Incidental Mutation 'R4773:Tex15'
ID 367681
Institutional Source Beutler Lab
Gene Symbol Tex15
Ensembl Gene ENSMUSG00000009628
Gene Name testis expressed gene 15
Synonyms 2210014E14Rik
MMRRC Submission 042411-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.291) question?
Stock # R4773 (G1)
Quality Score 225
Status Validated
Chromosome 8
Chromosomal Location 34006766-34075610 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 34072760 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 2769 (V2769A)
Ref Sequence ENSEMBL: ENSMUSP00000009772 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000009772] [ENSMUST00000124501]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000009772
AA Change: V2769A

PolyPhen 2 Score 0.422 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000009772
Gene: ENSMUSG00000009628
AA Change: V2769A

DomainStartEndE-ValueType
low complexity region 262 274 N/A INTRINSIC
low complexity region 302 313 N/A INTRINSIC
low complexity region 524 536 N/A INTRINSIC
low complexity region 665 674 N/A INTRINSIC
low complexity region 713 725 N/A INTRINSIC
low complexity region 946 961 N/A INTRINSIC
low complexity region 1497 1508 N/A INTRINSIC
Pfam:TEX15 1572 1788 1.3e-109 PFAM
Pfam:TEX15 1901 2119 1.1e-16 PFAM
low complexity region 2758 2770 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000124501
SMART Domains Protein: ENSMUSP00000138070
Gene: ENSMUSG00000009628

DomainStartEndE-ValueType
Pfam:DUF3715 96 251 2.4e-52 PFAM
Meta Mutation Damage Score 0.0731 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.2%
Validation Efficiency 100% (89/89)
MGI Phenotype PHENOTYPE: Male mice are infertile due to arrest of meiosis stemming from failure to repair double-strand breaks. However, female mice are fertile. [provided by MGI curators]
Allele List at MGI

All alleles(4) : Targeted(3) Gene trapped(1)

Other mutations in this stock
Total: 82 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9230009I02Rik A G 11: 50,982,089 (GRCm39) noncoding transcript Het
Actl7b T C 4: 56,740,972 (GRCm39) I129V probably benign Het
Adipor2 A G 6: 119,336,047 (GRCm39) L225P probably benign Het
Arhgap25 A G 6: 87,473,053 (GRCm39) F35L probably benign Het
Asah2 A T 19: 32,030,258 (GRCm39) M138K probably damaging Het
Asxl1 T A 2: 153,243,905 (GRCm39) M1486K probably damaging Het
B4galt4 T A 16: 38,572,658 (GRCm39) S114R probably benign Het
Brpf3 T G 17: 29,040,233 (GRCm39) S885A probably benign Het
Cacna1g G T 11: 94,302,298 (GRCm39) H1944N possibly damaging Het
Cby2 T A 14: 75,820,546 (GRCm39) Y393F probably damaging Het
Ccdc110 G A 8: 46,396,245 (GRCm39) C712Y probably damaging Het
Ccdc175 A T 12: 72,182,822 (GRCm39) I399N probably damaging Het
Cct8l1 A T 5: 25,722,754 (GRCm39) T490S probably benign Het
