Mutagenetix > Incidental Mutation

Incidental Mutation 'R4777:Tnxb'

368061

Institutional Source

Beutler Lab

Gene Symbol

Tnxb

Ensembl Gene

ENSMUSG00000033327

Gene Name

tenascin XB

Synonyms

Tnx, TN-MHC

MMRRC Submission

041992-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R4777 (G1)

Quality Score

139

Status

Not validated

Chromosome

Chromosomal Location

34879431-34938789 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 34890917 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Leucine at position 420 (R420L)

Ref Sequence

ENSEMBL: ENSMUSP00000084661 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000087399] [ENSMUST00000168533]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000087399
AA Change: R420L

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000084661
Gene: ENSMUSG00000033327
AA Change: R420L

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
low complexity region	33	44	N/A	INTRINSIC
low complexity region	69	89	N/A	INTRINSIC
low complexity region	92	103	N/A	INTRINSIC
EGF	173	201	1.59e1	SMART
EGF	204	232	7.41e0	SMART
EGF	235	263	2.64e1	SMART
EGF	266	294	2.64e1	SMART
EGF	297	325	9.13e0	SMART
EGF	328	356	2.07e1	SMART
EGF_like	359	387	3.16e1	SMART
EGF_like	390	418	4.64e1	SMART
EGF_like	421	449	3.29e1	SMART
EGF_like	452	480	7.09e1	SMART
EGF	483	511	1.15e1	SMART
EGF	514	542	1.91e1	SMART
EGF_like	545	573	4.11e1	SMART
EGF	576	604	7.95e0	SMART
EGF	607	635	1.23e1	SMART
EGF_like	638	666	4.93e1	SMART
EGF_like	674	702	5.24e1	SMART
EGF	705	733	2.29e1	SMART
FN3	736	816	4.12e-3	SMART
FN3	827	904	1.21e-9	SMART
FN3	1047	1126	3.97e-5	SMART
FN3	1142	1223	3.62e-8	SMART
low complexity region	1230	1241	N/A	INTRINSIC
FN3	1242	1320	2.31e-6	SMART
FN3	1351	1431	8.77e-7	SMART
FN3	1460	1539	3.01e-5	SMART
FN3	1556	1636	2.76e-4	SMART
FN3	1657	1736	5.78e-7	SMART
FN3	1752	1832	4.7e-7	SMART
FN3	1851	1929	1.95e-4	SMART
FN3	1955	2034	4.56e-5	SMART
FN3	2066	2145	2.23e-8	SMART
FN3	2164	2244	7.75e-8	SMART
FN3	2279	2358	8.5e-5	SMART
FN3	2387	2467	2.94e-8	SMART
FN3	2501	2580	1.7e-4	SMART
low complexity region	2588	2598	N/A	INTRINSIC
FN3	2607	2687	6.75e-8	SMART
FN3	2716	2795	7.4e-5	SMART
FN3	2822	2902	1.35e-7	SMART
FN3	2931	3010	5.61e-5	SMART
FN3	3026	3106	6.01e-5	SMART
FN3	3120	3199	6.45e-5	SMART
FN3	3214	3293	9.54e-8	SMART
FN3	3316	3396	2.81e-5	SMART
FN3	3416	3502	1.98e-5	SMART
FN3	3518	3596	5.65e-10	SMART
FN3	3607	3682	7.63e-7	SMART
FN3	3695	3770	6.54e-6	SMART
FBG	3787	3997	8.88e-125	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000168533
AA Change: R420L

SMART Domains

Protein: ENSMUSP00000127487
Gene: ENSMUSG00000033327
AA Change: R420L

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
low complexity region	33	44	N/A	INTRINSIC
low complexity region	69	89	N/A	INTRINSIC
low complexity region	92	103	N/A	INTRINSIC
EGF	173	201	1.59e1	SMART
EGF	204	232	7.41e0	SMART
EGF	235	263	2.64e1	SMART
EGF	266	294	2.64e1	SMART
EGF	297	325	9.13e0	SMART
EGF	328	356	2.07e1	SMART
EGF_like	359	387	3.16e1	SMART
EGF_like	390	418	4.64e1	SMART
EGF_like	421	449	3.29e1	SMART
EGF_like	452	480	7.09e1	SMART
EGF	483	511	1.15e1	SMART
EGF	514	542	1.91e1	SMART
EGF_like	545	573	4.11e1	SMART
EGF	576	604	7.95e0	SMART
EGF	607	635	1.23e1	SMART
EGF_like	638	666	4.93e1	SMART
EGF_like	674	702	5.24e1	SMART
EGF	705	733	2.29e1	SMART
FN3	736	816	4.12e-3	SMART
FN3	827	904	1.21e-9	SMART
FN3	924	1003	3.97e-5	SMART
FN3	1019	1100	3.62e-8	SMART
low complexity region	1107	1118	N/A	INTRINSIC
FN3	1119	1197	2.31e-6	SMART
FN3	1228	1308	8.77e-7	SMART
FN3	1337	1416	3.01e-5	SMART
FN3	1433	1513	2.76e-4	SMART
FN3	1534	1613	5.78e-7	SMART
FN3	1629	1709	4.7e-7	SMART
FN3	1728	1806	1.95e-4	SMART
FN3	1832	1911	4.56e-5	SMART
FN3	1943	2022	2.23e-8	SMART
FN3	2051	2130	5.61e-5	SMART
FN3	2146	2226	6.01e-5	SMART
FN3	2240	2319	6.45e-5	SMART
FN3	2334	2413	9.54e-8	SMART
FN3	2436	2516	2.81e-5	SMART
FN3	2536	2622	1.98e-5	SMART
FN3	2638	2716	5.65e-10	SMART
FN3	2727	2802	7.63e-7	SMART
FN3	2815	2890	6.54e-6	SMART
FBG	2907	3117	8.88e-125	SMART

