Incidental Mutation 'R4783:Ppp4r4'
| ID |
366747 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ppp4r4
|
| Ensembl Gene |
ENSMUSG00000021209 |
| Gene Name |
protein phosphatase 4, regulatory subunit 4 |
| Synonyms |
8430415E04Rik |
| MMRRC Submission |
042416-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.134)
|
| Stock # |
R4783 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
12 |
| Chromosomal Location |
103498542-103580090 bp(+) (GRCm39) |
| Type of Mutation |
critical splice donor site (2 bp from exon) |
| DNA Base Change (assembly) |
T to A
at 103557117 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000140874
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021631]
[ENSMUST00000187155]
[ENSMUST00000187155]
[ENSMUST00000189871]
[ENSMUST00000190664]
|
| AlphaFold |
Q8C0Y0 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000021631
|
| SMART Domains |
Protein: ENSMUSP00000021631
Gene: ENSMUSG00000021209
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1gw5a_
|
55 |
577 |
6e-27 |
SMART |
|
PDB:3FGA|A
|
178 |
666 |
8e-6 |
PDB |
|
coiled coil region
|
690 |
726 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000187155
|
| SMART Domains |
Protein: ENSMUSP00000140874
Gene: ENSMUSG00000021209
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:HEAT
|
145 |
175 |
2.8e-3 |
PFAM |
|
low complexity region
|
484 |
495 |
N/A |
INTRINSIC |
|
coiled coil region
|
581 |
617 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000187155
|
| SMART Domains |
Protein: ENSMUSP00000140874
Gene: ENSMUSG00000021209
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:HEAT
|
145 |
175 |
2.8e-3 |
PFAM |
|
low complexity region
|
484 |
495 |
N/A |
INTRINSIC |
|
coiled coil region
|
581 |
617 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000189871
|
| SMART Domains |
Protein: ENSMUSP00000139786
Gene: ENSMUSG00000021209
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1gw5a_
|
95 |
577 |
7e-26 |
SMART |
|
PDB:1B3U|B
|
178 |
666 |
2e-6 |
PDB |
|
coiled coil region
|
690 |
726 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000190664
|
| SMART Domains |
Protein: ENSMUSP00000140295
Gene: ENSMUSG00000021209
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:HEAT
|
38 |
68 |
5.8e-4 |
PFAM |
|
| Meta Mutation Damage Score |
0.9490 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.6%
|
| Validation Efficiency |
100% (99/99) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a HEAT-like repeat-containing protein. The HEAT repeat is a tandemly repeated, 37-47 amino acid long module occurring in a number of cytoplasmic proteins. Arrays of HEAT repeats form a rod-like helical structure and appear to function as protein-protein interaction surfaces. The repeat-containing region of this protein has some similarity to the constant regulatory domain of the protein phosphatase 2A PR65/A subunit. The encoded protein binds protein serine/threonine phosphatase 4c in the cytoplasm. [provided by RefSeq, Jan 2017]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 95 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 3110082J24Rik |
G |
A |
5: 30,310,198 (GRCm39) |
R54* |
probably null |
Het |
| Acsl6 |
A |
T |
11: 54,227,819 (GRCm39) |
M350L |
probably damaging |
Het |
| Adgrv1 |
T |
C |
13: 81,243,564 (GRCm39) |
T6279A |
probably damaging |
Het |
| Ago3 |
A |
T |
4: 126,262,296 (GRCm39) |
M418K |
probably benign |
Het |
| Ascc2 |
G |
A |
11: 4,596,653 (GRCm39) |
R58H |
probably benign |
Het |
| Brinp3 |
A |
G |
1: 146,603,378 (GRCm39) |
