Incidental Mutation 'R4773:Shroom3'
| ID |
367664 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Shroom3
|
| Ensembl Gene |
ENSMUSG00000029381 |
| Gene Name |
shroom family member 3 |
| Synonyms |
Shrm3, D5Ertd287e, Shrm |
| MMRRC Submission |
042411-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R4773 (G1)
|
| Quality Score |
216 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
92831294-93113177 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 93090945 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Phenylalanine
at position 1151
(V1151F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153516
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000113051]
[ENSMUST00000113054]
[ENSMUST00000113055]
[ENSMUST00000168878]
[ENSMUST00000172706]
[ENSMUST00000225438]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000113051
AA Change: V1057F
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000108674
Gene: ENSMUSG00000029381
AA Change: V1057F
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
27 |
N/A |
INTRINSIC |
|
low complexity region
|
83 |
93 |
N/A |
INTRINSIC |
|
low complexity region
|
572 |
586 |
N/A |
INTRINSIC |
|
low complexity region
|
621 |
639 |
N/A |
INTRINSIC |
|
low complexity region
|
685 |
704 |
N/A |
INTRINSIC |
|
Pfam:ASD1
|
706 |
885 |
2.3e-65 |
PFAM |
|
low complexity region
|
939 |
952 |
N/A |
INTRINSIC |
|
low complexity region
|
1132 |
1143 |
N/A |
INTRINSIC |
|
low complexity region
|
1172 |
1184 |
N/A |
INTRINSIC |
|
low complexity region
|
1274 |
1288 |
N/A |
INTRINSIC |
|
low complexity region
|
1333 |
1345 |
N/A |
INTRINSIC |
|
Pfam:ASD2
|
1478 |
1765 |
3.1e-107 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000113054
AA Change: V1057F
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000108677
Gene: ENSMUSG00000029381
AA Change: V1057F
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
27 |
N/A |
INTRINSIC |
|
low complexity region
|
83 |
93 |
N/A |
INTRINSIC |
|
low complexity region
|
572 |
586 |
N/A |
INTRINSIC |
|
low complexity region
|
621 |
639 |
N/A |
INTRINSIC |
|
low complexity region
|
685 |
704 |
N/A |
INTRINSIC |
|
Pfam:ASD1
|
706 |
885 |
2.3e-65 |
PFAM |
|
low complexity region
|
939 |
952 |
N/A |
INTRINSIC |
|
low complexity region
|
1132 |
1143 |
N/A |
INTRINSIC |
|
low complexity region
|
1172 |
1184 |
N/A |
INTRINSIC |
|
low complexity region
|
1274 |
1288 |
N/A |
INTRINSIC |
|
low complexity region
|
1333 |
1345 |
N/A |
INTRINSIC |
|
Pfam:ASD2
|
1478 |
1765 |
3.1e-107 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000113055
AA Change: V1232F
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000108678
Gene: ENSMUSG00000029381
AA Change: V1232F
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
35 |
109 |
5.81e-11 |
SMART |
|
low complexity region
|
191 |
202 |
N/A |
INTRINSIC |
|
low complexity region
|
258 |
268 |
N/A |
INTRINSIC |
|
low complexity region
|
747 |
761 |
N/A |
INTRINSIC |
|
low complexity region
|
796 |
814 |
N/A |
INTRINSIC |
|
low complexity region
|
860 |
879 |
N/A |
INTRINSIC |
|
Pfam:ASD1
|
882 |
1060 |
1e-57 |
PFAM |
|
low complexity region
|
1114 |
1127 |
N/A |
INTRINSIC |
|
low complexity region
|
1307 |
1318 |
N/A |
INTRINSIC |
|
low complexity region
|
1347 |
1359 |
N/A |
INTRINSIC |
|
low complexity region
|
1449 |
1463 |
N/A |
INTRINSIC |
|
low complexity region
|
1508 |
1520 |
N/A |
INTRINSIC |
|
Pfam:ASD2
|
1654 |
1940 |
9.9e-112 |
PFAM |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000168878
AA Change: V1101F
|
| SMART Domains |
Protein: ENSMUSP00000130419
Gene: ENSMUSG00000029381
AA Change: V1101F
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
35 |
109 |
5.81e-11 |
SMART |
|
low complexity region
|
191 |
202 |
N/A |
INTRINSIC |
|
low complexity region
|
258 |
268 |
N/A |
INTRINSIC |
|
low complexity region
|
747 |
761 |
N/A |
INTRINSIC |
|
low complexity region
|
796 |
814 |
N/A |
INTRINSIC |
|
low complexity region
|
860 |
879 |
N/A |
INTRINSIC |
|
low complexity region
|
983 |
996 |
N/A |
INTRINSIC |
|
low complexity region
|
