) |
I816T |
possibly damaging |
Het |
| Or7d10 |
A |
C |
9: 19,831,841 (GRCm39) |
N112T |
possibly damaging |
Het |
| Or8b12 |
T |
C |
9: 37,658,177 (GRCm39) |
L249P |
probably damaging |
Het |
| Or8b55 |
T |
A |
9: 38,727,245 (GRCm39) |
Y149N |
probably damaging |
Het |
| Or8k28 |
A |
T |
2: 86,285,994 (GRCm39) |
L207* |
probably null |
Het |
| Pde4d |
A |
G |
13: 110,070,408 (GRCm39) |
R6G |
probably damaging |
Het |
| Pilrb1 |
G |
A |
5: 137,855,788 (GRCm39) |
|
probably benign |
Het |
| Prrx1 |
A |
G |
1: 163,085,334 (GRCm39) |
Y199H |
probably damaging |
Het |
| Rxfp1 |
T |
C |
3: 79,594,175 (GRCm39) |
D73G |
probably damaging |
Het |
| Ryr1 |
G |
T |
7: 28,704,246 (GRCm39) |
|
probably benign |
Het |
| Shprh |
A |
G |
10: 11,057,284 (GRCm39) |
E1068G |
probably damaging |
Het |
| Slc19a3 |
G |
A |
1: 83,000,834 (GRCm39) |
T61I |
probably damaging |
Het |
| Slc9a2 |
G |
A |
1: 40,765,534 (GRCm39) |
R308Q |
probably damaging |
Het |
| Suclg2 |
T |
G |
6: 95,543,469 (GRCm39) |
I321L |
probably damaging |
Het |
| Top3a |
A |
G |
11: 60,653,316 (GRCm39) |
F53L |
probably damaging |
Het |
| Ttn |
C |
T |
2: 76,599,110 (GRCm39) |
|
probably benign |
Het |
| Upp2 |
T |
C |
2: 58,667,907 (GRCm39) |
V182A |
probably damaging |
Het |
| Vmn2r65 |
A |
G |
7: 84,596,602 (GRCm39) |
L151P |
probably damaging |
Het |
| Xylt2 |
T |
C |
11: 94,561,298 (GRCm39) |
D155G |
probably benign |
Het |
| Zzz3 |
A |
G |
3: 152,154,420 (GRCm39) |
D557G |
probably damaging |
Het |
|
| Other mutations in Fam13c |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01106:Fam13c
|
APN |
10 |
70,284,646 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02060:Fam13c
|
APN |
10 |
70,388,971 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03218:Fam13c
|
APN |
10 |
70,284,599 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R0270:Fam13c
|
UTSW |
10 |
70,380,343 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0418:Fam13c
|
UTSW |
10 |
70,370,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0617:Fam13c
|
UTSW |
10 |
70,372,182 (GRCm39) |
splice site |
probably benign |
|
|
R1712:Fam13c
|
UTSW |
10 |
70,390,403 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R1967:Fam13c
|
UTSW |
10 |
70,387,565 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2165:Fam13c
|
UTSW |
10 |
70,378,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3836:Fam13c
|
UTSW |
10 |
70,378,478 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3837:Fam13c
|
UTSW |
10 |
70,378,478 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3838:Fam13c
|
UTSW |
10 |
70,378,478 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3839:Fam13c
|
UTSW |
10 |
70,378,478 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4059:Fam13c
|
UTSW |
10 |
70,390,338 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4951:Fam13c
|
UTSW |
10 |
70,387,621 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5259:Fam13c
|
UTSW |
10 |
70,276,893 (GRCm39) |
missense |
probably benign |
0.16 |
|
R5384:Fam13c
|
UTSW |
10 |
70,388,899 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5715:Fam13c
|
UTSW |
10 |
70,370,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6322:Fam13c
|
UTSW |
10 |
70,334,721 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6404:Fam13c
|
UTSW |
10 |
70,284,646 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6723:Fam13c
|
UTSW |
10 |
70,390,355 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7111:Fam13c
|
UTSW |
10 |
70,390,336 (GRCm39) |
missense |
probably benign |
0.23 |
|
R8253:Fam13c
|
UTSW |
10 |
70,389,033 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8306:Fam13c
|
UTSW |
10 |
70,388,983 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8748:Fam13c
|
UTSW |
10 |
70,378,516 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9112:Fam13c
|
UTSW |
10 |
70,286,978 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9206:Fam13c
|
UTSW |
10 |
70,388,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9208:Fam13c
|
UTSW |
10 |
70,388,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GACTTTGTCTCGGTCCACAC -3'
(R):5'- TAGCCATTGTTAAGCACTGGGC -3'
Sequencing Primer
(F):5'- GGTCCACACTGCTTGTCAAG -3'
(R):5'- CCACAGTAGCTGGTAGGAAC -3'
|
| Posted On |
2015-12-21 |
Incidental Mutation