Incidental Mutation 'R4778:Myo16'
ID 368088
Institutional Source Beutler Lab
Gene Symbol Myo16
Ensembl Gene ENSMUSG00000039057
Gene Name myosin XVI
Synonyms C230040D10Rik, BM140241, Nyap3
MMRRC Submission 042414-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.325) question?
Stock # R4778 (G1)
Quality Score 225
Status Validated
Chromosome 8
Chromosomal Location 10203911-10684742 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 10619694 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 1415 (V1415E)
Ref Sequence ENSEMBL: ENSMUSP00000049345 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042103] [ENSMUST00000207204] [ENSMUST00000207477]
AlphaFold Q5DU14
Predicted Effect probably damaging
Transcript: ENSMUST00000042103
AA Change: V1415E

PolyPhen 2 Score 0.970 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000049345
Gene: ENSMUSG00000039057
AA Change: V1415E

DomainStartEndE-ValueType
ANK 92 121 1.65e-1 SMART
ANK 125 154 3.46e-4 SMART
ANK 158 189 2.11e2 SMART
ANK 221 250 2.85e-5 SMART
ANK 254 283 3.51e-5 SMART
low complexity region 333 349 N/A INTRINSIC
MYSc 394 1144 2.27e-144 SMART
IQ 1144 1166 4.06e-2 SMART
Pfam:NYAP_N 1207 1591 4.1e-135 PFAM
low complexity region 1670 1690 N/A INTRINSIC
low complexity region 1841 1860 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000207204
AA Change: V1359E
Predicted Effect unknown
Transcript: ENSMUST00000207477
AA Change: V1415E
Meta Mutation Damage Score 0.0803 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.3%
Validation Efficiency 98% (54/55)
MGI Phenotype PHENOTYPE: Triple KO of Nyap1, Nyap2 and Myo16 results in decreased brain weight and cortex and striatum size and reduced neurite length in cortical neurons. [provided by MGI curators]
Allele List at MGI

All alleles(3) : Targeted(2) Gene trapped(1)

Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc10 T C 17: 46,615,342 (GRCm39) N1349S probably damaging Het
Ahnak T C 19: 8,989,339 (GRCm39) V3541A possibly damaging Het
Arhgap33 T A 7: 30,231,518 (GRCm39) T156S probably benign Het
Bltp1 T A 3: 36,991,214 (GRCm39) M897K possibly damaging Het
Card11 G T 5: 140,869,537 (GRCm39) probably null Het
Cdh3 T A 8: 107,270,458 (GRCm39) I445N probably damaging Het
Csrp3 T G 7: 48,482,311 (GRCm39) K169N probably damaging Het
Cyp2c69 T C 19: 39,866,038 (GRCm39) N185S probably benign Het
Czib T C 4: 107,749,195 (GRCm39) V64A probably damaging Het
Dpysl3 C T 18: 43,487,867 (GRCm39) V159I probably benign Het
Erc1 A T 6: 119,774,298 (GRCm39) probably null Het
Fat1 T C 8: 45,491,363 (GRCm39) V3808A probably benign Het
Fbxw19 T C 9: 109,323,714 (GRCm39) D87G probably damaging Het
Gm1123 T C 9: 98,900,560 (GRCm39) I99V probably benign Het
Gm11677 C T 11: 111,615,537 (GRCm39) noncoding transcript Het
Hand1 T C 11: 57,722,449 (GRCm39) D55G possibly damaging Het
Lrguk T A 6: 34,033,015 (GRCm39) I227K probably damaging Het
Mdn1 C T 4: 32,683,583 (GRCm39) R726* probably null Het
Minar1 T A 9: 89,485,155 (GRCm39) I81F probably damaging Het
Myof T C 19: 37,938,011 (GRCm39) D901G probably damaging Het
Naip1 A G 13: 100,563,156 (GRCm39) Y670H probably damaging Het
