Mutagenetix > Incidental Mutation

Incidental Mutation 'R4779:Lrp2'

368120

Institutional Source

Beutler Lab

Gene Symbol

Lrp2

Ensembl Gene

ENSMUSG00000027070

Gene Name

low density lipoprotein receptor-related protein 2

Synonyms

Gp330, D230004K18Rik, b2b1625.2Clo, Megalin

MMRRC Submission

045240-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R4779 (G1)

Quality Score

208

Status

Validated

Chromosome

Chromosomal Location

69424340-69586065 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 69459715 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Glutamine at position 3593 (H3593Q)

Ref Sequence

ENSEMBL: ENSMUSP00000079752 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080953]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000080953
AA Change: H3593Q

PolyPhen 2 Score 0.754 (Sensitivity: 0.85; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000079752
Gene: ENSMUSG00000027070
AA Change: H3593Q

Domain	Start	End	E-Value	Type
low complexity region	5	21	N/A	INTRINSIC
LDLa	27	64	5.63e-13	SMART
LDLa	66	105	2.25e-12	SMART
EGF	107	143	2.59e1	SMART
LDLa	107	144	9.29e-14	SMART
LDLa	146	181	6.18e-10	SMART
LDLa	182	219	1.08e-14	SMART
LDLa	221	258	1.05e-12	SMART
LDLa	264	302	1.66e-10	SMART
EGF	310	346	3.23e0	SMART
EGF	350	385	2.32e-1	SMART
LY	414	457	3.88e-3	SMART
LY	458	500	1.17e-6	SMART
LY	501	547	5.96e-13	SMART
LY	548	590	1.94e-12	SMART
LY	591	634	2.66e0	SMART
EGF	661	704	7.76e-3	SMART
LY	732	774	1.76e0	SMART
LY	775	817	3.64e-8	SMART
LY	818	860	1.11e-3	SMART
LY	861	903	2.11e-13	SMART
LY	905	946	9.33e-1	SMART
EGF	972	1013	1.73e0	SMART
LDLa	1024	1061	1.05e-12	SMART
LDLa	1065	1103	4.65e-14	SMART
LDLa	1109	1146	3.63e-16	SMART
LDLa	1149	1186	5.5e-16	SMART
LDLa	1187	1225	1.43e-14	SMART
LDLa	1230	1269	2.1e-12	SMART
LDLa	1271	1308	3.63e-16	SMART
LDLa	1312	1351	4.69e-10	SMART
EGF	1353	1390	9.7e-4	SMART
EGF_CA	1391	1430	6.54e-10	SMART
LY	1457	1501	1.43e-1	SMART
LY	1502	1544	2e-14	SMART
LY	1545	1590	3.03e-14	SMART
LY	1591	1633	5.48e-12	SMART
LY	1635	1677	1.18e-2	SMART
EGF	1704	1742	5.2e-4	SMART
LY	1771	1812	1.68e1	SMART
LY	1813	1856	1.91e-2	SMART
LY	1859	1911	1.88e-10	SMART
LY	1912	1954	7.69e-7	SMART
LY	1955	1994	3e1	SMART
EGF	2022	2060	1.18e-2	SMART
LY	2088	2135	1.14e1	SMART
LY	2136	2182	2.11e-4	SMART
LY	2183	2226	2.22e-12	SMART
LY	2227	2269	1.24e-10	SMART
EGF	2346	2384	2.07e1	SMART
LY	2459	2501	9.91e-10	SMART
LY	2503	2543	1.48e-8	SMART
LY	2544	2586	6.85e-13	SMART
LY	2587	2627	8.13e-1	SMART
EGF_like	2655	2694	3.5e1	SMART
LDLa	2700	2739	2.86e-14	SMART
LDLa	2741	2778	8.09e-14	SMART
LDLa	2780	2820	3.19e-12	SMART
LDLa	2822	2862	6.94e-13	SMART
LDLa	2864	2903	9.29e-14	SMART
LDLa	2907	2947	4.79e-16	SMART
LDLa	2949	2992	8.41e-12	SMART
LDLa	2994	3031	1.08e-14	SMART
LDLa	3033	3072	1.83e-12	SMART
LDLa	3076	3113	1.16e-14	SMART
EGF	3115	3153	8.57e-5	SMART
EGF_CA	3154	3194	3.56e-11	SMART
LY	3221	3263	9.77e-9	SMART
LY	3264	3306	1.22e-9	SMART
LY	3312	3358	5.44e-7	SMART
LY	3359	3401	1.83e-13	SMART
LY	3402	3443	1.41e-5	SMART
EGF	3470	3511	8.91e-3	SMART
LDLa	3513	3552	1.79e-15	SMART
LDLa	3554	3593	9.89e-9	SMART
LDLa	3595	3634	3.07e-14	SMART
LDLa	3636	3675	3.34e-15	SMART
LDLa	3679	3718	1.39e-12	SMART
LDLa	3720	3758	3.83e-15	SMART
LDLa	3760	3797	7.15e-15	SMART
LDLa	3799	3836	2.86e-14	SMART
LDLa	3843	3882	2.38e-11	SMART
LDLa	3884	3924	3.66e-12	SMART
LDLa	3929	3966	1.93e-11	SMART
EGF	3971	4008	6.3e-3	SMART
EGF_CA	4009	4050	1.36e-7	SMART
low complexity region	4072	4084	N/A	INTRINSIC
LY	4136	4178	6.2e-11	SMART
LY	4179	4222	4.32e-10	SMART
LY	4223	4266	3.78e-15	SMART
LY	4267	4306	4.53e1	SMART
EGF	4335	4367	3.46e0	SMART
EGF	4368	4413	1.53e-1	SMART
transmembrane domain	4425	4447	N/A	INTRINSIC
low complexity region	4454	4472	N/A	INTRINSIC
low complexity region	4616	4636	N/A	INTRINSIC

