Incidental Mutation 'R4770:Tut7'
ID 367438
Institutional Source Beutler Lab
Gene Symbol Tut7
Ensembl Gene ENSMUSG00000035248
Gene Name terminal uridylyl transferase 7
Synonyms Zcchc6, Tent3b, 6030448M23Rik
MMRRC Submission 042410-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.761) question?
Stock # R4770 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 59919690-59971060 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to G at 59920698 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000153175 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057115] [ENSMUST00000071703] [ENSMUST00000224480] [ENSMUST00000225850]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000057115
SMART Domains Protein: ENSMUSP00000054858
Gene: ENSMUSG00000044792

DomainStartEndE-ValueType
Pfam:Fe-S_biosyn 23 125 7.4e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000071703
SMART Domains Protein: ENSMUSP00000071623
Gene: ENSMUSG00000035248

DomainStartEndE-ValueType
low complexity region 15 27 N/A INTRINSIC
low complexity region 176 190 N/A INTRINSIC
ZnF_C2H2 244 268 2.61e1 SMART
SCOP:d1f5aa2 284 497 4e-25 SMART
low complexity region 522 534 N/A INTRINSIC
Pfam:PAP_assoc 550 603 6.7e-14 PFAM
low complexity region 811 825 N/A INTRINSIC
low complexity region 846 857 N/A INTRINSIC
low complexity region 882 898 N/A INTRINSIC
ZnF_C2HC 960 976 3.3e-3 SMART
Pfam:NTP_transf_2 1022 1134 4e-8 PFAM
Pfam:PAP_assoc 1229 1282 1.7e-17 PFAM
ZnF_C2HC 1342 1358 2.09e-3 SMART
Pfam:TUTF7_u4 1359 1446 1.6e-42 PFAM
ZnF_C2HC 1448 1464 1.06e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160628
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162450
Predicted Effect noncoding transcript
Transcript: ENSMUST00000163053
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224320
Predicted Effect probably benign
Transcript: ENSMUST00000224480
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224845
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224636
Predicted Effect probably benign
Transcript: ENSMUST00000225581
Predicted Effect probably benign
Transcript: ENSMUST00000225850
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225877
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225619
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225607
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.7%
Validation Efficiency 93% (89/96)
Allele List at MGI
Other mutations in this stock
Total: 83 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a A G 11: 109,962,341 (GRCm39) V503A possibly damaging Het
Agps T A 2: 75,722,199 (GRCm39) F463Y possibly damaging Het
Ajm1 G A 2: 25,469,759 (GRCm39) R51C possibly damaging Het
Amigo3 A T 9: 107,930,734 (GRCm39) L52F probably damaging Het
Anapc1 T C 2: 128,527,980 (GRCm39) probably benign Het
Ankrd36 G T 11: 5,540,870 (GRCm39) C312F possibly damaging Het
Asic2 A C 11: 80,862,318 (GRCm39) D226E probably benign Het
Atp8b2 T A 3: 89,864,374 (GRCm39) Q197L probably damaging Het
C2cd3 A G 7: 100,092,642 (GRCm39) Y495C probably damaging Het
Ccdc51 A G 9: 108,919,978 (GRCm39) T125A probably benign Het
Ccser1 A G 6: 61,288,485 (GRCm39) Y216C possibly damaging Het
Cimap1b A G 15: 89,263,326 (GRCm39) I19T probably damaging Het
Cntfr A T 4: 41,663,282 (GRCm39) I175N possibly damaging Het
