Incidental Mutation 'R4784:Kntc1'
| ID |
366819 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kntc1
|
| Ensembl Gene |
ENSMUSG00000029414 |
| Gene Name |
kinetochore associated 1 |
| Synonyms |
jgl |
| MMRRC Submission |
041994-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.948)
|
| Stock # |
R4784 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
123887779-123959656 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 123954825 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Arginine
at position 2081
(M2081R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000031366
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000031366]
|
| AlphaFold |
Q8C3Y4 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000031366
AA Change: M2081R
PolyPhen 2
Score 0.886 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000031366
Gene: ENSMUSG00000029414
AA Change: M2081R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
345 |
357 |
N/A |
INTRINSIC |
|
low complexity region
|
747 |
764 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1044 |
N/A |
INTRINSIC |
|
Pfam:Rod_C
|
1579 |
2128 |
3.2e-256 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000197002
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000197265
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 94.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. Experimental evidence indicated that the encoded protein functioned in a similar manner to that of the Drosophila rough deal protein. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice have a kinked tail. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 106 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adra1a |
T |
A |
14: 66,875,273 (GRCm39) |
S83T |
probably damaging |
Het |
| Aff1 |
T |
A |
5: 103,994,905 (GRCm39) |
Y1034* |
probably null |
Het |
| Ago3 |
A |
T |
4: 126,262,296 (GRCm39) |
M418K |
probably benign |
Het |
| Alpk1 |
G |
T |
3: 127,481,241 (GRCm39) |
N175K |
possibly damaging |
Het |
| Als2 |
A |
G |
1: 59,254,472 (GRCm39) |
V295A |
probably benign |
Het |
| Arhgap32 |
A |
G |
9: 32,040,949 (GRCm39) |
D67G |
probably damaging |
Het |
| Arhgap32 |
T |
C |
9: 32,172,076 (GRCm39) |
C1619R |
probably damaging |
Het |
| Asns |
T |
G |
6: 7,678,029 (GRCm39) |
K350Q |
probably benign |
Het |
| Atp8b5 |
A |
T |
4: 43,356,980 (GRCm39) |
D576V |
probably damaging |
Het |
| Atrnl1 |
A |
G |
19: 57,617,590 (GRCm39) |
I122V |
probably damaging |
Het |
| Baz1b |
T |
G |
5: 135,246,267 (GRCm39) |
L572R |
possibly damaging |
Het |
| C4b |
T |
C |
17: 34,952,380 (GRCm39) |
T1220A |
probably benign |
Het |
| Carmil3 |
T |
C |
14: 55,738,778 (GRCm39) |
|
probably null |
Het |
| Ccndbp1 |
A |
T |
2: 120,839,003 (GRCm39) |
T5S |
probably benign |
Het |
| Chaf1b |
T |
C |
16: 93,681,430 (GRCm39) |
V16A |
probably damaging |
Het |
| Chd8 |
C |
A |
14: 52,442,825 (GRCm39) |
C575F |
probably damaging |
Het |
| Chrna10 |
G |
A |
7: 101,762,426 (GRCm39) |
P255S |
possibly damaging |
Het |
| Clip1 |
T |
C |
5: 123,717,356 (GRCm39) |
D1387G |
probably damaging |
Het |
| Col12a1 |
C |
A |
9: 79,585,776 (GRCm39) |
V1228F |
possibly damaging |
Het |
| Cxcr5 |
T |
C |
9: 44,424,638 (GRCm39) |
T340A |
probably benign |
Het |
| Cyp2e1 |
G |
A |
7: 140,343,821 (GRCm39) |
V20I |
possibly damaging |
Het |
| Dchs1 |
A |
G |
7: 105,415,133 (GRCm39) |
Y684H |
probably damaging |
Het |
| Dcun1d3 |
T |
C |
7: 119,456,887 (GRCm39) |
E275G |
probably damaging |
Het |
| Dgcr8 |
G |
A |
16: 18,076,174 (GRCm39) |
R4* |
probably null |
Het |
| Dglucy |
A |
T |
