Incidental Mutation 'R4780:Anks1b'
| ID |
366431 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Anks1b
|
| Ensembl Gene |
ENSMUSG00000058589 |
| Gene Name |
ankyrin repeat and sterile alpha motif domain containing 1B |
| Synonyms |
C030032C09Rik, Gm10937, AIDA-1b, LOC380650, E530015N03Rik |
| MMRRC Submission |
041993-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4780 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
89709371-90809162 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 89709594 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Glutamic Acid
at position 21
(K21E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000096968
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000099368]
[ENSMUST00000182907]
[ENSMUST00000182936]
[ENSMUST00000183156]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000099368
AA Change: K21E
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000096968
Gene: ENSMUSG00000058589
AA Change: K21E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
21 |
46 |
N/A |
INTRINSIC |
|
ANK
|
58 |
87 |
1.88e-5 |
SMART |
|
ANK
|
91 |
123 |
3.13e-2 |
SMART |
|
ANK
|
127 |
156 |
6.92e-4 |
SMART |
|
ANK
|
160 |
189 |
3.08e-1 |
SMART |
|
ANK
|
193 |
222 |
1.43e-5 |
SMART |
|
ANK
|
225 |
254 |
4.75e-2 |
SMART |
|
low complexity region
|
498 |
513 |
N/A |
INTRINSIC |
|
low complexity region
|
551 |
577 |
N/A |
INTRINSIC |
|
low complexity region
|
659 |
670 |
N/A |
INTRINSIC |
|
SAM
|
806 |
875 |
2.06e-19 |
SMART |
|
SAM
|
880 |
931 |
4.44e-1 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000182907
AA Change: K21E
|
| SMART Domains |
Protein: ENSMUSP00000138614
Gene: ENSMUSG00000058589
AA Change: K21E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
21 |
45 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000182936
AA Change: K21E
PolyPhen 2
Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000138209
Gene: ENSMUSG00000058589
AA Change: K21E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
21 |
46 |
N/A |
INTRINSIC |
|
ANK
|
58 |
87 |
1.88e-5 |
SMART |
|
ANK
|
91 |
123 |
3.13e-2 |
SMART |
|
ANK
|
127 |
156 |
6.92e-4 |
SMART |
|
ANK
|
160 |
189 |
3.08e-1 |
SMART |
|
ANK
|
193 |
222 |
1.43e-5 |
SMART |
|
ANK
|
225 |
254 |
5.03e2 |
SMART |
|
low complexity region
|
464 |
479 |
N/A |
INTRINSIC |
|
low complexity region
|
517 |
543 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000183156
AA Change: K21E
PolyPhen 2
Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
|
| SMART Domains |
Protein: ENSMUSP00000138539
Gene: ENSMUSG00000058589
AA Change: K21E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
21 |
46 |
N/A |
INTRINSIC |
|
ANK
|
58 |
87 |
1.88e-5 |
SMART |
|
ANK
|
91 |
123 |
3.13e-2 |
SMART |
|
ANK
|
127 |
156 |
6.92e-4 |
SMART |
|
ANK
|
160 |
189 |
3.08e-1 |
SMART |
|
ANK
|
193 |
222 |
1.43e-5 |
SMART |
|
ANK
|
225 |
254 |
4.75e-2 |
SMART |
|
low complexity region
|
498 |
513 |
N/A |
INTRINSIC |
|
low complexity region
|
551 |
577 |
N/A |
INTRINSIC |
|
low complexity region
|
659 |
670 |
N/A |
INTRINSIC |
|
SAM
|
806 |
875 |
2.06e-19 |
SMART |
|
SAM
|
880 |
948 |
5.66e-17 |
SMART |
|
low complexity region
|
968 |
983 |
N/A |
INTRINSIC |
|
PTB
|
1056 |
1194 |