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.7%
20x: 93.7%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice have stretchy skin, similar to patients with human Ehlers-Danlos syndrome. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 75 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110002E22Rik	A	C	3: 137,771,503 (GRCm39)	S231R	probably benign	Het
5730455P16Rik	A	T	11: 80,265,041 (GRCm39)	I137N	probably damaging	Het
Abhd10	G	A	16: 45,557,279 (GRCm39)	Q176*	probably null	Het
Acer3	T	C	7: 97,910,804 (GRCm39)	Y86C	probably damaging	Het
Ankrd36	T	C	11: 5,557,120 (GRCm39)	V356A	probably benign	Het
Atp1a1	A	G	3: 101,502,312 (GRCm39)		probably null	Het
Bmp8b	G	A	4: 123,015,793 (GRCm39)	R260Q	possibly damaging	Het
C2cd3	T	A	7: 100,065,539 (GRCm39)	V775D	possibly damaging	Het
Cacna1b	T	A	2: 24,622,337 (GRCm39)	I216F	probably damaging	Het
Capn5	T	A	7: 97,780,925 (GRCm39)	N284I	probably damaging	Het
Cbr1	C	A	16: 93,406,942 (GRCm39)	D219E	probably benign	Het
Cdca2	C	T	14: 67,950,589 (GRCm39)	R114Q	probably damaging	Het
Cdh20	G	A	1: 109,922,055 (GRCm39)	W49*	probably null	Het
Cep152	C	T	2: 125,406,015 (GRCm39)	V1506I	probably benign	Het
Cfap97	C	T	8: 46,648,334 (GRCm39)	Q537*	probably null	Het
Cpsf2	T	A	12: 101,963,091 (GRCm39)	V385E	probably damaging	Het
Dse	A	G	10: 34,029,584 (GRCm39)	V502A	possibly damaging	Het
Fam171a1	T	A	2: 3,224,550 (GRCm39)	F300L	probably benign	Het
Fnip1	T	G	11: 54,391,382 (GRCm39)	N438K	probably damaging	Het
Fstl5	C	T	3: 76,500,807 (GRCm39)	T412M	probably damaging	Het
Gm11938	T	A	11: 99,494,059 (GRCm39)	Q12L	unknown	Het
Hcls1	G	T	16: 36,775,678 (GRCm39)	A171S	probably damaging	Het
Hcn1	ACAGCAGCAGCAGCAGCAGCAGCAACAGCAACAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGC	ACAGCAGCAGCAGCAGCAGCAACAGCAACAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGC	13: 118,112,269 (GRCm39)		probably benign	Het
Hydin	G	T	8: 111,137,096 (GRCm39)	C633F	probably damaging	Het
Ica1	A	T	6: 8,644,145 (GRCm39)	D381E	probably benign	Het
Ift74	A	G	4: 94,541,234 (GRCm39)	K220E	probably benign	Het
Igfn1	A	T	1: 135,882,600 (GRCm39)	D2748E	probably benign	Het
Il16	A	C	7: 83,300,104 (GRCm39)	D396E	probably benign	Het
Impdh1	G	T	6: 29,205,201 (GRCm39)	A200E	possibly damaging	Het
Itga4	C	T	2: 79,144,054 (GRCm39)	T647I	possibly damaging	Het
Jpt1	A	T	11: 115,391,497 (GRCm39)	M104K	probably benign	Het
Krt73	C	A	15: 101,702,436 (GRCm39)	A476S	probably benign	Het
Lama3	T	C	18: 12,546,828 (GRCm39)	Y363H	probably damaging	Het
Lgr4	C	T	2: 109,827,027 (GRCm39)	P177L	probably damaging	Het