Cox10 G A 11: 63,854,989 (GRCm39) R431W probably benign Het
Cubn T C 2: 13,319,578 (GRCm39) T2881A possibly damaging Het
Cyp2d9 T A 15: 82,336,774 (GRCm39) V41E probably damaging Het
Dmrtb1 C T 4: 107,540,986 (GRCm39) G125D probably benign Het
Dscaml1 C T 9: 45,581,404 (GRCm39) R408C probably damaging Het
Duox2 A T 2: 122,115,397 (GRCm39) S1052T probably benign Het
Ecm1 A G 3: 95,645,273 (GRCm39) probably benign Het
Edrf1 G T 7: 133,260,339 (GRCm39) M83I probably damaging Het
Epb41l1 T A 2: 156,371,344 (GRCm39) M727K probably benign Het
Exosc9 T C 3: 36,607,984 (GRCm39) V64A probably damaging Het
Ezh2 A T 6: 47,517,630 (GRCm39) I564N probably damaging Het
Fam89b C A 19: 5,779,482 (GRCm39) R25L probably damaging Het
Fgr C T 4: 132,714,602 (GRCm39) T98M probably damaging Het
Fhip2b T A 14: 70,825,727 (GRCm39) D351V probably damaging Het
Gapvd1 A G 2: 34,581,193 (GRCm39) S1089P probably damaging Het
Gbp5 A T 3: 142,213,837 (GRCm39) I544F possibly damaging Het
Gli2 C A 1: 118,910,318 (GRCm39) probably benign Het
Gm9934 A G 7: 92,702,192 (GRCm39) noncoding transcript Het
Greb1 A T 12: 16,731,357 (GRCm39) D1660E probably benign Het
Gtf2i T A 5: 134,272,414 (GRCm39) N750I possibly damaging Het
H2-DMb2 G C 17: 34,367,698 (GRCm39) D171H probably damaging Het
Il11ra1 A G 4: 41,768,187 (GRCm39) E366G probably damaging Het
Itga2b A G 11: 102,351,582 (GRCm39) F581S probably damaging Het
Itsn2 T A 12: 4,677,892 (GRCm39) M83K probably damaging Het
Kif27 G A 13: 58,492,191 (GRCm39) T316M probably damaging Het
Lad1 A T 1: 135,753,531 (GRCm39) Q26L probably damaging Het
Lrrn3 T A 12: 41,502,442 (GRCm39) H625L probably benign Het
Mast1 A G 8: 85,655,875 (GRCm39) V155A probably benign Het
Mast3 G A 8: 71,238,864 (GRCm39) T480M probably damaging Het
Mpc1 C T 17: 8,512,377 (GRCm39) probably benign Het
Mycbp2 T A 14: 103,457,380 (GRCm39) M1606L probably benign Het
Myo1c T A 11: 75,551,139 (GRCm39) L238* probably null Het
Nanog T G 6: 122,688,550 (GRCm39) S44A possibly damaging Het
Neb T C 2: 52,039,165 (GRCm39) Q6958R probably benign Het
Ngef C T 1: 87,405,283 (GRCm39) R709H probably damaging Het
Nr1d1 A G 11: 98,661,471 (GRCm39) V265A probably benign Het
Nr3c2 A G 8: 77,634,872 (GRCm39) probably null Het
Olfm5 A G 7: 103,809,685 (GRCm39) S164P probably benign Het
Parvb T C 15: 84,188,106 (GRCm39) probably null Het
Pde4dip G T 3: 97,674,400 (GRCm39) A172D probably damaging Het
Phf2 A G 13: 48,957,079 (GRCm39) L1096P probably damaging Het
Pik3r6 T A 11: 68,420,720 (GRCm39) V155E probably damaging Het
Pinx1 T G 14: 64,109,820 (GRCm39) V124G probably damaging Het
Poglut1 A G 16: 38,355,119 (GRCm39) Y236H probably damaging Het
Pou4f2 T A 8: 79,163,030 (GRCm39) M2L unknown Het
Ppfia2 G C 10: 106,597,978 (GRCm39) L180F probably damaging Het
Pramel26 C T 4: 143,538,519 (GRCm39) E151K probably damaging Het
Prkaca A G 8: 84,717,499 (GRCm39) N209S probably benign Het
Ring1 G A 17: 34,242,361 (GRCm39) P49S probably damaging Het
Rnf20 T A 4: 49,633,412 (GRCm39) probably null Het
Rnf25 G A 1: 74,633,099 (GRCm39) R418C probably damaging Het
Ryr1 G T 7: 28,808,707 (GRCm39) P462Q probably damaging Het
Serpinb3d A G 1: 107,006,008 (GRCm39) F360S probably damaging Het
Setd7 T C 3: 51,428,843 (GRCm39) E329G probably damaging Het