12: 100,804,923 (GRCm39) |
D168V |
probably damaging |
Het |
| Dnah1 |
T |
A |
14: 30,985,436 (GRCm39) |
K3818N |
probably damaging |
Het |
| Dnajc17 |
T |
C |
2: 119,009,909 (GRCm39) |
D239G |
probably benign |
Het |
| Dok2 |
C |
T |
14: 71,015,314 (GRCm39) |
P347L |
probably benign |
Het |
| Elavl2 |
T |
C |
4: 91,142,379 (GRCm39) |
R265G |
probably null |
Het |
| Elf1 |
T |
A |
14: 79,818,183 (GRCm39) |
N567K |
probably benign |
Het |
| Epha8 |
A |
T |
4: 136,660,633 (GRCm39) |
I695N |
probably damaging |
Het |
| Fam178b |
C |
A |
1: 36,671,496 (GRCm39) |
|
probably null |
Het |
| Fam76a |
A |
T |
4: 132,629,428 (GRCm39) |
|
probably null |
Het |
| Fam76a |
A |
G |
4: 132,643,501 (GRCm39) |
Y78H |
probably damaging |
Het |
| Fbn1 |
A |
T |
2: 125,166,839 (GRCm39) |
C2026S |
probably damaging |
Het |
| Fbxo4 |
T |
C |
15: 3,998,523 (GRCm39) |
T312A |
probably benign |
Het |
| Fscn2 |
T |
C |
11: 120,258,813 (GRCm39) |
F453L |
possibly damaging |
Het |
| Gabrb2 |
T |
C |
11: 42,488,469 (GRCm39) |
C312R |
probably damaging |
Het |
| Gba2 |
A |
C |
4: 43,568,315 (GRCm39) |
L684R |
probably damaging |
Het |
| Golga2 |
T |
A |
2: 32,187,168 (GRCm39) |
N89K |
probably damaging |
Het |
| Gpx6 |
C |
T |
13: 21,496,434 (GRCm39) |
Q3* |
probably null |
Het |
| Grin1 |
T |
A |
2: 25,182,393 (GRCm39) |
H956L |
possibly damaging |
Het |
| H2-Q7 |
T |
G |
17: 35,658,914 (GRCm39) |
C122G |
probably damaging |
Het |
| Hcar2 |
C |
G |
5: 124,002,513 (GRCm39) |
G330A |
probably benign |
Het |
| Hes3 |
A |
G |
4: 152,372,289 (GRCm39) |
S37P |
probably damaging |
Het |
| Hs3st3b1 |
T |
C |
11: 63,780,086 (GRCm39) |
H347R |
probably benign |
Het |
| Il1rl1 |
A |
G |
1: 40,489,348 (GRCm39) |
R367G |
probably damaging |
Het |
| Kcnc1 |
G |
T |
7: 46,086,711 (GRCm39) |
S570I |
probably benign |
Het |
| Kctd3 |
T |
C |
1: 188,706,665 (GRCm39) |
I523M |
probably damaging |
Het |
| Klk14 |
G |
A |
7: 43,341,501 (GRCm39) |
C51Y |
probably damaging |
Het |
| Krt87 |
A |
G |
15: 101,385,837 (GRCm39) |
S253P |
probably damaging |
Het |
| Ktn1 |
T |
A |
14: 47,930,953 (GRCm39) |
|
probably null |
Het |
| Lair1 |
T |
A |
7: 4,012,731 (GRCm39) |
M251L |
probably benign |
Het |
| Lama3 |
A |
T |
18: 12,582,601 (GRCm39) |
H631L |
probably benign |
Het |
| Lamc1 |
T |
C |
1: 153,107,486 (GRCm39) |
N1231S |
probably damaging |
Het |
| Lin54 |
A |
G |
5: 100,607,597 (GRCm39) |
I250T |
probably damaging |
Het |
| Lrit1 |
C |
T |
14: 36,784,193 (GRCm39) |
T507M |
possibly damaging |
Het |
| Lrp11 |
A |
G |
10: 7,479,965 (GRCm39) |
H345R |
possibly damaging |
Het |
| Lrp6 |
A |
C |
6: 134,456,502 (GRCm39) |
S921A |
probably benign |
Het |
| Lrrc27 |
A |
G |
7: 138,822,614 (GRCm39) |
T502A |
probably benign |
Het |
| Marf1 |
A |
C |
16: 13,970,321 (GRCm39) |
S133A |
probably benign |
Het |
| Mga |
C |
T |
2: 119,733,538 (GRCm39) |
P129S |
probably damaging |
Het |
| Mgat4e |
T |
C |
1: 134,469,063 (GRCm39) |
N327S |
probably damaging |
Het |
| Mlh1 |
A |
G |
9: 111,068,866 (GRCm39) |
Y499H |
probably benign |
Het |
| Mrgpra1 |
A |
G |
7: 46,985,218 (GRCm39) |
S154P |
probably damaging |
Het |
| Myo1h |
A |
G |
5: 114,498,660 (GRCm39) |
I919V |
possibly damaging |
Het |
| Naalad2 |
T |
C |
9: 18,262,214 (GRCm39) |
R442G |
probably damaging |
Het |
| Nat8f4 |
T |
C |
6: 85,878,481 (GRCm39) |
H14R |
probably benign |
Het |
| Nav1 |
A |
G |
1: 135,386,477 (GRCm39) |
S1184P |
probably damaging |
Het |
| Nckap1 |
T |
A |
2: 80,337,278 (GRCm39) |
N986I |
probably benign |
Het |
| Ndufaf2 |
C |
G |
13: 108,189,314 (GRCm39) |
A145P |