Nmd3 T A 3: 69,638,924 (GRCm39) Y171* probably null Het
Notch4 C T 17: 34,801,485 (GRCm39) A1111V possibly damaging Het
Nphp4 T A 4: 152,640,748 (GRCm39) D1038E probably benign Het
Or2ag1b A C 7: 106,288,874 (GRCm39) S21R probably damaging Het
Or5p60 A T 7: 107,723,687 (GRCm39) I261N possibly damaging Het
Osbpl10 C T 9: 114,938,598 (GRCm39) S86L probably damaging Het
Pcsk6 G A 7: 65,608,893 (GRCm39) G252R probably damaging Het
Pole T G 5: 110,478,698 (GRCm39) H15Q probably benign Het
Pstpip1 A G 9: 56,035,904 (GRCm39) D383G possibly damaging Het
Ptprq T C 10: 107,426,883 (GRCm39) T1551A probably benign Het
Rasgrf2 A G 13: 92,131,780 (GRCm39) F626L probably damaging Het
Retreg1 C A 15: 25,971,871 (GRCm39) N394K possibly damaging Het
Rpl7-ps8 T A 15: 59,083,252 (GRCm39) noncoding transcript Het
Rpp14 T A 14: 8,090,203 (GRCm38) D42E probably benign Het
Rrp8 T A 7: 105,386,481 (GRCm39) probably benign Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Snx1 T C 9: 66,008,698 (GRCm39) probably benign Het
Stau1 A T 2: 166,805,442 (GRCm39) N51K probably benign Het
Tdrd5 T A 1: 156,083,157 (GRCm39) D960V probably damaging Het
Tex10 T C 4: 48,436,468 (GRCm39) D750G probably damaging Het
Tmem43 T C 6: 91,459,237 (GRCm39) V236A probably damaging Het
Tmem89 T C 9: 108,744,443 (GRCm39) V112A probably damaging Het
Traf7 C G 17: 24,729,412 (GRCm39) probably benign Het
Vmn1r41 A C 6: 89,724,257 (GRCm39) K266T probably damaging Het
Vmn2r65 T C 7: 84,592,801 (GRCm39) K469E possibly damaging Het
Zfp831 A G 2: 174,488,600 (GRCm39) T1092A possibly damaging Het
Zfp981 T A 4: 146,622,112 (GRCm39) S346T probably benign Het
Other mutations in Myo16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00421:Myo16 APN 8 10,488,889 (GRCm39) missense probably damaging 1.00
IGL00567:Myo16 APN 8 10,512,154 (GRCm39) missense probably damaging 1.00
IGL00671:Myo16 APN 8 10,411,067 (GRCm39) missense probably damaging 1.00
IGL00897:Myo16 APN 8 10,365,518 (GRCm39) missense probably damaging 1.00
IGL01458:Myo16 APN 8 10,485,853 (GRCm39) missense probably damaging 1.00
IGL01523:Myo16 APN 8 10,420,908 (GRCm39) missense probably damaging 1.00
IGL01532:Myo16 APN 8 10,450,551 (GRCm39) missense probably benign 0.00
IGL01680:Myo16 APN 8 10,322,630 (GRCm39) missense probably damaging 1.00
IGL01747:Myo16 APN 8 10,654,877 (GRCm39) missense probably damaging 1.00
IGL02084:Myo16 APN 8 10,411,088 (GRCm39) missense probably damaging 0.99
IGL02203:Myo16 APN 8 10,620,132 (GRCm39) missense possibly damaging 0.52
IGL02506:Myo16 APN 8 10,440,217 (GRCm39) missense probably damaging 1.00
IGL02819:Myo16 APN 8 10,372,600 (GRCm39) missense probably damaging 1.00
IGL02935:Myo16 APN 8 10,582,990 (GRCm39) missense probably benign 0.41
IGL02943:Myo16 APN 8 10,450,595 (GRCm39) splice site probably benign
IGL03347:Myo16 APN 8 10,426,120 (GRCm39) critical splice acceptor site probably null
3-1:Myo16 UTSW 8 10,488,869 (GRCm39) missense probably damaging 0.99
P0016:Myo16 UTSW 8 10,450,596 (GRCm39) splice site probably benign
R0006:Myo16 UTSW 8 10,525,988 (GRCm39) missense probably damaging 0.98