Lrp2	T	C	2: 69,312,608 (GRCm39)	D2560G	probably damaging	Het
Ly6m	T	C	15: 74,752,532 (GRCm39)	N48S	probably benign	Het
Macf1	A	T	4: 123,270,295 (GRCm39)	F6617I	probably damaging	Het
Mcf2l	T	A	8: 13,068,051 (GRCm39)		probably null	Het
Mcub	T	A	3: 129,763,600 (GRCm39)	Q42L	probably damaging	Het
Mfsd9	C	T	1: 40,820,700 (GRCm39)	V150I	possibly damaging	Het
Myo15b	T	C	11: 115,770,478 (GRCm39)	V96A	probably damaging	Het
Nfkb2	G	T	19: 46,296,006 (GRCm39)	E170D	probably benign	Het
Or10aa3	T	G	1: 173,878,244 (GRCm39)	Y102D	probably damaging	Het
Or10g6	T	C	9: 39,933,994 (GRCm39)	F102L	possibly damaging	Het
Or1r1	A	G	11: 73,875,221 (GRCm39)	V71A	probably benign	Het
Pgap6	T	C	17: 26,340,515 (GRCm39)	V633A	probably damaging	Het
Pinlyp	T	A	7: 24,241,568 (GRCm39)	I153F	possibly damaging	Het
Plk2	A	C	13: 110,534,307 (GRCm39)	M296L	probably benign	Het
Plvap	T	C	8: 71,960,630 (GRCm39)	Y262C	probably benign	Het
Ppfia3	C	A	7: 44,990,581 (GRCm39)	G1066V	probably damaging	Het
Prokr1	A	G	6: 87,565,842 (GRCm39)	M1T	probably null	Het
Ptgs2	G	T	1: 149,981,138 (GRCm39)	A474S	probably benign	Het
Pth2r	A	G	1: 65,427,676 (GRCm39)	T450A	possibly damaging	Het
Ranbp6	A	T	19: 29,789,037 (GRCm39)	F438L	probably damaging	Het
Ripor1	A	T	8: 106,341,622 (GRCm39)	Q102L	probably damaging	Het
Rprd2	C	T	3: 95,694,686 (GRCm39)	V116I	probably benign	Het
Sacs	T	C	14: 61,449,258 (GRCm39)	V3768A	probably damaging	Het
Scn8a	T	C	15: 100,913,832 (GRCm39)	Y1075H	probably damaging	Het
Senp3	C	T	11: 69,569,063 (GRCm39)	G366D	probably damaging	Het
Smim1	T	C	4: 154,108,107 (GRCm39)		probably benign	Het
Sptan1	A	G	2: 29,886,447 (GRCm39)	I817V	probably damaging	Het
Stag3	A	T	5: 138,307,461 (GRCm39)		probably benign	Het
Stk17b	A	T	1: 53,810,867 (GRCm39)	H79Q	probably damaging	Het
Svil	A	G	18: 5,088,813 (GRCm39)	K1296E	probably damaging	Het
Tmem117	T	A	15: 94,992,331 (GRCm39)	Y330*	probably null	Het
Trim9	C	A	12: 70,393,845 (GRCm39)	C33F	probably damaging	Het
Usp29	A	C	7: 6,965,747 (GRCm39)	Y530S	probably benign	Het
Vps26b	T	C	9: 26,921,752 (GRCm39)	T258A	possibly damaging	Het
Vrtn	C	A	12: 84,695,600 (GRCm39)	H117N	probably damaging	Het
Wdr33	C	T	18: 32,014,301 (GRCm39)	H388Y	probably damaging	Het
Zfp451	A	T	1: 33,821,186 (GRCm39)	V222D	possibly damaging	Het
Zfp953	A	G	13: 67,491,193 (GRCm39)	I253T	probably benign	Het
Zfy2	A	G	Y: 2,116,194 (GRCm39)	V282A	probably benign	Het
Zscan29	A	T	2: 120,999,805 (GRCm39)	V132D	probably damaging	Het
Zswim4	G	T	8: 84,963,586 (GRCm39)	D16E	probably benign	Het