probably damaging |
Het |
| Nop9 |
AGAGGAGGAGGAGGAGGA |
AGAGGAGGAGGAGGA |
14: 55,983,859 (GRCm39) |
|
probably benign |
Het |
| Nphp4 |
G |
A |
4: 152,639,003 (GRCm39) |
R878K |
probably benign |
Het |
| Nutm1 |
G |
A |
2: 112,079,281 (GRCm39) |
A878V |
probably benign |
Het |
| Or4f56 |
A |
T |
2: 111,703,395 (GRCm39) |
D268E |
possibly damaging |
Het |
| Or52e8b |
A |
C |
7: 104,673,737 (GRCm39) |
I150S |
probably damaging |
Het |
| Or5k1b |
G |
T |
16: 58,580,911 (GRCm39) |
F209L |
probably damaging |
Het |
| Orc6 |
T |
A |
8: 86,029,579 (GRCm39) |
I41K |
probably damaging |
Het |
| Pikfyve |
A |
G |
1: 65,307,005 (GRCm39) |
T1798A |
probably benign |
Het |
| Ppp1r14a |
A |
T |
7: 28,991,486 (GRCm39) |
E98V |
possibly damaging |
Het |
| Prpf8 |
T |
A |
11: 75,383,331 (GRCm39) |
D521E |
probably damaging |
Het |
| Pudp |
A |
G |
18: 50,701,136 (GRCm39) |
V199A |
probably damaging |
Het |
| Rab3c |
T |
C |
13: 110,198,434 (GRCm39) |
E198G |
probably benign |
Het |
| Ramac |
T |
A |
7: 81,418,163 (GRCm39) |
W73R |
probably damaging |
Het |
| Rbl2 |
A |
G |
8: 91,812,196 (GRCm39) |
Y255C |
probably damaging |
Het |
| Rbm12 |
T |
C |
2: 155,938,484 (GRCm39) |
D596G |
possibly damaging |
Het |
| Sipa1l3 |
A |
G |
7: 29,077,066 (GRCm39) |
V902A |
probably damaging |
Het |
| Slc37a3 |
T |
G |
6: 39,314,157 (GRCm39) |
Q485P |
probably benign |
Het |
| Slc44a3 |
T |
C |
3: 121,320,723 (GRCm39) |
T93A |
possibly damaging |
Het |
| Slc66a1 |
G |
T |
4: 139,027,312 (GRCm39) |
H343Q |
probably benign |
Het |
| Sun3 |
G |
A |
11: 8,988,266 (GRCm39) |
L19F |
probably benign |
Het |
| Tas2r125 |
A |
G |
6: 132,886,866 (GRCm39) |
I85V |
probably benign |
Het |
| Tenm4 |
A |
C |
7: 96,423,253 (GRCm39) |
K683Q |
probably damaging |
Het |
| Tmprss11d |
C |
T |
5: 86,454,140 (GRCm39) |
V222M |
probably damaging |
Het |
| Tnip1 |
A |
C |
11: 54,806,365 (GRCm39) |
S570A |
possibly damaging |
Het |
| Top1mt |
G |
A |
15: 75,529,552 (GRCm39) |
P554S |
probably damaging |
Het |
| Top1mt |
A |
G |
15: 75,547,880 (GRCm39) |
F69L |
possibly damaging |
Het |
| Ttc7 |
A |
G |
17: 87,648,325 (GRCm39) |
K508R |
probably benign |
Het |
| Ttll4 |
A |
T |
1: 74,718,166 (GRCm39) |
T6S |
possibly damaging |
Het |
| Xpo5 |
T |
C |
17: 46,533,643 (GRCm39) |
Y500H |
possibly damaging |
Het |
| Xpot |
C |
T |
10: 121,450,968 (GRCm39) |
|
probably null |
Het |
| Zbbx |
T |
C |
3: 74,992,348 (GRCm39) |
I268V |
probably benign |
Het |
| Zbtb40 |
G |
A |
4: 136,734,408 (GRCm39) |
P360S |
probably damaging |
Het |
| Zfp324 |
T |
C |
7: 12,705,233 (GRCm39) |
L474P |
probably damaging |
Het |
| Zfp398 |
A |
G |
6: 47,817,186 (GRCm39) |
T9A |
probably benign |
Het |
| Zfp692 |
A |
C |
11: 58,200,997 (GRCm39) |
S293R |
probably null |
Het |
|
| Other mutations in Kntc1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00087:Kntc1
|
APN |
5 |
123,928,222 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL00514:Kntc1
|
APN |
5 |
123,929,590 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01103:Kntc1
|
APN |
5 |
123,902,283 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01106:Kntc1
|
APN |
5 |
123,900,666 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01357:Kntc1
|
APN |
5 |
123,895,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01367:Kntc1
|
APN |
5 |
123,896,546 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01538:Kntc1
|
APN |
5 |
123,919,721 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01546:Kntc1
|
APN |
5 |
123,903,068 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01595:Kntc1
|
APN |
5 |