1176 |
1187 |
N/A |
INTRINSIC |
|
low complexity region
|
1216 |
1228 |
N/A |
INTRINSIC |
|
low complexity region
|
1318 |
1332 |
N/A |
INTRINSIC |
|
low complexity region
|
1377 |
1389 |
N/A |
INTRINSIC |
|
Pfam:ASD2
|
1522 |
1809 |
8.9e-108 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000172706
|
| SMART Domains |
Protein: ENSMUSP00000133690
Gene: ENSMUSG00000029381
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
27 |
N/A |
INTRINSIC |
|
low complexity region
|
83 |
93 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000200869
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000201800
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000225438
AA Change: V1151F
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 94.2%
|
| Validation Efficiency |
100% (89/89) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a PDZ-domain-containing protein that belongs to a family of Shroom-related proteins. This protein may be involved in regulating cell shape in certain tissues. A similar protein in mice is required for proper neurulation. [provided by RefSeq, Jan 2011]
PHENOTYPE: Homozygous mutation of this locus results in failed neural tube closure leading to exencephaly, acrania, facial clefting, and spina bifida. Homozygotes develop to term but die either at birth or shortly thereafter. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 82 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9230009I02Rik |
A |
G |
11: 50,982,089 (GRCm39) |
|
noncoding transcript |
Het |
| Actl7b |
T |
C |
4: 56,740,972 (GRCm39) |
I129V |
probably benign |
Het |
| Adipor2 |
A |
G |
6: 119,336,047 (GRCm39) |
L225P |
probably benign |
Het |
| Arhgap25 |
A |
G |
6: 87,473,053 (GRCm39) |
F35L |
probably benign |
Het |
| Asah2 |
A |
T |
19: 32,030,258 (GRCm39) |
M138K |
probably damaging |
Het |
| Asxl1 |
T |
A |
2: 153,243,905 (GRCm39) |
M1486K |
probably damaging |
Het |
| B4galt4 |
T |
A |
16: 38,572,658 (GRCm39) |
S114R |
probably benign |
Het |
| Brpf3 |
T |
G |
17: 29,040,233 (GRCm39) |
S885A |
probably benign |
Het |
| Cacna1g |
G |
T |
11: 94,302,298 (GRCm39) |
H1944N |
possibly damaging |
Het |
| Cby2 |
T |
A |
14: 75,820,546 (GRCm39) |
Y393F |
probably damaging |
Het |
| Ccdc110 |
G |
A |
8: 46,396,245 (GRCm39) |
C712Y |
probably damaging |
Het |
| Ccdc175 |
A |
T |
12: 72,182,822 (GRCm39) |
I399N |
probably damaging |
Het |
| Cct8l1 |
A |
T |
5: 25,722,754 (GRCm39) |
T490S |
probably benign |
Het |
| Cd109 |
CATTTATTTATTTATTTATTTATTTATTTATTTAT |
CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT |
9: 78,619,782 (GRCm39) |
|
probably benign |
Het |
| Copa |
A |
G |
1: 171,932,787 (GRCm39) |
N371D |
probably damaging |
Het |
| Cpeb1 |
A |
T |
7: 81,005,695 (GRCm39) |
H381Q |
probably benign |
Het |
| Cyp2d40 |
T |
A |
15: 82,645,763 (GRCm39) |
I81F |
possibly damaging |
Het |
| Dscc1 |
A |
T |
15: 54,943,654 (GRCm39) |
D405E |
probably benign |
Het |
| Ece1 |
A |
G |
4: 137,672,464 (GRCm39) |
D369G |
probably benign |
Het |
| Exd2 |
T |
C |
12: 80,522,592 (GRCm39) |
V17A |
possibly damaging |
Het |
| Fam111a |
A |
T |
19: 12,565,772 (GRCm39) |
N507I |
possibly damaging |
Het |
| Flnc |
T |
C |
6: 29,445,038 (GRCm39) |
V719A |
possibly damaging |
Het |
| Fscb |
C |
T |
12: 64,520,464 (GRCm39) |
G334D |
probably damaging |
Het |
| Glud1 |
T |
C |
14: 34,043,782 (GRCm39) |
|
probably null |
Het |
| Gm8126 |
T |
A |
14: 43,119,072 (GRCm39) |
Y180* |
probably null |
Het |
| Grip2 |
G |
A |
6: 91,759,413 (GRCm39) |
P347L |
possibly damaging |
Het |
| H1f3 |
T |
C |
13: 23,739,576 (GRCm39) |
S105P |
probably damaging |
Het |
| H60b |
C |
T |
10: 22,164,644 (GRCm39) |
|
probably benign |
Het |
| Iqca1l |
A |
G |
5: 24,755,596 (GRCm39) |
|
probably null |
Het |
| Itga6 |
T |
C |
2: 71,652,788 (GRCm39) |
V217A |
probably benign |
Het |
| Kndc1 |
G |
A |
7: 139,503,946 (GRCm39) |
W1083* |
probably null |
Het |
| Limch1 |
A |
T |
5: 67,184,850 (GRCm39) |
D613V |
probably damaging |
Het |
| Lpl |
T |
A |
8: 69,349,403 (GRCm39) |
C310S |
probably damaging |
Het |
| Marchf1 |
T |
