Incidental Mutation 'R4785:Atrnl1'
ID 367045
Institutional Source Beutler Lab
Gene Symbol Atrnl1
Ensembl Gene ENSMUSG00000054843
Gene Name attractin like 1
Synonyms Alp
MMRRC Submission 042417-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.210) question?
Stock # R4785 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 57611034-58133338 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 57629158 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 122 (I122V)
Ref Sequence ENSEMBL: ENSMUSP00000076514 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077282]
AlphaFold Q6A051
Predicted Effect probably damaging
Transcript: ENSMUST00000077282
AA Change: I122V

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000076514
Gene: ENSMUSG00000054843
AA Change: I122V

DomainStartEndE-ValueType
low complexity region 25 32 N/A INTRINSIC
EGF 61 90 5.71e-1 SMART
CUB 92 208 1.43e-11 SMART
EGF 209 244 1.95e1 SMART
Pfam:EGF_2 248 279 5.8e-7 PFAM
Pfam:Kelch_5 350 391 2.1e-9 PFAM
Pfam:Kelch_6 354 401 5.8e-8 PFAM
Pfam:Kelch_4 465 517 4.3e-7 PFAM
Pfam:Kelch_1 519 573 2.7e-6 PFAM
PSI 613 656 3.38e-1 SMART
PSI 665 708 2e-3 SMART
PSI 714 759 1.72e-2 SMART
CLECT 747 872 2.86e-20 SMART
PSI 888 938 6.26e-5 SMART
PSI 941 1011 1.73e-7 SMART
EGF_Lam 1013 1056 1.07e-5 SMART
low complexity region 1157 1173 N/A INTRINSIC
transmembrane domain 1229 1251 N/A INTRINSIC
low complexity region 1261 1272 N/A INTRINSIC
low complexity region 1326 1339 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.4%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele exhibit normal coat coloring and normal brain morphology. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 145 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921517D22Rik T C 13: 59,691,592 (GRCm38) D13G probably benign Het
4930442H23Rik C T 10: 81,183,144 (GRCm38) probably benign Het
Adamts13 T A 2: 26,983,042 (GRCm38) S341T probably damaging Het
Adamts2 A G 11: 50,792,722 (GRCm38) I944V probably benign Het
Adcy3 A G 12: 4,206,542 (GRCm38) T783A probably benign Het
Ago3 A T 4: 126,368,503 (GRCm38) M418K probably benign Het
Alpk1 G T 3: 127,687,592 (GRCm38) N175K possibly damaging Het
Als2 A G 1: 59,215,313 (GRCm38) V295A probably benign Het
Anapc13 T C 9: 102,629,821 (GRCm38) I11T probably benign Het
Ankrd12 T A 17: 65,982,999 (GRCm38) N1813I probably damaging Het
Anks1b A T 10: 90,914,750 (GRCm38) I176F probably null Het
Ap3d1 TTCTCTCTCTCTCTCTCT TTCTCTCTCTCTCTCT 10: 80,712,778 (GRCm38) probably null Het
Arhgap32 A G 9: 32,129,653 (GRCm38) D67G probably damaging Het
Arhgap32 T C 9: 32,260,780 (GRCm38) C1619R probably damaging Het
Atp1a4 A T 1: 172,254,110 (GRCm38) Y158* probably null Het
Atp8b5 A T 4: 43,356,980 (GRCm38) D576V probably damaging Het
B430203G13Rik A T 12: 17,924,519 (GRCm38) noncoding transcript Het