2.94e-38 |
SMART |
|
| Meta Mutation Damage Score |
0.1160 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.6%
|
| Validation Efficiency |
98% (107/109) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene. [provided by RefSeq, Aug 2011]
PHENOTYPE: Mice homozygous for a conditional allele activated in neurons alters hippocampal synaptic transmission. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 105 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
A |
G |
3: 137,771,131 (GRCm39) |
N107D |
probably benign |
Het |
| 4833413E03Rik |
A |
C |
17: 31,777,738 (GRCm39) |
|
noncoding transcript |
Het |
| 4931429L15Rik |
G |
T |
9: 46,220,144 (GRCm39) |
H129Q |
possibly damaging |
Het |
| A730018C14Rik |
A |
G |
12: 112,382,069 (GRCm39) |
|
noncoding transcript |
Het |
| Abcc6 |
T |
A |
7: 45,646,115 (GRCm39) |
K791N |
probably benign |
Het |
| Adcy4 |
T |
G |
14: 56,012,493 (GRCm39) |
Q550P |
probably benign |
Het |
| Add3 |
C |
A |
19: 53,223,223 (GRCm39) |
A325E |
possibly damaging |
Het |
| Agbl4 |
T |
A |
4: 111,514,528 (GRCm39) |
I513N |
possibly damaging |
Het |
| Agfg1 |
C |
A |
1: 82,864,108 (GRCm39) |
T392K |
probably damaging |
Het |
| Akna |
C |
A |
4: 63,297,491 (GRCm39) |
M854I |
probably benign |
Het |
| Ankrd44 |
T |
C |
1: 54,802,916 (GRCm39) |
N194S |
probably benign |
Het |
| Ap1s3 |
A |
G |
1: 79,586,889 (GRCm39) |
F154L |
probably benign |
Het |
| Apbb2 |
T |
A |
5: 66,520,160 (GRCm39) |
N477I |
probably damaging |
Het |
| Apobec3 |
T |
C |
15: 79,783,225 (GRCm39) |
C101R |
possibly damaging |
Het |
| Arnt |
G |
T |
3: 95,395,696 (GRCm39) |
V410F |
probably damaging |
Het |
| Arsg |
G |
A |
11: 109,424,839 (GRCm39) |
R270H |
possibly damaging |
Het |
| B3gnt7 |
T |
A |
1: 86,232,992 (GRCm39) |
D79E |
probably damaging |
Het |
| Cd44 |
G |
T |
2: 102,691,910 (GRCm39) |
A126D |
probably damaging |
Het |
| Cd69 |
A |
G |
6: 129,248,318 (GRCm39) |
I56T |
probably damaging |
Het |
| Cep120 |
G |
A |
18: 53,857,608 (GRCm39) |
P286S |
probably benign |
Het |
| Ces2a |
T |
C |
8: 105,463,840 (GRCm39) |
F184S |
probably damaging |
Het |
| Chrng |
A |
G |
1: 87,135,246 (GRCm39) |
N185S |
probably damaging |
Het |
| Cldn6 |
A |
T |
17: 23,900,221 (GRCm39) |
M62L |
probably benign |
Het |
| Cntn6 |
T |
A |
6: 104,822,745 (GRCm39) |
N765K |
probably damaging |
Het |
| Cspg4b |
A |
G |
13: 113,454,392 (GRCm39) |
Y146C |
probably damaging |
Het |
| Ctnnal1 |
T |
C |
4: 56,847,857 (GRCm39) |
D94G |
probably damaging |
Het |
| Cyp2c69 |
T |
C |
19: 39,866,038 (GRCm39) |
N185S |
probably benign |
Het |
| Depdc1a |
A |
G |
3: 159,232,343 (GRCm39) |
N698S |
probably benign |
Het |
| Dnah2 |
A |
T |
11: 69,364,697 (GRCm39) |
I1986N |
probably damaging |
Het |
| Dnah7b |
A |
G |
1: 46,392,174 (GRCm39) |
E3845G |
probably benign |
Het |
| Dpysl3 |
C |
T |
18: 43,487,867 (GRCm39) |
V159I |
probably benign |
Het |
| Dync1h1 |
T |
C |
12: 110,627,630 (GRCm39) |
Y4047H |
probably damaging |
Het |
| E130308A19Rik |
C |
T |
4: 59,691,057 (GRCm39) |
P297L |
probably benign |
Het |
| E2f5 |
A |
G |
3: 14,652,379 (GRCm39) |
T72A |
probably benign |
Het |
| Ephb6 |
G |
T |
6: 41,593,073 (GRCm39) |
R437L |
probably damaging |
Het |
| Erbb4 |
