Incidental Mutation 'R4785:Lrp1'
ID 366992
Institutional Source Beutler Lab
Gene Symbol Lrp1
Ensembl Gene ENSMUSG00000040249
Gene Name low density lipoprotein receptor-related protein 1
Synonyms b2b1554Clo, CD91, A2mr
MMRRC Submission 042417-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R4785 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 127374030-127457017 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 127394002 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 2621 (N2621S)
Ref Sequence ENSEMBL: ENSMUSP00000044004 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049149]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000049149
AA Change: N2621S

PolyPhen 2 Score 0.121 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000044004
Gene: ENSMUSG00000040249
AA Change: N2621S

DomainStartEndE-ValueType
low complexity region 2 13 N/A INTRINSIC
LDLa 27 67 1.03e-15 SMART
LDLa 72 111 1.04e-11 SMART
EGF 115 150 8.78e-2 SMART
EGF_CA 151 190 4.49e-8 SMART
low complexity region 222 232 N/A INTRINSIC
LY 273 315 7.07e-6 SMART
LY 316 359 2.31e-10 SMART
LY 360 402 8.3e-12 SMART
EGF 478 521 9.93e-1 SMART
LY 552 594 8.84e-7 SMART
LY 595 638 6.54e-10 SMART
LY 641 690 2.5e-15 SMART
LY 691 734 1.06e-9 SMART
EGF 807 844 1.38e1 SMART
LDLa 854 893 3.39e-16 SMART
LDLa 895 934 1.73e-13 SMART
LDLa 936 974 4.47e-16 SMART
LDLa 976 1014 2.53e-15 SMART
LDLa 1015 1054 2.95e-16 SMART
LDLa 1062 1100 3.24e-13 SMART
LDLa 1104 1143 2.97e-12 SMART
LDLa 1145 1185 1.24e-9 SMART
EGF 1185 1223 4.97e-1 SMART
EGF 1227 1263 6.02e0 SMART
LY 1290 1332 3.76e-1 SMART
LY 1337 1379 8.56e-14 SMART
LY 1380 1424 8.43e-13 SMART
LY 1425 1469 3.05e-10 SMART
LY 1471 1513 3.88e-3 SMART
EGF 1540 1580 1.85e0 SMART
LY 1606 1650 2.83e-5 SMART
LY 1651 1695 2.01e-10 SMART
LY 1698 1735 1.87e-5 SMART
LY 1736 1777 3.54e-6 SMART
LY 1778 1820 4.17e1 SMART
EGF 1850 1888 1.24e-1 SMART
LY 1915 1957 3.2e-4 SMART
LY 1958 2000 2.33e-15 SMART
LY 2001 2044 7.45e-14 SMART
LY 2045 2087 3.87e-12 SMART
LY 2089 2131 1.37e0 SMART
EGF 2159 2196 1.66e1 SMART
LY 2276 2318 5.57e-4 SMART
LY 2324 2369 3.3e-6 SMART
LY 2370 2412 3.93e-13 SMART
LY 2413 2454 3.62e-3 SMART
EGF_like 2482 2519 3.16e1 SMART
LDLa 2524 2564 3.31e-10 SMART
LDLa 2566 2603 7.21e-11 SMART
LDLa 2605 2642 1.09e-10 SMART
LDLa 2660 2691 6.05e-4 SMART
LDLa 2696 2733 2.49e-14 SMART
LDLa 2734 2772 4.65e-14 SMART
LDLa 2774 2815 3.92e-12 SMART
LDLa 2818 2856 1.51e-13 SMART
LDLa 2858 2900 1.93e-11 SMART
LDLa 2904 2942 1.73e-13 SMART
EGF_CA 2941 2982 6.16e-6 SMART
EGF_CA 2983 3023 2.66e-10 SMART
LY 3050 3094 6.64e-11 SMART
LY 3095 3137 7.17e-16 SMART
LY 3138 3181 4.28e-14 SMART
LY 3182 3224 8.11e-15 SMART
LY 3225 3265 1.44e-6 SMART
EGF 3294 3332 1.02e-2 SMART
LDLa 3334 3372 2.25e-12 SMART
LDLa 3374 3411 9.81e-13 SMART
LDLa 3413 3451 9.81e-13 SMART
LDLa 3453 3492 5.67e-18 SMART
LDLa 3494 3534 7.15e-15 SMART
LDLa 3536 3573 1.79e-15 SMART
EGF_like 3575 3611 4.83e1 SMART
LDLa 3575 3612 1.92e-15 SMART
LDLa 3613 3650 1.18e-15 SMART
LDLa 3654 3693 7.55e-14 SMART
LDLa 3695 3734 1.14e-8 SMART
LDLa 3741 3779 6.28e-11 SMART
EGF 3785 3824 1.06e1 SMART
EGF 3828 3862 1.51e0 SMART
LY 3893 3935 9.43e0 SMART
LY 3951 3993 1.23e-14 SMART
LY 3994 4037 2.98e-13 SMART
LY 4038 4080 4.28e-14 SMART
EGF 4151 4184 3.76e-1 SMART
low complexity region 4185 4198 N/A INTRINSIC
EGF 4200 4233 3.82e-2 SMART
EGF 4236 4269 4.03e-1 SMART
EGF 4272 4305 5.2e-4 SMART
EGF 4308 4341 1.22e0 SMART
EGF_like 4344 4376 4.11e1 SMART
EGF 4377 4410 5.12e-3 SMART
transmembrane domain 4423 4445 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit lethality during late organogenesis. [provided by MGI curators]
Allele List at MGI

All alleles(42) : Targeted(9) Gene trapped(33)

Other mutations in this stock