123,941,758 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL01725:Kntc1
|
APN |
5 |
123,902,253 (GRCm39) |
missense |
probably benign |
|
|
IGL01916:Kntc1
|
APN |
5 |
123,939,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01936:Kntc1
|
APN |
5 |
123,949,439 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01942:Kntc1
|
APN |
5 |
123,916,330 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01973:Kntc1
|
APN |
5 |
123,904,021 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01982:Kntc1
|
APN |
5 |
123,947,159 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL02145:Kntc1
|
APN |
5 |
123,900,661 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL02510:Kntc1
|
APN |
5 |
123,957,125 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02611:Kntc1
|
APN |
5 |
123,950,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02669:Kntc1
|
APN |
5 |
123,893,727 (GRCm39) |
splice site |
probably benign |
|
|
IGL02737:Kntc1
|
APN |
5 |
123,957,183 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL02793:Kntc1
|
APN |
5 |
123,916,340 (GRCm39) |
splice site |
probably null |
|
|
IGL02809:Kntc1
|
APN |
5 |
123,914,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02860:Kntc1
|
APN |
5 |
123,907,936 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02875:Kntc1
|
APN |
5 |
123,916,340 (GRCm39) |
splice site |
probably null |
|
|
IGL02931:Kntc1
|
APN |
5 |
123,937,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03169:Kntc1
|
APN |
5 |
123,913,884 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL03267:Kntc1
|
APN |
5 |
123,896,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0006:Kntc1
|
UTSW |
5 |
123,927,201 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0006:Kntc1
|
UTSW |
5 |
123,927,201 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0017:Kntc1
|
UTSW |
5 |
123,919,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0125:Kntc1
|
UTSW |
5 |
123,903,120 (GRCm39) |
splice site |
probably benign |
|
|
R0324:Kntc1
|
UTSW |
5 |
123,916,175 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0580:Kntc1
|
UTSW |
5 |
123,941,732 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0608:Kntc1
|
UTSW |
5 |
123,924,137 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0725:Kntc1
|
UTSW |
5 |
123,907,767 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0733:Kntc1
|
UTSW |
5 |
123,928,979 (GRCm39) |
missense |
probably null |
|
|
R0781:Kntc1
|
UTSW |
5 |
123,937,965 (GRCm39) |
splice site |
probably benign |
|
|
R0787:Kntc1
|
UTSW |
5 |
123,934,167 (GRCm39) |
missense |
probably benign |
|
|
R1250:Kntc1
|
UTSW |
5 |
123,922,262 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1253:Kntc1
|
UTSW |
5 |
123,948,925 (GRCm39) |
frame shift |
probably null |
|
|
R1467:Kntc1
|
UTSW |
5 |
123,925,047 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1467:Kntc1
|
UTSW |
5 |
123,925,047 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1481:Kntc1
|
UTSW |
5 |
123,916,338 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1572:Kntc1
|
UTSW |
5 |
123,910,176 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1624:Kntc1
|
UTSW |
5 |
123,896,540 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R1749:Kntc1
|
UTSW |
5 |
123,927,162 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1993:Kntc1
|
UTSW |
5 |
123,948,874 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1993:Kntc1
|
UTSW |
5 |
123,897,162 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2071:Kntc1
|
UTSW |
5 |
123,932,340 (GRCm39) |
splice site |
probably null |
|
|
R2237:Kntc1