T |
C |
1: 68,337,473 (GRCm39) |
H615R |
probably damaging |
Het |
| Erbin |
T |
C |
13: 104,020,714 (GRCm39) |
T82A |
probably damaging |
Het |
| Eri2 |
T |
C |
7: 119,384,903 (GRCm39) |
N533D |
probably benign |
Het |
| Fkbp9 |
A |
G |
6: 56,827,701 (GRCm39) |
N174S |
probably damaging |
Het |
| Fsbp |
C |
T |
4: 11,583,709 (GRCm39) |
T136I |
possibly damaging |
Het |
| Fubp3 |
C |
A |
2: 31,473,223 (GRCm39) |
D47E |
probably damaging |
Het |
| Gm21850 |
G |
A |
2: 153,898,419 (GRCm39) |
|
noncoding transcript |
Het |
| Gm5141 |
T |
A |
13: 62,922,764 (GRCm39) |
Y135F |
unknown |
Het |
| Gm7353 |
T |
A |
7: 3,160,725 (GRCm39) |
|
noncoding transcript |
Het |
| Gm9925 |
T |
C |
18: 74,198,344 (GRCm39) |
|
probably benign |
Het |
| Greb1l |
T |
C |
18: 10,541,792 (GRCm39) |
S1180P |
probably benign |
Het |
| H2ac11 |
G |
A |
13: 22,227,079 (GRCm39) |
Q7* |
probably null |
Het |
| Ift70a2 |
A |
C |
2: 75,807,920 (GRCm39) |
C197W |
probably benign |
Het |
| Kiz |
A |
G |
2: 146,731,166 (GRCm39) |
T192A |
possibly damaging |
Het |
| Klhl24 |
T |
A |
16: 19,925,708 (GRCm39) |
C79S |
probably damaging |
Het |
| Map3k11 |
A |
G |
19: 5,740,966 (GRCm39) |
H231R |
probably damaging |
Het |
| Mbd4 |
C |
A |
6: 115,826,345 (GRCm39) |
R194S |
probably benign |
Het |
| Mettl21e |
A |
C |
1: 44,250,303 (GRCm39) |
S34R |
probably benign |
Het |
| Mrps5 |
T |
C |
2: 127,440,161 (GRCm39) |
V245A |
probably benign |
Het |
| Mtrf1 |
T |
C |
14: 79,639,128 (GRCm39) |
Y87H |
probably benign |
Het |
| Myh15 |
T |
C |
16: 48,940,420 (GRCm39) |
I790T |
probably benign |
Het |
| Necab1 |
T |
G |
4: 14,989,248 (GRCm39) |
I176L |
probably benign |
Het |
| Nfkb2 |
T |
A |
19: 46,298,361 (GRCm39) |
L555Q |
probably damaging |
Het |
| Nhlrc3 |
T |
A |
3: 53,365,988 (GRCm39) |
E168D |
probably benign |
Het |
| Nlrp5 |
T |
A |
7: 23,135,203 (GRCm39) |
C949S |
probably damaging |
Het |
| Nup155 |
C |
A |
15: 8,187,187 (GRCm39) |
A1372E |
probably benign |
Het |
| Nynrin |
G |
T |
14: 56,100,720 (GRCm39) |
R170L |
probably damaging |
Het |
| Ogfrl1 |
T |
A |
1: 23,409,402 (GRCm39) |
N275Y |
probably damaging |
Het |
| Olr1 |
A |
T |
6: 129,465,839 (GRCm39) |
S56T |
probably damaging |
Het |
| Or4k52 |
A |
G |
2: 111,611,190 (GRCm39) |
D175G |
probably damaging |
Het |
| Or5aq1 |
C |
T |
2: 86,966,221 (GRCm39) |
S148N |
probably damaging |
Het |
| Or5b121 |
A |
G |
19: 13,507,319 (GRCm39) |
N138S |
probably benign |
Het |
| Or8b48 |
A |
G |
9: 38,493,265 (GRCm39) |
T231A |
possibly damaging |
Het |
| Ovol2 |
A |
T |
2: 144,173,203 (GRCm39) |
|
probably benign |
Het |
| Pcdha6 |
A |
T |
18: 37,102,906 (GRCm39) |
I700F |
probably damaging |
Het |
| Prkcz |
C |
T |
4: 155,374,159 (GRCm39) |
V86M |
probably damaging |
Het |
| Ptpn13 |
A |
G |
5: 103,734,639 (GRCm39) |
T2124A |
probably benign |
Het |
| Ranbp3 |
G |
T |
17: 56,980,346 (GRCm39) |
|
probably benign |
Het |
| Rapgef2 |
A |
G |
3: 79,077,076 (GRCm39) |
|
probably benign |
Het |
| Rbl1 |
A |
G |
2: 157,016,724 (GRCm39) |
V625A |
probably benign |
Het |
| Rbm38 |
G |
T |
2: 172,863,944 (GRCm39) |
G38C |
probably damaging |
Het |
| Reg1 |
T |
G |
6: 78,403,333 (GRCm39) |
F7C |
possibly damaging |
Het |
| Retnlg |
A |