Total: 145 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921517D22Rik T C 13: 59,839,406 (GRCm39) D13G probably benign Het
4930442H23Rik C T 10: 81,018,978 (GRCm39) probably benign Het
Adamts13 T A 2: 26,873,054 (GRCm39) S341T probably damaging Het
Adamts2 A G 11: 50,683,549 (GRCm39) I944V probably benign Het
Adcy3 A G 12: 4,256,542 (GRCm39) T783A probably benign Het
Ago3 A T 4: 126,262,296 (GRCm39) M418K probably benign Het
Alpk1 G T 3: 127,481,241 (GRCm39) N175K possibly damaging Het
Als2 A G 1: 59,254,472 (GRCm39) V295A probably benign Het
Anapc13 T C 9: 102,507,020 (GRCm39) I11T probably benign Het
Ankrd12 T A 17: 66,289,994 (GRCm39) N1813I probably damaging Het
Anks1b A T 10: 90,750,612 (GRCm39) I176F probably null Het
Ap3d1 TTCTCTCTCTCTCTCTCT TTCTCTCTCTCTCTCT 10: 80,548,612 (GRCm39) probably null Het
Arhgap32 T C 9: 32,172,076 (GRCm39) C1619R probably damaging Het
Arhgap32 A G 9: 32,040,949 (GRCm39) D67G probably damaging Het
Atp1a4 A T 1: 172,081,677 (GRCm39) Y158* probably null Het
Atp8b5 A T 4: 43,356,980 (GRCm39) D576V probably damaging Het
Atrnl1 A G 19: 57,617,590 (GRCm39) I122V probably damaging Het
B430203G13Rik A T 12: 17,974,520 (GRCm39) noncoding transcript Het
Baz1b T G 5: 135,246,267 (GRCm39) L572R possibly damaging Het
Ccn3 A T 15: 54,615,603 (GRCm39) probably null Het
Ccnd2 T C 6: 127,125,761 (GRCm39) T92A possibly damaging Het
Ccndbp1 A T 2: 120,839,003 (GRCm39) T5S probably benign Het
Ccr2 G A 9: 123,906,409 (GRCm39) V230I probably benign Het
Cct4 T A 11: 22,952,866 (GRCm39) V514E probably damaging Het
Cep152 A G 2: 125,428,249 (GRCm39) probably null Het
Cflar C T 1: 58,791,726 (GRCm39) T343M probably benign Het
Chrm5 A C 2: 112,309,930 (GRCm39) N395K probably benign Het
Chrna10 G A 7: 101,762,426 (GRCm39) P255S possibly damaging Het
Chrna6 T A 8: 27,897,134 (GRCm39) I248F probably damaging Het
Clip1 T C 5: 123,717,356 (GRCm39) D1387G probably damaging Het
Clstn3 T C 6: 124,414,331 (GRCm39) probably null Het
Cntnap5a C T 1: 116,029,295 (GRCm39) R250W probably benign Het
Col12a1 C A 9: 79,585,776 (GRCm39) V1228F possibly damaging Het
Cxcr5 T C 9: 44,424,638 (GRCm39) T340A probably benign Het
Cyp2a4 G A 7: 26,012,300 (GRCm39) R361K probably damaging Het
Dnah1 T A 14: 30,985,436 (GRCm39) K3818N probably damaging Het
Dnah3 T A 7: 119,567,047 (GRCm39) K2393M probably benign Het
Dpy19l1 A T 9: 24,336,119 (GRCm39) L529Q probably damaging Het
Eif4g2 C T 7: 110,676,003 (GRCm39) R399H probably damaging Het
Elapor1 A T 3: 108,365,543 (GRCm39) probably benign Het
Fam76a A T 4: 132,629,428 (GRCm39) probably null Het
Fam76a A G 4: 132,643,501 (GRCm39) Y78H probably damaging Het
Fbn1 A T 2: 125,166,839 (GRCm39) C2026S probably damaging Het
Fbxo4 T C 15: 3,998,523 (GRCm39) T312A probably benign Het
Fbxw26 A G 9: 109,553,868 (GRCm39) V257A possibly damaging Het
Fhip1a G T 3: 85,595,877 (GRCm39) T115K probably damaging Het
Flnb A T 14: 7,905,701 (GRCm38) E1150D probably benign Het
Fndc3c1 A T X: 105,481,308 (GRCm39) S661R possibly damaging Het
Gba2 A C 4: 43,568,315 (GRCm39) L684R probably damaging Het
Gbf1 G T 19: 46,256,834 (GRCm39) C812F possibly damaging Het
Glt8d2 A T 10: 82,496,583 (GRCm39) D158E probably damaging Het
Golga2 T A 2: 32,187,168 (GRCm39) N89K probably damaging Het
Got1 A G 19: 43,491,376 (GRCm39) I358T possibly damaging Het
Gpx6 C T 13: 21,496,434 (GRCm39) Q3* probably null Het
Grin1 T A 2: 25,182,393 (GRCm39) H956L possibly damaging Het
Grin2d A G 7: 45,506,205 (GRCm39) V562A probably damaging Het
Grm6 A G 11: 50,748,104 (GRCm39) I405V probably benign Het
Hcar2 C G 5: 124,002,513 (GRCm39) G330A probably benign Het
Hcfc1 T C X: 73,009,552 (GRCm39) K20E probably damaging Het
Iars1 T A 13: 49,878,139 (GRCm39) Y888N probably damaging Het
