Incidental Mutation 'R4770:Tut7'
ID |
367438 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Tut7
|
Ensembl Gene |
ENSMUSG00000035248 |
Gene Name |
terminal uridylyl transferase 7 |
Synonyms |
Zcchc6, Tent3b, 6030448M23Rik |
MMRRC Submission |
042410-MU
|
Accession Numbers |
|
Essential gene? |
Probably essential
(E-score: 0.761)
|
Stock # |
R4770 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
13 |
Chromosomal Location |
59919690-59971060 bp(-) (GRCm39) |
Type of Mutation |
unclassified |
DNA Base Change (assembly) |
A to G
at 59920698 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000153175
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000057115]
[ENSMUST00000071703]
[ENSMUST00000224480]
[ENSMUST00000225850]
|
AlphaFold |
no structure available at present |
Predicted Effect |
probably benign
Transcript: ENSMUST00000057115
|
SMART Domains |
Protein: ENSMUSP00000054858 Gene: ENSMUSG00000044792
Domain | Start | End | E-Value | Type |
Pfam:Fe-S_biosyn
|
23 |
125 |
7.4e-23 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000071703
|
SMART Domains |
Protein: ENSMUSP00000071623 Gene: ENSMUSG00000035248
Domain | Start | End | E-Value | Type |
low complexity region
|
15 |
27 |
N/A |
INTRINSIC |
low complexity region
|
176 |
190 |
N/A |
INTRINSIC |
ZnF_C2H2
|
244 |
268 |
2.61e1 |
SMART |
SCOP:d1f5aa2
|
284 |
497 |
4e-25 |
SMART |
low complexity region
|
522 |
534 |
N/A |
INTRINSIC |
Pfam:PAP_assoc
|
550 |
603 |
6.7e-14 |
PFAM |
low complexity region
|
811 |
825 |
N/A |
INTRINSIC |
low complexity region
|
846 |
857 |
N/A |
INTRINSIC |
low complexity region
|
882 |
898 |
N/A |
INTRINSIC |
ZnF_C2HC
|
960 |
976 |
3.3e-3 |
SMART |
Pfam:NTP_transf_2
|
1022 |
1134 |
4e-8 |
PFAM |
Pfam:PAP_assoc
|
1229 |
1282 |
1.7e-17 |
PFAM |
ZnF_C2HC
|
1342 |
1358 |
2.09e-3 |
SMART |
Pfam:TUTF7_u4
|
1359 |
1446 |
1.6e-42 |
PFAM |
ZnF_C2HC
|
1448 |
1464 |
1.06e-4 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000160628
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162450
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000163053
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000224320
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000224480
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000224845
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000224636
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000225581
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000225850
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000225877
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000225619
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000225607
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.7%
|
Validation Efficiency |
93% (89/96) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 83 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abca8a |
A |
G |
11: 109,962,341 (GRCm39) |
V503A |
possibly damaging |
Het |
Agps |
T |
A |
2: 75,722,199 (GRCm39) |
F463Y |
possibly damaging |
Het |
Ajm1 |
G |
A |
2: 25,469,759 (GRCm39) |
R51C |
possibly damaging |
Het |
Amigo3 |
A |
T |
9: 107,930,734 (GRCm39) |
