Mutagenetix > Incidental Mutation

Incidental Mutation 'R4769:Vmn1r11'

366327

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r11

Ensembl Gene

ENSMUSG00000115236

Gene Name

vomeronasal 1 receptor 11

Synonyms

V1rc3

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.103) question?

Stock #

R4769 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

57133455-57139617 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 57137612 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Lysine at position 87 (R87K)

Ref Sequence

ENSEMBL: ENSMUSP00000154588 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071304] [ENSMUST00000176954] [ENSMUST00000226968] [ENSMUST00000228235]

AlphaFold

Q3SXA2

Predicted Effect

probably damaging
Transcript: ENSMUST00000071304
AA Change: R87K

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000071272
Gene: ENSMUSG00000115236
AA Change: R87K

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	4.5e-56	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000176954
AA Change: R87K

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000135192
Gene: ENSMUSG00000093635
AA Change: R87K

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	9.7e-59	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000226968
AA Change: R87K

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

Predicted Effect

probably damaging
Transcript: ENSMUST00000228235
AA Change: R50K

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.7%
20x: 93.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3425401B19Rik	A	C	14: 32,660,217	S1264A	probably benign	Het
Adamts13	T	G	2: 27,008,711	Y1361*	probably null	Het
Ahrr	A	T	13: 74,214,212	D389E	probably damaging	Het
Alx3	T	C	3: 107,600,691	F172S	probably damaging	Het
Antxrl	A	G	14: 34,073,070	H485R	possibly damaging	Het
Aox4	A	G	1: 58,259,148	D1091G	probably null	Het
Btbd1	T	A	7: 81,805,810	Q271L	probably benign	Het
Cd209c	A	T	8: 3,944,953	N70K	probably benign	Het
Cdc14a	C	T	3: 116,294,750		probably null	Het
Cenpe	A	G	3: 135,248,151	M1641V	probably benign	Het
Clec2e	G	A	6: 129,100,827	T16I	probably benign	Het
Clp1	T	C	2: 84,725,875	D87G	possibly damaging	Het
Dpy19l1	A	T	9: 24,426,148	F517I	probably damaging	Het
Dzip3	T	C	16: 48,938,474	N646S	probably damaging	Het
Ephx1	T	A	1: 180,995,978	Y188F	possibly damaging	Het
Etfa	A	T	9: 55,495,767	H81Q	possibly damaging	Het
Gigyf2	T	A	1: 87,440,849	F1084I	probably damaging	Het
Heatr3	T	C	8: 88,141,783		probably null	Het
Ift81	G	T	5: 122,594,593	H293N	probably benign	Het
Igkv9-120	G	T	6: 68,050,367	R88S	possibly damaging	Het
Il6	T	G	5: 30,018,078	L114*	probably null	Het
Ism2	A	T	12: 87,299,581	M42K	probably benign	Het
Lhx5	A	G	5: 120,436,438	E269G	probably benign	Het
Marveld1	T	G	19: 42,147,995	M116R	possibly damaging	Het
Micall2	A	G	5: 139,706,886	S911P	probably damaging	Het
Mier1	G	A	4: 103,140,220	R195H	probably benign	Het
Muc2	T	A	7: 141,699,691		probably null	Het
Mybbp1a	A	G	11: 72,445,640	K486R	probably damaging	Het
Ncapd2	A	C	6: 125,185,745	L179R	probably damaging	Het
Nos1	C	T	5: 117,943,245	Q1171*	probably null	Het
Nrg1	T	A	8: 31,917,972	I78F	probably damaging	Het
Olfr1163	T	G	2: 88,070,729	T218P	probably benign	Het
Olfr220	T	G	1: 174,448,958	F112V	possibly damaging	Het
Plek2	C	T	12: 78,906,890		probably null	Het
Plod2	A	G	9: 92,595,272	H339R	probably damaging	Het
Pold1	C	T	7: 44,535,071	C835Y	probably damaging	Het
Polr1a	A	G	6: 71,950,868	I868V	probably benign	Het
Prss54	C	A	8: 95,559,375	V357L	probably benign	Het
Rbbp8	T	A	18: 11,722,670	S625T	probably damaging	Het
Rgs1	A	T	1: 144,247,929	L86Q	probably damaging	Het
Ripk4	T	A	16: 97,744,062	N462Y	probably damaging	Het
Rsf1	C	T	7: 97,676,222	L1011F	probably damaging	Het
Slc19a3	G	A	1: 83,019,341	T382I	probably damaging	Het
Slc9a2	G	A	1: 40,726,374	R308Q	probably damaging	Het
Top2b	T	A	14: 16,398,991	L537Q	probably damaging	Het
Trim45	C	A	3: 100,931,734		probably benign	Het
Umodl1	G	T	17: 30,984,002	R443M	possibly damaging	Het
Vmn1r78	T	A	7: 12,152,798	I112N	probably damaging	Het
Zeb2	T	G	2: 44,996,435	E825A	probably damaging	Het
Zfp930	A	T	8: 69,226,692	I50F	probably benign	Het