Ifi206 A T 1: 173,308,432 (GRCm39) H521Q probably benign Het
Impg1 A G 9: 80,305,732 (GRCm39) S112P probably benign Het
Incenp C A 19: 9,855,054 (GRCm39) R619M unknown Het
Incenp T A 19: 9,855,055 (GRCm39) R619W unknown Het
Kat2b A G 17: 53,960,231 (GRCm39) E513G possibly damaging Het
Kbtbd12 G T 6: 88,595,003 (GRCm39) L276I probably damaging Het
Kctd9 T A 14: 67,971,613 (GRCm39) D229E probably damaging Het
Kdm1b C T 13: 47,216,553 (GRCm39) R308W probably damaging Het
Kif2b G A 11: 91,467,254 (GRCm39) P343L probably benign Het
Kntc1 T G 5: 123,954,825 (GRCm39) M2081R possibly damaging Het
Lamc1 T C 1: 153,107,486 (GRCm39) N1231S probably damaging Het
Lclat1 T A 17: 73,547,065 (GRCm39) Y327* probably null Het
Lgals3bp G A 11: 118,284,340 (GRCm39) T413I probably damaging Het
Lin54 A G 5: 100,607,597 (GRCm39) I250T probably damaging Het
Lrrtm3 T A 10: 63,923,781 (GRCm39) H462L probably benign Het
Lysmd1 A G 3: 95,042,297 (GRCm39) Y57C probably damaging Het
Mccc1 C A 3: 36,030,022 (GRCm39) M429I probably damaging Het
Metrnl A G 11: 121,598,750 (GRCm39) E40G probably benign Het
Mios T A 6: 8,222,464 (GRCm39) M466K probably benign Het
Mrgpra1 A G 7: 46,985,218 (GRCm39) S154P probably damaging Het
Mrpl24 T C 3: 87,829,357 (GRCm39) probably null Het
Myo1f A G 17: 33,817,165 (GRCm39) N736S possibly damaging Het
Myo1h A G 5: 114,498,660 (GRCm39) I919V possibly damaging Het
Nampt T C 12: 32,898,713 (GRCm39) L443P possibly damaging Het
Ndufaf2 C G 13: 108,189,314 (GRCm39) A145P probably damaging Het
Nek10 A T 14: 14,855,714 (GRCm38) T403S probably benign Het
Nme8 C A 13: 19,842,100 (GRCm39) V219L probably damaging Het
Nps T A 7: 134,870,517 (GRCm39) L13Q probably damaging Het
Nutm1 G A 2: 112,079,281 (GRCm39) A878V probably benign Het
Ogdh T C 11: 6,299,875 (GRCm39) F794L probably damaging Het
Or14a259 C A 7: 86,012,943 (GRCm39) G201C probably damaging Het
Or14c39 T C 7: 86,343,736 (GRCm39) L24P probably damaging Het
Or2t35 A C 14: 14,407,729 (GRCm38) Y167S possibly damaging Het
Or4f56 A T 2: 111,703,395 (GRCm39) D268E possibly damaging Het
Or5a3 A T 19: 12,400,341 (GRCm39) I223F probably damaging Het
Or5g29 A G 2: 85,421,282 (GRCm39) T133A probably benign Het
Pik3cg T C 12: 32,255,198 (GRCm39) E263G probably damaging Het
Pikfyve A G 1: 65,307,005 (GRCm39) T1798A probably benign Het
Poldip3 T C 15: 83,015,702 (GRCm39) Y305C probably damaging Het
Prkdc T C 16: 15,466,840 (GRCm39) I107T probably benign Het
Prmt2 A G 10: 76,062,055 (GRCm39) I50T probably damaging Het
Ptprd T C 4: 76,058,790 (GRCm39) T168A probably benign Het
Pudp A G 18: 50,701,136 (GRCm39) V199A probably damaging Het
Rab3c T C 13: 110,198,434 (GRCm39) E198G probably benign Het
Rasl12 A G 9: 65,320,730 (GRCm39) Y156C probably damaging Het
Rbm12 T C 2: 155,938,484 (GRCm39) D596G possibly damaging Het
Rbm6 T C 9: 107,664,551 (GRCm39) E694G probably benign Het
Rif1 T C 2: 52,002,759 (GRCm39) V2071A probably damaging Het
Ripply2 A T 9: 86,901,849 (GRCm39) N125I probably damaging Het
Rps6kc1 A T 1: 190,482,385 (GRCm39) H284Q probably benign Het
Scara3 A T 14: 66,190,950 (GRCm39) M1K probably null Het
Sfswap A G 5: 129,590,147 (GRCm39) T215A probably damaging Het
Shroom2 A C X: 151,443,903 (GRCm39) F421V probably benign Het
Sipa1l3 A G 7: 29,077,066 (GRCm39) V902A probably damaging Het
Slamf8 G T 1: 172,411,781 (GRCm39) P238Q probably damaging Het
Slc44a3 T C 3: 121,320,723 (GRCm39) T93A possibly damaging Het
Slc5a7 A T 17: 54,585,728 (GRCm39) I363N probably damaging Het
Slc66a1 G T 4: 139,027,312 (GRCm39) H343Q probably benign Het
Slc7a2 T A 8: 41,364,095 (GRCm39) M436K probably benign Het
Spindoc A G 19: 7,351,456 (GRCm39) S223P probably benign Het
Stk11ip T C 1: 75,506,925 (GRCm39) F669L possibly damaging Het