L52F |
probably damaging |
Het |
Anapc1 |
T |
C |
2: 128,527,980 (GRCm39) |
|
probably benign |
Het |
Ankrd36 |
G |
T |
11: 5,540,870 (GRCm39) |
C312F |
possibly damaging |
Het |
Asic2 |
A |
C |
11: 80,862,318 (GRCm39) |
D226E |
probably benign |
Het |
Atp8b2 |
T |
A |
3: 89,864,374 (GRCm39) |
Q197L |
probably damaging |
Het |
C2cd3 |
A |
G |
7: 100,092,642 (GRCm39) |
Y495C |
probably damaging |
Het |
Ccdc51 |
A |
G |
9: 108,919,978 (GRCm39) |
T125A |
probably benign |
Het |
Ccser1 |
A |
G |
6: 61,288,485 (GRCm39) |
Y216C |
possibly damaging |
Het |
Cimap1b |
A |
G |
15: 89,263,326 (GRCm39) |
I19T |
probably damaging |
Het |
Cntfr |
A |
T |
4: 41,663,282 (GRCm39) |
I175N |
possibly damaging |
Het |
Cox10 |
G |
A |
11: 63,854,989 (GRCm39) |
R431W |
probably benign |
Het |
Cubn |
T |
C |
2: 13,319,578 (GRCm39) |
T2881A |
possibly damaging |
Het |
Cyp2d9 |
T |
A |
15: 82,336,774 (GRCm39) |
V41E |
probably damaging |
Het |
Dmrtb1 |
C |
T |
4: 107,540,986 (GRCm39) |
G125D |
probably benign |
Het |
Dscaml1 |
C |
T |
9: 45,581,404 (GRCm39) |
R408C |
probably damaging |
Het |
Duox2 |
A |
T |
2: 122,115,397 (GRCm39) |
S1052T |
probably benign |
Het |
Ecm1 |
A |
G |
3: 95,645,273 (GRCm39) |
|
probably benign |
Het |
Edrf1 |
G |
T |
7: 133,260,339 (GRCm39) |
M83I |
probably damaging |
Het |
Epb41l1 |
T |
A |
2: 156,371,344 (GRCm39) |
M727K |
probably benign |
Het |
Exosc9 |
T |
C |
3: 36,607,984 (GRCm39) |
V64A |
probably damaging |
Het |
Ezh2 |
A |
T |
6: 47,517,630 (GRCm39) |
I564N |
probably damaging |
Het |
Fam89b |
C |
A |
19: 5,779,482 (GRCm39) |
R25L |
probably damaging |
Het |
Fgr |
C |
T |
4: 132,714,602 (GRCm39) |
T98M |
probably damaging |
Het |
Fhip2b |
T |
A |
14: 70,825,727 (GRCm39) |
D351V |
probably damaging |
Het |
Gapvd1 |
A |
G |
2: 34,581,193 (GRCm39) |
S1089P |
probably damaging |
Het |
Gbp5 |
A |
T |
3: 142,213,837 (GRCm39) |
I544F |
possibly damaging |
Het |
Gli2 |
C |
A |
1: 118,910,318 (GRCm39) |
|
probably benign |
Het |
Gm9934 |
A |
G |
7: 92,702,192 (GRCm39) |
|
noncoding transcript |
Het |
Greb1 |
A |
T |
12: 16,731,357 (GRCm39) |
D1660E |
probably benign |
Het |
Gtf2i |
T |
A |
5: 134,272,414 (GRCm39) |
N750I |
possibly damaging |
Het |
H2-DMb2 |
G |
C |
17: 34,367,698 (GRCm39) |
D171H |
probably damaging |
Het |
Il11ra1 |
A |
G |
4: 41,768,187 (GRCm39) |
E366G |
probably damaging |
Het |
Itga2b |
A |
G |
11: 102,351,582 (GRCm39) |
F581S |
probably damaging |
Het |
Itsn2 |
T |
A |
12: 4,677,892 (GRCm39) |
M83K |
probably damaging |
Het |
Kif27 |
G |
A |
13: 58,492,191 (GRCm39) |
T316M |
probably damaging |
Het |
Lad1 |
A |
T |
1: 135,753,531 (GRCm39) |
Q26L |
probably damaging |
Het |
Lrrn3 |
T |
A |
12: 41,502,442 (GRCm39) |
H625L |
probably benign |
Het |
Mast1 |
A |
G |
8: 85,655,875 (GRCm39) |
V155A |
probably benign |
Het |
Mast3 |
G |
A |
8: 71,238,864 (GRCm39) |
T480M |
probably damaging |
Het |
Mpc1 |
C |
T |
17: 8,512,377 (GRCm39) |
|
probably benign |
Het |
Mycbp2 |
T |
A |
14: 103,457,380 (GRCm39) |
M1606L |
probably benign |
Het |
Myo1c |
T |
A |
11: 75,551,139 (GRCm39) |
L238* |
probably null |
Het |
Nanog |
T |
G |
