Incidental Mutation 'R4772:Tnik'
| ID |
367587 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tnik
|
| Ensembl Gene |
ENSMUSG00000027692 |
| Gene Name |
TRAF2 and NCK interacting kinase |
| Synonyms |
C530008O15Rik, 4831440I19Rik, 1500031A17Rik, C630040K21Rik |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4772 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
28317362-28724734 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 28661359 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Serine
at position 587
(T587S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124011
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000159236]
[ENSMUST00000159308]
[ENSMUST00000159680]
[ENSMUST00000160307]
[ENSMUST00000160518]
[ENSMUST00000160934]
[ENSMUST00000161964]
[ENSMUST00000162777]
[ENSMUST00000162485]
|
| AlphaFold |
P83510 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159236
AA Change: T587S
PolyPhen 2
Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
|
| SMART Domains |
Protein: ENSMUSP00000124681
Gene: ENSMUSG00000027692
AA Change: T587S
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
793 |
812 |
N/A |
INTRINSIC |
|
low complexity region
|
951 |
958 |
N/A |
INTRINSIC |
|
CNH
|
1005 |
1303 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159308
AA Change: T532S
PolyPhen 2
Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
|
| SMART Domains |
Protein: ENSMUSP00000125466
Gene: ENSMUSG00000027692
AA Change: T532S
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
|
low complexity region
|
746 |
765 |
N/A |
INTRINSIC |
|
low complexity region
|
904 |
911 |
N/A |
INTRINSIC |
|
CNH
|
958 |
1256 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159680
AA Change: T616S
PolyPhen 2
Score 0.081 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000124876
Gene: ENSMUSG00000027692
AA Change: T616S
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
755 |
N/A |
INTRINSIC |
|
low complexity region
|
822 |
841 |
N/A |
INTRINSIC |
|
low complexity region
|
980 |
987 |
N/A |
INTRINSIC |
|
CNH
|
1034 |
1332 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160307
AA Change: T616S
PolyPhen 2
Score 0.042 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000125081
Gene: ENSMUSG00000027692
AA Change: T616S
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
755 |
N/A |
INTRINSIC |
|
low complexity region
|
830 |
849 |
N/A |
INTRINSIC |
|
low complexity region
|
988 |
995 |
N/A |
INTRINSIC |
|
CNH
|
1042 |
1340 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160518
AA Change: T587S
PolyPhen 2
Score 0.086 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000124011
Gene: ENSMUSG00000027692
AA Change: T587S
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
5.9e-99 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
801 |
820 |
N/A |
INTRINSIC |
|
low complexity region
|
959 |
966 |
N/A |
INTRINSIC |
|
CNH
|
1013 |
1311 |
9.3e-120 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160934
|
| SMART Domains |
Protein: ENSMUSP00000123859
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase_Tyr
|
25 |
212 |
2.2e-37 |
PFAM |
|
Pfam:Pkinase
|
25 |
219 |
5.9e-52 |
PFAM |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000161964
AA Change: T532S
|
| SMART Domains |
Protein: ENSMUSP00000125411
Gene: ENSMUSG00000027692
AA Change: T532S
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
|
low complexity region
|
738 |
757 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
903 |
N/A |
INTRINSIC |
|
CNH
|
950 |
1248 |
1.92e-117 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000162777