Sun3 G A 11: 8,988,266 (GRCm39) L19F probably benign Het
Sycp1 C A 3: 102,760,805 (GRCm39) A703S possibly damaging Het
Tas2r139 T G 6: 42,118,218 (GRCm39) F117V probably damaging Het
Tdrd6 T C 17: 43,936,467 (GRCm39) Y1527C probably damaging Het
Tenm4 A C 7: 96,423,253 (GRCm39) K683Q probably damaging Het
Tfeb T A 17: 48,099,152 (GRCm39) probably null Het
Tmco4 T C 4: 138,725,350 (GRCm39) S121P probably damaging Het
Tmprss11d C T 5: 86,454,140 (GRCm39) V222M probably damaging Het
Tnks1bp1 T C 2: 84,893,378 (GRCm39) W440R probably damaging Het
Trp53bp2 A G 1: 182,276,562 (GRCm39) T848A probably benign Het
Tssk1 G A 16: 17,712,926 (GRCm39) R237H probably benign Het
Ttll4 A T 1: 74,718,166 (GRCm39) T6S possibly damaging Het
Ttn G T 2: 76,552,141 (GRCm39) Y29419* probably null Het
Ttn A G 2: 76,599,947 (GRCm39) Y19076H probably damaging Het
Ubr3 T A 2: 69,789,947 (GRCm39) V867D probably damaging Het
Usp29 A G 7: 6,964,390 (GRCm39) T78A probably damaging Het
Utrn T G 10: 12,530,489 (GRCm39) Q2108P probably benign Het
Vcan T C 13: 89,853,908 (GRCm39) N351D probably damaging Het
Vmn1r61 A T 7: 5,614,124 (GRCm39) Y63* probably null Het
Vmn1r61 A T 7: 5,614,126 (GRCm39) Y63N probably benign Het
Vmn1r85 A T 7: 12,818,788 (GRCm39) W119R probably damaging Het
Zbtb21 A C 16: 97,751,655 (GRCm39) V190G possibly damaging Het
Zfp157 C A 5: 138,443,051 (GRCm39) T14N probably damaging Het
Zfp942 A T 17: 22,148,400 (GRCm39) H76Q probably damaging Het
Other mutations in Lrp1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00793:Lrp1 APN 10 127,378,074 (GRCm39) missense possibly damaging 0.89
IGL01065:Lrp1 APN 10 127,410,907 (GRCm39) missense probably benign 0.10
IGL01121:Lrp1 APN 10 127,419,722 (GRCm39) nonsense probably null
IGL01360:Lrp1 APN 10 127,381,689 (GRCm39) missense possibly damaging 0.93
IGL01402:Lrp1 APN 10 127,430,901 (GRCm39) missense probably damaging 1.00
IGL01404:Lrp1 APN 10 127,430,901 (GRCm39) missense probably damaging 1.00
IGL01411:Lrp1 APN 10 127,417,634 (GRCm39) nonsense probably null
IGL01469:Lrp1 APN 10 127,420,283 (GRCm39) missense probably damaging 1.00
IGL01552:Lrp1 APN 10 127,424,379 (GRCm39) nonsense probably null
IGL01682:Lrp1 APN 10 127,410,847 (GRCm39) missense probably benign 0.00
IGL01760:Lrp1 APN 10 127,409,370 (GRCm39) missense probably benign 0.00
IGL01918:Lrp1 APN 10 127,390,458 (GRCm39) missense probably damaging 0.99
IGL01989:Lrp1 APN 10 127,413,998 (GRCm39) missense probably damaging 1.00
IGL02105:Lrp1 APN 10 127,380,448 (GRCm39) missense probably damaging 1.00
IGL02158:Lrp1 APN 10 127,390,140 (GRCm39) missense probably benign 0.02
IGL02164:Lrp1 APN 10 127,399,536 (GRCm39) missense probably benign 0.39
IGL02337:Lrp1 APN 10 127,412,756 (GRCm39) missense possibly damaging 0.87
IGL02425:Lrp1 APN 10 127,407,756 (GRCm39) critical splice donor site probably null
IGL02493:Lrp1 APN 10 127,417,647 (GRCm39) missense probably damaging 0.99
IGL02563:Lrp1 APN 10 127,387,555 (GRCm39) missense probably damaging 1.00
IGL02590:Lrp1 APN 10 127,388,660 (GRCm39) missense probably damaging 1.00
IGL02624:Lrp1 APN 10 127,408,291 (GRCm39) missense probably damaging 0.98
IGL02625:Lrp1 APN 10 127,410,355 (GRCm39) missense probably damaging 1.00
IGL02825:Lrp1 APN 10 127,378,474 (GRCm39) missense probably damaging 1.00
IGL02880:Lrp1 APN 10 127,376,091 (GRCm39) missense probably benign 0.12
IGL02900:Lrp1 APN 10 127,412,516 (GRCm39) splice site probably benign
IGL02956:Lrp1 APN 10 127,380,428 (GRCm39) missense probably benign 0.00
IGL02974:Lrp1 APN 10 127,390,885 (GRCm39) missense probably damaging 0.99
IGL02983:Lrp1 APN 10 127,386,068 (GRCm39) missense probably damaging 1.00
IGL03002:Lrp1 APN 10 127,425,505 (GRCm39) missense probably damaging 1.00