|
UTSW |
5 |
123,941,733 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2239:Kntc1
|
UTSW |
5 |
123,941,733 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2366:Kntc1
|
UTSW |
5 |
123,919,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2367:Kntc1
|
UTSW |
5 |
123,919,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2382:Kntc1
|
UTSW |
5 |
123,898,411 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2389:Kntc1
|
UTSW |
5 |
123,919,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2413:Kntc1
|
UTSW |
5 |
123,902,212 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2442:Kntc1
|
UTSW |
5 |
123,948,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2504:Kntc1
|
UTSW |
5 |
123,916,410 (GRCm39) |
nonsense |
probably null |
|
|
R2943:Kntc1
|
UTSW |
5 |
123,935,847 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R3116:Kntc1
|
UTSW |
5 |
123,940,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4107:Kntc1
|
UTSW |
5 |
123,900,661 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4176:Kntc1
|
UTSW |
5 |
123,914,680 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R4275:Kntc1
|
UTSW |
5 |
123,905,842 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4440:Kntc1
|
UTSW |
5 |
123,932,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4575:Kntc1
|
UTSW |
5 |
123,904,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4576:Kntc1
|
UTSW |
5 |
123,904,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4578:Kntc1
|
UTSW |
5 |
123,904,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4612:Kntc1
|
UTSW |
5 |
123,950,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4704:Kntc1
|
UTSW |
5 |
123,949,496 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4720:Kntc1
|
UTSW |
5 |
123,903,086 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R4785:Kntc1
|
UTSW |
5 |
123,954,825 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4824:Kntc1
|
UTSW |
5 |
123,928,196 (GRCm39) |
nonsense |
probably null |
|
|
R4847:Kntc1
|
UTSW |
5 |
123,940,337 (GRCm39) |
missense |
probably benign |
0.18 |
|
R4849:Kntc1
|
UTSW |
5 |
123,897,128 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4904:Kntc1
|
UTSW |
5 |
123,916,396 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4922:Kntc1
|
UTSW |
5 |
123,940,309 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5080:Kntc1
|
UTSW |
5 |
123,900,649 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R5114:Kntc1
|
UTSW |
5 |
123,919,118 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5171:Kntc1
|
UTSW |
5 |
123,937,907 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5220:Kntc1
|
UTSW |
5 |
123,950,160 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5226:Kntc1
|
UTSW |
5 |
123,932,235 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5278:Kntc1
|
UTSW |
5 |
123,919,077 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5329:Kntc1
|
UTSW |
5 |
123,902,254 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5496:Kntc1
|
UTSW |
5 |
123,922,245 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5503:Kntc1
|
UTSW |
5 |
123,957,939 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5633:Kntc1
|
UTSW |
5 |
123,957,120 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5638:Kntc1
|
UTSW |
5 |
123,956,538 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5697:Kntc1
|
UTSW |
5 |
123,903,070 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5757:Kntc1
|
UTSW |
5 |
123,945,372 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5773:Kntc1
|
UTSW |
5 |
123,932,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5940:Kntc1