Cd109 CATTTATTTATTTATTTATTTATTTATTTATTTAT CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT 9: 78,619,782 (GRCm39) probably benign Het
Copa A G 1: 171,932,787 (GRCm39) N371D probably damaging Het
Cpeb1 A T 7: 81,005,695 (GRCm39) H381Q probably benign Het
Cyp2d40 T A 15: 82,645,763 (GRCm39) I81F possibly damaging Het
Dscc1 A T 15: 54,943,654 (GRCm39) D405E probably benign Het
Ece1 A G 4: 137,672,464 (GRCm39) D369G probably benign Het
Exd2 T C 12: 80,522,592 (GRCm39) V17A possibly damaging Het
Fam111a A T 19: 12,565,772 (GRCm39) N507I possibly damaging Het
Flnc T C 6: 29,445,038 (GRCm39) V719A possibly damaging Het
Fscb C T 12: 64,520,464 (GRCm39) G334D probably damaging Het
Glud1 T C 14: 34,043,782 (GRCm39) probably null Het
Gm8126 T A 14: 43,119,072 (GRCm39) Y180* probably null Het
Grip2 G A 6: 91,759,413 (GRCm39) P347L possibly damaging Het
H1f3 T C 13: 23,739,576 (GRCm39) S105P probably damaging Het
H60b C T 10: 22,164,644 (GRCm39) probably benign Het
Iqca1l A G 5: 24,755,596 (GRCm39) probably null Het
Itga6 T C 2: 71,652,788 (GRCm39) V217A probably benign Het
Kndc1 G A 7: 139,503,946 (GRCm39) W1083* probably null Het
Limch1 A T 5: 67,184,850 (GRCm39) D613V probably damaging Het
Lpl T A 8: 69,349,403 (GRCm39) C310S probably damaging Het
Marchf1 T A 8: 66,839,876 (GRCm39) C220S probably benign Het
Mbd5 A C 2: 49,164,623 (GRCm39) H308P probably damaging Het
Med13 T C 11: 86,167,746 (GRCm39) D2003G probably damaging Het
Mettl16 T A 11: 74,708,127 (GRCm39) V442D possibly damaging Het
Mstn A T 1: 53,101,267 (GRCm39) T115S probably benign Het
Mtcl2 G T 2: 156,872,489 (GRCm39) Q953K probably benign Het
Nfil3 A G 13: 53,122,050 (GRCm39) S285P probably damaging Het
Odad4 C A 11: 100,440,742 (GRCm39) N74K probably benign Het
Or10j3 A C 1: 173,031,796 (GRCm39) Y291S probably damaging Het
Or51a24 A G 7: 103,733,502 (GRCm39) S262P probably damaging Het
Otof A G 5: 30,552,026 (GRCm39) V321A probably benign Het
Pcdha8 G T 18: 37,127,626 (GRCm39) A703S probably damaging Het
Pcdhb18 A G 18: 37,623,507 (GRCm39) Y279C probably damaging Het
Pdgfa T C 5: 138,979,051 (GRCm39) D51G probably benign Het
Pdzd8 A G 19: 59,289,292 (GRCm39) Y703H probably damaging Het
Pecr G T 1: 72,306,594 (GRCm39) P229Q probably damaging Het
Phkg1 G T 5: 129,902,114 (GRCm39) probably null Het
Plxnb2 A T 15: 89,051,150 (GRCm39) H356Q probably benign Het
Polr1b T C 2: 128,947,248 (GRCm39) I191T probably benign Het
Ppp4r3a A G 12: 101,049,026 (GRCm39) L35P possibly damaging Het
Rasa2 C T 9: 96,426,470 (GRCm39) G792D probably benign Het
Rps11-ps4 T C 12: 51,344,406 (GRCm39) noncoding transcript Het
Sema3g A G 14: 30,942,666 (GRCm39) D89G probably benign Het
Shroom3 G T 5: 93,090,945 (GRCm39) V1151F probably damaging Het
Slfn8 A G 11: 82,908,219 (GRCm39) V108A probably damaging Het
Smg9 T A 7: 24,107,019 (GRCm39) M221K possibly damaging Het