T |
16: 48,694,697 (GRCm39) |
Q115L |
possibly damaging |
Het |
| Rhobtb1 |
G |
A |
10: 69,105,983 (GRCm39) |
V183I |
probably benign |
Het |
| Rims1 |
T |
C |
1: 22,361,329 (GRCm39) |
Q1186R |
probably damaging |
Het |
| Ryr1 |
A |
G |
7: 28,794,522 (GRCm39) |
F1246L |
possibly damaging |
Het |
| Samm50 |
A |
G |
15: 84,094,811 (GRCm39) |
N401S |
possibly damaging |
Het |
| Scn3a |
T |
A |
2: 65,336,537 (GRCm39) |
I690F |
probably damaging |
Het |
| Sdk1 |
A |
G |
5: 141,944,993 (GRCm39) |
D304G |
probably damaging |
Het |
| Skint6 |
T |
C |
4: 113,093,594 (GRCm39) |
Y183C |
probably damaging |
Het |
| Slamf1 |
A |
T |
1: 171,604,829 (GRCm39) |
T200S |
probably benign |
Het |
| Slc34a2 |
C |
T |
5: 53,226,793 (GRCm39) |
R639C |
probably damaging |
Het |
| Smap1 |
A |
T |
1: 23,892,517 (GRCm39) |
M149K |
probably benign |
Het |
| Sorcs1 |
T |
C |
19: 50,132,419 (GRCm39) |
|
probably benign |
Het |
| Sp140 |
T |
A |
1: 85,538,549 (GRCm39) |
D95E |
possibly damaging |
Het |
| Spata13 |
G |
A |
14: 60,991,356 (GRCm39) |
W366* |
probably null |
Het |
| Spata31e4 |
C |
A |
13: 50,855,116 (GRCm39) |
S251R |
probably damaging |
Het |
| Strip1 |
G |
A |
3: 107,534,314 (GRCm39) |
T136I |
probably benign |
Het |
| Tacr1 |
A |
T |
6: 82,534,053 (GRCm39) |
T360S |
probably benign |
Het |
| Tbc1d14 |
T |
A |
5: 36,728,600 (GRCm39) |
|
probably benign |
Het |
| Tcaf2 |
T |
C |
6: 42,604,996 (GRCm39) |
Y596C |
probably damaging |
Het |
| Tspoap1 |
C |
T |
11: 87,669,269 (GRCm39) |
T1454I |
possibly damaging |
Het |
| Ttn |
A |
T |
2: 76,744,927 (GRCm39) |
M5374K |
probably benign |
Het |
| Uts2r |
G |
A |
11: 121,051,705 (GRCm39) |
V190I |
possibly damaging |
Het |
| Vmn1r181 |
A |
G |
7: 23,684,008 (GRCm39) |
T158A |
possibly damaging |
Het |
| Wdr35 |
A |
T |
12: 9,068,150 (GRCm39) |
T778S |
probably benign |
Het |
| Xrn1 |
A |
T |
9: 95,856,797 (GRCm39) |
|
probably benign |
Het |
| Zfp35 |
A |
T |
18: 24,136,326 (GRCm39) |
K223N |
probably damaging |
Het |
| Zfp764 |
T |
C |
7: 127,003,943 (GRCm39) |
Q396R |
probably benign |
Het |
| Zfyve1 |
T |
C |
12: 83,605,421 (GRCm39) |
Y11C |
probably damaging |
Het |
|
| Other mutations in Anks1b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01669:Anks1b
|
APN |
10 |
90,733,100 (GRCm39) |
splice site |
probably benign |
|
|
IGL01890:Anks1b
|
APN |
10 |
90,480,389 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL01966:Anks1b
|
APN |
10 |
90,730,994 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02176:Anks1b
|
APN |
10 |
89,878,530 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02205:Anks1b
|
APN |
10 |
89,906,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02465:Anks1b
|
APN |
10 |
89,999,127 (GRCm39) |
nonsense |
probably null |
|
|
IGL02534:Anks1b
|
APN |
10 |
90,730,979 (GRCm39) |
missense |
probably benign |
0.45 |
|
IGL02554:Anks1b
|
APN |
10 |
90,757,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02820:Anks1b
|
APN |
10 |
89,912,921 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03164:Anks1b
|
APN |
10 |
89,878,554 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0096:Anks1b
|
UTSW |
10 |
89,909,924 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0096:Anks1b