Baz1b T G 5: 135,217,413 (GRCm38) L572R possibly damaging Het
Ccn3 A T 15: 54,752,207 (GRCm38) probably null Het
Ccnd2 T C 6: 127,148,798 (GRCm38) T92A possibly damaging Het
Ccndbp1 A T 2: 121,008,522 (GRCm38) T5S probably benign Het
Ccr2 G A 9: 124,106,372 (GRCm38) V230I probably benign Het
Cct4 T A 11: 23,002,866 (GRCm38) V514E probably damaging Het
Cep152 A G 2: 125,586,329 (GRCm38) probably null Het
Cflar C T 1: 58,752,567 (GRCm38) T343M probably benign Het
Chrm5 A C 2: 112,479,585 (GRCm38) N395K probably benign Het
Chrna10 G A 7: 102,113,219 (GRCm38) P255S possibly damaging Het
Chrna6 T A 8: 27,407,106 (GRCm38) I248F probably damaging Het
Clip1 T C 5: 123,579,293 (GRCm38) D1387G probably damaging Het
Clstn3 T C 6: 124,437,372 (GRCm38) probably null Het
Cntnap5a C T 1: 116,101,565 (GRCm38) R250W probably benign Het
Col12a1 C A 9: 79,678,494 (GRCm38) V1228F possibly damaging Het
Cxcr5 T C 9: 44,513,341 (GRCm38) T340A probably benign Het
Cyp2a4 G A 7: 26,312,875 (GRCm38) R361K probably damaging Het
Dnah1 T A 14: 31,263,479 (GRCm38) K3818N probably damaging Het
Dnah3 T A 7: 119,967,824 (GRCm38) K2393M probably benign Het
Dpy19l1 A T 9: 24,424,823 (GRCm38) L529Q probably damaging Het
Eif4g2 C T 7: 111,076,796 (GRCm38) R399H probably damaging Het
Elapor1 A T 3: 108,458,227 (GRCm38) probably benign Het
Fam76a A T 4: 132,902,117 (GRCm38) probably null Het
Fam76a A G 4: 132,916,190 (GRCm38) Y78H probably damaging Het
Fbn1 A T 2: 125,324,919 (GRCm38) C2026S probably damaging Het
Fbxo4 T C 15: 3,969,041 (GRCm38) T312A probably benign Het
Fbxw26 A G 9: 109,724,800 (GRCm38) V257A possibly damaging Het
Fhip1a G T 3: 85,688,570 (GRCm38) T115K probably damaging Het
Flnb A T 14: 7,905,701 (GRCm38) E1150D probably benign Het
Fndc3c1 A T X: 106,437,702 (GRCm38) S661R possibly damaging Het
Gba2 A C 4: 43,568,315 (GRCm38) L684R probably damaging Het
Gbf1 G T 19: 46,268,395 (GRCm38) C812F possibly damaging Het
Glt8d2 A T 10: 82,660,749 (GRCm38) D158E probably damaging Het
Golga2 T A 2: 32,297,156 (GRCm38) N89K probably damaging Het
Got1 A G 19: 43,502,937 (GRCm38) I358T possibly damaging Het
Gpx6 C T 13: 21,312,264 (GRCm38) Q3* probably null Het
Grin1 T A 2: 25,292,381 (GRCm38) H956L possibly damaging Het
Grin2d A G 7: 45,856,781 (GRCm38) V562A probably damaging Het
Grm6 A G 11: 50,857,277 (GRCm38) I405V probably benign Het
Hcar2 C G 5: 123,864,450 (GRCm38) G330A probably benign Het
Hcfc1 T C X: 73,965,946 (GRCm38) K20E probably damaging Het
Iars1 T A 13: 49,724,663 (GRCm38) Y888N probably damaging Het
Ifi206 A T 1: 173,480,866 (GRCm38) H521Q probably benign Het
Impg1 A G 9: 80,398,450 (GRCm38) S112P probably benign Het
Incenp T A 19: 9,877,691 (GRCm38) R619W unknown Het
Incenp C A 19: 9,877,690 (GRCm38) R619M unknown Het