|
probably benign |
Het |
| Carmil3 |
T |
C |
14: 55,738,778 (GRCm39) |
|
probably null |
Het |
| Ccdc47 |
T |
A |
11: 106,094,430 (GRCm39) |
H7L |
probably benign |
Het |
| Ccndbp1 |
A |
T |
2: 120,839,003 (GRCm39) |
T5S |
probably benign |
Het |
| Cdr2 |
A |
T |
7: 120,557,644 (GRCm39) |
F294I |
probably benign |
Het |
| Chd8 |
C |
A |
14: 52,442,825 (GRCm39) |
C575F |
probably damaging |
Het |
| Ctsll3 |
G |
A |
13: 60,948,209 (GRCm39) |
T156I |
probably damaging |
Het |
| Dgcr8 |
G |
A |
16: 18,076,174 (GRCm39) |
R4* |
probably null |
Het |
| Dnah1 |
T |
A |
14: 30,985,436 (GRCm39) |
K3818N |
probably damaging |
Het |
| Dok2 |
C |
T |
14: 71,015,314 (GRCm39) |
P347L |
probably benign |
Het |
| Elf1 |
T |
A |
14: 79,818,183 (GRCm39) |
N567K |
probably benign |
Het |
| Emsy |
T |
C |
7: 98,295,686 (GRCm39) |
N72S |
possibly damaging |
Het |
| Fam76a |
A |
G |
4: 132,643,501 (GRCm39) |
Y78H |
probably damaging |
Het |
| Fam76a |
A |
T |
4: 132,629,428 (GRCm39) |
|
probably null |
Het |
| Fbn1 |
A |
T |
2: 125,166,839 (GRCm39) |
C2026S |
probably damaging |
Het |
| Fbxo4 |
T |
C |
15: 3,998,523 (GRCm39) |
T312A |
probably benign |
Het |
| Fhip1a |
G |
T |
3: 85,595,877 (GRCm39) |
T115K |
probably damaging |
Het |
| Flnb |
A |
T |
14: 7,905,701 (GRCm38) |
E1150D |
probably benign |
Het |
| Galt |
T |
C |
4: 41,758,189 (GRCm39) |
V318A |
probably damaging |
Het |
| Git1 |
T |
G |
11: 77,390,663 (GRCm39) |
L133R |
probably damaging |
Het |
| Gm11168 |
G |
A |
9: 3,006,915 (GRCm39) |
M213I |
probably benign |
Het |
| Gm7233 |
A |
G |
14: 43,037,423 (GRCm39) |
E25G |
probably benign |
Het |
| Golga2 |
T |
A |
2: 32,187,168 (GRCm39) |
N89K |
probably damaging |
Het |
| Grin1 |
T |
A |
2: 25,182,393 (GRCm39) |
H956L |
possibly damaging |
Het |
| Hlcs |
C |
T |
16: 94,069,398 (GRCm39) |
V164I |
possibly damaging |
Het |
| Hmgcr |
G |
A |
13: 96,802,701 (GRCm39) |
T66M |
probably damaging |
Het |
| Ifi206 |
A |
T |
1: 173,308,432 (GRCm39) |
H521Q |
probably benign |
Het |
| Lgals3bp |
G |
A |
11: 118,284,340 (GRCm39) |
T413I |
probably damaging |
Het |
| Lrrc7 |
A |
G |
3: 157,832,850 (GRCm39) |
|
probably null |
Het |
| Mapk11 |
T |
C |
15: 89,033,691 (GRCm39) |
Y9C |
probably damaging |
Het |
| Mccc1 |
C |
A |
3: 36,030,022 (GRCm39) |
M429I |
probably damaging |
Het |
| Metrnl |
A |
G |
11: 121,598,750 (GRCm39) |
E40G |
probably benign |
Het |
| Mrgpra1 |
A |
G |
7: 46,985,218 (GRCm39) |
S154P |
probably damaging |
Het |
| Myh13 |
A |
T |
11: 67,232,096 (GRCm39) |
I459F |
probably damaging |
Het |
| Nalf1 |
T |
C |
8: 9,258,026 (GRCm39) |
Y374C |
probably damaging |
Het |
| Nedd4l |
C |
A |
18: 65,305,998 (GRCm39) |
D424E |
probably damaging |
Het |
| Nid1 |
C |
T |
13: 13,674,326 (GRCm39) |
R902W |
probably damaging |
Het |
| Nphp4 |
G |
A |
4: 152,639,003 (GRCm39) |
R878K |
probably benign |
Het |
| Numa1 |
A |
G |
7: 101,662,773 (GRCm39) |
T1997A |
probably damaging |
Het |
| Nutm1 |
G |
A |
2: 112,079,281 (GRCm39) |
A878V |
probably benign |
Het |
| Nxf1 |
G |
A |
19: 8,744,162 (GRCm39) |
A339T |
probably benign |
Het |
| Oas1b |
C |
A |
5: 120,952,578 (GRCm39) |
Q90K |
probably benign |
Het |
| Optn |
T |
C |
2: 5,059,438 (GRCm39) |
M27V |
probably benign |
Het |
| Or1r1 |
A |
G |
11: 73,874,834 (GRCm39) |
F200S |
probably damaging |
Het |
| Or2t35 |
A |
C |
14: 14,407,729 (GRCm38) |
Y167S |
possibly damaging |
Het |
| Or4f56 |
A |
T |
2: 111,703,395 (GRCm39) |
D268E |
possibly damaging |
Het |
| Or5ac17 |
G |
T |
16: 59,036,222 (GRCm39) |
F251L |