IGL03091:Lrp1 APN 10 127,394,993 (GRCm39) missense probably benign 0.30
IGL03109:Lrp1 APN 10 127,402,514 (GRCm39) missense probably benign
IGL03194:Lrp1 APN 10 127,404,554 (GRCm39) missense probably damaging 1.00
IGL03232:Lrp1 APN 10 127,375,245 (GRCm39) missense probably damaging 1.00
calculus UTSW 10 127,393,937 (GRCm39) splice site probably null
Delimiter UTSW 10 127,382,731 (GRCm39) missense probably damaging 1.00
extremis UTSW 10 127,392,857 (GRCm39) missense probably benign 0.00
Jockey UTSW 10 127,396,005 (GRCm39) missense probably damaging 1.00
peripheral UTSW 10 127,446,250 (GRCm39) missense probably damaging 1.00
tangential UTSW 10 127,429,717 (GRCm39) missense probably damaging 0.99
P0015:Lrp1 UTSW 10 127,402,532 (GRCm39) missense probably damaging 0.99
PIT4519001:Lrp1 UTSW 10 127,443,843 (GRCm39) missense possibly damaging 0.91
PIT4520001:Lrp1 UTSW 10 127,443,843 (GRCm39) missense possibly damaging 0.91
R0004:Lrp1 UTSW 10 127,377,694 (GRCm39) splice site probably null
R0034:Lrp1 UTSW 10 127,381,520 (GRCm39) missense probably benign 0.42
R0091:Lrp1 UTSW 10 127,376,848 (GRCm39) missense probably damaging 1.00
R0098:Lrp1 UTSW 10 127,388,607 (GRCm39) missense probably benign
R0098:Lrp1 UTSW 10 127,388,607 (GRCm39) missense probably benign
R0143:Lrp1 UTSW 10 127,429,811 (GRCm39) missense probably damaging 1.00
R0372:Lrp1 UTSW 10 127,428,005 (GRCm39) missense probably damaging 1.00
R0379:Lrp1 UTSW 10 127,430,838 (GRCm39) missense probably damaging 1.00
R0445:Lrp1 UTSW 10 127,426,505 (GRCm39) nonsense probably null
R0529:Lrp1 UTSW 10 127,377,463 (GRCm39) splice site probably null
R0551:Lrp1 UTSW 10 127,407,827 (GRCm39) missense probably benign
R0570:Lrp1 UTSW 10 127,390,878 (GRCm39) nonsense probably null
R0600:Lrp1 UTSW 10 127,403,252 (GRCm39) missense probably benign 0.00
R0626:Lrp1 UTSW 10 127,403,233 (GRCm39) missense probably damaging 1.00
R0647:Lrp1 UTSW 10 127,407,346 (GRCm39) missense probably damaging 1.00
R0680:Lrp1 UTSW 10 127,425,530 (GRCm39) missense probably damaging 1.00
R0792:Lrp1 UTSW 10 127,411,155 (GRCm39) missense probably benign 0.04
R0792:Lrp1 UTSW 10 127,403,233 (GRCm39) missense probably damaging 1.00
R0848:Lrp1 UTSW 10 127,389,231 (GRCm39) splice site probably null
R0866:Lrp1 UTSW 10 127,375,147 (GRCm39) missense probably damaging 1.00
R0918:Lrp1 UTSW 10 127,429,834 (GRCm39) missense probably damaging 1.00
R1076:Lrp1 UTSW 10 127,399,666 (GRCm39) splice site probably benign
R1107:Lrp1 UTSW 10 127,393,304 (GRCm39) missense probably damaging 1.00
R1346:Lrp1 UTSW 10 127,441,735 (GRCm39) missense probably damaging 1.00
R1403:Lrp1 UTSW 10 127,417,760 (GRCm39) critical splice acceptor site probably null
R1403:Lrp1 UTSW 10 127,417,760 (GRCm39) critical splice acceptor site probably null
R1496:Lrp1 UTSW 10 127,374,880 (GRCm39) missense probably damaging 1.00
R1522:Lrp1 UTSW 10 127,411,155 (GRCm39) missense probably benign 0.04
R1522:Lrp1 UTSW 10 127,403,233 (GRCm39) missense probably damaging 1.00
R1525:Lrp1 UTSW 10 127,375,398 (GRCm39) missense probably damaging 1.00
R1539:Lrp1 UTSW 10 127,420,250 (GRCm39) splice site probably null
R1589:Lrp1 UTSW 10 127,441,475 (GRCm39) missense probably benign 0.00
R1591:Lrp1 UTSW 10 127,441,475 (GRCm39) missense probably benign 0.00
R1663:Lrp1 UTSW 10 127,392,790 (GRCm39) missense probably damaging 1.00
R1682:Lrp1 UTSW 10 127,410,201 (GRCm39) missense probably damaging 1.00
R1717:Lrp1 UTSW 10 127,399,534 (GRCm39) missense probably damaging 1.00
R1717:Lrp1 UTSW 10 127,392,138 (GRCm39) missense possibly damaging 0.59
R1758:Lrp1 UTSW 10 127,424,453 (GRCm39) missense possibly damaging 0.76
R1826:Lrp1 UTSW 10 127,389,576 (GRCm39) missense probably damaging 1.00
R1842:Lrp1 UTSW 10 127,409,337 (GRCm39) missense possibly damaging 0.93