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.7%
20x: 93.8%

Validation Efficiency

98% (95/97)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit lung and kidney epithelial defects, impaired B12 uptake, reduced proliferation of the neuroepithelium resulting in lack of olfactory bulbs, forebrain fusions, ventricular defects, and perinatal lethality. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 87 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2410089E03Rik	T	C	15: 8,218,838	S1624P	probably benign	Het
4930562C15Rik	T	A	16: 4,849,749	S335T	unknown	Het
4933421I07Rik	T	A	7: 42,448,031	H13L	possibly damaging	Het
6030468B19Rik	A	G	11: 117,806,008	T185A	probably benign	Het
Abcc1	T	A	16: 14,410,771	V294E	probably benign	Het
Abhd16b	A	G	2: 181,493,460	T52A	possibly damaging	Het
Actl7a	A	T	4: 56,743,632	N53I	probably benign	Het
Ankmy1	T	C	1: 92,886,723	E354G	probably benign	Het
Arap1	T	C	7: 101,404,367	F1301S	probably damaging	Het
Arfgef1	A	T	1: 10,153,733	W1447R	probably damaging	Het
Atoh7	ATGGCGCT	AT	10: 63,100,408		probably benign	Het
BC067074	A	T	13: 113,368,336	N2000Y	possibly damaging	Het
Ccl24	T	A	5: 135,572,957	T6S	possibly damaging	Het
Cep152	G	T	2: 125,568,892	P1292Q	possibly damaging	Het
Cfap46	T	C	7: 139,659,815		probably benign	Het
Chd6	A	T	2: 160,949,557	S2627T	probably damaging	Het
Chd8	A	T	14: 52,231,506	S552T	probably damaging	Het
Ciita	C	A	16: 10,511,366	L502M	probably damaging	Het
Clic1	T	C	17: 35,052,487	F31S	probably damaging	Het
Cntnap1	T	A	11: 101,178,072	I147N	possibly damaging	Het
Crispld1	T	A	1: 17,749,607	D276E	probably benign	Het
Cspg4	A	T	9: 56,885,808	N276Y	probably damaging	Het
Cwf19l2	A	G	9: 3,410,035	M55V	possibly damaging	Het
Cyp2c69	T	C	19: 39,877,594	N185S	probably benign	Het
Dopey2	T	C	16: 93,757,081	I301T	probably damaging	Het
Epg5	T	C	18: 77,991,365	V1443A	probably benign	Het
Ephb4	T	C	5: 137,365,702	V612A	probably benign	Het
Fcgbp	T	A	7: 28,094,937	C1189S	probably damaging	Het
Fgfr2	T	G	7: 130,185,193		probably benign	Het
Fmn2	A	G	1: 174,609,895	E1144G	probably damaging	Het
Fmo3	T	C	1: 162,968,838	Y55C	probably damaging	Het
Frmpd1	A	G	4: 45,229,865	T11A	probably damaging	Het
Ghdc	G	T	11: 100,770,103	Q79K	possibly damaging	Het
Gm11677	C	T	11: 111,724,711		noncoding transcript	Het
Gm5591	T	C	7: 38,522,256	T130A	probably damaging	Het
Heg1	T	G	16: 33,719,772	D367E	probably benign	Het
Igkv13-84	C	T	6: 68,939,910	P64S	probably damaging	Het
Il10rb	T	A	16: 91,414,657	S128T	possibly damaging	Het