|
UTSW |
10 |
89,909,924 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0482:Anks1b
|
UTSW |
10 |
90,195,057 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0542:Anks1b
|
UTSW |
10 |
89,909,829 (GRCm39) |
splice site |
probably benign |
|
|
R0848:Anks1b
|
UTSW |
10 |
89,906,987 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1056:Anks1b
|
UTSW |
10 |
90,757,291 (GRCm39) |
splice site |
probably null |
|
|
R1398:Anks1b
|
UTSW |
10 |
89,885,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1446:Anks1b
|
UTSW |
10 |
90,346,935 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1548:Anks1b
|
UTSW |
10 |
89,885,847 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1551:Anks1b
|
UTSW |
10 |
89,912,843 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1607:Anks1b
|
UTSW |
10 |
89,878,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1667:Anks1b
|
UTSW |
10 |
90,347,046 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1701:Anks1b
|
UTSW |
10 |
89,885,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1843:Anks1b
|
UTSW |
10 |
90,348,751 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1899:Anks1b
|
UTSW |
10 |
90,096,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1957:Anks1b
|
UTSW |
10 |
89,885,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2036:Anks1b
|
UTSW |
10 |
90,805,715 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2279:Anks1b
|
UTSW |
10 |
89,885,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2280:Anks1b
|
UTSW |
10 |
90,802,164 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2937:Anks1b
|
UTSW |
10 |
89,912,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3739:Anks1b
|
UTSW |
10 |
89,869,078 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4061:Anks1b
|
UTSW |
10 |
90,143,484 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4459:Anks1b
|
UTSW |
10 |
90,346,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4479:Anks1b
|
UTSW |
10 |
89,885,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4510:Anks1b
|
UTSW |
10 |
90,346,652 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4511:Anks1b
|
UTSW |
10 |
90,346,652 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4785:Anks1b
|
UTSW |
10 |
90,750,612 (GRCm39) |
missense |
probably null |
0.88 |
|
R4790:Anks1b
|
UTSW |
10 |
89,999,137 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5012:Anks1b
|
UTSW |
10 |
90,194,999 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5400:Anks1b
|
UTSW |
10 |
90,348,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5586:Anks1b
|
UTSW |
10 |
89,912,926 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5687:Anks1b
|
UTSW |
10 |
90,750,573 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5899:Anks1b
|
UTSW |
10 |
90,759,379 (GRCm39) |
splice site |
probably null |
|
|
R5917:Anks1b
|
UTSW |
10 |
90,412,803 (GRCm39) |
intron |
probably benign |
|
|
R5999:Anks1b
|
UTSW |
10 |
90,194,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6080:Anks1b
|
UTSW |
10 |
90,802,211 (GRCm39) |
nonsense |
probably null |
|
|
R6216:Anks1b
|
UTSW |
10 |
90,096,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6265:Anks1b
|
UTSW |
10 |
