Mutagenetix > Incidental Mutation

Incidental Mutation 'R4777:Or10g6'

368033

Institutional Source

Beutler Lab

Gene Symbol

Or10g6

Ensembl Gene

ENSMUSG00000046678

Gene Name

olfactory receptor family 10 subfamily G member 6

Synonyms

MOR223-8, GA_x6K02T2PVTD-33720892-33721824, Olfr981

MMRRC Submission

041992-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.150) question?

Stock #

R4777 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

39933691-39934623 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 39933994 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 102 (F102L)

Ref Sequence

ENSEMBL: ENSMUSP00000149436 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000059859] [ENSMUST00000215956]

AlphaFold

Q8VEU2

Predicted Effect

possibly damaging
Transcript: ENSMUST00000059859
AA Change: F102L

PolyPhen 2 Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000057952
Gene: ENSMUSG00000046678
AA Change: F102L

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	304	1.4e-54	PFAM
Pfam:7tm_1	41	288	8.8e-21	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000215956
AA Change: F102L

PolyPhen 2 Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000219526

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000220338

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.7%
20x: 93.7%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 75 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110002E22Rik	A	C	3: 137,771,503 (GRCm39)	S231R	probably benign	Het
5730455P16Rik	A	T	11: 80,265,041 (GRCm39)	I137N	probably damaging	Het
Abhd10	G	A	16: 45,557,279 (GRCm39)	Q176*	probably null	Het
Acer3	T	C	7: 97,910,804 (GRCm39)	Y86C	probably damaging	Het
Ankrd36	T	C	11: 5,557,120 (GRCm39)	V356A	probably benign	Het
Atp1a1	A	G	3: 101,502,312 (GRCm39)		probably null	Het
Bmp8b	G	A	4: 123,015,793 (GRCm39)	R260Q	possibly damaging	Het
C2cd3	T	A	7: 100,065,539 (GRCm39)	V775D	possibly damaging	Het
Cacna1b	T	A	2: 24,622,337 (GRCm39)	I216F	probably damaging	Het
Capn5	T	A	7: 97,780,925 (GRCm39)	N284I	probably damaging	Het
Cbr1	C	A	16: 93,406,942 (GRCm39)	D219E	probably benign	Het
Cdca2	C	T	14: 67,950,589 (GRCm39)	R114Q	probably damaging	Het
Cdh20	G	A	1: 109,922,055 (GRCm39)	W49*	probably null	Het
Cep152	C	T	2: 125,406,015 (GRCm39)	V1506I	probably benign	Het
Cfap97	C	T	8: 46,648,334 (GRCm39)	Q537*	probably null	Het
Cpsf2	T	A	12: 101,963,091 (GRCm39)	V385E	probably damaging	Het
Dse	A	G	10: 34,029,584 (GRCm39)	V502A	possibly damaging	Het
Fam171a1	T	A	2: 3,224,550 (GRCm39)	F300L	probably benign	Het
Fnip1	T	G	11: 54,391,382 (GRCm39)	N438K	probably damaging	Het
Fstl5	C	T	3: 76,500,807 (GRCm39)	T412M	probably damaging	Het
Gm11938	T	A	11: 99,494,059 (GRCm39)	Q12L	unknown	Het
Hcls1	G	T	16: 36,775,678 (GRCm39)	A171S	probably damaging	Het
Hcn1	ACAGCAGCAGCAGCAGCAGCAGCAACAGCAACAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGC	ACAGCAGCAGCAGCAGCAGCAACAGCAACAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGC	13: 118,112,269 (GRCm39)		probably benign	Het
Hydin	G	T	8: 111,137,096 (GRCm39)	C633F	probably damaging	Het