Il15ra	T	A	2: 11,718,306	I47N	probably damaging	Het
Il33	C	A	19: 29,958,911	S207*	probably null	Het
Itgb7	A	G	15: 102,224,413	Y155H	possibly damaging	Het
Kdm5a	A	G	6: 120,369,099		probably benign	Het
Kif11	G	A	19: 37,417,949	V987I	probably benign	Het
Krtap19-2	G	A	16: 88,873,874		probably benign	Het
Krtap24-1	T	A	16: 88,611,529	R236S	probably damaging	Het
L3mbtl2	A	G	15: 81,682,612	I406V	probably benign	Het
Mavs	G	T	2: 131,240,365	W56C	probably damaging	Het
Mn1	C	T	5: 111,419,660	P499S	probably damaging	Het
Ntn5	T	A	7: 45,691,471	C178S	probably damaging	Het
Nufip2	A	G	11: 77,686,328	H34R	unknown	Het
Olfr470	T	A	7: 107,845,548	M62L	possibly damaging	Het
Olfr523	T	A	7: 140,176,450	L110Q	probably damaging	Het
Osbpl10	C	T	9: 115,109,530	S86L	probably damaging	Het
Pitpna	T	A	11: 75,620,327	M242K	possibly damaging	Het
Pnpla6	T	C	8: 3,522,838	V345A	probably benign	Het
Polk	A	G	13: 96,496,491		probably null	Het
Polr3k	A	G	2: 181,864,547	Y30C	probably damaging	Het
Pramel6	A	G	2: 87,509,597	H235R	probably benign	Het
Ptpra	G	A	2: 130,537,617	V364I	probably damaging	Het
Recql	A	G	6: 142,363,700		probably benign	Het
Ring1	T	C	17: 34,022,289		probably benign	Het
Rufy4	T	C	1: 74,147,663	C537R	probably damaging	Het
Samsn1	C	A	16: 75,947,289		noncoding transcript	Het
Scara5	A	G	14: 65,730,749	H157R	probably benign	Het
Sdc3	C	T	4: 130,819,065	P245L	probably damaging	Het
Slc18b1	T	A	10: 23,820,869	M318K	possibly damaging	Het
Slc26a10	C	T	10: 127,173,355	A638T	possibly damaging	Het
Slc35f2	T	A	9: 53,809,729	W259R	possibly damaging	Het
Spata13	G	A	14: 60,753,907	W366*	probably null	Het
Sptlc3	A	G	2: 139,589,589	T344A	probably benign	Het
Tap1	T	C	17: 34,193,891	V560A	probably damaging	Het
Tbc1d1	T	C	5: 64,278,046		probably null	Het
Tlr11	A	G	14: 50,361,250	Y231C	possibly damaging	Het
Tmem245	A	T	4: 56,936,468	S230T	possibly damaging	Het
Tnnt3	C	T	7: 142,514,283		probably benign	Het
Traf7	C	G	17: 24,510,438		probably benign	Het
Tshz2	A	G	2: 169,962,681		probably benign	Het
Tshz3	T	C	7: 36,768,972	S129P	probably damaging	Het
Ttc6	A	T	12: 57,729,451	N1727I	probably damaging	Het
Ttc7b	A	G	12: 100,403,362	S383P	probably damaging	Het
Tulp3	T	A	6: 128,323,120	I448F	probably damaging	Het
Ube3b	T	C	5: 114,404,717		probably null	Het
Vav1	G	A	17: 57,296,552	V84I	probably damaging	Het
Vav3	A	T	3: 109,508,794	K243I	possibly damaging	Het
Vmn1r25	T	A	6: 57,979,026	I93F	probably damaging	Het
Vmn2r73	C	T	7: 85,871,715	W348*	probably null	Het
Zdbf2	A	G	1: 63,303,238	R259G	possibly damaging	Het

