Mutagenetix > Incidental Mutation

Incidental Mutation 'R4769:Vmn1r78'

366332

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r78

Ensembl Gene

ENSMUSG00000061602

Gene Name

vomeronasal 1 receptor 78

Synonyms

V1rg7

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.060) question?

Stock #

R4769 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

12150257-12159959 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 12152798 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 112 (I112N)

Ref Sequence

ENSEMBL: ENSMUSP00000154797 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078039] [ENSMUST00000228244] [ENSMUST00000228664]

AlphaFold

K7N608

Predicted Effect

probably damaging
Transcript: ENSMUST00000078039
AA Change: I112N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000077186
Gene: ENSMUSG00000061602
AA Change: I112N

Domain	Start	End	E-Value	Type
Pfam:TAS2R	3	304	5.7e-8	PFAM
Pfam:V1R	12	301	1.5e-29	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000209489

Predicted Effect

probably damaging
Transcript: ENSMUST00000228244
AA Change: I112N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

Predicted Effect

probably damaging
Transcript: ENSMUST00000228664
AA Change: I112N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.7%
20x: 93.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3425401B19Rik	A	C	14: 32,660,217	S1264A	probably benign	Het
Adamts13	T	G	2: 27,008,711	Y1361*	probably null	Het
Ahrr	A	T	13: 74,214,212	D389E	probably damaging	Het
Alx3	T	C	3: 107,600,691	F172S	probably damaging	Het
Antxrl	A	G	14: 34,073,070	H485R	possibly damaging	Het
Aox4	A	G	1: 58,259,148	D1091G	probably null	Het
Btbd1	T	A	7: 81,805,810	Q271L	probably benign	Het
Cd209c	A	T	8: 3,944,953	N70K	probably benign	Het
Cdc14a	C	T	3: 116,294,750		probably null	Het
Cenpe	A	G	3: 135,248,151	M1641V	probably benign	Het
Clec2e	G	A	6: 129,100,827	T16I	probably benign	Het
Clp1	T	C	2: 84,725,875	D87G	possibly damaging	Het
Dpy19l1	A	T	9: 24,426,148	F517I	probably damaging	Het
Dzip3	T	C	16: 48,938,474	N646S	probably damaging	Het
Ephx1	T	A	1: 180,995,978	Y188F	possibly damaging	Het
Etfa	A	T	9: 55,495,767	H81Q	possibly damaging	Het
Gigyf2	T	A	1: 87,440,849	F1084I	probably damaging	Het
Heatr3	T	C	8: 88,141,783		probably null	Het
Ift81	G	T	5: 122,594,593	H293N	probably benign	Het
Igkv9-120	G	T	6: 68,050,367	R88S	possibly damaging	Het
Il6	T	G	5: 30,018,078	L114*	probably null	Het
Ism2	A	T	12: 87,299,581	M42K	probably benign	Het
Lhx5	A	G	5: 120,436,438	E269G	probably benign	Het
Marveld1	T	G	19: 42,147,995	M116R	possibly damaging	Het
Micall2	A	G	5: 139,706,886	S911P	probably damaging	Het
Mier1	G	A	4: 103,140,220	R195H	probably benign	Het
Muc2	T	A	7: 141,699,691		probably null	Het
Mybbp1a	A	G	11: 72,445,640	K486R	probably damaging	Het
Ncapd2	A	C	6: 125,185,745	L179R	probably damaging	Het
Nos1	C	T	5: 117,943,245	Q1171*	probably null	Het
Nrg1	T	A	8: 31,917,972	I78F	probably damaging	Het
Olfr1163	T	G	2: 88,070,729	T218P	probably benign	Het
Olfr220	T	G	1: 174,448,958	F112V	possibly damaging	Het
Plek2	C	T	12: 78,906,890		probably null	Het
Plod2	A	G	9: 92,595,272	H339R	probably damaging	Het
Pold1	C	T	7: 44,535,071	C835Y	probably damaging	Het
Polr1a	A	G	6: 71,950,868	I868V	probably benign	Het
Prss54	C	A	8: 95,559,375	V357L	probably benign	Het
Rbbp8	T	A	18: 11,722,670	S625T	probably damaging	Het
Rgs1	A	T	1: 144,247,929	L86Q	probably damaging	Het
Ripk4	T	A	16: 97,744,062	N462Y	probably damaging	Het
Rsf1	C	T	7: 97,676,222	L1011F	probably damaging	Het
Slc19a3	G	A	1: 83,019,341	T382I	probably damaging	Het
Slc9a2	G	A	1: 40,726,374	R308Q	probably damaging	Het
Top2b	T	A	14: 16,398,991	L537Q	probably damaging	Het
Trim45	C	A	3: 100,931,734		probably benign	Het
Umodl1	G	T	17: 30,984,002	R443M	possibly damaging	Het
Vmn1r11	G	A	6: 57,137,612	R87K	probably damaging	Het
Zeb2	T	G	2: 44,996,435	E825A	probably damaging	Het
Zfp930	A	T	8: 69,226,692	I50F	probably benign	Het