Sos1 A G 17: 80,705,660 (GRCm39) S1304P probably damaging Het
Sqle C A 15: 59,189,688 (GRCm39) A110E possibly damaging Het
Stab2 G A 10: 86,743,235 (GRCm39) Q1154* probably null Het
Taf4b A G 18: 14,937,577 (GRCm39) T217A probably benign Het
Tmem156 A T 5: 65,237,502 (GRCm39) C53S probably damaging Het
Tmtc3 T A 10: 100,293,001 (GRCm39) K452N possibly damaging Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Tph1 T C 7: 46,306,376 (GRCm39) E195G probably damaging Het
Trpc6 T A 9: 8,609,852 (GRCm39) Y107N possibly damaging Het
Tsga10 G A 1: 37,874,606 (GRCm39) T93I probably damaging Het
Ttn T A 2: 76,571,778 (GRCm39) N26372Y probably damaging Het
Tubd1 T C 11: 86,446,128 (GRCm39) L256P possibly damaging Het
Txnrd2 C G 16: 18,259,569 (GRCm39) A126G probably benign Het
Vmn1r210 T G 13: 23,011,374 (GRCm39) K304T probably benign Het
Vps25 T C 11: 101,149,655 (GRCm39) S160P probably benign Het
Vrk3 T A 7: 44,424,900 (GRCm39) D438E probably benign Het
Vwa5b1 A G 4: 138,309,066 (GRCm39) L708P probably benign Het
Washc3 C T 10: 88,055,124 (GRCm39) Q105* probably null Het
Wdr83os T A 8: 85,807,410 (GRCm39) probably benign Het
Wwc1 T C 11: 35,758,123 (GRCm39) H741R probably benign Het
Zan T C 5: 137,434,575 (GRCm39) probably benign Het
Zdhhc4 A T 5: 143,311,931 (GRCm39) L14I possibly damaging Het
Zfp568 T A 7: 29,697,195 (GRCm39) D38E probably damaging Het
Other mutations in Tex15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00639:Tex15 APN 8 34,065,339 (GRCm39) missense probably benign 0.18
IGL00705:Tex15 APN 8 34,071,620 (GRCm39) missense probably damaging 1.00
IGL00820:Tex15 APN 8 34,069,034 (GRCm39) splice site probably benign
IGL01288:Tex15 APN 8 34,061,412 (GRCm39) missense probably benign 0.02
IGL01328:Tex15 APN 8 34,061,424 (GRCm39) nonsense probably null
IGL01359:Tex15 APN 8 34,071,926 (GRCm39) missense probably damaging 0.99
IGL01603:Tex15 APN 8 34,063,575 (GRCm39) missense possibly damaging 0.93
IGL01861:Tex15 APN 8 34,060,717 (GRCm39) missense probably damaging 1.00
IGL02052:Tex15 APN 8 34,072,493 (GRCm39) missense probably benign 0.28
IGL02560:Tex15 APN 8 34,071,779 (GRCm39) missense probably benign 0.00
IGL02677:Tex15 APN 8 34,061,108 (GRCm39) missense probably benign 0.03
IGL02739:Tex15 APN 8 34,071,721 (GRCm39) missense possibly damaging 0.68
Big_gulp UTSW 8 34,071,762 (GRCm39) missense probably damaging 1.00
P0005:Tex15 UTSW 8 34,060,896 (GRCm39) missense probably benign 0.00
P0037:Tex15 UTSW 8 34,071,608 (GRCm39) missense probably benign 0.00
PIT4377001:Tex15 UTSW 8 34,061,129 (GRCm39) missense probably damaging 1.00
R0056:Tex15 UTSW 8 34,072,055 (GRCm39) missense probably benign 0.00
R0056:Tex15 UTSW 8 34,072,055 (GRCm39) missense probably benign 0.00
R0058:Tex15 UTSW 8 34,071,530 (GRCm39) splice site probably benign