Other mutations in Tnxb

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00094:Tnxb	APN	17	34,904,603 (GRCm39)	missense	probably damaging	1.00
IGL00424:Tnxb	APN	17	34,933,666 (GRCm39)	missense	probably damaging	1.00
IGL00486:Tnxb	APN	17	34,911,356 (GRCm39)	missense	probably damaging	1.00
IGL00952:Tnxb	APN	17	34,932,102 (GRCm39)	missense	probably damaging	1.00
IGL00974:Tnxb	APN	17	34,937,707 (GRCm39)	critical splice donor site	probably null
IGL01017:Tnxb	APN	17	34,912,782 (GRCm39)	missense	probably damaging	0.98
IGL01082:Tnxb	APN	17	34,933,584 (GRCm39)	missense	probably damaging	0.97
IGL01397:Tnxb	APN	17	34,933,647 (GRCm39)	missense	probably damaging	0.99
IGL01473:Tnxb	APN	17	34,904,675 (GRCm39)	missense	probably damaging	0.99
IGL01642:Tnxb	APN	17	34,937,488 (GRCm39)	missense	probably damaging	1.00
IGL01774:Tnxb	APN	17	34,907,813 (GRCm39)	missense	probably damaging	1.00
IGL01971:Tnxb	APN	17	34,891,271 (GRCm39)	missense	probably damaging	1.00
IGL02016:Tnxb	APN	17	34,891,249 (GRCm39)	missense	probably damaging	0.98
IGL02160:Tnxb	APN	17	34,933,719 (GRCm39)	missense	probably benign	0.01
IGL02473:Tnxb	APN	17	34,936,736 (GRCm39)	missense	probably damaging	1.00
IGL02666:Tnxb	APN	17	34,903,913 (GRCm39)	missense	probably benign	0.20
IGL02831:Tnxb	APN	17	34,922,545 (GRCm39)	missense	possibly damaging	0.93
IGL02838:Tnxb	APN	17	34,908,606 (GRCm39)	missense	possibly damaging	0.74
IGL02965:Tnxb	APN	17	34,928,628 (GRCm39)	missense	possibly damaging	0.93
IGL03155:Tnxb	APN	17	34,932,569 (GRCm39)	missense	probably damaging	1.00
IGL03194:Tnxb	APN	17	34,914,921 (GRCm39)	nonsense	probably null
IGL03215:Tnxb	APN	17	34,911,499 (GRCm39)	missense	possibly damaging	0.66
IGL03256:Tnxb	APN	17	34,907,694 (GRCm39)	missense	probably damaging	1.00
BB008:Tnxb	UTSW	17	34,907,672 (GRCm39)	missense	probably damaging	1.00
BB018:Tnxb	UTSW	17	34,907,672 (GRCm39)	missense	probably damaging	1.00
E0370:Tnxb	UTSW	17	34,897,917 (GRCm39)	missense	probably damaging	1.00
R0006:Tnxb	UTSW	17	34,901,266 (GRCm39)	missense	probably benign	0.07
R0049:Tnxb	UTSW	17	34,928,542 (GRCm39)	missense	possibly damaging	0.93
R0050:Tnxb	UTSW	17	34,892,299 (GRCm39)	missense	probably damaging	1.00
R0233:Tnxb	UTSW	17	34,918,007 (GRCm39)	missense	probably benign	0.32
R0233:Tnxb	UTSW	17	34,918,007 (GRCm39)	missense	probably benign	0.32
R0311:Tnxb	UTSW	17	34,935,958 (GRCm39)	missense	probably damaging	0.97
R0326:Tnxb	UTSW	17	34,917,153 (GRCm39)	missense	probably benign	0.32
R0387:Tnxb	UTSW	17	34,902,548 (GRCm39)	missense	probably benign	0.30
R0396:Tnxb	UTSW	17	34,890,707 (GRCm39)	missense	probably damaging	1.00
R0511:Tnxb	UTSW	17	34,937,219 (GRCm39)	missense	probably damaging	0.96
R0540:Tnxb	UTSW	17	34,890,892 (GRCm39)	missense	probably damaging	1.00
R0563:Tnxb	UTSW	17	34,935,921 (GRCm39)	missense	probably benign	0.05
R0575:Tnxb	UTSW	17	34,936,180 (GRCm39)	missense	possibly damaging	0.91
R0586:Tnxb	UTSW	17	34,891,118 (GRCm39)	missense	probably damaging	1.00
R0607:Tnxb	UTSW	17	34,890,892 (GRCm39)	missense	probably damaging	1.00
R0622:Tnxb	UTSW	17	34,937,703 (GRCm39)	missense	probably damaging	1.00