6: 122,688,550 (GRCm39) |
S44A |
possibly damaging |
Het |
Neb |
T |
C |
2: 52,039,165 (GRCm39) |
Q6958R |
probably benign |
Het |
Ngef |
C |
T |
1: 87,405,283 (GRCm39) |
R709H |
probably damaging |
Het |
Nr1d1 |
A |
G |
11: 98,661,471 (GRCm39) |
V265A |
probably benign |
Het |
Nr3c2 |
A |
G |
8: 77,634,872 (GRCm39) |
|
probably null |
Het |
Olfm5 |
A |
G |
7: 103,809,685 (GRCm39) |
S164P |
probably benign |
Het |
Parvb |
T |
C |
15: 84,188,106 (GRCm39) |
|
probably null |
Het |
Pde4dip |
G |
T |
3: 97,674,400 (GRCm39) |
A172D |
probably damaging |
Het |
Phf2 |
A |
G |
13: 48,957,079 (GRCm39) |
L1096P |
probably damaging |
Het |
Pik3r6 |
T |
A |
11: 68,420,720 (GRCm39) |
V155E |
probably damaging |
Het |
Pinx1 |
T |
G |
14: 64,109,820 (GRCm39) |
V124G |
probably damaging |
Het |
Poglut1 |
A |
G |
16: 38,355,119 (GRCm39) |
Y236H |
probably damaging |
Het |
Pou4f2 |
T |
A |
8: 79,163,030 (GRCm39) |
M2L |
unknown |
Het |
Ppfia2 |
G |
C |
10: 106,597,978 (GRCm39) |
L180F |
probably damaging |
Het |
Pramel26 |
C |
T |
4: 143,538,519 (GRCm39) |
E151K |
probably damaging |
Het |
Prkaca |
A |
G |
8: 84,717,499 (GRCm39) |
N209S |
probably benign |
Het |
Ring1 |
G |
A |
17: 34,242,361 (GRCm39) |
P49S |
probably damaging |
Het |
Rnf20 |
T |
A |
4: 49,633,412 (GRCm39) |
|
probably null |
Het |
Rnf25 |
G |
A |
1: 74,633,099 (GRCm39) |
R418C |
probably damaging |
Het |
Ryr1 |
G |
T |
7: 28,808,707 (GRCm39) |
P462Q |
probably damaging |
Het |
Serpinb3d |
A |
G |
1: 107,006,008 (GRCm39) |
F360S |
probably damaging |
Het |
Setd7 |
T |
C |
3: 51,428,843 (GRCm39) |
E329G |
probably damaging |
Het |
Slco2b1 |
C |
T |
7: 99,320,156 (GRCm39) |
|
probably null |
Het |
Snap91 |
G |
A |
9: 86,655,654 (GRCm39) |
T844I |
possibly damaging |
Het |
Snhg5 |
C |
T |
9: 88,404,424 (GRCm39) |
|
noncoding transcript |
Het |
Son |
T |
A |
16: 91,455,756 (GRCm39) |
V1501E |
probably damaging |
Het |
Syncrip |
T |
A |
9: 88,361,905 (GRCm39) |
E70V |
probably damaging |
Het |
Tas2r125 |
A |
G |
6: 132,886,750 (GRCm39) |
D46G |
probably damaging |
Het |
Tmem115 |
G |
A |
9: 107,412,156 (GRCm39) |
R160Q |
probably benign |
Het |
Trerf1 |
G |
A |
17: 47,630,581 (GRCm39) |
|
noncoding transcript |
Het |
Uggt2 |
A |
T |
14: 119,266,466 (GRCm39) |
|
probably null |
Het |
Ush2a |
G |
T |
1: 188,282,076 (GRCm39) |
V1864F |
probably benign |
Het |
Xkr4 |
A |
T |
1: 3,286,714 (GRCm39) |
V492D |
probably damaging |
Het |
Zfp646 |
T |
A |
7: 127,482,649 (GRCm39) |
S1609T |
possibly damaging |
Het |
Zfp65 |
A |
T |
13: 67,856,477 (GRCm39) |
H277Q |
probably damaging |
Het |
Zfp69 |
A |
G |
4: 120,791,614 (GRCm39) |
S176P |
probably damaging |
Het |
Zfp747 |
C |
T |
7: 126,974,971 (GRCm39) |
A10T |
probably damaging |
Het |
Zfp850 |
T |
C |
7: 27,684,411 (GRCm39) |
|
probably null |
Het |
|
Other mutations in Tut7 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00088:Tut7
|
APN |
13 |
59,964,512 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01361:Tut7
|
APN |
13 |
59,933,614 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02002:Tut7
|
APN |
13 |
59,929,910 (GRCm39) |
missense |
possibly damaging |
0.76 |