Kat2b A G 17: 53,653,203 (GRCm38) E513G possibly damaging Het
Kbtbd12 G T 6: 88,618,021 (GRCm38) L276I probably damaging Het
Kctd9 T A 14: 67,734,164 (GRCm38) D229E probably damaging Het
Kdm1b C T 13: 47,063,077 (GRCm38) R308W probably damaging Het
Kif2b G A 11: 91,576,428 (GRCm38) P343L probably benign Het
Kntc1 T G 5: 123,816,762 (GRCm38) M2081R possibly damaging Het
Lamc1 T C 1: 153,231,740 (GRCm38) N1231S probably damaging Het
Lclat1 T A 17: 73,240,070 (GRCm38) Y327* probably null Het
Lgals3bp G A 11: 118,393,514 (GRCm38) T413I probably damaging Het
Lin54 A G 5: 100,459,738 (GRCm38) I250T probably damaging Het
Lrp1 T C 10: 127,558,133 (GRCm38) N2621S probably benign Het
Lrrtm3 T A 10: 64,088,002 (GRCm38) H462L probably benign Het
Lysmd1 A G 3: 95,134,986 (GRCm38) Y57C probably damaging Het
Mccc1 C A 3: 35,975,873 (GRCm38) M429I probably damaging Het
Metrnl A G 11: 121,707,924 (GRCm38) E40G probably benign Het
Mios T A 6: 8,222,464 (GRCm38) M466K probably benign Het
Mrgpra1 A G 7: 47,335,470 (GRCm38) S154P probably damaging Het
Mrpl24 T C 3: 87,922,050 (GRCm38) probably null Het
Myo1f A G 17: 33,598,191 (GRCm38) N736S possibly damaging Het
Myo1h A G 5: 114,360,599 (GRCm38) I919V possibly damaging Het
Nampt T C 12: 32,848,714 (GRCm38) L443P possibly damaging Het
Ndufaf2 C G 13: 108,052,780 (GRCm38) A145P probably damaging Het
Nek10 A T 14: 14,855,714 (GRCm38) T403S probably benign Het
Nme8 C A 13: 19,657,930 (GRCm38) V219L probably damaging Het
Nps T A 7: 135,268,788 (GRCm38) L13Q probably damaging Het
Nutm1 G A 2: 112,248,936 (GRCm38) A878V probably benign Het
Ogdh T C 11: 6,349,875 (GRCm38) F794L probably damaging Het
Olfr721-ps1 A C 14: 14,407,729 (GRCm38) Y167S possibly damaging Het
Or14a259 C A 7: 86,363,735 (GRCm38) G201C probably damaging Het
Or14c39 T C 7: 86,694,528 (GRCm38) L24P probably damaging Het
Or4f56 A T 2: 111,873,050 (GRCm38) D268E possibly damaging Het
Or5a3 A T 19: 12,422,977 (GRCm38) I223F probably damaging Het
Or5g29 A G 2: 85,590,938 (GRCm38) T133A probably benign Het
Pik3cg T C 12: 32,205,199 (GRCm38) E263G probably damaging Het
Pikfyve A G 1: 65,267,846 (GRCm38) T1798A probably benign Het
Poldip3 T C 15: 83,131,501 (GRCm38) Y305C probably damaging Het
Prkdc T C 16: 15,648,976 (GRCm38) I107T probably benign Het
Prmt2 A G 10: 76,226,221 (GRCm38) I50T probably damaging Het
Ptprd T C 4: 76,140,553 (GRCm38) T168A probably benign Het
Pudp A G 18: 50,568,065 (GRCm38) V199A probably damaging Het
Rab3c T C 13: 110,061,900 (GRCm38) E198G probably benign Het
Rasl12 A G 9: 65,413,448 (GRCm38) Y156C probably damaging Het
Rbm12 T C 2: 156,096,564 (GRCm38) D596G possibly damaging Het
Rbm6 T C 9: 107,787,352 (GRCm38) E694G probably benign Het
Rif1 T C 2: 52,112,747 (GRCm38) V2071A probably damaging Het
