Incidental Mutation 'R4769:Or5d36'
ID 366315
Institutional Source Beutler Lab
Gene Symbol Or5d36
Ensembl Gene ENSMUSG00000075137
Gene Name olfactory receptor family 5 subfamily D member 36
Synonyms Olfr1163, MOR174-8, GA_x6K02T2Q125-49563265-49562315
Accession Numbers
Essential gene? Probably non essential (E-score: 0.078) question?
Stock # R4769 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 87900709-87901751 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 87901073 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Proline at position 218 (T218P)
Ref Sequence ENSEMBL: ENSMUSP00000149399 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099835] [ENSMUST00000215268]
AlphaFold Q8VFR4
Predicted Effect probably benign
Transcript: ENSMUST00000099835
AA Change: T218P

PolyPhen 2 Score 0.252 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000097423
Gene: ENSMUSG00000075137
AA Change: T218P

DomainStartEndE-ValueType
Pfam:7tm_4 33 310 1.2e-44 PFAM
Pfam:7tm_1 43 292 2.3e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215268
AA Change: T218P

PolyPhen 2 Score 0.252 (Sensitivity: 0.91; Specificity: 0.88)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.7%
  • 20x: 93.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik A C 14: 32,382,174 (GRCm39) S1264A probably benign Het
Adamts13 T G 2: 26,898,723 (GRCm39) Y1361* probably null Het
Ahrr A T 13: 74,362,331 (GRCm39) D389E probably damaging Het
Alx3 T C 3: 107,508,007 (GRCm39) F172S probably damaging Het
Antxrl A G 14: 33,795,027 (GRCm39) H485R possibly damaging Het
Aox4 A G 1: 58,298,307 (GRCm39) D1091G probably null Het
Btbd1 T A 7: 81,455,558 (GRCm39) Q271L probably benign Het
Cd209c A T 8: 3,994,953 (GRCm39) N70K probably benign Het
Cdc14a C T 3: 116,088,399 (GRCm39) probably null Het
Cenpe A G 3: 134,953,912 (GRCm39) M1641V probably benign Het
Clec2e G A 6: 129,077,790 (GRCm39) T16I probably benign Het
Clp1 T C 2: 84,556,219 (GRCm39) D87G possibly damaging Het
Dpy19l1 A T 9: 24,337,444 (GRCm39) F517I probably damaging Het
Dzip3 T C 16: 48,758,837 (GRCm39) N646S probably damaging Het
Ephx1 T A 1: 180,823,543 (GRCm39) Y188F possibly damaging Het
Etfa A T 9: 55,403,051 (GRCm39) H81Q possibly damaging Het
Gigyf2 T A 1: 87,368,571 (GRCm39) F1084I probably damaging Het
Heatr3 T C 8: 88,868,411 (GRCm39) probably null Het
Ift81 G T 5: 122,732,656 (GRCm39) H293N probably benign Het
Igkv9-120 G T 6: 68,027,351 (GRCm39) R88S possibly damaging Het
Il6 T G 5: 30,223,076 (GRCm39) L114* probably null Het
Ism2 A T 12: 87,346,355 (GRCm39) M42K probably benign Het
Lhx5 A G 5: 120,574,503 (GRCm39) E269G probably benign Het
Marveld1 T G 19: 42,136,434 (GRCm39) M116R possibly damaging Het
Micall2 A G 5: 139,692,641 (GRCm39) S911P probably damaging Het
Mier1 G A 4: 102,997,417 (GRCm39) R195H probably benign Het
Muc2 T A 7: 141,286,260 (GRCm39) probably null Het