IGL02015:Tut7
|
APN |
13 |
59,937,072 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02029:Tut7
|
APN |
13 |
59,932,702 (GRCm39) |
unclassified |
probably benign |
|
IGL02216:Tut7
|
APN |
13 |
59,948,237 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02705:Tut7
|
APN |
13 |
59,937,017 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02742:Tut7
|
APN |
13 |
59,964,156 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02810:Tut7
|
APN |
13 |
59,929,830 (GRCm39) |
critical splice donor site |
probably null |
|
IGL02942:Tut7
|
APN |
13 |
59,959,335 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL03104:Tut7
|
APN |
13 |
59,962,717 (GRCm39) |
missense |
probably benign |
0.04 |
R0025:Tut7
|
UTSW |
13 |
59,953,142 (GRCm39) |
missense |
probably benign |
0.08 |
R0025:Tut7
|
UTSW |
13 |
59,953,142 (GRCm39) |
missense |
probably benign |
0.08 |
R0153:Tut7
|
UTSW |
13 |
59,930,150 (GRCm39) |
nonsense |
probably null |
|
R0269:Tut7
|
UTSW |
13 |
59,964,669 (GRCm39) |
splice site |
probably null |
|
R0358:Tut7
|
UTSW |
13 |
59,929,918 (GRCm39) |
missense |
probably damaging |
0.99 |
R0555:Tut7
|
UTSW |
13 |
59,948,131 (GRCm39) |
missense |
probably benign |
0.00 |
R0599:Tut7
|
UTSW |
13 |
59,957,301 (GRCm39) |
missense |
probably damaging |
1.00 |
R0609:Tut7
|
UTSW |
13 |
59,947,596 (GRCm39) |
nonsense |
probably null |
|
R0617:Tut7
|
UTSW |
13 |
59,964,669 (GRCm39) |
splice site |
probably null |
|
R0680:Tut7
|
UTSW |
13 |
59,948,413 (GRCm39) |
missense |
possibly damaging |
0.79 |
R0699:Tut7
|
UTSW |
13 |
59,929,828 (GRCm39) |
splice site |
probably benign |
|
R1214:Tut7
|
UTSW |
13 |
59,953,140 (GRCm39) |
missense |
possibly damaging |
0.76 |
R1271:Tut7
|
UTSW |
13 |
59,969,669 (GRCm39) |
missense |
probably damaging |
0.99 |
R1556:Tut7
|
UTSW |
13 |
59,948,054 (GRCm39) |
missense |
probably benign |
0.02 |
R1662:Tut7
|
UTSW |
13 |
59,947,717 (GRCm39) |
missense |
possibly damaging |
0.93 |
R1777:Tut7
|
UTSW |
13 |
59,939,635 (GRCm39) |
missense |
probably damaging |
1.00 |
R1834:Tut7
|
UTSW |
13 |
59,962,749 (GRCm39) |
nonsense |
probably null |
|
R1928:Tut7
|
UTSW |
13 |
59,964,548 (GRCm39) |
missense |
probably damaging |
1.00 |
R2012:Tut7
|
UTSW |
13 |
59,959,352 (GRCm39) |
missense |
probably damaging |
0.99 |
R2045:Tut7
|
UTSW |
13 |
59,948,470 (GRCm39) |
missense |
probably damaging |
1.00 |
R2336:Tut7
|
UTSW |
13 |
59,946,868 (GRCm39) |
missense |
probably damaging |
1.00 |
R3764:Tut7
|
UTSW |
13 |
59,948,194 (GRCm39) |
missense |
probably damaging |
0.98 |
R3899:Tut7
|
UTSW |
13 |
59,937,069 (GRCm39) |
nonsense |
probably null |
|
R3918:Tut7
|
UTSW |
13 |
59,929,838 (GRCm39) |
missense |
probably damaging |
1.00 |
R4423:Tut7
|
UTSW |
13 |
59,969,863 (GRCm39) |
missense |
probably damaging |
0.96 |
R4664:Tut7
|
UTSW |
13 |
59,948,413 (GRCm39) |
missense |
possibly damaging |
0.79 |
R4673:Tut7
|
UTSW |
13 |
59,944,659 (GRCm39) |
missense |
probably damaging |
1.00 |
R4884:Tut7
|
UTSW |
13 |
59,937,266 (GRCm39) |
missense |
probably damaging |
1.00 |
R5186:Tut7
|
UTSW |
13 |
59,964,470 (GRCm39) |
critical splice donor site |
probably null |
|