R0624:Tnxb	UTSW	17	34,902,522 (GRCm39)	missense	probably damaging	1.00
R0709:Tnxb	UTSW	17	34,908,328 (GRCm39)	missense	probably damaging	1.00
R0898:Tnxb	UTSW	17	34,889,719 (GRCm39)	missense	probably damaging	1.00
R0970:Tnxb	UTSW	17	34,917,917 (GRCm39)	missense	possibly damaging	0.85
R0972:Tnxb	UTSW	17	34,904,117 (GRCm39)	missense	probably damaging	1.00
R1118:Tnxb	UTSW	17	34,904,017 (GRCm39)	missense	probably damaging	1.00
R1119:Tnxb	UTSW	17	34,904,017 (GRCm39)	missense	probably damaging	1.00
R1226:Tnxb	UTSW	17	34,907,903 (GRCm39)	missense	probably damaging	1.00
R1296:Tnxb	UTSW	17	34,890,551 (GRCm39)	missense	probably damaging	1.00
R1297:Tnxb	UTSW	17	34,929,140 (GRCm39)	missense	probably damaging	0.96
R1349:Tnxb	UTSW	17	34,929,267 (GRCm39)	missense	possibly damaging	0.67
R1356:Tnxb	UTSW	17	34,914,446 (GRCm39)	missense	possibly damaging	0.53
R1372:Tnxb	UTSW	17	34,929,267 (GRCm39)	missense	possibly damaging	0.67
R1521:Tnxb	UTSW	17	34,930,477 (GRCm39)	missense	probably damaging	1.00
R1522:Tnxb	UTSW	17	34,937,612 (GRCm39)	missense	probably damaging	1.00
R1532:Tnxb	UTSW	17	34,929,804 (GRCm39)	missense	probably damaging	1.00
R1735:Tnxb	UTSW	17	34,936,944 (GRCm39)	missense	probably damaging	1.00
R1778:Tnxb	UTSW	17	34,902,548 (GRCm39)	missense	probably benign	0.30
R1802:Tnxb	UTSW	17	34,922,863 (GRCm39)	missense	probably damaging	0.98
R1824:Tnxb	UTSW	17	34,911,307 (GRCm39)	nonsense	probably null
R1838:Tnxb	UTSW	17	34,897,884 (GRCm39)	missense	probably damaging	0.96
R1863:Tnxb	UTSW	17	34,889,848 (GRCm39)	missense	probably damaging	1.00
R1865:Tnxb	UTSW	17	34,922,431 (GRCm39)	nonsense	probably null
R1867:Tnxb	UTSW	17	34,890,821 (GRCm39)	missense	probably damaging	1.00
R1883:Tnxb	UTSW	17	34,908,539 (GRCm39)	missense	probably benign	0.01
R1884:Tnxb	UTSW	17	34,908,539 (GRCm39)	missense	probably benign	0.01
R1889:Tnxb	UTSW	17	34,914,799 (GRCm39)	missense	probably damaging	0.97
R1969:Tnxb	UTSW	17	34,898,055 (GRCm39)	missense	probably benign	0.20
R1989:Tnxb	UTSW	17	34,912,859 (GRCm39)	missense	probably damaging	1.00
R1989:Tnxb	UTSW	17	34,902,351 (GRCm39)	missense	probably benign	0.08
R1991:Tnxb	UTSW	17	34,901,225 (GRCm39)	missense	probably damaging	1.00
R1991:Tnxb	UTSW	17	34,890,878 (GRCm39)	missense	probably damaging	1.00
R1992:Tnxb	UTSW	17	34,890,878 (GRCm39)	missense	probably damaging	1.00
R2001:Tnxb	UTSW	17	34,911,553 (GRCm39)	missense	possibly damaging	0.82
R2018:Tnxb	UTSW	17	34,890,724 (GRCm39)	missense	probably benign	0.04
R2030:Tnxb	UTSW	17	34,937,443 (GRCm39)	missense	probably damaging	1.00
R2037:Tnxb	UTSW	17	34,918,179 (GRCm39)	missense	probably damaging	1.00
R2103:Tnxb	UTSW	17	34,901,225 (GRCm39)	missense	probably damaging	1.00
R2116:Tnxb	UTSW	17	34,891,201 (GRCm39)	missense	probably damaging	1.00
R2206:Tnxb	UTSW	17	34,928,391 (GRCm39)	missense	possibly damaging	0.86
R2207:Tnxb	UTSW	17	34,928,391 (GRCm39)	missense	possibly damaging	0.86
R2215:Tnxb	UTSW	17	34,923,114 (GRCm39)	missense	possibly damaging	0.93
R2413:Tnxb	UTSW	17	34,937,252 (GRCm39)	missense	probably damaging	0.99
R2680:Tnxb	UTSW	17	34,922,594 (GRCm39)	missense	possibly damaging	0.51
R2910:Tnxb	UTSW	17	34,891,424 (GRCm39)	missense	probably damaging	1.00