R1844:Lrp1 UTSW 10 127,431,152 (GRCm39) critical splice donor site probably null
R1845:Lrp1 UTSW 10 127,414,542 (GRCm39) missense probably damaging 1.00
R1896:Lrp1 UTSW 10 127,395,867 (GRCm39) missense possibly damaging 0.64
R1952:Lrp1 UTSW 10 127,403,300 (GRCm39) missense probably damaging 1.00
R2009:Lrp1 UTSW 10 127,380,385 (GRCm39) missense probably damaging 1.00
R2015:Lrp1 UTSW 10 127,376,563 (GRCm39) missense probably benign 0.00
R2116:Lrp1 UTSW 10 127,412,362 (GRCm39) nonsense probably null
R2161:Lrp1 UTSW 10 127,391,607 (GRCm39) missense probably damaging 1.00
R2199:Lrp1 UTSW 10 127,382,709 (GRCm39) missense probably damaging 1.00
R2213:Lrp1 UTSW 10 127,376,571 (GRCm39) missense probably damaging 1.00
R2300:Lrp1 UTSW 10 127,392,784 (GRCm39) nonsense probably null
R2324:Lrp1 UTSW 10 127,402,455 (GRCm39) missense possibly damaging 0.92
R2849:Lrp1 UTSW 10 127,378,165 (GRCm39) missense probably damaging 1.00
R2926:Lrp1 UTSW 10 127,423,982 (GRCm39) missense probably damaging 0.98
R2993:Lrp1 UTSW 10 127,446,250 (GRCm39) missense probably damaging 1.00
R3522:Lrp1 UTSW 10 127,389,424 (GRCm39) missense probably damaging 1.00
R3702:Lrp1 UTSW 10 127,430,972 (GRCm39) missense probably damaging 1.00
R3789:Lrp1 UTSW 10 127,407,838 (GRCm39) missense possibly damaging 0.94
R3898:Lrp1 UTSW 10 127,427,969 (GRCm39) nonsense probably null
R3941:Lrp1 UTSW 10 127,389,265 (GRCm39) missense probably damaging 1.00
R3958:Lrp1 UTSW 10 127,407,827 (GRCm39) missense probably benign
R4369:Lrp1 UTSW 10 127,386,155 (GRCm39) missense possibly damaging 0.87
R4510:Lrp1 UTSW 10 127,429,717 (GRCm39) missense probably damaging 0.99
R4511:Lrp1 UTSW 10 127,429,717 (GRCm39) missense probably damaging 0.99
R4576:Lrp1 UTSW 10 127,376,057 (GRCm39) small deletion probably benign
R4583:Lrp1 UTSW 10 127,377,241 (GRCm39) missense probably benign 0.00
R4662:Lrp1 UTSW 10 127,388,054 (GRCm39) nonsense probably null
R4721:Lrp1 UTSW 10 127,390,928 (GRCm39) missense possibly damaging 0.58
R4728:Lrp1 UTSW 10 127,399,606 (GRCm39) missense probably damaging 1.00
R4745:Lrp1 UTSW 10 127,385,813 (GRCm39) missense probably benign 0.20
R4841:Lrp1 UTSW 10 127,419,805 (GRCm39) missense probably damaging 1.00
R4842:Lrp1 UTSW 10 127,419,805 (GRCm39) missense probably damaging 1.00
R4855:Lrp1 UTSW 10 127,446,311 (GRCm39) missense probably benign 0.03
R4860:Lrp1 UTSW 10 127,389,693 (GRCm39) missense probably damaging 1.00
R4860:Lrp1 UTSW 10 127,389,693 (GRCm39) missense probably damaging 1.00
R4891:Lrp1 UTSW 10 127,377,621 (GRCm39) missense probably damaging 1.00
R4925:Lrp1 UTSW 10 127,410,944 (GRCm39) nonsense probably null
R4970:Lrp1 UTSW 10 127,375,389 (GRCm39) missense probably benign 0.11
R4999:Lrp1 UTSW 10 127,389,648 (GRCm39) missense probably damaging 1.00
R5044:Lrp1 UTSW 10 127,403,364 (GRCm39) missense probably damaging 1.00
R5127:Lrp1 UTSW 10 127,375,503 (GRCm39) intron probably benign
R5188:Lrp1 UTSW 10 127,443,821 (GRCm39) missense probably damaging 1.00
R5218:Lrp1 UTSW 10 127,384,488 (GRCm39) missense probably damaging 1.00
R5225:Lrp1 UTSW 10 127,391,965 (GRCm39) missense probably benign 0.04
R5291:Lrp1 UTSW 10 127,429,747 (GRCm39) missense probably damaging 1.00
R5386:Lrp1 UTSW 10 127,427,983 (GRCm39) missense probably damaging 1.00
R5395:Lrp1 UTSW 10 127,431,166 (GRCm39) missense probably damaging 1.00
R5413:Lrp1 UTSW 10 127,423,936 (GRCm39) critical splice donor site probably null
R5430:Lrp1 UTSW 10 127,376,930 (GRCm39) missense probably damaging 0.99
R5499:Lrp1 UTSW 10 127,408,813 (GRCm39) missense possibly damaging 0.58
R5526:Lrp1 UTSW 10 127,391,593 (GRCm39) missense probably benign 0.37
R5580:Lrp1 UTSW 10 127,424,389 (GRCm39) missense probably benign
R5583:Lrp1 UTSW 10 127,424,332 (GRCm39) missense probably benign 0.08