Other mutations in Lrp2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00094:Lrp2	APN	2	69,507,779 (GRCm38)	missense	probably damaging	1.00
IGL00594:Lrp2	APN	2	69,486,280 (GRCm38)	missense	probably benign	0.00
IGL00782:Lrp2	APN	2	69,501,645 (GRCm38)	missense	probably benign	0.14
IGL00821:Lrp2	APN	2	69,459,516 (GRCm38)	missense	probably damaging	1.00
IGL00897:Lrp2	APN	2	69,521,881 (GRCm38)	missense	possibly damaging	0.86
IGL01065:Lrp2	APN	2	69,469,436 (GRCm38)	missense	possibly damaging	0.94
IGL01087:Lrp2	APN	2	69,524,073 (GRCm38)	missense	probably damaging	1.00
IGL01095:Lrp2	APN	2	69,492,432 (GRCm38)	nonsense	probably null
IGL01131:Lrp2	APN	2	69,499,239 (GRCm38)	missense	probably damaging	1.00
IGL01350:Lrp2	APN	2	69,510,984 (GRCm38)	missense	probably damaging	0.96
IGL01352:Lrp2	APN	2	69,503,526 (GRCm38)	missense	possibly damaging	0.77
IGL01358:Lrp2	APN	2	69,552,470 (GRCm38)	splice site	probably benign
IGL01375:Lrp2	APN	2	69,478,566 (GRCm38)	splice site	probably benign
IGL01384:Lrp2	APN	2	69,483,502 (GRCm38)	missense	probably damaging	1.00
IGL01384:Lrp2	APN	2	69,453,812 (GRCm38)	missense	probably null	1.00
IGL01411:Lrp2	APN	2	69,482,267 (GRCm38)	missense	probably damaging	1.00
IGL01418:Lrp2	APN	2	69,525,286 (GRCm38)	missense	probably benign
IGL01444:Lrp2	APN	2	69,443,716 (GRCm38)	missense	possibly damaging	0.94
IGL01464:Lrp2	APN	2	69,472,439 (GRCm38)	missense	probably damaging	0.98
IGL01528:Lrp2	APN	2	69,492,460 (GRCm38)	missense	probably damaging	1.00
IGL01663:Lrp2	APN	2	69,428,706 (GRCm38)	missense	probably benign
IGL01761:Lrp2	APN	2	69,481,235 (GRCm38)	missense	possibly damaging	0.85
IGL01780:Lrp2	APN	2	69,486,184 (GRCm38)	missense	possibly damaging	0.66
IGL01994:Lrp2	APN	2	69,483,601 (GRCm38)	missense	probably benign	0.08
IGL02015:Lrp2	APN	2	69,527,578 (GRCm38)	missense	probably benign	0.00
IGL02104:Lrp2	APN	2	69,510,418 (GRCm38)	missense	probably damaging	1.00
IGL02132:Lrp2	APN	2	69,537,616 (GRCm38)	missense	probably benign	0.01
IGL02134:Lrp2	APN	2	69,513,379 (GRCm38)	critical splice acceptor site	probably null
IGL02197:Lrp2	APN	2	69,466,880 (GRCm38)	missense	probably benign	0.01
IGL02212:Lrp2	APN	2	69,451,264 (GRCm38)	missense	probably benign	0.00
IGL02240:Lrp2	APN	2	69,535,046 (GRCm38)	missense	probably benign
IGL02248:Lrp2	APN	2	69,482,808 (GRCm38)	missense	probably damaging	1.00
IGL02369:Lrp2	APN	2	69,464,636 (GRCm38)	missense	probably damaging	1.00
IGL02416:Lrp2	APN	2	69,469,633 (GRCm38)	missense	probably damaging	1.00
IGL02417:Lrp2	APN	2	69,461,305 (GRCm38)	missense	probably damaging	1.00
IGL02458:Lrp2	APN	2	69,521,773 (GRCm38)	missense	probably damaging	0.97
IGL02479:Lrp2	APN	2	69,464,801 (GRCm38)	splice site	probably benign
IGL02508:Lrp2	APN	2	69,503,430 (GRCm38)	missense	probably benign	0.04
IGL02751:Lrp2	APN	2	69,533,462 (GRCm38)	missense	possibly damaging	0.56