A |
8: 66,839,876 (GRCm39) |
C220S |
probably benign |
Het |
| Mbd5 |
A |
C |
2: 49,164,623 (GRCm39) |
H308P |
probably damaging |
Het |
| Med13 |
T |
C |
11: 86,167,746 (GRCm39) |
D2003G |
probably damaging |
Het |
| Mettl16 |
T |
A |
11: 74,708,127 (GRCm39) |
V442D |
possibly damaging |
Het |
| Mstn |
A |
T |
1: 53,101,267 (GRCm39) |
T115S |
probably benign |
Het |
| Mtcl2 |
G |
T |
2: 156,872,489 (GRCm39) |
Q953K |
probably benign |
Het |
| Nfil3 |
A |
G |
13: 53,122,050 (GRCm39) |
S285P |
probably damaging |
Het |
| Odad4 |
C |
A |
11: 100,440,742 (GRCm39) |
N74K |
probably benign |
Het |
| Or10j3 |
A |
C |
1: 173,031,796 (GRCm39) |
Y291S |
probably damaging |
Het |
| Or51a24 |
A |
G |
7: 103,733,502 (GRCm39) |
S262P |
probably damaging |
Het |
| Otof |
A |
G |
5: 30,552,026 (GRCm39) |
V321A |
probably benign |
Het |
| Pcdha8 |
G |
T |
18: 37,127,626 (GRCm39) |
A703S |
probably damaging |
Het |
| Pcdhb18 |
A |
G |
18: 37,623,507 (GRCm39) |
Y279C |
probably damaging |
Het |
| Pdgfa |
T |
C |
5: 138,979,051 (GRCm39) |
D51G |
probably benign |
Het |
| Pdzd8 |
A |
G |
19: 59,289,292 (GRCm39) |
Y703H |
probably damaging |
Het |
| Pecr |
G |
T |
1: 72,306,594 (GRCm39) |
P229Q |
probably damaging |
Het |
| Phkg1 |
G |
T |
5: 129,902,114 (GRCm39) |
|
probably null |
Het |
| Plxnb2 |
A |
T |
15: 89,051,150 (GRCm39) |
H356Q |
probably benign |
Het |
| Polr1b |
T |
C |
2: 128,947,248 (GRCm39) |
I191T |
probably benign |
Het |
| Ppp4r3a |
A |
G |
12: 101,049,026 (GRCm39) |
L35P |
possibly damaging |
Het |
| Rasa2 |
C |
T |
9: 96,426,470 (GRCm39) |
G792D |
probably benign |
Het |
| Rps11-ps4 |
T |
C |
12: 51,344,406 (GRCm39) |
|
noncoding transcript |
Het |
| Sema3g |
A |
G |
14: 30,942,666 (GRCm39) |
D89G |
probably benign |
Het |
| Slfn8 |
A |
G |
11: 82,908,219 (GRCm39) |
V108A |
probably damaging |
Het |
| Smg9 |
T |
A |
7: 24,107,019 (GRCm39) |
M221K |
possibly damaging |
Het |
| Sos1 |
A |
G |
17: 80,705,660 (GRCm39) |
S1304P |
probably damaging |
Het |
| Sqle |
C |
A |
15: 59,189,688 (GRCm39) |
A110E |
possibly damaging |
Het |
| Stab2 |
G |
A |
10: 86,743,235 (GRCm39) |
Q1154* |
probably null |
Het |
| Taf4b |
A |
G |
18: 14,937,577 (GRCm39) |
T217A |
probably benign |
Het |
| Tex15 |
T |
C |
8: 34,072,760 (GRCm39) |
V2769A |
probably benign |
Het |
| Tmem156 |
A |
T |
5: 65,237,502 (GRCm39) |
C53S |
probably damaging |
Het |
| Tmtc3 |
T |
A |
10: 100,293,001 (GRCm39) |
K452N |
possibly damaging |
Het |
| Tns2 |
C |
T |
15: 102,017,369 (GRCm39) |
R281C |
probably damaging |
Het |
| Tph1 |
T |
C |
7: 46,306,376 (GRCm39) |
E195G |
probably damaging |
Het |
| Trpc6 |
T |
A |
9: 8,609,852 (GRCm39) |
Y107N |
possibly damaging |
Het |
| Tsga10 |
G |
A |
1: 37,874,606 (GRCm39) |
T93I |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,571,778 (GRCm39) |
N26372Y |
probably damaging |
Het |
| Tubd1 |
T |
C |
11: 86,446,128 (GRCm39) |
L256P |
possibly damaging |
Het |
| Txnrd2 |
C |
G |
16: 18,259,569 (GRCm39) |
A126G |
probably benign |
Het |
| Vmn1r210 |
T |
G |
13: 23,011,374 (GRCm39) |
K304T |
probably benign |
Het |
| Vps25 |
T |
C |
11: 101,149,655 (GRCm39) |
S160P |
probably benign |
Het |
| Vrk3 |
T |
A |
7: 44,424,900 (GRCm39) |
D438E |
probably benign |
Het |
| Vwa5b1 |
A |
G |
4: 138,309,066 (GRCm39) |
L708P |
probably benign |
Het |
| Washc3 |
C |
T |
10: 88,055,124 (GRCm39) |
Q105* |
probably null |
Het |
| Wdr83os |
T |
A |
8: 85,807,410 (GRCm39) |
|
probably benign |
Het |
| Wwc1 |
T |
C |
11: 35,758,123 (GRCm39) |
H741R |
probably benign |
Het |
| Zan |
T |
C |
5: 137,434,575 (GRCm39) |
|
probably benign |
Het |
| Zdhhc4 |
A |
T |
5: 143,311,931 (GRCm39) |
L14I |
possibly damaging |
Het |
| Zfp568 |
T |
A |
7: 29,697,195 (GRCm39) |
D38E |
probably damaging |
Het |
|
| Other mutations in Shroom3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00850:Shroom3
|
APN |
5 |
93,098,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01086:Shroom3
|
APN |
5 |
93,096,311 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01363:Shroom3
|
APN |
5 |