R5599:Lrp1 UTSW 10 127,429,738 (GRCm39) missense probably damaging 1.00
R5639:Lrp1 UTSW 10 127,429,708 (GRCm39) missense probably damaging 0.99
R5677:Lrp1 UTSW 10 127,410,298 (GRCm39) missense probably damaging 1.00
R5730:Lrp1 UTSW 10 127,419,703 (GRCm39) missense probably benign 0.00
R5742:Lrp1 UTSW 10 127,384,216 (GRCm39) missense probably damaging 0.98
R5764:Lrp1 UTSW 10 127,431,187 (GRCm39) missense probably benign 0.41
R5864:Lrp1 UTSW 10 127,403,374 (GRCm39) missense possibly damaging 0.58
R5937:Lrp1 UTSW 10 127,419,745 (GRCm39) missense possibly damaging 0.93
R5947:Lrp1 UTSW 10 127,425,423 (GRCm39) critical splice donor site probably null
R5976:Lrp1 UTSW 10 127,419,770 (GRCm39) missense probably damaging 1.00
R6021:Lrp1 UTSW 10 127,413,883 (GRCm39) missense probably damaging 1.00
R6026:Lrp1 UTSW 10 127,409,272 (GRCm39) missense probably damaging 1.00
R6045:Lrp1 UTSW 10 127,402,469 (GRCm39) missense probably damaging 0.98
R6057:Lrp1 UTSW 10 127,403,359 (GRCm39) missense probably damaging 1.00
R6084:Lrp1 UTSW 10 127,396,422 (GRCm39) missense probably benign 0.09
R6131:Lrp1 UTSW 10 127,396,026 (GRCm39) missense probably benign
R6235:Lrp1 UTSW 10 127,424,046 (GRCm39) missense probably damaging 1.00
R6280:Lrp1 UTSW 10 127,425,453 (GRCm39) missense probably benign 0.04
R6307:Lrp1 UTSW 10 127,427,944 (GRCm39) missense probably damaging 1.00
R6532:Lrp1 UTSW 10 127,385,276 (GRCm39) missense probably damaging 1.00
R6532:Lrp1 UTSW 10 127,377,551 (GRCm39) missense probably damaging 1.00
R6536:Lrp1 UTSW 10 127,393,937 (GRCm39) splice site probably null
R6605:Lrp1 UTSW 10 127,396,005 (GRCm39) missense probably damaging 1.00
R6607:Lrp1 UTSW 10 127,396,005 (GRCm39) missense probably damaging 1.00
R6631:Lrp1 UTSW 10 127,410,201 (GRCm39) missense probably damaging 1.00
R6676:Lrp1 UTSW 10 127,396,005 (GRCm39) missense probably damaging 1.00
R6678:Lrp1 UTSW 10 127,396,005 (GRCm39) missense probably damaging 1.00
R6809:Lrp1 UTSW 10 127,390,925 (GRCm39) missense probably benign 0.04
R6884:Lrp1 UTSW 10 127,394,986 (GRCm39) missense probably benign 0.00
R6925:Lrp1 UTSW 10 127,392,857 (GRCm39) missense probably benign 0.00
R6987:Lrp1 UTSW 10 127,410,874 (GRCm39) missense probably damaging 1.00
R7016:Lrp1 UTSW 10 127,395,836 (GRCm39) critical splice donor site probably null
R7030:Lrp1 UTSW 10 127,388,745 (GRCm39) missense probably damaging 0.97
R7053:Lrp1 UTSW 10 127,376,963 (GRCm39) missense probably damaging 1.00
R7076:Lrp1 UTSW 10 127,386,052 (GRCm39) critical splice donor site probably null
R7136:Lrp1 UTSW 10 127,394,491 (GRCm39) missense probably damaging 1.00
R7180:Lrp1 UTSW 10 127,392,834 (GRCm39) missense probably damaging 1.00
R7199:Lrp1 UTSW 10 127,409,325 (GRCm39) missense probably damaging 0.99
R7219:Lrp1 UTSW 10 127,393,097 (GRCm39) missense probably benign 0.40
R7233:Lrp1 UTSW 10 127,430,930 (GRCm39) missense probably damaging 1.00
R7251:Lrp1 UTSW 10 127,408,423 (GRCm39) missense probably damaging 1.00
R7264:Lrp1 UTSW 10 127,427,962 (GRCm39) missense probably damaging 1.00
R7302:Lrp1 UTSW 10 127,374,856 (GRCm39) missense probably benign 0.01
R7313:Lrp1 UTSW 10 127,389,337 (GRCm39) missense probably damaging 1.00
R7322:Lrp1 UTSW 10 127,381,433 (GRCm39) missense probably benign 0.24
R7354:Lrp1 UTSW 10 127,407,277 (GRCm39) missense probably damaging 1.00
R7375:Lrp1 UTSW 10 127,375,217 (GRCm39) missense probably damaging 1.00
R7388:Lrp1 UTSW 10 127,419,766 (GRCm39) nonsense probably null
R7404:Lrp1 UTSW 10 127,418,577 (GRCm39) missense
R7405:Lrp1 UTSW 10 127,417,620 (GRCm39) missense possibly damaging 0.93
R7477:Lrp1 UTSW 10 127,404,789 (GRCm39) missense probably damaging 1.00
R7555:Lrp1 UTSW 10 127,382,731 (GRCm39) missense probably damaging 1.00