R0058:Tex15 UTSW 8 34,071,530 (GRCm39) splice site probably benign
R0595:Tex15 UTSW 8 34,062,645 (GRCm39) missense probably damaging 1.00
R0646:Tex15 UTSW 8 34,072,354 (GRCm39) missense possibly damaging 0.83
R0688:Tex15 UTSW 8 34,063,528 (GRCm39) missense probably damaging 1.00
R0842:Tex15 UTSW 8 34,061,575 (GRCm39) missense possibly damaging 0.95
R0987:Tex15 UTSW 8 34,066,875 (GRCm39) missense probably damaging 1.00
R1084:Tex15 UTSW 8 34,067,032 (GRCm39) missense probably benign 0.28
R1183:Tex15 UTSW 8 34,064,893 (GRCm39) missense probably benign 0.35
R1186:Tex15 UTSW 8 34,061,661 (GRCm39) missense probably benign 0.19
R1378:Tex15 UTSW 8 34,065,244 (GRCm39) missense probably damaging 0.99
R1500:Tex15 UTSW 8 34,065,120 (GRCm39) missense probably damaging 0.96
R1508:Tex15 UTSW 8 34,066,880 (GRCm39) missense probably damaging 1.00
R1597:Tex15 UTSW 8 34,061,511 (GRCm39) missense probably damaging 0.96
R1636:Tex15 UTSW 8 34,066,415 (GRCm39) nonsense probably null
R1639:Tex15 UTSW 8 34,060,845 (GRCm39) missense possibly damaging 0.94
R1809:Tex15 UTSW 8 34,064,262 (GRCm39) missense probably benign
R1843:Tex15 UTSW 8 34,066,682 (GRCm39) missense probably benign 0.27
R2029:Tex15 UTSW 8 34,061,302 (GRCm39) missense probably damaging 0.99
R2228:Tex15 UTSW 8 34,061,265 (GRCm39) missense probably benign 0.05
R2229:Tex15 UTSW 8 34,061,265 (GRCm39) missense probably benign 0.05
R2245:Tex15 UTSW 8 34,061,524 (GRCm39) missense possibly damaging 0.77
R2246:Tex15 UTSW 8 34,072,540 (GRCm39) missense possibly damaging 0.49
R2880:Tex15 UTSW 8 34,064,935 (GRCm39) nonsense probably null
R2881:Tex15 UTSW 8 34,064,935 (GRCm39) nonsense probably null
R2882:Tex15 UTSW 8 34,064,935 (GRCm39) nonsense probably null
R3001:Tex15 UTSW 8 34,064,556 (GRCm39) missense probably benign 0.15
R3002:Tex15 UTSW 8 34,064,556 (GRCm39) missense probably benign 0.15
R3020:Tex15 UTSW 8 34,066,698 (GRCm39) missense probably damaging 1.00
R3084:Tex15 UTSW 8 34,064,913 (GRCm39) missense probably benign 0.11
R3085:Tex15 UTSW 8 34,064,913 (GRCm39) missense probably benign 0.11
R3701:Tex15 UTSW 8 34,064,194 (GRCm39) missense probably benign 0.00
R3702:Tex15 UTSW 8 34,064,194 (GRCm39) missense probably benign 0.00
R3752:Tex15 UTSW 8 34,061,443 (GRCm39) missense probably benign
R4162:Tex15 UTSW 8 34,071,586 (GRCm39) missense probably damaging 1.00
R4231:Tex15 UTSW 8 34,062,165 (GRCm39) missense probably damaging 0.99
R4589:Tex15 UTSW 8 34,047,401 (GRCm39) missense probably damaging 1.00
R4707:Tex15 UTSW 8 34,072,525 (GRCm39) missense probably benign 0.00
R4967:Tex15 UTSW 8 34,064,498 (GRCm39) missense probably benign 0.34
R5063:Tex15 UTSW 8 34,072,638 (GRCm39) missense possibly damaging 0.59
R5121:Tex15 UTSW 8 34,061,794 (GRCm39) missense probably damaging 1.00