Ica1	A	T	6: 8,644,145 (GRCm39)	D381E	probably benign	Het
Ift74	A	G	4: 94,541,234 (GRCm39)	K220E	probably benign	Het
Igfn1	A	T	1: 135,882,600 (GRCm39)	D2748E	probably benign	Het
Il16	A	C	7: 83,300,104 (GRCm39)	D396E	probably benign	Het
Impdh1	G	T	6: 29,205,201 (GRCm39)	A200E	possibly damaging	Het
Itga4	C	T	2: 79,144,054 (GRCm39)	T647I	possibly damaging	Het
Jpt1	A	T	11: 115,391,497 (GRCm39)	M104K	probably benign	Het
Krt73	C	A	15: 101,702,436 (GRCm39)	A476S	probably benign	Het
Lama3	T	C	18: 12,546,828 (GRCm39)	Y363H	probably damaging	Het
Lgr4	C	T	2: 109,827,027 (GRCm39)	P177L	probably damaging	Het
Lrp2	T	C	2: 69,312,608 (GRCm39)	D2560G	probably damaging	Het
Ly6m	T	C	15: 74,752,532 (GRCm39)	N48S	probably benign	Het
Macf1	A	T	4: 123,270,295 (GRCm39)	F6617I	probably damaging	Het
Mcf2l	T	A	8: 13,068,051 (GRCm39)		probably null	Het
Mcub	T	A	3: 129,763,600 (GRCm39)	Q42L	probably damaging	Het
Mfsd9	C	T	1: 40,820,700 (GRCm39)	V150I	possibly damaging	Het
Myo15b	T	C	11: 115,770,478 (GRCm39)	V96A	probably damaging	Het
Nfkb2	G	T	19: 46,296,006 (GRCm39)	E170D	probably benign	Het
Or10aa3	T	G	1: 173,878,244 (GRCm39)	Y102D	probably damaging	Het
Or1r1	A	G	11: 73,875,221 (GRCm39)	V71A	probably benign	Het
Pgap6	T	C	17: 26,340,515 (GRCm39)	V633A	probably damaging	Het
Pinlyp	T	A	7: 24,241,568 (GRCm39)	I153F	possibly damaging	Het
Plk2	A	C	13: 110,534,307 (GRCm39)	M296L	probably benign	Het
Plvap	T	C	8: 71,960,630 (GRCm39)	Y262C	probably benign	Het
Ppfia3	C	A	7: 44,990,581 (GRCm39)	G1066V	probably damaging	Het
Prokr1	A	G	6: 87,565,842 (GRCm39)	M1T	probably null	Het
Ptgs2	G	T	1: 149,981,138 (GRCm39)	A474S	probably benign	Het
Pth2r	A	G	1: 65,427,676 (GRCm39)	T450A	possibly damaging	Het
Ranbp6	A	T	19: 29,789,037 (GRCm39)	F438L	probably damaging	Het
Ripor1	A	T	8: 106,341,622 (GRCm39)	Q102L	probably damaging	Het
Rprd2	C	T	3: 95,694,686 (GRCm39)	V116I	probably benign	Het
Sacs	T	C	14: 61,449,258 (GRCm39)	V3768A	probably damaging	Het
Scn8a	T	C	15: 100,913,832 (GRCm39)	Y1075H	probably damaging	Het
Senp3	C	T	11: 69,569,063 (GRCm39)	G366D	probably damaging	Het
Smim1	T	C	4: 154,108,107 (GRCm39)		probably benign	Het
Sptan1	A	G	2: 29,886,447 (GRCm39)	I817V	probably damaging	Het
Stag3	A	T	5: 138,307,461 (GRCm39)		probably benign	Het
Stk17b	A	T	1: 53,810,867 (GRCm39)	H79Q	probably damaging	Het
Svil	A	G	18: 5,088,813 (GRCm39)	K1296E	probably damaging	Het
Tmem117	T	A	15: 94,992,331 (GRCm39)	Y330*	probably null	Het
Tnxb	G	T	17: 34,890,917 (GRCm39)	R420L	probably damaging	Het
Trim9	C	A	12: 70,393,845 (GRCm39)	C33F	probably damaging	Het
Usp29	A	C	7: 6,965,747 (GRCm39)	Y530S	probably benign	Het
Vps26b	T	C	9: 26,921,752 (GRCm39)	T258A	possibly damaging	Het
Vrtn	C	A	12: 84,695,600 (GRCm39)	H117N	probably damaging	Het
Wdr33	C	T	18: 32,014,301 (GRCm39)	H388Y	probably damaging	Het
Zfp451	A	T	1: 33,821,186 (GRCm39)	V222D	possibly damaging	Het
Zfp953	A	G	13: 67,491,193 (GRCm39)	I253T	probably benign	Het
Zfy2	A	G	Y: 2,116,194 (GRCm39)	V282A	probably benign	Het
Zscan29	A	T	2: 120,999,805 (GRCm39)	V132D	probably damaging	Het
Zswim4	G	T	8: 84,963,586 (GRCm39)	D16E	probably benign	Het

