Incidental Mutation 'R4772:Bicdl1'
ID 367599
Institutional Source Beutler Lab
Gene Symbol Bicdl1
Ensembl Gene ENSMUSG00000041609
Gene Name BICD family like cargo adaptor 1
Synonyms 2210403N09Rik, BICDR-1, Ccdc64
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.372) question?
Stock # R4772 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 115786234-115869680 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 115799537 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 184 (I184T)
Ref Sequence ENSEMBL: ENSMUSP00000119664 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055408] [ENSMUST00000148276]
AlphaFold A0JNT9
Predicted Effect probably benign
Transcript: ENSMUST00000055408
SMART Domains Protein: ENSMUSP00000053547
Gene: ENSMUSG00000041609

DomainStartEndE-ValueType
low complexity region 47 68 N/A INTRINSIC
Pfam:HAP1_N 97 162 2e-11 PFAM
low complexity region 305 316 N/A INTRINSIC
low complexity region 336 374 N/A INTRINSIC
low complexity region 389 410 N/A INTRINSIC
coiled coil region 467 529 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000148276
AA Change: I184T

PolyPhen 2 Score 0.361 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000119664
Gene: ENSMUSG00000041609
AA Change: I184T

DomainStartEndE-ValueType
coiled coil region 1 110 N/A INTRINSIC
low complexity region 120 141 N/A INTRINSIC
coiled coil region 178 284 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148627
Meta Mutation Damage Score 0.0609 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.1%
Validation Efficiency 95% (74/78)
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T A 11: 9,265,339 (GRCm39) probably null Het
Adamts19 A G 18: 58,970,848 (GRCm39) Q144R possibly damaging Het
Adgrb3 C A 1: 25,570,956 (GRCm39) C507F probably damaging Het
Atg9b T C 5: 24,590,237 (GRCm39) *923W probably null Het
Atp13a4 T C 16: 29,239,653 (GRCm39) probably benign Het
Baz2b G T 2: 59,788,795 (GRCm39) R697S probably damaging Het
Bpifb4 C T 2: 153,784,903 (GRCm39) L204F possibly damaging Het
Cep120 C T 18: 53,851,561 (GRCm39) R577Q probably damaging Het
Cplx4 T C 18: 66,103,048 (GRCm39) E24G possibly damaging Het
Dcxr T C 11: 120,616,923 (GRCm39) T147A probably benign Het
Dnajc10 C A 2: 80,170,870 (GRCm39) H454N probably damaging Het
Dsp G T 13: 38,351,504 (GRCm39) G108* probably null Het
Entpd6 T A 2: 150,609,014 (GRCm39) I366K probably damaging Het
Fam111a A G 19: 12,565,057 (GRCm39) K269E probably benign Het
Grid2ip T G 5: 143,361,455 (GRCm39) V222G possibly damaging Het
Hmcn2 T G 2: 31,335,326 (GRCm39) V4421G probably benign Het
Ifi207 T C 1: 173,555,253 (GRCm39) T817A probably damaging Het
Irak2 A T 6: 113,670,683 (GRCm39) E533V probably damaging Het
Katnip A G 7: 125,464,523 (GRCm39) S1297G probably damaging Het
Kbtbd6 T C 14: 79,689,596 (GRCm39) F97S probably damaging Het
Kctd14 A T 7: 97,106,883 (GRCm39) E99V probably damaging Het
Klhl10 A T 11: 100,338,557 (GRCm39) Y432F probably benign Het
Lrrc49 T C 9: 60,592,335 (GRCm39) N53S possibly damaging Het
Mief2 T A 11: 60,621,288 (GRCm39) probably benign Het
Mog A T 17: 37,334,049 (GRCm39) S15T unknown Het
Mpi T C 9: 57,452,181 (GRCm39) D365G probably damaging Het
Mpp7 A G 18: 7,379,983 (GRCm39) probably null Het
Nes A G 3: 87,883,486 (GRCm39) T582A probably benign Het
Nlrp14 A G 7: 106,780,393 (GRCm39) D5G probably benign Het
Nr1i3 C T 1: 171,044,719 (GRCm39) T218I probably damaging Het
Nup43 C T 10: 7,554,433 (GRCm39) R339* probably null Het
Nup58 T A 14: 60,457,471 (GRCm39) R577S probably benign Het
Olfr908 C T 9: 38,427,897 (GRCm39) probably benign Het
Or4l15 AAATTTGAA AAA 14: 50,198,452 (GRCm39) probably benign Het
Or52n4b T A 7: 108,144,092 (GRCm39) M120K probably damaging Het
Or5d35 T A 2: 87,855,207 (GRCm39) I47K probably damaging Het
Or6c38 A T 10: 128,929,537 (GRCm39) V102D possibly damaging Het
Or9g20 G A 2: 85,630,338 (GRCm39) S92F probably damaging Het
Orc1 T C 4: 108,436,765 (GRCm39) probably benign Het
Pax6 C A 2: 105,526,847 (GRCm39) P251Q probably benign Het
Phactr3 C T 2: 177,925,729 (GRCm39) R330W probably damaging Het
Phldb1 G A 9: 44,622,324 (GRCm39) R81W probably damaging Het
Pip5k1c C T 10: 81,151,774 (GRCm39) P656L probably benign Het