R0006:Myo16 UTSW 8 10,525,988 (GRCm39) missense probably damaging 0.98
R0033:Myo16 UTSW 8 10,420,955 (GRCm39) missense probably damaging 1.00
R0033:Myo16 UTSW 8 10,420,955 (GRCm39) missense probably damaging 1.00
R0142:Myo16 UTSW 8 10,619,790 (GRCm39) missense probably benign 0.01
R0195:Myo16 UTSW 8 10,365,538 (GRCm39) splice site probably benign
R0418:Myo16 UTSW 8 10,619,918 (GRCm39) missense probably benign 0.01
R0576:Myo16 UTSW 8 10,612,318 (GRCm39) critical splice donor site probably null
R0627:Myo16 UTSW 8 10,489,689 (GRCm39) missense probably benign 0.15
R0826:Myo16 UTSW 8 10,426,285 (GRCm39) splice site probably benign
R0835:Myo16 UTSW 8 10,322,766 (GRCm39) missense probably damaging 1.00
R1015:Myo16 UTSW 8 10,440,183 (GRCm39) missense probably benign 0.17
R1052:Myo16 UTSW 8 10,620,181 (GRCm39) missense possibly damaging 0.92
R1180:Myo16 UTSW 8 10,446,908 (GRCm39) missense probably damaging 1.00
R1185:Myo16 UTSW 8 10,683,624 (GRCm39) missense probably damaging 1.00
R1185:Myo16 UTSW 8 10,683,624 (GRCm39) missense probably damaging 1.00
R1474:Myo16 UTSW 8 10,552,796 (GRCm39) missense probably damaging 1.00
R1484:Myo16 UTSW 8 10,610,145 (GRCm39) missense probably damaging 1.00
R1503:Myo16 UTSW 8 10,552,817 (GRCm39) missense probably benign 0.44
R1733:Myo16 UTSW 8 10,492,283 (GRCm39) missense probably damaging 0.98
R1873:Myo16 UTSW 8 10,322,789 (GRCm39) missense probably damaging 1.00
R1885:Myo16 UTSW 8 10,372,656 (GRCm39) missense probably damaging 1.00
R1943:Myo16 UTSW 8 10,644,905 (GRCm39) missense possibly damaging 0.63
R2013:Myo16 UTSW 8 10,552,796 (GRCm39) missense probably damaging 1.00
R2019:Myo16 UTSW 8 10,426,260 (GRCm39) missense probably benign 0.05
R2022:Myo16 UTSW 8 10,322,633 (GRCm39) missense probably benign 0.08
R2214:Myo16 UTSW 8 10,488,803 (GRCm39) missense probably damaging 1.00
R2228:Myo16 UTSW 8 10,644,905 (GRCm39) missense possibly damaging 0.63
R2351:Myo16 UTSW 8 10,644,905 (GRCm39) missense possibly damaging 0.63
R2352:Myo16 UTSW 8 10,644,905 (GRCm39) missense possibly damaging 0.63
R2357:Myo16 UTSW 8 10,644,905 (GRCm39) missense possibly damaging 0.63
R2566:Myo16 UTSW 8 10,644,820 (GRCm39) missense probably benign 0.43
R3402:Myo16 UTSW 8 10,434,719 (GRCm39) missense probably benign
R3870:Myo16 UTSW 8 10,492,239 (GRCm39) missense probably benign 0.25
R4080:Myo16 UTSW 8 10,612,240 (GRCm39) missense probably damaging 1.00
R4498:Myo16 UTSW 8 10,485,869 (GRCm39) missense probably benign 0.01
R4631:Myo16 UTSW 8 10,556,984 (GRCm39) missense probably damaging 1.00
R4689:Myo16 UTSW 8 10,488,890 (GRCm39) missense probably damaging 1.00
R4736:Myo16 UTSW 8 10,423,527 (GRCm39) missense probably damaging 1.00
R4738:Myo16 UTSW 8 10,423,527 (GRCm39) missense probably damaging 1.00
R4739:Myo16 UTSW 8 10,423,527 (GRCm39) missense probably damaging 1.00
R4764:Myo16 UTSW 8 10,485,880 (GRCm39) missense probably damaging 1.00
R4852:Myo16 UTSW 8 10,423,474 (GRCm39) missense probably damaging 1.00
R4885:Myo16 UTSW 8 10,488,892 (GRCm39) missense probably damaging 0.98
R4993:Myo16 UTSW 8 10,526,094 (GRCm39) missense probably damaging 0.99