R2984:Tnxb	UTSW	17	34,897,636 (GRCm39)	nonsense	probably null
R3120:Tnxb	UTSW	17	34,911,329 (GRCm39)	missense	possibly damaging	0.86
R3429:Tnxb	UTSW	17	34,922,561 (GRCm39)	missense	probably damaging	0.98
R3429:Tnxb	UTSW	17	34,891,605 (GRCm39)	nonsense	probably null
R3552:Tnxb	UTSW	17	34,937,695 (GRCm39)	missense	probably damaging	1.00
R3698:Tnxb	UTSW	17	34,909,407 (GRCm39)	critical splice donor site	probably null
R3720:Tnxb	UTSW	17	34,931,938 (GRCm39)	missense	possibly damaging	0.95
R3841:Tnxb	UTSW	17	34,917,897 (GRCm39)	missense	possibly damaging	0.72
R3848:Tnxb	UTSW	17	34,909,369 (GRCm39)	missense	possibly damaging	0.82
R3886:Tnxb	UTSW	17	34,937,885 (GRCm39)	missense	probably damaging	1.00
R4074:Tnxb	UTSW	17	34,890,845 (GRCm39)	missense	probably benign	0.22
R4159:Tnxb	UTSW	17	34,930,491 (GRCm39)	missense	probably damaging	0.99
R4160:Tnxb	UTSW	17	34,930,491 (GRCm39)	missense	probably damaging	0.99
R4161:Tnxb	UTSW	17	34,930,491 (GRCm39)	missense	probably damaging	0.99
R4181:Tnxb	UTSW	17	34,928,428 (GRCm39)	missense	possibly damaging	0.93
R4210:Tnxb	UTSW	17	34,929,951 (GRCm39)	missense	possibly damaging	0.84
R4275:Tnxb	UTSW	17	34,917,205 (GRCm39)	missense	probably damaging	0.98
R4329:Tnxb	UTSW	17	34,912,838 (GRCm39)	missense	probably damaging	1.00
R4394:Tnxb	UTSW	17	34,897,636 (GRCm39)	nonsense	probably null
R4395:Tnxb	UTSW	17	34,897,636 (GRCm39)	nonsense	probably null
R4397:Tnxb	UTSW	17	34,897,636 (GRCm39)	nonsense	probably null
R4540:Tnxb	UTSW	17	34,922,309 (GRCm39)	missense	possibly damaging	0.86
R4673:Tnxb	UTSW	17	34,891,514 (GRCm39)	missense	probably damaging	0.99
R4719:Tnxb	UTSW	17	34,908,394 (GRCm39)	missense	probably damaging	1.00
R4725:Tnxb	UTSW	17	34,918,041 (GRCm39)	missense	probably damaging	0.99
R4753:Tnxb	UTSW	17	34,914,909 (GRCm39)	missense	possibly damaging	0.71
R4837:Tnxb	UTSW	17	34,936,981 (GRCm39)	missense	probably damaging	0.98
R4898:Tnxb	UTSW	17	34,914,566 (GRCm39)	missense	possibly damaging	0.95
R4938:Tnxb	UTSW	17	34,932,606 (GRCm39)	missense	probably damaging	1.00
R5044:Tnxb	UTSW	17	34,936,457 (GRCm39)	missense	probably damaging	1.00
R5100:Tnxb	UTSW	17	34,929,902 (GRCm39)	missense	probably damaging	0.99
R5223:Tnxb	UTSW	17	34,923,052 (GRCm39)	missense	possibly damaging	0.51
R5269:Tnxb	UTSW	17	34,922,582 (GRCm39)	missense	possibly damaging	0.95
R5333:Tnxb	UTSW	17	34,909,205 (GRCm39)	missense	probably damaging	1.00
R5454:Tnxb	UTSW	17	34,928,599 (GRCm39)	missense	possibly damaging	0.71
R5470:Tnxb	UTSW	17	34,935,947 (GRCm39)	missense	probably null	1.00
R5475:Tnxb	UTSW	17	34,908,567 (GRCm39)	missense	probably damaging	1.00
R5574:Tnxb	UTSW	17	34,929,998 (GRCm39)	missense	probably benign
R5596:Tnxb	UTSW	17	34,907,778 (GRCm39)	missense	probably damaging	1.00
R5599:Tnxb	UTSW	17	34,909,179 (GRCm39)	missense	probably benign	0.22
R5599:Tnxb	UTSW	17	34,909,176 (GRCm39)	missense	probably damaging	1.00
R5615:Tnxb	UTSW	17	34,902,392 (GRCm39)	missense	probably damaging	1.00
R5620:Tnxb	UTSW	17	34,936,504 (GRCm39)	nonsense	probably null
R5625:Tnxb	UTSW	17	34,904,185 (GRCm39)	missense	probably benign	0.30
R5734:Tnxb	UTSW	17	34,917,884 (GRCm39)	missense	possibly damaging	0.53