Other mutations in Vmn1r78

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01129:Vmn1r78	APN	7	12153238	missense	probably benign	0.10
IGL02019:Vmn1r78	APN	7	12152707	missense	probably damaging	0.99
IGL02143:Vmn1r78	APN	7	12152480	missense	probably benign
IGL02154:Vmn1r78	APN	7	12152545	missense	probably benign	0.22
IGL02290:Vmn1r78	APN	7	12153155	missense	probably damaging	1.00
IGL03012:Vmn1r78	APN	7	12153364	missense	probably benign	0.32
IGL03256:Vmn1r78	APN	7	12152798	missense	probably damaging	1.00
IGL03373:Vmn1r78	APN	7	12153343	missense	possibly damaging	0.86
IGL03384:Vmn1r78	APN	7	12153209	missense	possibly damaging	0.94
R0016:Vmn1r78	UTSW	7	12153352	missense	probably benign	0.02
R1445:Vmn1r78	UTSW	7	12152581	missense	possibly damaging	0.64
R1748:Vmn1r78	UTSW	7	12153323	missense	probably damaging	1.00
R2017:Vmn1r78	UTSW	7	12153343	missense	possibly damaging	0.86
R2032:Vmn1r78	UTSW	7	12153283	missense	probably benign	0.00
R2198:Vmn1r78	UTSW	7	12152560	missense	probably benign	0.06
R4330:Vmn1r78	UTSW	7	12152459	splice site	probably null
R4564:Vmn1r78	UTSW	7	12152558	missense	probably damaging	1.00
R4801:Vmn1r78	UTSW	7	12152964	nonsense	probably null
R4802:Vmn1r78	UTSW	7	12152964	nonsense	probably null
R4860:Vmn1r78	UTSW	7	12152756	missense	probably damaging	1.00
R4860:Vmn1r78	UTSW	7	12152756	missense	probably damaging	1.00
R5648:Vmn1r78	UTSW	7	12152766	missense	possibly damaging	0.92
R6561:Vmn1r78	UTSW	7	12152899	missense	probably damaging	1.00
R6869:Vmn1r78	UTSW	7	12152749	missense	probably benign	0.01
R6945:Vmn1r78	UTSW	7	12152905	missense	probably benign	0.01
R7793:Vmn1r78	UTSW	7	12153314	missense	probably benign	0.01
R7954:Vmn1r78	UTSW	7	12153300	nonsense	probably null
R8698:Vmn1r78	UTSW	7	12152612	missense	probably benign	0.06
R8830:Vmn1r78	UTSW	7	12153191	missense	probably damaging	0.98
R9624:Vmn1r78	UTSW	7	12152483	missense	probably benign
Z1088:Vmn1r78	UTSW	7	12152714	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AAGCACTTGACTTTTGCTAACTGC -3'
(R):5'- TACAGAGCAGTTGCCACATTTC -3'

Sequencing Primer
(F):5'- ACTTGACTTTTGCTAACTGCTTAAC -3'
(R):5'- AGCAGTTGCCACATTTCTGGAAG -3'

Posted On

2015-12-21