R5147:Tex15 UTSW 8 34,062,340 (GRCm39) nonsense probably null
R5166:Tex15 UTSW 8 34,066,420 (GRCm39) missense probably benign 0.07
R5173:Tex15 UTSW 8 34,061,768 (GRCm39) missense possibly damaging 0.73
R5439:Tex15 UTSW 8 34,064,199 (GRCm39) missense possibly damaging 0.93
R5537:Tex15 UTSW 8 34,061,641 (GRCm39) missense probably damaging 1.00
R5580:Tex15 UTSW 8 34,062,457 (GRCm39) missense probably damaging 1.00
R5588:Tex15 UTSW 8 34,067,215 (GRCm39) missense probably damaging 1.00
R5696:Tex15 UTSW 8 34,063,220 (GRCm39) missense probably benign 0.01
R5734:Tex15 UTSW 8 34,036,364 (GRCm39) missense probably benign 0.01
R5756:Tex15 UTSW 8 34,065,861 (GRCm39) missense probably benign 0.17
R5823:Tex15 UTSW 8 34,060,962 (GRCm39) missense possibly damaging 0.67
R6126:Tex15 UTSW 8 34,063,591 (GRCm39) missense probably benign 0.19
R6129:Tex15 UTSW 8 34,064,158 (GRCm39) missense possibly damaging 0.90
R6276:Tex15 UTSW 8 34,067,217 (GRCm39) missense possibly damaging 0.93
R6374:Tex15 UTSW 8 34,065,940 (GRCm39) missense probably damaging 1.00
R6430:Tex15 UTSW 8 34,061,329 (GRCm39) missense probably benign 0.01
R6452:Tex15 UTSW 8 34,062,844 (GRCm39) missense probably damaging 1.00
R6471:Tex15 UTSW 8 34,071,762 (GRCm39) missense probably damaging 1.00
R6700:Tex15 UTSW 8 34,064,917 (GRCm39) missense possibly damaging 0.93
R6918:Tex15 UTSW 8 34,063,212 (GRCm39) missense probably benign 0.27
R6958:Tex15 UTSW 8 34,060,899 (GRCm39) missense probably benign 0.01
R6970:Tex15 UTSW 8 34,047,456 (GRCm39) missense probably benign 0.03
R7059:Tex15 UTSW 8 34,064,758 (GRCm39) missense possibly damaging 0.57
R7069:Tex15 UTSW 8 34,060,748 (GRCm39) missense probably benign
R7072:Tex15 UTSW 8 34,065,459 (GRCm39) missense possibly damaging 0.85
R7212:Tex15 UTSW 8 34,063,023 (GRCm39) missense probably damaging 1.00
R7212:Tex15 UTSW 8 34,060,854 (GRCm39) nonsense probably null
R7216:Tex15 UTSW 8 34,063,014 (GRCm39) missense possibly damaging 0.93
R7219:Tex15 UTSW 8 34,036,268 (GRCm39) missense probably benign 0.40
R7313:Tex15 UTSW 8 34,064,845 (GRCm39) missense possibly damaging 0.82
R7315:Tex15 UTSW 8 34,071,544 (GRCm39) missense probably benign 0.01
R7444:Tex15 UTSW 8 34,066,590 (GRCm39) missense possibly damaging 0.92
R7455:Tex15 UTSW 8 34,067,025 (GRCm39) missense possibly damaging 0.91
R7643:Tex15 UTSW 8 34,065,148 (GRCm39) missense probably damaging 1.00
R7644:Tex15 UTSW 8 34,064,445 (GRCm39) missense probably benign 0.01
R7724:Tex15 UTSW 8 34,036,291 (GRCm39) missense possibly damaging 0.60
R7779:Tex15 UTSW 8 34,065,309 (GRCm39) missense probably damaging 1.00
R7798:Tex15 UTSW 8 34,071,875 (GRCm39) missense possibly damaging 0.69
R7816:Tex15 UTSW 8 34,071,683 (GRCm39) missense probably benign 0.14
R7820:Tex15 UTSW 8 34,065,090 (GRCm39) missense probably damaging 0.98
R8041:Tex15 UTSW 8 34,065,874 (GRCm39) missense probably damaging 1.00