R5896:Tnxb	UTSW	17	34,891,126 (GRCm39)	missense	probably damaging	1.00
R5961:Tnxb	UTSW	17	34,937,609 (GRCm39)	missense	probably damaging	1.00
R5974:Tnxb	UTSW	17	34,904,681 (GRCm39)	missense	probably damaging	1.00
R6091:Tnxb	UTSW	17	34,929,338 (GRCm39)	missense	probably damaging	0.98
R6134:Tnxb	UTSW	17	34,890,986 (GRCm39)	missense	probably damaging	0.96
R6325:Tnxb	UTSW	17	34,911,398 (GRCm39)	missense	probably damaging	1.00
R6358:Tnxb	UTSW	17	34,897,968 (GRCm39)	missense	probably damaging	0.98
R6362:Tnxb	UTSW	17	34,913,362 (GRCm39)	missense	probably damaging	1.00
R6432:Tnxb	UTSW	17	34,936,891 (GRCm39)	missense	probably damaging	1.00
R6461:Tnxb	UTSW	17	34,890,872 (GRCm39)	missense	probably damaging	1.00
R6467:Tnxb	UTSW	17	34,912,898 (GRCm39)	missense	probably damaging	1.00
R6476:Tnxb	UTSW	17	34,909,166 (GRCm39)	missense	probably damaging	0.98
R6477:Tnxb	UTSW	17	34,938,513 (GRCm39)	missense	probably damaging	1.00
R6631:Tnxb	UTSW	17	34,937,222 (GRCm39)	missense	probably damaging	1.00
R6774:Tnxb	UTSW	17	34,928,606 (GRCm39)	nonsense	probably null
R6787:Tnxb	UTSW	17	34,929,710 (GRCm39)	missense	probably benign	0.02
R6805:Tnxb	UTSW	17	34,917,127 (GRCm39)	missense	possibly damaging	0.93
R6860:Tnxb	UTSW	17	34,932,131 (GRCm39)	missense	probably damaging	0.99
R6883:Tnxb	UTSW	17	34,937,493 (GRCm39)	missense	probably damaging	1.00
R7049:Tnxb	UTSW	17	34,936,242 (GRCm39)	critical splice donor site	probably null
R7107:Tnxb	UTSW	17	34,890,314 (GRCm39)	missense	unknown
R7172:Tnxb	UTSW	17	34,914,994 (GRCm39)	missense	probably damaging	1.00
R7206:Tnxb	UTSW	17	34,923,075 (GRCm39)	missense	possibly damaging	0.71
R7219:Tnxb	UTSW	17	34,898,039 (GRCm39)	missense	probably benign	0.08
R7237:Tnxb	UTSW	17	34,901,170 (GRCm39)	missense	possibly damaging	0.82
R7257:Tnxb	UTSW	17	34,935,475 (GRCm39)	missense	probably benign	0.44
R7269:Tnxb	UTSW	17	34,914,428 (GRCm39)	missense	probably damaging	1.00
R7302:Tnxb	UTSW	17	34,897,875 (GRCm39)	missense	probably benign	0.41
R7372:Tnxb	UTSW	17	34,936,228 (GRCm39)	missense	possibly damaging	0.72
R7384:Tnxb	UTSW	17	34,937,492 (GRCm39)	missense	probably damaging	1.00
R7447:Tnxb	UTSW	17	34,937,444 (GRCm39)	missense	probably damaging	1.00
R7449:Tnxb	UTSW	17	34,922,335 (GRCm39)	missense	possibly damaging	0.93
R7480:Tnxb	UTSW	17	34,934,747 (GRCm39)	missense	probably damaging	0.96
R7506:Tnxb	UTSW	17	34,934,665 (GRCm39)	missense	possibly damaging	0.89
R7586:Tnxb	UTSW	17	34,935,382 (GRCm39)	missense	probably damaging	0.98
R7688:Tnxb	UTSW	17	34,890,880 (GRCm39)	missense	probably benign	0.23
R7690:Tnxb	UTSW	17	34,908,501 (GRCm39)	missense	probably damaging	1.00
R7690:Tnxb	UTSW	17	34,908,494 (GRCm39)	missense	probably benign	0.03
R7732:Tnxb	UTSW	17	34,913,254 (GRCm39)	missense	probably damaging	1.00
R7735:Tnxb	UTSW	17	34,890,398 (GRCm39)	missense	unknown
R7760:Tnxb	UTSW	17	34,931,911 (GRCm39)	missense	probably damaging	0.96
R7874:Tnxb	UTSW	17	34,930,417 (GRCm39)	missense	probably damaging	1.00
R7909:Tnxb	UTSW	17	34,911,428 (GRCm39)	missense	probably benign	0.02
R7922:Tnxb	UTSW	17	34,933,577 (GRCm39)	missense	probably damaging	1.00