Slco2b1 C T 7: 99,320,156 (GRCm39) probably null Het
Snap91 G A 9: 86,655,654 (GRCm39) T844I possibly damaging Het
Snhg5 C T 9: 88,404,424 (GRCm39) noncoding transcript Het
Son T A 16: 91,455,756 (GRCm39) V1501E probably damaging Het
Syncrip T A 9: 88,361,905 (GRCm39) E70V probably damaging Het
Tas2r125 A G 6: 132,886,750 (GRCm39) D46G probably damaging Het
Tmem115 G A 9: 107,412,156 (GRCm39) R160Q probably benign Het
Trerf1 G A 17: 47,630,581 (GRCm39) noncoding transcript Het
Uggt2 A T 14: 119,266,466 (GRCm39) probably null Het
Ush2a G T 1: 188,282,076 (GRCm39) V1864F probably benign Het
Xkr4 A T 1: 3,286,714 (GRCm39) V492D probably damaging Het
Zfp646 T A 7: 127,482,649 (GRCm39) S1609T possibly damaging Het
Zfp65 A T 13: 67,856,477 (GRCm39) H277Q probably damaging Het
Zfp69 A G 4: 120,791,614 (GRCm39) S176P probably damaging Het
Zfp747 C T 7: 126,974,971 (GRCm39) A10T probably damaging Het
Zfp850 T C 7: 27,684,411 (GRCm39) probably null Het
Other mutations in Tut7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Tut7 APN 13 59,964,512 (GRCm39) missense probably damaging 1.00
IGL01361:Tut7 APN 13 59,933,614 (GRCm39) missense probably damaging 1.00
IGL02002:Tut7 APN 13 59,929,910 (GRCm39) missense possibly damaging 0.76
IGL02015:Tut7 APN 13 59,937,072 (GRCm39) missense probably damaging 1.00
IGL02029:Tut7 APN 13 59,932,702 (GRCm39) unclassified probably benign
IGL02216:Tut7 APN 13 59,948,237 (GRCm39) missense probably benign 0.01
IGL02705:Tut7 APN 13 59,937,017 (GRCm39) missense probably damaging 1.00
IGL02742:Tut7 APN 13 59,964,156 (GRCm39) missense probably damaging 0.99
IGL02810:Tut7 APN 13 59,929,830 (GRCm39) critical splice donor site probably null
IGL02942:Tut7 APN 13 59,959,335 (GRCm39) missense probably damaging 0.98
IGL03104:Tut7 APN 13 59,962,717 (GRCm39) missense probably benign 0.04
R0025:Tut7 UTSW 13 59,953,142 (GRCm39) missense probably benign 0.08
R0025:Tut7 UTSW 13 59,953,142 (GRCm39) missense probably benign 0.08
R0153:Tut7 UTSW 13 59,930,150 (GRCm39) nonsense probably null
R0269:Tut7 UTSW 13 59,964,669 (GRCm39) splice site probably null
R0358:Tut7 UTSW 13 59,929,918 (GRCm39) missense probably damaging 0.99
R0555:Tut7 UTSW 13 59,948,131 (GRCm39) missense probably benign 0.00
R0599:Tut7 UTSW 13 59,957,301 (GRCm39) missense probably damaging 1.00
R0609:Tut7 UTSW 13 59,947,596 (GRCm39) nonsense probably null
R0617:Tut7 UTSW 13 59,964,669 (GRCm39) splice site probably null
R0680:Tut7 UTSW 13 59,948,413 (GRCm39) missense possibly damaging 0.79
R0699:Tut7 UTSW 13 59,929,828 (GRCm39) splice site probably benign
R1214:Tut7 UTSW 13 59,953,140 (GRCm39) missense possibly damaging 0.76
R1271:Tut7 UTSW 13 59,969,669 (GRCm39) missense probably damaging 0.99
R1556:Tut7 UTSW 13 59,948,054 (GRCm39) missense probably benign 0.02
R1662:Tut7 UTSW 13 59,947,717 (GRCm39) missense possibly damaging 0.93
R1777:Tut7 UTSW 13 59,939,635 (GRCm39) missense probably damaging 1.00
R1834:Tut7 UTSW 13 59,962,749 (GRCm39) nonsense probably null
R1928:Tut7 UTSW 13 59,964,548 (GRCm39) missense probably damaging 1.00
R2012:Tut7 UTSW 13 59,959,352 (GRCm39) missense probably damaging 0.99
R2045:Tut7 UTSW 13 59,948,470 (GRCm39) missense probably damaging 1.00