Ripply2 A T 9: 87,019,796 (GRCm38) N125I probably damaging Het
Rps6kc1 A T 1: 190,750,188 (GRCm38) H284Q probably benign Het
Scara3 A T 14: 65,953,501 (GRCm38) M1K probably null Het
Sfswap A G 5: 129,513,083 (GRCm38) T215A probably damaging Het
Shroom2 A C X: 152,660,907 (GRCm38) F421V probably benign Het
Sipa1l3 A G 7: 29,377,641 (GRCm38) V902A probably damaging Het
Slamf8 G T 1: 172,584,214 (GRCm38) P238Q probably damaging Het
Slc44a3 T C 3: 121,527,074 (GRCm38) T93A possibly damaging Het
Slc5a7 A T 17: 54,278,700 (GRCm38) I363N probably damaging Het
Slc66a1 G T 4: 139,300,001 (GRCm38) H343Q probably benign Het
Slc7a2 T A 8: 40,911,058 (GRCm38) M436K probably benign Het
Spindoc A G 19: 7,374,091 (GRCm38) S223P probably benign Het
Stk11ip T C 1: 75,530,281 (GRCm38) F669L possibly damaging Het
Sun3 G A 11: 9,038,266 (GRCm38) L19F probably benign Het
Sycp1 C A 3: 102,853,489 (GRCm38) A703S possibly damaging Het
Tas2r139 T G 6: 42,141,284 (GRCm38) F117V probably damaging Het
Tdrd6 T C 17: 43,625,576 (GRCm38) Y1527C probably damaging Het
Tenm4 A C 7: 96,774,046 (GRCm38) K683Q probably damaging Het
Tfeb T A 17: 47,788,227 (GRCm38) probably null Het
Tmco4 T C 4: 138,998,039 (GRCm38) S121P probably damaging Het
Tmprss11d C T 5: 86,306,281 (GRCm38) V222M probably damaging Het
Tnks1bp1 T C 2: 85,063,034 (GRCm38) W440R probably damaging Het
Trp53bp2 A G 1: 182,448,997 (GRCm38) T848A probably benign Het
Tssk1 G A 16: 17,895,062 (GRCm38) R237H probably benign Het
Ttll4 A T 1: 74,679,007 (GRCm38) T6S possibly damaging Het
Ttn G T 2: 76,721,797 (GRCm38) Y29419* probably null Het
Ttn A G 2: 76,769,603 (GRCm38) Y19076H probably damaging Het
Ubr3 T A 2: 69,959,603 (GRCm38) V867D probably damaging Het
Usp29 A G 7: 6,961,391 (GRCm38) T78A probably damaging Het
Utrn T G 10: 12,654,745 (GRCm38) Q2108P probably benign Het
Vcan T C 13: 89,705,789 (GRCm38) N351D probably damaging Het
Vmn1r61 A T 7: 5,611,127 (GRCm38) Y63N probably benign Het
Vmn1r61 A T 7: 5,611,125 (GRCm38) Y63* probably null Het
Vmn1r85 A T 7: 13,084,861 (GRCm38) W119R probably damaging Het
Zbtb21 A C 16: 97,950,455 (GRCm38) V190G possibly damaging Het
Zfp157 C A 5: 138,444,789 (GRCm38) T14N probably damaging Het
Zfp942 A T 17: 21,929,419 (GRCm38) H76Q probably damaging Het
Other mutations in Atrnl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00323:Atrnl1 APN 19 57,691,817 (GRCm38) missense probably benign 0.02
IGL00707:Atrnl1 APN 19 57,673,265 (GRCm38) missense probably damaging 0.96
IGL00921:Atrnl1 APN 19 57,702,153 (GRCm38) missense probably damaging 1.00
IGL01410:Atrnl1 APN 19 58,131,104 (GRCm38) missense probably damaging 1.00
IGL01468:Atrnl1 APN 19 57,699,712 (GRCm38) missense probably benign 0.02
IGL01756:Atrnl1 APN 19 57,652,948 (GRCm38) missense probably benign