R5337:Tut7
|
UTSW |
13 |
59,939,666 (GRCm39) |
missense |
probably damaging |
1.00 |
R5385:Tut7
|
UTSW |
13 |
59,937,660 (GRCm39) |
critical splice donor site |
probably null |
|
R5452:Tut7
|
UTSW |
13 |
59,948,471 (GRCm39) |
missense |
probably damaging |
1.00 |
R5534:Tut7
|
UTSW |
13 |
59,936,367 (GRCm39) |
missense |
probably damaging |
1.00 |
R5566:Tut7
|
UTSW |
13 |
59,936,443 (GRCm39) |
nonsense |
probably null |
|
R5928:Tut7
|
UTSW |
13 |
59,969,880 (GRCm39) |
missense |
probably benign |
0.16 |
R5994:Tut7
|
UTSW |
13 |
59,937,023 (GRCm39) |
missense |
probably damaging |
1.00 |
R6415:Tut7
|
UTSW |
13 |
59,964,110 (GRCm39) |
splice site |
probably null |
|
R6495:Tut7
|
UTSW |
13 |
59,947,753 (GRCm39) |
missense |
possibly damaging |
0.95 |
R6577:Tut7
|
UTSW |
13 |
59,955,975 (GRCm39) |
missense |
probably damaging |
1.00 |
R7205:Tut7
|
UTSW |
13 |
59,936,364 (GRCm39) |
missense |
probably damaging |
1.00 |
R7286:Tut7
|
UTSW |
13 |
59,969,463 (GRCm39) |
missense |
probably benign |
0.18 |
R7355:Tut7
|
UTSW |
13 |
59,969,616 (GRCm39) |
missense |
probably benign |
0.00 |
R7369:Tut7
|
UTSW |
13 |
59,929,867 (GRCm39) |
missense |
possibly damaging |
0.71 |
R7455:Tut7
|
UTSW |
13 |
59,969,871 (GRCm39) |
missense |
probably benign |
0.03 |
R7557:Tut7
|
UTSW |
13 |
59,936,280 (GRCm39) |
missense |
possibly damaging |
0.89 |
R7635:Tut7
|
UTSW |
13 |
59,947,904 (GRCm39) |
missense |
probably benign |
0.03 |
R7727:Tut7
|
UTSW |
13 |
59,947,496 (GRCm39) |
missense |
probably benign |
0.00 |
R7798:Tut7
|
UTSW |
13 |
59,963,389 (GRCm39) |
missense |
possibly damaging |
0.81 |
R7912:Tut7
|
UTSW |
13 |
59,946,819 (GRCm39) |
missense |
probably damaging |
1.00 |
R7915:Tut7
|
UTSW |
13 |
59,932,628 (GRCm39) |
missense |
probably benign |
0.12 |
R8035:Tut7
|
UTSW |
13 |
59,937,004 (GRCm39) |
missense |
probably benign |
0.00 |
R8531:Tut7
|
UTSW |
13 |
59,937,074 (GRCm39) |
missense |
probably damaging |
1.00 |
R8777:Tut7
|
UTSW |
13 |
59,933,597 (GRCm39) |
missense |
probably benign |
0.15 |
R8777-TAIL:Tut7
|
UTSW |
13 |
59,933,597 (GRCm39) |
missense |
probably benign |
0.15 |
R8850:Tut7
|
UTSW |
13 |
59,937,011 (GRCm39) |
missense |
possibly damaging |
0.83 |
R8929:Tut7
|
UTSW |
13 |
59,947,942 (GRCm39) |
missense |
probably benign |
|
R9254:Tut7
|
UTSW |
13 |
59,936,288 (GRCm39) |
missense |
possibly damaging |
0.48 |
R9313:Tut7
|
UTSW |
13 |
59,947,798 (GRCm39) |
missense |
probably benign |
0.01 |
R9373:Tut7
|
UTSW |
13 |
59,944,681 (GRCm39) |
missense |
probably damaging |
1.00 |
R9379:Tut7
|
UTSW |
13 |
59,936,288 (GRCm39) |
missense |
possibly damaging |
0.48 |
R9404:Tut7
|
UTSW |
13 |
59,947,701 (GRCm39) |
missense |
probably benign |
0.00 |
R9461:Tut7
|
UTSW |
13 |
59,963,512 (GRCm39) |
missense |
probably damaging |
1.00 |
R9462:Tut7
|
UTSW |
13 |
59,929,957 (GRCm39) |
missense |
possibly damaging |
0.89 |
R9661:Tut7
|
UTSW |
13 |
59,937,332 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- TGATCTGTGTCACTGTGTCC -3'
(R):5'- CTGTGGCTGCATTGAACAG -3'
Sequencing Primer
(F):5'- ACTGTGTCCTGTGCCATGAAC -3'
(R):5'- TGTACCTTACCAGCACTGAGG -3'
|
Posted On |
2015-12-29 |