|
UTSW |
5 |
123,924,258 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6019:Kntc1
|
UTSW |
5 |
123,900,579 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6230:Kntc1
|
UTSW |
5 |
123,927,072 (GRCm39) |
splice site |
probably null |
|
|
R6437:Kntc1
|
UTSW |
5 |
123,907,754 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6888:Kntc1
|
UTSW |
5 |
123,949,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6907:Kntc1
|
UTSW |
5 |
123,939,888 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7123:Kntc1
|
UTSW |
5 |
123,919,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7262:Kntc1
|
UTSW |
5 |
123,925,036 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7381:Kntc1
|
UTSW |
5 |
123,948,971 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7485:Kntc1
|
UTSW |
5 |
123,925,019 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R7512:Kntc1
|
UTSW |
5 |
123,929,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7581:Kntc1
|
UTSW |
5 |
123,954,818 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7687:Kntc1
|
UTSW |
5 |
123,897,152 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7798:Kntc1
|
UTSW |
5 |
123,957,180 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7798:Kntc1
|
UTSW |
5 |
123,924,357 (GRCm39) |
missense |
probably benign |
|
|
R7871:Kntc1
|
UTSW |
5 |
123,922,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7876:Kntc1
|
UTSW |
5 |
123,913,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7947:Kntc1
|
UTSW |
5 |
123,919,951 (GRCm39) |
missense |
unknown |
|
|
R7997:Kntc1
|
UTSW |
5 |
123,916,117 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8231:Kntc1
|
UTSW |
5 |
123,920,959 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R8257:Kntc1
|
UTSW |
5 |
123,896,586 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8345:Kntc1
|
UTSW |
5 |
123,924,993 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8354:Kntc1
|
UTSW |
5 |
123,916,330 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8732:Kntc1
|
UTSW |
5 |
123,928,180 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8754:Kntc1
|
UTSW |
5 |
123,897,115 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8947:Kntc1
|
UTSW |
5 |
123,925,041 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9041:Kntc1
|
UTSW |
5 |
123,927,093 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9182:Kntc1
|
UTSW |
5 |
123,940,355 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9432:Kntc1
|
UTSW |
5 |
123,925,112 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9460:Kntc1
|
UTSW |
5 |
123,941,378 (GRCm39) |
nonsense |
probably null |
|
|
R9468:Kntc1
|
UTSW |
5 |
123,954,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9643:Kntc1
|
UTSW |
5 |
123,949,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9646:Kntc1
|
UTSW |
5 |
123,897,119 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9721:Kntc1
|
UTSW |
5 |
123,939,948 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9789:Kntc1
|
UTSW |
5 |
123,898,706 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
X0027:Kntc1
|
UTSW |
5 |
123,948,992 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0065:Kntc1
|
UTSW |
5 |
123,916,100 (GRCm39) |
nonsense |
probably null |
|
|
X0067:Kntc1
|
UTSW |
5 |
123,916,137 (GRCm39) |
unclassified |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGGCCAGGAAACATCTGTGG -3'
(R):5'- ACCAGTTTCTCCCAGATAACAG -3'
Sequencing Primer
(F):5'- CCAGGAAACATCTGTGGAAATG -3'
(R):5'- GGCCGAACTCTTTTTAAGATATCC -3'
|
| Posted On |
2015-12-29 |
Incidental Mutation