IGL02814:Lrp2	APN	2	69,506,736 (GRCm38)	missense	probably damaging	1.00
IGL02867:Lrp2	APN	2	69,552,450 (GRCm38)	missense	possibly damaging	0.67
IGL02889:Lrp2	APN	2	69,552,450 (GRCm38)	missense	possibly damaging	0.67
IGL02943:Lrp2	APN	2	69,455,510 (GRCm38)	missense	possibly damaging	0.86
IGL02948:Lrp2	APN	2	69,487,837 (GRCm38)	missense	probably damaging	1.00
IGL02960:Lrp2	APN	2	69,455,453 (GRCm38)	splice site	probably benign
IGL02990:Lrp2	APN	2	69,441,396 (GRCm38)	missense	possibly damaging	0.56
IGL03027:Lrp2	APN	2	69,537,553 (GRCm38)	missense	probably benign	0.43
IGL03038:Lrp2	APN	2	69,475,464 (GRCm38)	missense	probably damaging	0.99
IGL03064:Lrp2	APN	2	69,483,133 (GRCm38)	missense	probably damaging	0.98
IGL03107:Lrp2	APN	2	69,454,833 (GRCm38)	missense	probably damaging	1.00
IGL03141:Lrp2	APN	2	69,477,026 (GRCm38)	missense	probably damaging	0.99
IGL03154:Lrp2	APN	2	69,549,042 (GRCm38)	missense	probably damaging	1.00
IGL03155:Lrp2	APN	2	69,455,452 (GRCm38)	splice site	probably benign
IGL03163:Lrp2	APN	2	69,501,526 (GRCm38)	nonsense	probably null
IGL03164:Lrp2	APN	2	69,464,699 (GRCm38)	missense	probably damaging	1.00
IGL03169:Lrp2	APN	2	69,523,194 (GRCm38)	missense	probably damaging	1.00
IGL03174:Lrp2	APN	2	69,466,265 (GRCm38)	missense	probably damaging	1.00
IGL03189:Lrp2	APN	2	69,438,478 (GRCm38)	splice site	probably benign
IGL03288:Lrp2	APN	2	69,426,039 (GRCm38)	missense	probably benign	0.02
IGL03350:Lrp2	APN	2	69,438,453 (GRCm38)	missense	probably damaging	1.00
IGL03378:Lrp2	APN	2	69,431,152 (GRCm38)	missense	probably damaging	1.00
casual	UTSW	2	69,499,263 (GRCm38)	missense	probably benign
nonchalant	UTSW	2	69,489,329 (GRCm38)	missense	probably damaging	1.00
Presto	UTSW	2	69,459,531 (GRCm38)	nonsense	probably null
relaxed	UTSW	2	69,535,005 (GRCm38)	missense	probably damaging	1.00
unguarded	UTSW	2	69,465,758 (GRCm38)	missense	probably benign	0.00
Unintended	UTSW	2	69,518,443 (GRCm38)	missense	probably damaging	1.00
BB009:Lrp2	UTSW	2	69,426,027 (GRCm38)	missense	probably benign	0.00
BB019:Lrp2	UTSW	2	69,426,027 (GRCm38)	missense	probably benign	0.00
IGL02835:Lrp2	UTSW	2	69,505,304 (GRCm38)	missense	probably damaging	1.00
IGL03055:Lrp2	UTSW	2	69,458,448 (GRCm38)	missense	probably damaging	1.00
PIT4362001:Lrp2	UTSW	2	69,537,538 (GRCm38)	missense	probably damaging	1.00
PIT4504001:Lrp2	UTSW	2	69,475,403 (GRCm38)	missense	probably damaging	1.00
R0008:Lrp2	UTSW	2	69,516,551 (GRCm38)	missense	probably benign	0.42
R0008:Lrp2	UTSW	2	69,516,551 (GRCm38)	missense	probably benign	0.42
R0044:Lrp2	UTSW	2	69,527,555 (GRCm38)	missense	probably damaging	0.96
R0044:Lrp2	UTSW	2	69,527,555 (GRCm38)	missense	probably benign	0.01
R0048:Lrp2	UTSW	2	69,465,627 (GRCm38)	missense	probably damaging	1.00
R0098:Lrp2	UTSW	2	69,475,412 (GRCm38)	missense	probably damaging	1.00