Pkn3 T G 2: 29,974,692 (GRCm39) probably null Het
Plcb2 T A 2: 118,543,615 (GRCm39) H752L probably benign Het
Plch1 G A 3: 63,660,746 (GRCm39) T291M probably damaging Het
Plekhg1 A T 10: 3,823,127 (GRCm39) M32L probably benign Het
Plekhg1 A T 10: 3,823,130 (GRCm39) T33S probably damaging Het
Plk4 A G 3: 40,759,625 (GRCm39) T174A probably damaging Het
Ppip5k2 C A 1: 97,648,792 (GRCm39) probably benign Het
Prl2a1 G A 13: 27,988,961 (GRCm39) V29M probably benign Het
R3hcc1l T C 19: 42,571,996 (GRCm39) probably benign Het
Rasa3 C T 8: 13,648,289 (GRCm39) G125D probably damaging Het
Sema3f A T 9: 107,566,919 (GRCm39) Y136* probably null Het
Slc13a5 T A 11: 72,141,672 (GRCm39) probably null Het
Slc16a1 T C 3: 104,560,880 (GRCm39) V395A possibly damaging Het
Sparcl1 C T 5: 104,236,356 (GRCm39) A466T probably benign Het
Srrm1 G A 4: 135,069,690 (GRCm39) probably benign Het
Styxl1 G A 5: 135,797,755 (GRCm39) R50* probably null Het
Tex264 T A 9: 106,550,901 (GRCm39) I99F possibly damaging Het
Tgtp2 T C 11: 48,949,811 (GRCm39) T254A probably damaging Het
Tmem245 A C 4: 56,937,989 (GRCm39) probably null Het
Tnik A T 3: 28,661,359 (GRCm39) T587S probably benign Het
Tpr T G 1: 150,288,864 (GRCm39) S648A possibly damaging Het
Ttn T C 2: 76,596,313 (GRCm39) E18454G probably damaging Het
Utp20 A C 10: 88,645,797 (GRCm39) H527Q probably benign Het
Vmn1r1 A T 1: 181,985,111 (GRCm39) S185T probably benign Het
Vps54 C T 11: 21,262,952 (GRCm39) H680Y probably damaging Het
Vwa5b2 A G 16: 20,419,553 (GRCm39) probably null Het
Wscd1 T C 11: 71,662,802 (GRCm39) probably null Het
Zbtb41 C T 1: 139,375,152 (GRCm39) P871S probably damaging Het
Zcchc4 T C 5: 52,953,549 (GRCm39) L186P possibly damaging Het
Zdhhc13 A G 7: 48,449,621 (GRCm39) Y73C probably benign Het
Zfp12 A G 5: 143,225,755 (GRCm39) E21G probably damaging Het
Other mutations in Bicdl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01434:Bicdl1 APN 5 115,808,215 (GRCm39) nonsense probably null
IGL01902:Bicdl1 APN 5 115,789,933 (GRCm39) missense probably damaging 1.00
IGL02416:Bicdl1 APN 5 115,801,944 (GRCm39) missense probably damaging 1.00
IGL02417:Bicdl1 APN 5 115,811,217 (GRCm39) missense probably damaging 1.00
IGL03088:Bicdl1 APN 5 115,801,881 (GRCm39) missense possibly damaging 0.83
IGL03275:Bicdl1 APN 5 115,869,219 (GRCm39) missense probably damaging 1.00
bargain UTSW 5 115,808,212 (GRCm39) critical splice donor site probably null
R6807_Bicdl1_588 UTSW 5 115,810,202 (GRCm39) critical splice donor site probably null
R0837:Bicdl1 UTSW 5 115,869,351 (GRCm39) missense probably benign 0.06
R0924:Bicdl1 UTSW 5 115,799,587 (GRCm39) splice site probably benign
R1581:Bicdl1 UTSW 5 115,789,326 (GRCm39) unclassified probably benign
R1589:Bicdl1 UTSW 5 115,789,325 (GRCm39) unclassified probably benign
R1669:Bicdl1 UTSW 5 115,794,075 (GRCm39) missense possibly damaging 0.84
R2076:Bicdl1 UTSW 5 115,793,987 (GRCm39) missense probably damaging 0.96
R2089:Bicdl1 UTSW 5 115,862,638 (GRCm39) missense probably damaging 1.00
R2091:Bicdl1 UTSW 5 115,862,638 (GRCm39) missense probably damaging 1.00
R2091:Bicdl1 UTSW 5 115,862,638 (GRCm39) missense probably damaging 1.00
R6185:Bicdl1 UTSW 5 115,808,212 (GRCm39) critical splice donor site probably null
R6807:Bicdl1 UTSW 5 115,810,202 (GRCm39) critical splice donor site probably null
R7107:Bicdl1 UTSW 5 115,808,229 (GRCm39) missense probably benign 0.03
R7157:Bicdl1 UTSW 5 115,789,916 (GRCm39) missense possibly damaging 0.92
R7205:Bicdl1 UTSW 5 115,808,340 (GRCm39) missense probably damaging 1.00
R7485:Bicdl1 UTSW 5 115,801,845 (GRCm39) nonsense probably null
R7781:Bicdl1 UTSW 5 115,799,546 (GRCm39) missense probably damaging 1.00
R8236:Bicdl1 UTSW 5 115,787,618 (GRCm39) missense probably benign 0.28
R8816:Bicdl1 UTSW 5 115,862,804 (GRCm39) missense probably damaging 1.00
R9320:Bicdl1 UTSW 5 115,862,769 (GRCm39) missense probably damaging 0.96
R9527:Bicdl1 UTSW 5 115,811,188 (GRCm39) missense possibly damaging 0.96
Predicted Primers PCR Primer
(F):5'- CTCAACTTTGGGTCCCAGTC -3'
(R):5'- AGATGCCAGTGCTTTTGCCG -3'

Sequencing Primer
(F):5'- TCCCCTCGGCTCACACAG -3'
(R):5'- GTTTGTAGCGCGCGCAG -3'
Posted On 2015-12-29