93,088,852 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01468:Shroom3
|
APN |
5 |
93,088,201 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01675:Shroom3
|
APN |
5 |
93,089,539 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01862:Shroom3
|
APN |
5 |
93,110,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01987:Shroom3
|
APN |
5 |
93,090,048 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02104:Shroom3
|
APN |
5 |
93,088,248 (GRCm39) |
missense |
probably benign |
0.32 |
|
IGL03248:Shroom3
|
APN |
5 |
93,100,399 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03386:Shroom3
|
APN |
5 |
93,096,342 (GRCm39) |
splice site |
probably benign |
|
|
R0167:Shroom3
|
UTSW |
5 |
93,096,254 (GRCm39) |
splice site |
probably benign |
|
|
R0388:Shroom3
|
UTSW |
5 |
93,099,152 (GRCm39) |
missense |
probably benign |
0.39 |
|
R0395:Shroom3
|
UTSW |
5 |
92,928,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0567:Shroom3
|
UTSW |
5 |
93,112,312 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1496:Shroom3
|
UTSW |
5 |
93,090,693 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R1772:Shroom3
|
UTSW |
5 |
93,088,515 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1845:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1921:Shroom3
|
UTSW |
5 |
93,110,224 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2059:Shroom3
|
UTSW |
5 |
92,831,643 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2203:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2204:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2205:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2301:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2344:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2345:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2346:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2348:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2371:Shroom3
|
UTSW |
5 |
92,928,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2435:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2829:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2830:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2831:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2897:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2898:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3079:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3080:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3433:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3729:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3730:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3735:Shroom3
|
UTSW |
5 |
93,112,303 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R3736:Shroom3
|
UTSW |
5 |
93,112,303 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R3851:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3852:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3943:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3969:Shroom3
|
UTSW |
5 |
93,088,738 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4008:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4009:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4012:Shroom3
|
UTSW |
5 |
93,096,342 (GRCm39) |
splice site |
probably benign |
|
|
R4154:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4157:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4172:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4173:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4201:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4202:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4204:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4205:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4206:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4284:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4285:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4364:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4384:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4456:Shroom3
|
UTSW |
5 |