AA Change: T561S
|
| SMART Domains |
Protein: ENSMUSP00000124726
Gene: ENSMUSG00000027692
AA Change: T561S
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
|
low complexity region
|
767 |
786 |
N/A |
INTRINSIC |
|
low complexity region
|
925 |
932 |
N/A |
INTRINSIC |
|
CNH
|
979 |
1277 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000162485
AA Change: T561S
PolyPhen 2
Score 0.076 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000124387
Gene: ENSMUSG00000027692
AA Change: T561S
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
|
low complexity region
|
775 |
794 |
N/A |
INTRINSIC |
|
low complexity region
|
933 |
940 |
N/A |
INTRINSIC |
|
CNH
|
987 |
1285 |
1.92e-117 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162037
|
| Meta Mutation Damage Score |
0.0606 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.1%
|
| Validation Efficiency |
95% (74/78) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired postsynaptic signaling and cognitive function. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 74 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca13 |
T |
A |
11: 9,265,339 (GRCm39) |
|
probably null |
Het |
| Adamts19 |
A |
G |
18: 58,970,848 (GRCm39) |
Q144R |
possibly damaging |
Het |
| Adgrb3 |
C |
A |
1: 25,570,956 (GRCm39) |
C507F |
probably damaging |
Het |
| Atg9b |
T |
C |
5: 24,590,237 (GRCm39) |
*923W |
probably null |
Het |
| Atp13a4 |
T |
C |
16: 29,239,653 (GRCm39) |
|
probably benign |
Het |
| Baz2b |
G |
T |
2: 59,788,795 (GRCm39) |
R697S |
probably damaging |
Het |
| Bicdl1 |
A |
G |
5: 115,799,537 (GRCm39) |
I184T |
probably benign |
Het |
| Bpifb4 |
C |
T |
2: 153,784,903 (GRCm39) |
L204F |
possibly damaging |
Het |
| Cep120 |
C |
T |
18: 53,851,561 (GRCm39) |
R577Q |
probably damaging |
Het |
| Cplx4 |
T |
C |
18: 66,103,048 (GRCm39) |
E24G |
possibly damaging |
Het |
| Dcxr |
T |
C |
11: 120,616,923 (GRCm39) |
T147A |
probably benign |
Het |
| Dnajc10 |
C |
A |
2: 80,170,870 (GRCm39) |
H454N |
probably damaging |
Het |
| Dsp |
G |
T |
13: 38,351,504 (GRCm39) |
G108* |
probably null |
Het |
| Entpd6 |
T |
A |
2: 150,609,014 (GRCm39) |
I366K |
probably damaging |
Het |
| Fam111a |
A |
G |
19: 12,565,057 (GRCm39) |
K269E |
probably benign |
Het |
| Grid2ip |
T |
G |
5: 143,361,455 (GRCm39) |
V222G |
possibly damaging |
Het |
| Hmcn2 |
T |
G |
2: 31,335,326 (GRCm39) |
V4421G |
probably benign |
Het |
| Ifi207 |
T |
C |
1: 173,555,253 (GRCm39) |
T817A |
probably damaging |
Het |
| Irak2 |
A |
T |
6: 113,670,683 (GRCm39) |
E533V |
probably damaging |
Het |
| Katnip |
A |
G |
7: 125,464,523 (GRCm39) |
S1297G |
probably damaging |
Het |
| Kbtbd6 |
T |
C |
14: 79,689,596 (GRCm39) |
F97S |
probably damaging |
Het |
| Kctd14 |
A |
T |
7: 97,106,883 (GRCm39) |
E99V |
probably damaging |
Het |
| Klhl10 |
A |
T |
11: 100,338,557 (GRCm39) |
Y432F |
probably benign |
Het |
| Lrrc49 |
T |
C |
9: 60,592,335 (GRCm39) |
N53S |
possibly damaging |
Het |
| Mief2 |
T |
A |
11: 60,621,288 (GRCm39) |
|
probably benign |
Het |
| Mog |
A |
T |
17: 37,334,049 (GRCm39) |
S15T |
unknown |
Het |
| Mpi |
T |
C |
9: 57,452,181 (GRCm39) |
D365G |
probably damaging |
Het |
| Mpp7 |
A |
G |
18: 7,379,983 (GRCm39) |
|
probably null |
Het |
| Nes |
A |
G |
3: 87,883,486 (GRCm39) |
T582A |
probably benign |
Het |
| Nlrp14 |
A |
G |
7: 106,780,393 (GRCm39) |
D5G |
probably benign |
Het |
| Nr1i3 |
C |
T |
1: 171,044,719 (GRCm39) |
T218I |
probably damaging |
Het |
| Nup43 |
C |
T |
10: 7,554,433 (GRCm39) |
R339* |
probably null |
Het |
| Nup58 |
T |
A |
14: 60,457,471 (GRCm39) |
R577S |