R8150:Tex15 UTSW 8 34,063,534 (GRCm39) missense probably benign 0.06
R8152:Tex15 UTSW 8 34,062,921 (GRCm39) missense possibly damaging 0.82
R8237:Tex15 UTSW 8 34,067,427 (GRCm39) missense possibly damaging 0.72
R8250:Tex15 UTSW 8 34,055,233 (GRCm39) missense probably null 0.27
R8264:Tex15 UTSW 8 34,072,390 (GRCm39) missense probably benign 0.18
R8279:Tex15 UTSW 8 34,061,765 (GRCm39) missense probably damaging 0.96
R8353:Tex15 UTSW 8 34,066,899 (GRCm39) nonsense probably null
R8388:Tex15 UTSW 8 34,065,237 (GRCm39) missense probably benign 0.00
R8432:Tex15 UTSW 8 34,066,572 (GRCm39) missense probably damaging 0.99
R8453:Tex15 UTSW 8 34,066,899 (GRCm39) nonsense probably null
R8489:Tex15 UTSW 8 34,067,574 (GRCm39) missense probably benign 0.02
R8670:Tex15 UTSW 8 34,064,746 (GRCm39) missense probably benign 0.19
R8703:Tex15 UTSW 8 34,062,724 (GRCm39) missense probably benign 0.00
R8871:Tex15 UTSW 8 34,066,992 (GRCm39) missense possibly damaging 0.62
R8945:Tex15 UTSW 8 34,064,724 (GRCm39) missense probably benign 0.00
R9104:Tex15 UTSW 8 34,060,950 (GRCm39) missense possibly damaging 0.86
R9132:Tex15 UTSW 8 34,067,554 (GRCm39) missense possibly damaging 0.84
R9207:Tex15 UTSW 8 34,065,784 (GRCm39) missense probably damaging 1.00
R9210:Tex15 UTSW 8 34,064,319 (GRCm39) missense possibly damaging 0.91
R9330:Tex15 UTSW 8 34,065,143 (GRCm39) missense probably benign 0.01
R9354:Tex15 UTSW 8 34,063,344 (GRCm39) missense possibly damaging 0.86
R9365:Tex15 UTSW 8 34,064,564 (GRCm39) missense possibly damaging 0.56
R9440:Tex15 UTSW 8 34,072,273 (GRCm39) missense possibly damaging 0.90
R9534:Tex15 UTSW 8 34,060,999 (GRCm39) missense probably benign 0.45
R9570:Tex15 UTSW 8 34,067,309 (GRCm39) missense probably damaging 0.96
R9574:Tex15 UTSW 8 34,064,509 (GRCm39) missense probably benign 0.09
R9618:Tex15 UTSW 8 34,062,397 (GRCm39) missense probably benign 0.35
R9655:Tex15 UTSW 8 34,066,784 (GRCm39) nonsense probably null
R9786:Tex15 UTSW 8 34,062,457 (GRCm39) missense probably damaging 1.00
R9798:Tex15 UTSW 8 34,062,721 (GRCm39) missense probably damaging 0.98
RF005:Tex15 UTSW 8 34,066,705 (GRCm39) missense probably benign 0.05
X0020:Tex15 UTSW 8 34,066,607 (GRCm39) missense probably benign 0.03
X0065:Tex15 UTSW 8 34,065,545 (GRCm39) nonsense probably null
Z1088:Tex15 UTSW 8 34,061,343 (GRCm39) missense possibly damaging 0.89
Z1088:Tex15 UTSW 8 34,064,898 (GRCm39) missense probably benign
Z1088:Tex15 UTSW 8 34,061,838 (GRCm39) missense possibly damaging 0.68
Z1176:Tex15 UTSW 8 34,064,754 (GRCm39) missense possibly damaging 0.84
Predicted Primers PCR Primer
(F):5'- CTTTCCTGGACAGCCACAAG -3'
(R):5'- CCTCCCTAAAGATAGCTATGGAAG -3'

Sequencing Primer
(F):5'- AAGCAAATTCCTTTAACCCAGG -3'
(R):5'- TGTTTTCTGACACTGGATTTACAAC -3'
Posted On 2015-12-29