R5077:Myo16 UTSW 8 10,372,658 (GRCm39) missense probably damaging 1.00
R5135:Myo16 UTSW 8 10,526,114 (GRCm39) missense probably benign
R5170:Myo16 UTSW 8 10,619,745 (GRCm39) missense probably benign 0.30
R5203:Myo16 UTSW 8 10,410,995 (GRCm39) missense probably damaging 1.00
R5246:Myo16 UTSW 8 10,612,212 (GRCm39) nonsense probably null
R5517:Myo16 UTSW 8 10,610,226 (GRCm39) missense probably benign 0.22
R5567:Myo16 UTSW 8 10,372,676 (GRCm39) missense probably damaging 1.00
R5694:Myo16 UTSW 8 10,619,606 (GRCm39) missense probably benign 0.01
R5749:Myo16 UTSW 8 10,463,245 (GRCm39) missense probably benign 0.01
R6131:Myo16 UTSW 8 10,619,877 (GRCm39) missense probably benign
R6213:Myo16 UTSW 8 10,420,963 (GRCm39) critical splice donor site probably null
R6216:Myo16 UTSW 8 10,365,494 (GRCm39) missense probably benign 0.01
R6240:Myo16 UTSW 8 10,420,930 (GRCm39) missense probably damaging 1.00
R6628:Myo16 UTSW 8 10,620,638 (GRCm39) missense probably damaging 0.99
R6935:Myo16 UTSW 8 10,619,820 (GRCm39) missense probably benign 0.37
R6996:Myo16 UTSW 8 10,619,496 (GRCm39) missense probably damaging 1.00
R7103:Myo16 UTSW 8 10,619,673 (GRCm39) missense unknown
R7164:Myo16 UTSW 8 10,619,585 (GRCm39) missense unknown
R7255:Myo16 UTSW 8 10,549,169 (GRCm39) missense unknown
R7266:Myo16 UTSW 8 10,322,687 (GRCm39) missense unknown
R7319:Myo16 UTSW 8 10,526,185 (GRCm39) splice site probably null
R7398:Myo16 UTSW 8 10,612,183 (GRCm39) missense unknown
R7442:Myo16 UTSW 8 10,322,537 (GRCm39) missense probably damaging 1.00
R7498:Myo16 UTSW 8 10,450,589 (GRCm39) missense unknown
R7539:Myo16 UTSW 8 10,411,095 (GRCm39) critical splice donor site probably null
R7622:Myo16 UTSW 8 10,426,238 (GRCm39) missense unknown
R7794:Myo16 UTSW 8 10,619,913 (GRCm39) missense unknown
R7903:Myo16 UTSW 8 10,426,265 (GRCm39) missense probably null
R8055:Myo16 UTSW 8 10,612,186 (GRCm39) missense unknown
R8078:Myo16 UTSW 8 10,612,078 (GRCm39) missense unknown
R8081:Myo16 UTSW 8 10,372,743 (GRCm39) missense unknown
R8679:Myo16 UTSW 8 10,411,042 (GRCm39) missense unknown
R8700:Myo16 UTSW 8 10,463,172 (GRCm39) missense unknown
R8939:Myo16 UTSW 8 10,524,679 (GRCm39) missense probably damaging 0.99
R8955:Myo16 UTSW 8 10,426,175 (GRCm39) missense probably damaging 1.00
R8968:Myo16 UTSW 8 10,619,700 (GRCm39) missense unknown
R9187:Myo16 UTSW 8 10,492,233 (GRCm39) missense unknown
R9219:Myo16 UTSW 8 10,492,236 (GRCm39) missense unknown
R9287:Myo16 UTSW 8 10,526,114 (GRCm39) missense unknown
R9327:Myo16 UTSW 8 10,489,705 (GRCm39) critical splice donor site probably null
R9763:Myo16 UTSW 8 10,450,528 (GRCm39) missense unknown
R9765:Myo16 UTSW 8 10,620,401 (GRCm39) missense probably damaging 0.97
R9790:Myo16 UTSW 8 10,619,925 (GRCm39) missense unknown
R9791:Myo16 UTSW 8 10,619,925 (GRCm39) missense unknown
X0066:Myo16 UTSW 8 10,426,185 (GRCm39) missense probably damaging 1.00
Z1177:Myo16 UTSW 8 10,524,691 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TCTTATGAGGAGATCTGGGGAC -3'
(R):5'- TATCCTTTGAGGGCTGGCAG -3'

Sequencing Primer
(F):5'- GACCACCACGACCTTCTGG -3'
(R):5'- CCTCCAAGATGATGGCTTTTCGAG -3'
Posted On 2015-12-29