R7600:Lrp1 UTSW 10 127,391,575 (GRCm39) missense probably benign
R7678:Lrp1 UTSW 10 127,409,922 (GRCm39) missense probably damaging 1.00
R7679:Lrp1 UTSW 10 127,424,297 (GRCm39) nonsense probably null
R7951:Lrp1 UTSW 10 127,374,933 (GRCm39) nonsense probably null
R7964:Lrp1 UTSW 10 127,410,913 (GRCm39) missense possibly damaging 0.94
R8006:Lrp1 UTSW 10 127,425,488 (GRCm39) missense probably damaging 1.00
R8021:Lrp1 UTSW 10 127,384,215 (GRCm39) missense possibly damaging 0.92
R8098:Lrp1 UTSW 10 127,410,324 (GRCm39) missense possibly damaging 0.78
R8112:Lrp1 UTSW 10 127,441,715 (GRCm39) missense probably damaging 1.00
R8210:Lrp1 UTSW 10 127,412,354 (GRCm39) missense probably damaging 1.00
R8249:Lrp1 UTSW 10 127,441,412 (GRCm39) missense probably benign
R8291:Lrp1 UTSW 10 127,425,572 (GRCm39) missense probably damaging 1.00
R8332:Lrp1 UTSW 10 127,407,805 (GRCm39) missense probably damaging 1.00
R8435:Lrp1 UTSW 10 127,392,199 (GRCm39) missense probably damaging 0.97
R8467:Lrp1 UTSW 10 127,394,519 (GRCm39) missense probably damaging 1.00
R8468:Lrp1 UTSW 10 127,394,519 (GRCm39) missense probably damaging 1.00
R8474:Lrp1 UTSW 10 127,375,572 (GRCm39) missense probably damaging 1.00
R8481:Lrp1 UTSW 10 127,404,779 (GRCm39) missense probably damaging 1.00
R8483:Lrp1 UTSW 10 127,394,519 (GRCm39) missense probably damaging 1.00
R8485:Lrp1 UTSW 10 127,394,519 (GRCm39) missense probably damaging 1.00
R8488:Lrp1 UTSW 10 127,396,356 (GRCm39) missense probably damaging 1.00
R8715:Lrp1 UTSW 10 127,396,490 (GRCm39) missense possibly damaging 0.77
R8790:Lrp1 UTSW 10 127,374,946 (GRCm39) missense probably damaging 1.00
R8854:Lrp1 UTSW 10 127,378,968 (GRCm39) missense probably damaging 1.00
R8926:Lrp1 UTSW 10 127,381,671 (GRCm39) missense probably benign
R8949:Lrp1 UTSW 10 127,425,405 (GRCm39) intron probably benign
R8971:Lrp1 UTSW 10 127,391,896 (GRCm39) missense possibly damaging 0.94
R9103:Lrp1 UTSW 10 127,430,979 (GRCm39) nonsense probably null
R9108:Lrp1 UTSW 10 127,390,206 (GRCm39) missense probably damaging 0.99
R9130:Lrp1 UTSW 10 127,382,281 (GRCm39) missense probably benign 0.18
R9157:Lrp1 UTSW 10 127,410,209 (GRCm39) missense probably damaging 1.00
R9162:Lrp1 UTSW 10 127,441,368 (GRCm39) missense probably benign 0.32
R9205:Lrp1 UTSW 10 127,430,850 (GRCm39) nonsense probably null
R9228:Lrp1 UTSW 10 127,382,807 (GRCm39) missense probably damaging 0.98
R9231:Lrp1 UTSW 10 127,382,268 (GRCm39) missense probably benign 0.06
R9287:Lrp1 UTSW 10 127,403,233 (GRCm39) missense probably damaging 1.00
R9381:Lrp1 UTSW 10 127,441,337 (GRCm39) missense probably benign 0.17
R9412:Lrp1 UTSW 10 127,409,287 (GRCm39) missense probably damaging 1.00
R9434:Lrp1 UTSW 10 127,381,689 (GRCm39) missense possibly damaging 0.93
R9463:Lrp1 UTSW 10 127,429,334 (GRCm39) nonsense probably null
R9526:Lrp1 UTSW 10 127,431,229 (GRCm39) missense probably damaging 0.96
R9548:Lrp1 UTSW 10 127,388,733 (GRCm39) missense probably damaging 0.99
R9599:Lrp1 UTSW 10 127,410,246 (GRCm39) missense probably damaging 1.00
R9649:Lrp1 UTSW 10 127,409,368 (GRCm39) missense probably benign 0.14
R9687:Lrp1 UTSW 10 127,402,562 (GRCm39) missense probably damaging 1.00
R9707:Lrp1 UTSW 10 127,408,414 (GRCm39) missense probably benign 0.08
R9770:Lrp1 UTSW 10 127,420,268 (GRCm39) missense probably damaging 1.00
V3553:Lrp1 UTSW 10 127,407,311 (GRCm39) missense probably damaging 1.00
Y5406:Lrp1 UTSW 10 127,390,152 (GRCm39) missense probably damaging 1.00
Z1088:Lrp1 UTSW 10 127,420,248 (GRCm39) missense probably damaging 1.00
Z1176:Lrp1 UTSW 10 127,390,831 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAACTGTCAATCATGGGCAG -3'
(R):5'- AGCCATCTGCCTCATCACTG -3'

Sequencing Primer
(F):5'- TCAATCATGGGCAGGCTGTCAG -3'
(R):5'- AGTCTCAGACTGTACCCCG -3'
Posted On 2015-12-29