90,777,362 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6298:Anks1b
|
UTSW |
10 |
90,516,699 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6337:Anks1b
|
UTSW |
10 |
90,757,158 (GRCm39) |
missense |
probably benign |
0.27 |
|
R6522:Anks1b
|
UTSW |
10 |
90,733,189 (GRCm39) |
intron |
probably benign |
|
|
R6843:Anks1b
|
UTSW |
10 |
90,784,460 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6852:Anks1b
|
UTSW |
10 |
90,096,516 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6933:Anks1b
|
UTSW |
10 |
89,905,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7114:Anks1b
|
UTSW |
10 |
90,143,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7211:Anks1b
|
UTSW |
10 |
90,346,932 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7241:Anks1b
|
UTSW |
10 |
90,348,699 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7264:Anks1b
|
UTSW |
10 |
90,348,732 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7325:Anks1b
|
UTSW |
10 |
90,777,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7392:Anks1b
|
UTSW |
10 |
90,516,648 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7578:Anks1b
|
UTSW |
10 |
89,885,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7604:Anks1b
|
UTSW |
10 |
90,096,708 (GRCm39) |
splice site |
probably null |
|
|
R7633:Anks1b
|
UTSW |
10 |
90,784,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7881:Anks1b
|
UTSW |
10 |
90,802,880 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7910:Anks1b
|
UTSW |
10 |
90,516,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7941:Anks1b
|
UTSW |
10 |
90,413,017 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8045:Anks1b
|
UTSW |
10 |
90,516,722 (GRCm39) |
missense |
probably benign |
|
|
R8146:Anks1b
|
UTSW |
10 |
90,143,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8176:Anks1b
|
UTSW |
10 |
89,905,353 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8535:Anks1b
|
UTSW |
10 |
90,784,493 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8681:Anks1b
|
UTSW |
10 |
89,885,868 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9300:Anks1b
|
UTSW |
10 |
90,412,966 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9469:Anks1b
|
UTSW |
10 |
90,733,205 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R9541:Anks1b
|
UTSW |
10 |
90,412,947 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9550:Anks1b
|
UTSW |
10 |
90,412,360 (GRCm39) |
start codon destroyed |
probably null |
|
|
R9653:Anks1b
|
UTSW |
10 |
90,346,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF004:Anks1b
|
UTSW |
10 |
89,869,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF008:Anks1b
|
UTSW |
10 |
89,869,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF017:Anks1b
|
UTSW |
10 |
89,869,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF018:Anks1b
|
UTSW |
10 |
89,869,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF023:Anks1b
|
UTSW |
10 |
89,869,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0064:Anks1b
|
UTSW |
10 |
90,348,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCTCCCCATTGTAGAAGCTG -3'
(R):5'- ACCCTGAGGAGAGAACGTAC -3'
Sequencing Primer
(F):5'- CATTGTAGAAGCTGCGCGG -3'
(R):5'- CTGAGGAGAGAACGTACCCATC -3'
|
| Posted On |
2015-12-21 |
Incidental Mutation