R7931:Tnxb	UTSW	17	34,907,672 (GRCm39)	missense	probably damaging	1.00
R7949:Tnxb	UTSW	17	34,936,103 (GRCm39)	missense	probably damaging	1.00
R7953:Tnxb	UTSW	17	34,929,077 (GRCm39)	missense	probably benign	0.03
R7953:Tnxb	UTSW	17	34,928,509 (GRCm39)	missense	possibly damaging	0.86
R7977:Tnxb	UTSW	17	34,929,194 (GRCm39)	missense	possibly damaging	0.92
R7985:Tnxb	UTSW	17	34,935,984 (GRCm39)	critical splice donor site	probably null
R7987:Tnxb	UTSW	17	34,929,194 (GRCm39)	missense	possibly damaging	0.92
R8040:Tnxb	UTSW	17	34,935,532 (GRCm39)	missense	probably damaging	1.00
R8053:Tnxb	UTSW	17	34,923,153 (GRCm39)	missense	probably damaging	0.98
R8074:Tnxb	UTSW	17	34,922,955 (GRCm39)	missense	probably benign	0.32
R8089:Tnxb	UTSW	17	34,891,763 (GRCm39)	missense	unknown
R8169:Tnxb	UTSW	17	34,918,181 (GRCm39)	missense	possibly damaging	0.96
R8348:Tnxb	UTSW	17	34,929,102 (GRCm39)	missense	possibly damaging	0.92
R8352:Tnxb	UTSW	17	34,908,381 (GRCm39)	missense	probably damaging	1.00
R8362:Tnxb	UTSW	17	34,931,946 (GRCm39)	missense	probably damaging	0.99
R8452:Tnxb	UTSW	17	34,908,381 (GRCm39)	missense	probably damaging	1.00
R8527:Tnxb	UTSW	17	34,907,634 (GRCm39)	missense	probably damaging	1.00
R8754:Tnxb	UTSW	17	34,934,882 (GRCm39)	missense	probably damaging	1.00
R8813:Tnxb	UTSW	17	34,938,136 (GRCm39)	missense	probably damaging	1.00
R8936:Tnxb	UTSW	17	34,904,646 (GRCm39)	missense	probably damaging	1.00
R8986:Tnxb	UTSW	17	34,897,646 (GRCm39)	missense	possibly damaging	0.66
R9001:Tnxb	UTSW	17	34,922,410 (GRCm39)	missense	probably benign	0.32
R9215:Tnxb	UTSW	17	34,891,564 (GRCm39)	missense	unknown
R9226:Tnxb	UTSW	17	34,904,766 (GRCm39)	missense	probably damaging	1.00
R9276:Tnxb	UTSW	17	34,929,134 (GRCm39)	missense	possibly damaging	0.60
R9279:Tnxb	UTSW	17	34,898,088 (GRCm39)	missense	possibly damaging	0.46
R9363:Tnxb	UTSW	17	34,917,294 (GRCm39)	missense	possibly damaging	0.93
R9367:Tnxb	UTSW	17	34,931,993 (GRCm39)	missense	probably damaging	1.00
R9494:Tnxb	UTSW	17	34,904,796 (GRCm39)	missense	probably damaging	1.00
R9606:Tnxb	UTSW	17	34,914,578 (GRCm39)	missense	possibly damaging	0.82
R9650:Tnxb	UTSW	17	34,930,629 (GRCm39)	missense	probably damaging	0.99
R9677:Tnxb	UTSW	17	34,917,878 (GRCm39)	missense	possibly damaging	0.93
R9690:Tnxb	UTSW	17	34,936,171 (GRCm39)	missense	probably damaging	1.00
R9761:Tnxb	UTSW	17	34,903,987 (GRCm39)	missense	probably benign	0.32
X0004:Tnxb	UTSW	17	34,922,389 (GRCm39)	missense	possibly damaging	0.71
X0010:Tnxb	UTSW	17	34,890,908 (GRCm39)	missense	probably damaging	1.00
X0019:Tnxb	UTSW	17	34,913,163 (GRCm39)	missense	possibly damaging	0.51
X0063:Tnxb	UTSW	17	34,922,482 (GRCm39)	missense	probably damaging	0.98
X0064:Tnxb	UTSW	17	34,913,006 (GRCm39)	missense	probably damaging	1.00
Z1177:Tnxb	UTSW	17	34,937,700 (GRCm39)	missense	probably damaging	0.99
Z1177:Tnxb	UTSW	17	34,902,305 (GRCm39)	missense	probably damaging	1.00
Z1177:Tnxb	UTSW	17	34,890,740 (GRCm39)	missense	unknown

Predicted Primers

PCR Primer
(F):5'- ATTGCAGCATGAGGACCTGC -3'
(R):5'- ACCGTCTTATGCCACAGTC -3'

Sequencing Primer
(F):5'- TACTCGGGCGAAGACTGTAGC -3'
(R):5'- AGTGAAGCCCGGATTGCAC -3'

Posted On

2015-12-29