Other mutations in Vmn1r11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02134:Vmn1r11	APN	6	57138037	missense	possibly damaging	0.66
IGL02141:Vmn1r11	APN	6	57137379	nonsense	probably null
IGL03147:Vmn1r11	UTSW	6	57137665	missense	probably damaging	0.98
R0908:Vmn1r11	UTSW	6	57138064	missense	probably damaging	1.00
R1185:Vmn1r11	UTSW	6	57137507	missense	possibly damaging	0.89
R1185:Vmn1r11	UTSW	6	57137507	missense	possibly damaging	0.89
R1185:Vmn1r11	UTSW	6	57137507	missense	possibly damaging	0.89
R1347:Vmn1r11	UTSW	6	57137978	missense	probably benign	0.23
R1347:Vmn1r11	UTSW	6	57137978	missense	probably benign	0.23
R1348:Vmn1r11	UTSW	6	57137978	missense	probably benign	0.23
R1349:Vmn1r11	UTSW	6	57137978	missense	probably benign	0.23
R1373:Vmn1r11	UTSW	6	57137978	missense	probably benign	0.23
R1497:Vmn1r11	UTSW	6	57137409	missense	probably damaging	1.00
R2147:Vmn1r11	UTSW	6	57137598	missense	probably benign	0.29
R2367:Vmn1r11	UTSW	6	57137431	missense	probably benign	0.00
R3087:Vmn1r11	UTSW	6	57137706	missense	possibly damaging	0.94
R4445:Vmn1r11	UTSW	6	57137530	missense	probably benign	0.31
R4667:Vmn1r11	UTSW	6	57137498	missense	probably damaging	1.00
R5513:Vmn1r11	UTSW	6	57137632	missense	probably damaging	0.97
R5841:Vmn1r11	UTSW	6	57137802	missense	probably damaging	1.00
R6089:Vmn1r11	UTSW	6	57137660	missense	possibly damaging	0.95
R7155:Vmn1r11	UTSW	6	57138162	missense	probably benign	0.07
R7359:Vmn1r11	UTSW	6	57138199	missense	probably damaging	1.00
R8846:Vmn1r11	UTSW	6	57137822	missense	probably benign	0.19
R9222:Vmn1r11	UTSW	6	57138007	missense	possibly damaging	0.94
R9300:Vmn1r11	UTSW	6	57137887	missense	probably benign	0.00
R9517:Vmn1r11	UTSW	6	57137570	missense	possibly damaging	0.88

Predicted Primers

PCR Primer
(F):5'- AAGCTGGGTTAGGAGTCCTAG -3'
(R):5'- GCACCAACATAGAAGATCAGGTTAC -3'

Sequencing Primer
(F):5'- AGGAGTCCTAGCTAATATGTGTCTTC -3'
(R):5'- AAGATCAGGTTACTACTGAAGGAC -3'

Posted On

2015-12-21