probably damaging |
Het |
| Or5d45 |
A |
G |
2: 88,153,500 (GRCm39) |
I183T |
probably damaging |
Het |
| Or5g29 |
A |
G |
2: 85,421,282 (GRCm39) |
T133A |
probably benign |
Het |
| Or5h18 |
G |
T |
16: 58,848,260 (GRCm39) |
D3E |
probably benign |
Het |
| Oxgr1 |
T |
C |
14: 120,259,776 (GRCm39) |
I144V |
probably benign |
Het |
| Pax5 |
T |
A |
4: 44,570,086 (GRCm39) |
T127S |
probably damaging |
Het |
| Pcsk2 |
T |
C |
2: 143,529,599 (GRCm39) |
|
probably null |
Het |
| Pdxk |
A |
G |
10: 78,300,626 (GRCm39) |
V19A |
possibly damaging |
Het |
| Pik3c2a |
A |
T |
7: 116,017,060 (GRCm39) |
S232R |
probably damaging |
Het |
| Ppip5k1 |
T |
C |
2: 121,171,329 (GRCm39) |
D620G |
possibly damaging |
Het |
| Psmd1 |
A |
G |
1: 86,006,434 (GRCm39) |
N267D |
probably damaging |
Het |
| Pudp |
A |
G |
18: 50,701,136 (GRCm39) |
V199A |
probably damaging |
Het |
| Rasal3 |
T |
A |
17: 32,615,755 (GRCm39) |
D361V |
probably damaging |
Het |
| Rbm12 |
T |
C |
2: 155,938,484 (GRCm39) |
D596G |
possibly damaging |
Het |
| Rbm6 |
T |
C |
9: 107,730,102 (GRCm39) |
D182G |
probably damaging |
Het |
| Rif1 |
T |
C |
2: 52,002,759 (GRCm39) |
V2071A |
probably damaging |
Het |
| Rilp |
C |
T |
11: 75,401,467 (GRCm39) |
A110V |
possibly damaging |
Het |
| Rprd2 |
A |
G |
3: 95,681,645 (GRCm39) |
V332A |
probably benign |
Het |
| Sbpl |
T |
A |
17: 24,172,304 (GRCm39) |
D205V |
unknown |
Het |
| Scn9a |
T |
C |
2: 66,370,967 (GRCm39) |
I538V |
probably benign |
Het |
| Serpina1d |
T |
C |
12: 103,734,083 (GRCm39) |
S74G |
possibly damaging |
Het |
| Serpina3n |
T |
C |
12: 104,375,369 (GRCm39) |
I147T |
possibly damaging |
Het |
| Serpinb8 |
A |
G |
1: 107,532,472 (GRCm39) |
N188S |
probably benign |
Het |
| Sipa1l3 |
A |
G |
7: 29,077,066 (GRCm39) |
V902A |
probably damaging |
Het |
| Slc25a47 |
T |
A |
12: 108,821,260 (GRCm39) |
L123Q |
probably damaging |
Het |
| Slc30a2 |
A |
T |
4: 134,071,317 (GRCm39) |
|
probably null |
Het |
| Slc66a1 |
G |
T |
4: 139,027,312 (GRCm39) |
H343Q |
probably benign |
Het |
| Snx13 |
T |
A |
12: 35,148,285 (GRCm39) |
D271E |
probably damaging |
Het |
| Tbc1d9b |
A |
G |
11: 50,062,125 (GRCm39) |
N1211S |
probably benign |
Het |
| Tdrd3 |
T |
A |
14: 87,709,537 (GRCm39) |
I67N |
probably damaging |
Het |
| Thbs1 |
T |
C |
2: 117,945,273 (GRCm39) |
V282A |
probably benign |
Het |
| Tmc8 |
A |
G |
11: 117,682,431 (GRCm39) |
|
probably null |
Het |
| Trim11 |
T |
A |
11: 58,879,750 (GRCm39) |
F284Y |
probably null |
Het |
| Ttn |
G |
T |
2: 76,552,141 (GRCm39) |
Y29419* |
probably null |
Het |
| Ttn |
A |
G |
2: 76,599,947 (GRCm39) |
Y19076H |
probably damaging |
Het |
| Ubr4 |
T |
C |
4: 139,149,044 (GRCm39) |
S448P |
possibly damaging |
Het |
| Ugt2b34 |
T |
C |
5: 87,039,332 (GRCm39) |
E443G |
probably damaging |
Het |
| Usp29 |
A |
G |
7: 6,964,390 (GRCm39) |
T78A |
probably damaging |
Het |
| Vmn1r227 |
A |
G |
17: 20,955,396 (GRCm39) |
|
noncoding transcript |
Het |
| Vmn1r85 |
A |
T |
7: 12,818,788 (GRCm39) |
W119R |
probably damaging |
Het |
| Vmn2r12 |
A |
T |
5: 109,234,379 (GRCm39) |
V611E |
probably damaging |
Het |
| Vmn2r97 |
A |
T |
17: 19,149,550 (GRCm39) |
M313L |
probably benign |
Het |
| Zap70 |
T |
C |
1: 36,818,254 (GRCm39) |
Y314H |
probably damaging |
Het |
| Zfp667 |
T |
A |
7: 6,308,684 (GRCm39) |
F451I |
possibly damaging |
Het |
|
| Other mutations in Ppp4r4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00827:Ppp4r4
|
APN |
12 |
103,545,335 (GRCm39) |
missense |
probably benign |
|
|
IGL01388:Ppp4r4
|
APN |
12 |