IGL01971:Atrnl1 APN 19 57,753,283 (GRCm38) missense probably damaging 1.00
IGL02019:Atrnl1 APN 19 57,691,763 (GRCm38) splice site probably benign
IGL02580:Atrnl1 APN 19 57,714,576 (GRCm38) splice site probably benign
IGL02649:Atrnl1 APN 19 57,650,441 (GRCm38) splice site probably benign
IGL02676:Atrnl1 APN 19 57,691,884 (GRCm38) missense probably damaging 1.00
IGL03276:Atrnl1 APN 19 57,652,927 (GRCm38) missense probably damaging 0.99
IGL03379:Atrnl1 APN 19 57,642,541 (GRCm38) missense probably benign 0.02
Magnetogorsk UTSW 19 57,630,306 (GRCm38) missense probably damaging 1.00
polar UTSW 19 57,652,950 (GRCm38) missense probably benign 0.00
PIT4812001:Atrnl1 UTSW 19 57,731,623 (GRCm38) missense probably benign 0.08
R0109:Atrnl1 UTSW 19 57,755,517 (GRCm38) missense possibly damaging 0.78
R0308:Atrnl1 UTSW 19 57,753,288 (GRCm38) missense probably benign 0.04
R0394:Atrnl1 UTSW 19 57,673,176 (GRCm38) missense probably benign 0.10
R0734:Atrnl1 UTSW 19 57,654,861 (GRCm38) missense probably damaging 1.00
R0811:Atrnl1 UTSW 19 57,673,141 (GRCm38) missense probably benign 0.07
R0812:Atrnl1 UTSW 19 57,673,141 (GRCm38) missense probably benign 0.07
R1183:Atrnl1 UTSW 19 57,650,293 (GRCm38) missense probably damaging 0.97
R1213:Atrnl1 UTSW 19 57,638,462 (GRCm38) missense probably benign 0.25
R1344:Atrnl1 UTSW 19 57,935,705 (GRCm38) critical splice donor site probably null
R1418:Atrnl1 UTSW 19 57,935,705 (GRCm38) critical splice donor site probably null
R1707:Atrnl1 UTSW 19 57,686,737 (GRCm38) missense probably benign 0.00
R1748:Atrnl1 UTSW 19 57,714,702 (GRCm38) missense probably damaging 0.99
R2051:Atrnl1 UTSW 19 57,691,849 (GRCm38) missense probably benign 0.01
R2113:Atrnl1 UTSW 19 57,755,616 (GRCm38) nonsense probably null
R2130:Atrnl1 UTSW 19 57,654,994 (GRCm38) missense probably damaging 1.00
R3710:Atrnl1 UTSW 19 57,657,114 (GRCm38) missense probably damaging 1.00
R3916:Atrnl1 UTSW 19 57,935,652 (GRCm38) missense possibly damaging 0.82
R4524:Atrnl1 UTSW 19 57,630,306 (GRCm38) missense probably damaging 1.00
R4707:Atrnl1 UTSW 19 57,629,158 (GRCm38) missense probably damaging 0.97
R4712:Atrnl1 UTSW 19 57,652,950 (GRCm38) missense probably benign 0.00
R4784:Atrnl1 UTSW 19 57,629,158 (GRCm38) missense probably damaging 0.97
R4798:Atrnl1 UTSW 19 58,042,361 (GRCm38) missense probably benign
R5172:Atrnl1 UTSW 19 57,685,513 (GRCm38) nonsense probably null
R5226:Atrnl1 UTSW 19 57,650,335 (GRCm38) missense probably benign
R5289:Atrnl1 UTSW 19 57,657,082 (GRCm38) missense probably damaging 1.00
R5372:Atrnl1 UTSW 19 57,755,536 (GRCm38) missense probably benign
R5737:Atrnl1 UTSW 19 57,777,888 (GRCm38) missense possibly damaging 0.84
R5782:Atrnl1 UTSW 19 57,753,286 (GRCm38) missense possibly damaging 0.95
R5826:Atrnl1 UTSW 19 57,630,292 (GRCm38) nonsense probably null