probably benign |
Het |
| Olfr908 |
C |
T |
9: 38,427,897 (GRCm39) |
|
probably benign |
Het |
| Or4l15 |
AAATTTGAA |
AAA |
14: 50,198,452 (GRCm39) |
|
probably benign |
Het |
| Or52n4b |
T |
A |
7: 108,144,092 (GRCm39) |
M120K |
probably damaging |
Het |
| Or5d35 |
T |
A |
2: 87,855,207 (GRCm39) |
I47K |
probably damaging |
Het |
| Or6c38 |
A |
T |
10: 128,929,537 (GRCm39) |
V102D |
possibly damaging |
Het |
| Or9g20 |
G |
A |
2: 85,630,338 (GRCm39) |
S92F |
probably damaging |
Het |
| Orc1 |
T |
C |
4: 108,436,765 (GRCm39) |
|
probably benign |
Het |
| Pax6 |
C |
A |
2: 105,526,847 (GRCm39) |
P251Q |
probably benign |
Het |
| Phactr3 |
C |
T |
2: 177,925,729 (GRCm39) |
R330W |
probably damaging |
Het |
| Phldb1 |
G |
A |
9: 44,622,324 (GRCm39) |
R81W |
probably damaging |
Het |
| Pip5k1c |
C |
T |
10: 81,151,774 (GRCm39) |
P656L |
probably benign |
Het |
| Pkn3 |
T |
G |
2: 29,974,692 (GRCm39) |
|
probably null |
Het |
| Plcb2 |
T |
A |
2: 118,543,615 (GRCm39) |
H752L |
probably benign |
Het |
| Plch1 |
G |
A |
3: 63,660,746 (GRCm39) |
T291M |
probably damaging |
Het |
| Plekhg1 |
A |
T |
10: 3,823,127 (GRCm39) |
M32L |
probably benign |
Het |
| Plekhg1 |
A |
T |
10: 3,823,130 (GRCm39) |
T33S |
probably damaging |
Het |
| Plk4 |
A |
G |
3: 40,759,625 (GRCm39) |
T174A |
probably damaging |
Het |
| Ppip5k2 |
C |
A |
1: 97,648,792 (GRCm39) |
|
probably benign |
Het |
| Prl2a1 |
G |
A |
13: 27,988,961 (GRCm39) |
V29M |
probably benign |
Het |
| R3hcc1l |
T |
C |
19: 42,571,996 (GRCm39) |
|
probably benign |
Het |
| Rasa3 |
C |
T |
8: 13,648,289 (GRCm39) |
G125D |
probably damaging |
Het |
| Sema3f |
A |
T |
9: 107,566,919 (GRCm39) |
Y136* |
probably null |
Het |
| Slc13a5 |
T |
A |
11: 72,141,672 (GRCm39) |
|
probably null |
Het |
| Slc16a1 |
T |
C |
3: 104,560,880 (GRCm39) |
V395A |
possibly damaging |
Het |
| Sparcl1 |
C |
T |
5: 104,236,356 (GRCm39) |
A466T |
probably benign |
Het |
| Srrm1 |
G |
A |
4: 135,069,690 (GRCm39) |
|
probably benign |
Het |
| Styxl1 |
G |
A |
5: 135,797,755 (GRCm39) |
R50* |
probably null |
Het |
| Tex264 |
T |
A |
9: 106,550,901 (GRCm39) |
I99F |
possibly damaging |
Het |
| Tgtp2 |
T |
C |
11: 48,949,811 (GRCm39) |
T254A |
probably damaging |
Het |
| Tmem245 |
A |
C |
4: 56,937,989 (GRCm39) |
|
probably null |
Het |
| Tpr |
T |
G |
1: 150,288,864 (GRCm39) |
S648A |
possibly damaging |
Het |
| Ttn |
T |
C |
2: 76,596,313 (GRCm39) |
E18454G |
probably damaging |
Het |
| Utp20 |
A |
C |
10: 88,645,797 (GRCm39) |
H527Q |
probably benign |
Het |
| Vmn1r1 |
A |
T |
1: 181,985,111 (GRCm39) |
S185T |
probably benign |
Het |
| Vps54 |
C |
T |
11: 21,262,952 (GRCm39) |
H680Y |
probably damaging |
Het |
| Vwa5b2 |
A |
G |
16: 20,419,553 (GRCm39) |
|
probably null |
Het |
| Wscd1 |
T |
C |
11: 71,662,802 (GRCm39) |
|
probably null |
Het |
| Zbtb41 |
C |
T |
1: 139,375,152 (GRCm39) |
P871S |
probably damaging |
Het |
| Zcchc4 |
T |
C |
5: 52,953,549 (GRCm39) |
L186P |
possibly damaging |
Het |
| Zdhhc13 |
A |
G |
7: 48,449,621 (GRCm39) |
Y73C |
probably benign |
Het |
| Zfp12 |
A |
G |
5: 143,225,755 (GRCm39) |
E21G |
probably damaging |
Het |
|
| Other mutations in Tnik |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00516:Tnik
|
APN |
3 |
28,708,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00726:Tnik
|
APN |
3 |
28,587,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01022:Tnik
|
APN |
3 |
28,679,377 (GRCm39) |
splice site |
probably null |
|
|
IGL01145:Tnik
|
APN |
3 |
28,658,316 (GRCm39) |
intron |
probably benign |
|
|
IGL01664:Tnik
|
APN |
3 |
28,692,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01843:Tnik