R2336:Tut7 UTSW 13 59,946,868 (GRCm39) missense probably damaging 1.00
R3764:Tut7 UTSW 13 59,948,194 (GRCm39) missense probably damaging 0.98
R3899:Tut7 UTSW 13 59,937,069 (GRCm39) nonsense probably null
R3918:Tut7 UTSW 13 59,929,838 (GRCm39) missense probably damaging 1.00
R4423:Tut7 UTSW 13 59,969,863 (GRCm39) missense probably damaging 0.96
R4664:Tut7 UTSW 13 59,948,413 (GRCm39) missense possibly damaging 0.79
R4673:Tut7 UTSW 13 59,944,659 (GRCm39) missense probably damaging 1.00
R4884:Tut7 UTSW 13 59,937,266 (GRCm39) missense probably damaging 1.00
R5186:Tut7 UTSW 13 59,964,470 (GRCm39) critical splice donor site probably null
R5337:Tut7 UTSW 13 59,939,666 (GRCm39) missense probably damaging 1.00
R5385:Tut7 UTSW 13 59,937,660 (GRCm39) critical splice donor site probably null
R5452:Tut7 UTSW 13 59,948,471 (GRCm39) missense probably damaging 1.00
R5534:Tut7 UTSW 13 59,936,367 (GRCm39) missense probably damaging 1.00
R5566:Tut7 UTSW 13 59,936,443 (GRCm39) nonsense probably null
R5928:Tut7 UTSW 13 59,969,880 (GRCm39) missense probably benign 0.16
R5994:Tut7 UTSW 13 59,937,023 (GRCm39) missense probably damaging 1.00
R6415:Tut7 UTSW 13 59,964,110 (GRCm39) splice site probably null
R6495:Tut7 UTSW 13 59,947,753 (GRCm39) missense possibly damaging 0.95
R6577:Tut7 UTSW 13 59,955,975 (GRCm39) missense probably damaging 1.00
R7205:Tut7 UTSW 13 59,936,364 (GRCm39) missense probably damaging 1.00
R7286:Tut7 UTSW 13 59,969,463 (GRCm39) missense probably benign 0.18
R7355:Tut7 UTSW 13 59,969,616 (GRCm39) missense probably benign 0.00
R7369:Tut7 UTSW 13 59,929,867 (GRCm39) missense possibly damaging 0.71
R7455:Tut7 UTSW 13 59,969,871 (GRCm39) missense probably benign 0.03
R7557:Tut7 UTSW 13 59,936,280 (GRCm39) missense possibly damaging 0.89
R7635:Tut7 UTSW 13 59,947,904 (GRCm39) missense probably benign 0.03
R7727:Tut7 UTSW 13 59,947,496 (GRCm39) missense probably benign 0.00
R7798:Tut7 UTSW 13 59,963,389 (GRCm39) missense possibly damaging 0.81
R7912:Tut7 UTSW 13 59,946,819 (GRCm39) missense probably damaging 1.00
R7915:Tut7 UTSW 13 59,932,628 (GRCm39) missense probably benign 0.12
R8035:Tut7 UTSW 13 59,937,004 (GRCm39) missense probably benign 0.00
R8531:Tut7 UTSW 13 59,937,074 (GRCm39) missense probably damaging 1.00
R8777:Tut7 UTSW 13 59,933,597 (GRCm39) missense probably benign 0.15
R8777-TAIL:Tut7 UTSW 13 59,933,597 (GRCm39) missense probably benign 0.15
R8850:Tut7 UTSW 13 59,937,011 (GRCm39) missense possibly damaging 0.83
R8929:Tut7 UTSW 13 59,947,942 (GRCm39) missense probably benign
R9254:Tut7 UTSW 13 59,936,288 (GRCm39) missense possibly damaging 0.48
R9313:Tut7 UTSW 13 59,947,798 (GRCm39) missense probably benign 0.01
R9373:Tut7 UTSW 13 59,944,681 (GRCm39) missense probably damaging 1.00
R9379:Tut7 UTSW 13 59,936,288 (GRCm39) missense possibly damaging 0.48
R9404:Tut7 UTSW 13 59,947,701 (GRCm39) missense probably benign 0.00
R9461:Tut7 UTSW 13 59,963,512 (GRCm39) missense probably damaging 1.00
R9462:Tut7 UTSW 13 59,929,957 (GRCm39) missense possibly damaging 0.89
R9661:Tut7 UTSW 13 59,937,332 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGATCTGTGTCACTGTGTCC -3'
(R):5'- CTGTGGCTGCATTGAACAG -3'

Sequencing Primer
(F):5'- ACTGTGTCCTGTGCCATGAAC -3'
(R):5'- TGTACCTTACCAGCACTGAGG -3'
Posted On 2015-12-29