Mybbp1a A G 11: 72,336,466 (GRCm39) K486R probably damaging Het
Ncapd2 A C 6: 125,162,708 (GRCm39) L179R probably damaging Het
Nos1 C T 5: 118,081,310 (GRCm39) Q1171* probably null Het
Nrg1 T A 8: 32,408,000 (GRCm39) I78F probably damaging Het
Or6y1 T G 1: 174,276,524 (GRCm39) F112V possibly damaging Het
Plek2 C T 12: 78,953,664 (GRCm39) probably null Het
Plod2 A G 9: 92,477,325 (GRCm39) H339R probably damaging Het
Pold1 C T 7: 44,184,495 (GRCm39) C835Y probably damaging Het
Polr1a A G 6: 71,927,852 (GRCm39) I868V probably benign Het
Prss54 C A 8: 96,286,003 (GRCm39) V357L probably benign Het
Rbbp8 T A 18: 11,855,727 (GRCm39) S625T probably damaging Het
Rgs1 A T 1: 144,123,667 (GRCm39) L86Q probably damaging Het
Ripk4 T A 16: 97,545,262 (GRCm39) N462Y probably damaging Het
Rsf1 C T 7: 97,325,429 (GRCm39) L1011F probably damaging Het
Slc19a3 G A 1: 82,997,062 (GRCm39) T382I probably damaging Het
Slc9a2 G A 1: 40,765,534 (GRCm39) R308Q probably damaging Het
Top2b T A 14: 16,398,991 (GRCm38) L537Q probably damaging Het
Trim45 C A 3: 100,839,050 (GRCm39) probably benign Het
Umodl1 G T 17: 31,202,976 (GRCm39) R443M possibly damaging Het
Vmn1r11 G A 6: 57,114,597 (GRCm39) R87K probably damaging Het
Vmn1r78 T A 7: 11,886,725 (GRCm39) I112N probably damaging Het
Zeb2 T G 2: 44,886,447 (GRCm39) E825A probably damaging Het
Zfp930 A T 8: 69,679,344 (GRCm39) I50F probably benign Het
Other mutations in Or5d36
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01447:Or5d36 APN 2 87,901,468 (GRCm39) missense possibly damaging 0.56
IGL01472:Or5d36 APN 2 87,901,322 (GRCm39) missense possibly damaging 0.56
IGL02111:Or5d36 APN 2 87,901,571 (GRCm39) missense probably benign 0.22
R1274:Or5d36 UTSW 2 87,900,939 (GRCm39) missense probably damaging 1.00
R1938:Or5d36 UTSW 2 87,901,300 (GRCm39) missense probably damaging 1.00
R2012:Or5d36 UTSW 2 87,901,063 (GRCm39) missense probably benign 0.03
R3056:Or5d36 UTSW 2 87,901,583 (GRCm39) missense probably benign
R4127:Or5d36 UTSW 2 87,901,579 (GRCm39) missense probably benign 0.00
R4748:Or5d36 UTSW 2 87,900,956 (GRCm39) missense probably benign 0.44
R4749:Or5d36 UTSW 2 87,900,956 (GRCm39) missense probably benign 0.44
R6647:Or5d36 UTSW 2 87,901,053 (GRCm39) missense probably benign 0.03
R7111:Or5d36 UTSW 2 87,901,000 (GRCm39) missense probably damaging 1.00
R7168:Or5d36 UTSW 2 87,900,921 (GRCm39) missense probably benign 0.37
R8222:Or5d36 UTSW 2 87,901,381 (GRCm39) missense probably benign 0.00
R8869:Or5d36 UTSW 2 87,901,753 (GRCm39) critical splice acceptor site probably null
R9043:Or5d36 UTSW 2 87,900,983 (GRCm39) missense possibly damaging 0.94
R9205:Or5d36 UTSW 2 87,900,778 (GRCm39) missense probably benign 0.16
Predicted Primers PCR Primer
(F):5'- GAGGCTACTTTGACGGCATTCC -3'
(R):5'- ATCCTGCTTGTGACTGGGTC -3'

Sequencing Primer
(F):5'- CCTAGAATTTTTGGAGTTCGGTACAC -3'
(R):5'- ACTGGGTCATATATCTGGAGTACC -3'
Posted On 2015-12-21