|
APN |
3 |
28,625,007 (GRCm39) |
splice site |
probably null |
|
|
IGL02378:Tnik
|
APN |
3 |
28,692,608 (GRCm39) |
nonsense |
probably null |
|
|
IGL02448:Tnik
|
APN |
3 |
28,675,226 (GRCm39) |
missense |
probably null |
0.01 |
|
IGL02756:Tnik
|
APN |
3 |
28,596,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03332:Tnik
|
APN |
3 |
28,720,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
delightful
|
UTSW |
3 |
28,658,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Hottie
|
UTSW |
3 |
28,317,792 (GRCm39) |
start codon destroyed |
probably null |
0.93 |
|
Knockout
|
UTSW |
3 |
28,715,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
Looker
|
UTSW |
3 |
28,715,853 (GRCm39) |
nonsense |
probably null |
|
|
Lovely
|
UTSW |
3 |
28,666,119 (GRCm39) |
critical splice donor site |
probably null |
|
|
Usher
|
UTSW |
3 |
28,618,246 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R0135:Tnik
|
UTSW |
3 |
28,661,394 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R0418:Tnik
|
UTSW |
3 |
28,625,029 (GRCm39) |
nonsense |
probably null |
|
|
R0540:Tnik
|
UTSW |
3 |
28,704,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0549:Tnik
|
UTSW |
3 |
28,625,069 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0556:Tnik
|
UTSW |
3 |
28,679,367 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0586:Tnik
|
UTSW |
3 |
28,631,510 (GRCm39) |
splice site |
probably benign |
|
|
R0607:Tnik
|
UTSW |
3 |
28,704,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0842:Tnik
|
UTSW |
3 |
28,648,235 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R1068:Tnik
|
UTSW |
3 |
28,587,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1171:Tnik
|
UTSW |
3 |
28,587,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1597:Tnik
|
UTSW |
3 |
28,658,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1638:Tnik
|
UTSW |
3 |
28,719,889 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1652:Tnik
|
UTSW |
3 |
28,658,442 (GRCm39) |
missense |
probably benign |
0.22 |
|
R1996:Tnik
|
UTSW |
3 |
28,719,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2333:Tnik
|
UTSW |
3 |
28,587,145 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2426:Tnik
|
UTSW |
3 |
28,700,830 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2509:Tnik
|
UTSW |
3 |
28,722,064 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3774:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3775:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4007:Tnik
|
UTSW |
3 |
28,658,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4119:Tnik
|
UTSW |
3 |
28,720,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4209:Tnik
|
UTSW |
3 |
28,413,214 (GRCm39) |
splice site |
probably benign |
|
|
R4441:Tnik
|
UTSW |
3 |
28,618,246 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4611:Tnik
|
UTSW |
3 |
28,596,249 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4714:Tnik
|
UTSW |
3 |
28,648,226 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4829:Tnik
|
UTSW |
3 |
28,593,690 (GRCm39) |
intron |
probably benign |
|
|
R4839:Tnik
|
UTSW |
3 |
28,650,224 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4898:Tnik
|
UTSW |
3 |
28,704,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5029:Tnik
|
UTSW |
3 |
28,719,993 (GRCm39) |
splice site |
probably null |
|
|
R5278:Tnik
|
UTSW |
3 |
28,704,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5307:Tnik
|
UTSW |
3 |
28,596,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5330:Tnik
|
UTSW |
3 |
28,596,167 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5375:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5459:Tnik