103,543,108 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01662:Ppp4r4
|
APN |
12 |
103,569,225 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL01768:Ppp4r4
|
APN |
12 |
103,547,664 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL01894:Ppp4r4
|
APN |
12 |
103,559,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01921:Ppp4r4
|
APN |
12 |
103,542,569 (GRCm39) |
start codon destroyed |
probably null |
0.01 |
|
IGL01960:Ppp4r4
|
APN |
12 |
103,547,753 (GRCm39) |
splice site |
probably benign |
|
|
IGL02084:Ppp4r4
|
APN |
12 |
103,566,657 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02287:Ppp4r4
|
APN |
12 |
103,553,747 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02315:Ppp4r4
|
APN |
12 |
103,566,620 (GRCm39) |
splice site |
probably benign |
|
|
IGL03137:Ppp4r4
|
APN |
12 |
103,547,643 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03170:Ppp4r4
|
APN |
12 |
103,557,033 (GRCm39) |
intron |
probably benign |
|
|
cataract
|
UTSW |
12 |
103,579,074 (GRCm39) |
nonsense |
probably null |
|
|
downfall
|
UTSW |
12 |
103,559,357 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0114:Ppp4r4
|
UTSW |
12 |
103,542,633 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0390:Ppp4r4
|
UTSW |
12 |
103,567,619 (GRCm39) |
splice site |
probably benign |
|
|
R0403:Ppp4r4
|
UTSW |
12 |
103,550,361 (GRCm39) |
missense |
probably benign |
|
|
R0548:Ppp4r4
|
UTSW |
12 |
103,579,074 (GRCm39) |
nonsense |
probably null |
|
|
R0601:Ppp4r4
|
UTSW |
12 |
103,566,779 (GRCm39) |
splice site |
probably benign |
|
|
R0894:Ppp4r4
|
UTSW |
12 |
103,566,754 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1127:Ppp4r4
|
UTSW |
12 |
103,545,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1177:Ppp4r4
|
UTSW |
12 |
103,542,582 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1378:Ppp4r4
|
UTSW |
12 |
103,547,751 (GRCm39) |
splice site |
probably benign |
|
|
R1442:Ppp4r4
|
UTSW |
12 |
103,564,504 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1497:Ppp4r4
|
UTSW |
12 |
103,573,204 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1651:Ppp4r4
|
UTSW |
12 |
103,550,331 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1797:Ppp4r4
|
UTSW |
12 |
103,564,410 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1880:Ppp4r4
|
UTSW |
12 |
103,571,294 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R2008:Ppp4r4
|
UTSW |
12 |
103,552,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2038:Ppp4r4
|
UTSW |
12 |
103,542,539 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R2404:Ppp4r4
|
UTSW |
12 |
103,547,749 (GRCm39) |
splice site |
probably null |
|
|
R2696:Ppp4r4
|
UTSW |
12 |
103,547,653 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R2849:Ppp4r4
|
UTSW |
12 |
103,573,192 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2965:Ppp4r4
|
UTSW |
12 |
103,579,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3030:Ppp4r4
|
UTSW |
12 |
103,573,215 (GRCm39) |
missense |
probably benign |
|
|
R3805:Ppp4r4
|
UTSW |
12 |
103,566,625 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3862:Ppp4r4
|
UTSW |
12 |
103,562,680 (GRCm39) |
nonsense |
probably null |
|
|
R4194:Ppp4r4
|
UTSW |
12 |
103,524,704 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4320:Ppp4r4
|
UTSW |
12 |
103,564,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4558:Ppp4r4
|
UTSW |
12 |
103,573,192 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4866:Ppp4r4
|
UTSW |
12 |
103,566,706 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4903:Ppp4r4
|