93,088,858 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4707:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4712:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4751:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4755:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4760:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4774:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4776:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4801:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4802:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4856:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4857:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4860:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4860:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4882:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4883:Shroom3
|
UTSW |
5 |
93,098,993 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4886:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5262:Shroom3
|
UTSW |
5 |
93,112,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5271:Shroom3
|
UTSW |
5 |
93,110,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5719:Shroom3
|
UTSW |
5 |
93,090,877 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5726:Shroom3
|
UTSW |
5 |
93,090,864 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5993:Shroom3
|
UTSW |
5 |
93,088,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6078:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6079:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6138:Shroom3
|
UTSW |
5 |
93,090,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6153:Shroom3
|
UTSW |
5 |
93,112,267 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6493:Shroom3
|
UTSW |
5 |
93,089,420 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6495:Shroom3
|
UTSW |
5 |
93,089,928 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R6693:Shroom3
|
UTSW |
5 |
93,088,617 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R6801:Shroom3
|
UTSW |
5 |
93,088,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6893:Shroom3
|
UTSW |
5 |
93,090,063 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6912:Shroom3
|
UTSW |
5 |
93,090,876 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6924:Shroom3
|
UTSW |
5 |
93,112,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7083:Shroom3
|
UTSW |
5 |
93,112,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7197:Shroom3
|
UTSW |
5 |
93,090,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7366:Shroom3
|
UTSW |
5 |
93,112,465 (GRCm39) |
nonsense |
probably null |
|
|
R7712:Shroom3
|
UTSW |
5 |
93,098,806 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7725:Shroom3
|
UTSW |
5 |
93,089,512 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7728:Shroom3
|
UTSW |
5 |
92,831,566 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R7774:Shroom3
|
UTSW |
5 |
93,098,348 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7795:Shroom3
|
UTSW |
5 |
93,067,508 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7821:Shroom3
|
UTSW |
5 |
93,088,705 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7971:Shroom3
|
UTSW |
5 |
93,098,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8276:Shroom3
|
UTSW |
5 |
93,088,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8934:Shroom3
|
UTSW |
5 |
93,089,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8938:Shroom3
|
UTSW |
5 |
93,090,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9083:Shroom3
|
UTSW |
5 |
93,098,533 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9108:Shroom3
|
UTSW |
5 |
93,087,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9124:Shroom3
|
UTSW |
5 |
93,112,401 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9295:Shroom3
|
UTSW |
5 |
93,098,478 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAGGAGCACACTCATCCGTC -3'
(R):5'- CTTAACTGTCAGAACGGTAACCAAC -3'
Sequencing Primer
(F):5'- GTGATCGCAGCAGCTCCTTC -3'
(R):5'- AGACATTTATATATCTTTGTGCGGG -3'
|
| Posted On |
2015-12-29 |
Incidental Mutation