|
UTSW |
3 |
28,715,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5708:Tnik
|
UTSW |
3 |
28,666,120 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5749:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5751:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5780:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5837:Tnik
|
UTSW |
3 |
28,722,202 (GRCm39) |
unclassified |
probably benign |
|
|
R5969:Tnik
|
UTSW |
3 |
28,675,097 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6244:Tnik
|
UTSW |
3 |
28,704,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6273:Tnik
|
UTSW |
3 |
28,631,649 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6457:Tnik
|
UTSW |
3 |
28,593,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6464:Tnik
|
UTSW |
3 |
28,666,119 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6473:Tnik
|
UTSW |
3 |
28,317,792 (GRCm39) |
start codon destroyed |
probably null |
0.93 |
|
R6737:Tnik
|
UTSW |
3 |
28,650,235 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7049:Tnik
|
UTSW |
3 |
28,715,853 (GRCm39) |
nonsense |
probably null |
|
|
R7237:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7267:Tnik
|
UTSW |
3 |
28,700,776 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7445:Tnik
|
UTSW |
3 |
28,718,058 (GRCm39) |
splice site |
probably null |
|
|
R7499:Tnik
|
UTSW |
3 |
28,684,743 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7629:Tnik
|
UTSW |
3 |
28,715,877 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7654:Tnik
|
UTSW |
3 |
28,658,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7886:Tnik
|
UTSW |
3 |
28,720,288 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8096:Tnik
|
UTSW |
3 |
28,715,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8210:Tnik
|
UTSW |
3 |
28,658,482 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8233:Tnik
|
UTSW |
3 |
28,609,086 (GRCm39) |
missense |
unknown |
|
|
R8386:Tnik
|
UTSW |
3 |
28,317,823 (GRCm39) |
missense |
unknown |
|
|
R8399:Tnik
|
UTSW |
3 |
28,548,159 (GRCm39) |
missense |
unknown |
|
|
R8490:Tnik
|
UTSW |
3 |
28,650,321 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8539:Tnik
|
UTSW |
3 |
28,596,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8751:Tnik
|
UTSW |
3 |
28,666,057 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8804:Tnik
|
UTSW |
3 |
28,648,202 (GRCm39) |
missense |
unknown |
|
|
R8966:Tnik
|
UTSW |
3 |
28,587,044 (GRCm39) |
missense |
unknown |
|
|
R8998:Tnik
|
UTSW |
3 |
28,719,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8999:Tnik
|
UTSW |
3 |
28,719,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9016:Tnik
|
UTSW |
3 |
28,692,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9154:Tnik
|
UTSW |
3 |
28,704,235 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9284:Tnik
|
UTSW |
3 |
28,593,570 (GRCm39) |
missense |
unknown |
|
|
R9290:Tnik
|
UTSW |
3 |
28,675,124 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9411:Tnik
|
UTSW |
3 |
28,684,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9484:Tnik
|
UTSW |
3 |
28,649,093 (GRCm39) |
missense |
unknown |
|
|
X0022:Tnik
|
UTSW |
3 |
28,722,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Tnik
|
UTSW |
3 |
28,661,477 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1176:Tnik
|
UTSW |
3 |
28,658,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGAAGGGTTTCCAGATGTGCTC -3'
(R):5'- ATGCTACCTTTGGTGGAATGTC -3'
Sequencing Primer
(F):5'- TGAAAACTGCCCTGTCGTAG -3'
(R):5'- GTCTTCTTCCTGTCGTAACCAAGAG -3'
|
| Posted On |
2015-12-29 |
Incidental Mutation