R6169:Atrnl1 UTSW 19 57,642,463 (GRCm38) missense probably benign 0.00
R6242:Atrnl1 UTSW 19 57,642,478 (GRCm38) missense probably benign 0.02
R6342:Atrnl1 UTSW 19 57,638,510 (GRCm38) missense probably damaging 1.00
R6372:Atrnl1 UTSW 19 57,650,332 (GRCm38) missense probably benign 0.01
R6811:Atrnl1 UTSW 19 57,654,961 (GRCm38) missense probably damaging 0.98
R6897:Atrnl1 UTSW 19 58,042,368 (GRCm38) missense probably benign 0.01
R7024:Atrnl1 UTSW 19 57,638,450 (GRCm38) critical splice acceptor site probably null
R7085:Atrnl1 UTSW 19 57,691,857 (GRCm38) missense probably damaging 1.00
R7144:Atrnl1 UTSW 19 58,042,352 (GRCm38) missense probably damaging 1.00
R7259:Atrnl1 UTSW 19 57,935,606 (GRCm38) nonsense probably null
R7289:Atrnl1 UTSW 19 57,650,414 (GRCm38) missense probably benign 0.13
R7310:Atrnl1 UTSW 19 57,642,424 (GRCm38) missense possibly damaging 0.69
R7372:Atrnl1 UTSW 19 57,935,646 (GRCm38) missense possibly damaging 0.47
R7432:Atrnl1 UTSW 19 57,755,524 (GRCm38) missense probably damaging 1.00
R7478:Atrnl1 UTSW 19 57,696,312 (GRCm38) missense possibly damaging 0.89
R7556:Atrnl1 UTSW 19 57,654,846 (GRCm38) missense probably benign
R7567:Atrnl1 UTSW 19 57,699,523 (GRCm38) missense probably damaging 0.98
R7608:Atrnl1 UTSW 19 57,714,687 (GRCm38) missense probably damaging 1.00
R7632:Atrnl1 UTSW 19 57,630,306 (GRCm38) missense probably damaging 1.00
R7655:Atrnl1 UTSW 19 57,611,379 (GRCm38) nonsense probably null
R7656:Atrnl1 UTSW 19 57,611,379 (GRCm38) nonsense probably null
R7718:Atrnl1 UTSW 19 57,740,183 (GRCm38) nonsense probably null
R7721:Atrnl1 UTSW 19 57,696,331 (GRCm38) missense probably benign 0.00
R7726:Atrnl1 UTSW 19 57,702,072 (GRCm38) missense probably damaging 1.00
R7733:Atrnl1 UTSW 19 57,701,988 (GRCm38) missense probably benign 0.00
R7774:Atrnl1 UTSW 19 57,699,671 (GRCm38) missense probably damaging 1.00
R8010:Atrnl1 UTSW 19 57,682,446 (GRCm38) missense probably benign 0.14
R8119:Atrnl1 UTSW 19 57,642,463 (GRCm38) missense probably benign 0.00
R9242:Atrnl1 UTSW 19 57,657,228 (GRCm38) missense probably benign 0.07
R9265:Atrnl1 UTSW 19 57,777,927 (GRCm38) missense probably benign 0.11
R9272:Atrnl1 UTSW 19 57,654,988 (GRCm38) missense probably benign 0.00
R9480:Atrnl1 UTSW 19 57,701,988 (GRCm38) missense possibly damaging 0.61
R9526:Atrnl1 UTSW 19 57,629,119 (GRCm38) missense probably damaging 0.99
R9672:Atrnl1 UTSW 19 57,630,263 (GRCm38) missense possibly damaging 0.87
R9673:Atrnl1 UTSW 19 57,611,354 (GRCm38) start codon destroyed probably null 0.04
RF021:Atrnl1 UTSW 19 57,642,473 (GRCm38) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGTCAGTTGAAACAGCCGTG -3'
(R):5'- TACCATTAAGGGAAGACACTATGG -3'

Sequencing Primer
(F):5'- CAGTTGAAACAGCCGTGCTTTATC -3'
(R):5'- CATTAAGGGAAGACACTATGGTTTAC -3'
Posted On 2015-12-29