UTSW |
12 |
103,557,030 (GRCm39) |
splice site |
probably null |
|
|
R5309:Ppp4r4
|
UTSW |
12 |
103,573,147 (GRCm39) |
splice site |
probably null |
|
|
R5312:Ppp4r4
|
UTSW |
12 |
103,573,147 (GRCm39) |
splice site |
probably null |
|
|
R5381:Ppp4r4
|
UTSW |
12 |
103,559,357 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5383:Ppp4r4
|
UTSW |
12 |
103,550,427 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5447:Ppp4r4
|
UTSW |
12 |
103,550,410 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R5942:Ppp4r4
|
UTSW |
12 |
103,553,706 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6339:Ppp4r4
|
UTSW |
12 |
103,571,228 (GRCm39) |
nonsense |
probably null |
|
|
R6386:Ppp4r4
|
UTSW |
12 |
103,559,364 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6712:Ppp4r4
|
UTSW |
12 |
103,562,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6755:Ppp4r4
|
UTSW |
12 |
103,551,996 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6868:Ppp4r4
|
UTSW |
12 |
103,557,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6879:Ppp4r4
|
UTSW |
12 |
103,518,179 (GRCm39) |
splice site |
probably null |
|
|
R7355:Ppp4r4
|
UTSW |
12 |
103,570,841 (GRCm39) |
nonsense |
probably null |
|
|
R7397:Ppp4r4
|
UTSW |
12 |
103,579,065 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7447:Ppp4r4
|
UTSW |
12 |
103,551,985 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7576:Ppp4r4
|
UTSW |
12 |
103,562,708 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7653:Ppp4r4
|
UTSW |
12 |
103,550,404 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7683:Ppp4r4
|
UTSW |
12 |
103,553,364 (GRCm39) |
nonsense |
probably null |
|
|
R7748:Ppp4r4
|
UTSW |
12 |
103,571,320 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7831:Ppp4r4
|
UTSW |
12 |
103,557,080 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R7833:Ppp4r4
|
UTSW |
12 |
103,564,407 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8238:Ppp4r4
|
UTSW |
12 |
103,557,066 (GRCm39) |
missense |
probably benign |
0.20 |
|
R8559:Ppp4r4
|
UTSW |
12 |
103,559,420 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8674:Ppp4r4
|
UTSW |
12 |
103,562,720 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8799:Ppp4r4
|
UTSW |
12 |
103,567,623 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R8847:Ppp4r4
|
UTSW |
12 |
103,562,747 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8968:Ppp4r4
|
UTSW |
12 |
103,566,706 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9075:Ppp4r4
|
UTSW |
12 |
103,570,290 (GRCm39) |
nonsense |
probably null |
|
|
R9106:Ppp4r4
|
UTSW |
12 |
103,570,315 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9393:Ppp4r4
|
UTSW |
12 |
103,571,296 (GRCm39) |
nonsense |
probably null |
|
|
R9508:Ppp4r4
|
UTSW |
12 |
103,542,561 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R9520:Ppp4r4
|
UTSW |
12 |
103,500,378 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9636:Ppp4r4
|
UTSW |
12 |
103,564,688 (GRCm39) |
missense |
unknown |
|
|
R9641:Ppp4r4
|
UTSW |
12 |
103,567,811 (GRCm39) |
missense |
probably benign |
0.15 |
|
R9765:Ppp4r4
|
UTSW |
12 |
103,550,346 (GRCm39) |
nonsense |
probably null |
|
|
R9766:Ppp4r4
|
UTSW |
12 |
103,562,735 (GRCm39) |
missense |
probably benign |
0.40 |
|
X0025:Ppp4r4
|
UTSW |
12 |
103,566,739 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTGGCAGGAAACACATATATGC -3'
(R):5'- CAACAGTGCTTTCATTGAAGCTTC -3'
Sequencing Primer
(F):5'- GTCTCAAATCTGAGCGATT -3'
(R):5'- TCATTGAAGCTTCTCTTTTGTGTAC -3'
|
| Posted On |
2015-12-29 |
Incidental Mutation