Other mutations in Or10g6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01481:Or10g6	APN	9	39,934,574 (GRCm39)	missense	possibly damaging	0.61
IGL02089:Or10g6	APN	9	39,934,066 (GRCm39)	missense	probably damaging	1.00
R0722:Or10g6	UTSW	9	39,934,295 (GRCm39)	missense	probably damaging	1.00
R1117:Or10g6	UTSW	9	39,934,058 (GRCm39)	missense	probably damaging	0.99
R1781:Or10g6	UTSW	9	39,934,541 (GRCm39)	missense	probably damaging	1.00
R1874:Or10g6	UTSW	9	39,934,151 (GRCm39)	missense	possibly damaging	0.86
R1893:Or10g6	UTSW	9	39,934,270 (GRCm39)	missense	possibly damaging	0.64
R1942:Or10g6	UTSW	9	39,934,048 (GRCm39)	missense	probably damaging	1.00
R1942:Or10g6	UTSW	9	39,934,031 (GRCm39)	missense	probably damaging	1.00
R1999:Or10g6	UTSW	9	39,933,985 (GRCm39)	missense	probably benign
R2000:Or10g6	UTSW	9	39,933,985 (GRCm39)	missense	probably benign
R2173:Or10g6	UTSW	9	39,934,550 (GRCm39)	missense	probably damaging	0.97
R2760:Or10g6	UTSW	9	39,933,692 (GRCm39)	start codon destroyed	probably null	0.00
R4300:Or10g6	UTSW	9	39,934,435 (GRCm39)	missense	probably benign	0.02
R4530:Or10g6	UTSW	9	39,934,589 (GRCm39)	missense	probably benign
R4614:Or10g6	UTSW	9	39,934,255 (GRCm39)	missense	probably damaging	1.00
R4661:Or10g6	UTSW	9	39,933,823 (GRCm39)	missense	probably damaging	1.00
R5017:Or10g6	UTSW	9	39,933,672 (GRCm39)	start gained	probably benign
R5065:Or10g6	UTSW	9	39,934,546 (GRCm39)	missense	probably benign	0.44
R5467:Or10g6	UTSW	9	39,933,733 (GRCm39)	missense	probably benign	0.00
R5668:Or10g6	UTSW	9	39,933,964 (GRCm39)	missense	probably damaging	1.00
R5687:Or10g6	UTSW	9	39,933,731 (GRCm39)	missense	probably damaging	1.00
R6432:Or10g6	UTSW	9	39,933,824 (GRCm39)	missense	probably damaging	1.00
R6620:Or10g6	UTSW	9	39,934,225 (GRCm39)	missense	probably damaging	1.00
R6992:Or10g6	UTSW	9	39,933,896 (GRCm39)	nonsense	probably null
R7156:Or10g6	UTSW	9	39,934,526 (GRCm39)	missense	probably benign	0.23
R7250:Or10g6	UTSW	9	39,934,050 (GRCm39)	nonsense	probably null
R7273:Or10g6	UTSW	9	39,933,961 (GRCm39)	missense	probably benign	0.04
R8006:Or10g6	UTSW	9	39,933,770 (GRCm39)	missense	probably damaging	1.00
R8701:Or10g6	UTSW	9	39,933,815 (GRCm39)	missense	probably damaging	1.00
R8835:Or10g6	UTSW	9	39,934,171 (GRCm39)	missense	possibly damaging	0.48
R9497:Or10g6	UTSW	9	39,934,616 (GRCm39)	missense	probably benign
R9733:Or10g6	UTSW	9	39,934,171 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- ATGGGCTCATCATCCTCACTG -3'
(R):5'- TAGTCAACTCGGTTTGGGC -3'

Sequencing Primer
(F):5'- CACTGTCTTGGTGGACATCCG -3'
(R):5'- CAGCCTGAATATGAAACTCGTTTGG -3'

Posted On

2015-12-29