R0098:Lrp2	UTSW	2	69,475,412 (GRCm38)	missense	probably damaging	1.00
R0103:Lrp2	UTSW	2	69,477,040 (GRCm38)	missense	probably benign
R0167:Lrp2	UTSW	2	69,425,658 (GRCm38)	missense	possibly damaging	0.95
R0226:Lrp2	UTSW	2	69,537,563 (GRCm38)	missense	probably null	1.00
R0243:Lrp2	UTSW	2	69,428,630 (GRCm38)	missense	probably benign	0.00
R0308:Lrp2	UTSW	2	69,482,982 (GRCm38)	splice site	probably benign
R0323:Lrp2	UTSW	2	69,469,639 (GRCm38)	missense	probably damaging	1.00
R0372:Lrp2	UTSW	2	69,535,043 (GRCm38)	missense	probably benign	0.10
R0374:Lrp2	UTSW	2	69,430,307 (GRCm38)	missense	probably damaging	1.00
R0391:Lrp2	UTSW	2	69,456,858 (GRCm38)	missense	probably damaging	0.99
R0391:Lrp2	UTSW	2	69,460,337 (GRCm38)	splice site	probably benign
R0395:Lrp2	UTSW	2	69,433,077 (GRCm38)	missense	possibly damaging	0.89
R0401:Lrp2	UTSW	2	69,479,148 (GRCm38)	missense	probably damaging	0.98
R0471:Lrp2	UTSW	2	69,525,234 (GRCm38)	missense	probably damaging	0.97
R0483:Lrp2	UTSW	2	69,507,801 (GRCm38)	missense	probably damaging	0.99
R0502:Lrp2	UTSW	2	69,511,017 (GRCm38)	missense	probably damaging	1.00
R0542:Lrp2	UTSW	2	69,428,654 (GRCm38)	missense	probably benign	0.00
R0544:Lrp2	UTSW	2	69,491,931 (GRCm38)	missense	probably benign	0.18
R0548:Lrp2	UTSW	2	69,537,638 (GRCm38)	splice site	probably benign
R0593:Lrp2	UTSW	2	69,467,006 (GRCm38)	missense	probably benign
R0608:Lrp2	UTSW	2	69,486,243 (GRCm38)	missense	probably benign	0.02
R0633:Lrp2	UTSW	2	69,448,120 (GRCm38)	missense	probably damaging	1.00
R0691:Lrp2	UTSW	2	69,451,380 (GRCm38)	missense	probably benign	0.19
R0718:Lrp2	UTSW	2	69,510,948 (GRCm38)	missense	probably damaging	1.00
R0737:Lrp2	UTSW	2	69,448,169 (GRCm38)	missense	probably damaging	0.96
R0771:Lrp2	UTSW	2	69,507,990 (GRCm38)	missense	probably damaging	1.00
R0784:Lrp2	UTSW	2	69,518,365 (GRCm38)	missense	probably benign	0.32
R0885:Lrp2	UTSW	2	69,482,353 (GRCm38)	missense	possibly damaging	0.75
R0947:Lrp2	UTSW	2	69,487,838 (GRCm38)	missense	probably damaging	1.00
R1235:Lrp2	UTSW	2	69,524,036 (GRCm38)	missense	probably damaging	1.00
R1293:Lrp2	UTSW	2	69,523,302 (GRCm38)	splice site	probably null
R1301:Lrp2	UTSW	2	69,428,604 (GRCm38)	missense	probably damaging	0.98
R1387:Lrp2	UTSW	2	69,456,918 (GRCm38)	missense	probably damaging	1.00
R1459:Lrp2	UTSW	2	69,483,394 (GRCm38)	missense	probably damaging	0.99
R1459:Lrp2	UTSW	2	69,460,477 (GRCm38)	missense	probably damaging	1.00
R1529:Lrp2	UTSW	2	69,523,182 (GRCm38)	missense	probably damaging	1.00
R1543:Lrp2	UTSW	2	69,500,730 (GRCm38)	missense	probably damaging	1.00
R1546:Lrp2	UTSW	2	69,502,610 (GRCm38)	missense	probably damaging	1.00
R1550:Lrp2	UTSW	2	69,502,661 (GRCm38)	missense	possibly damaging	0.74
R1590:Lrp2	UTSW	2	69,466,763 (GRCm38)	critical splice donor site	probably null
R1689:Lrp2	UTSW	2	69,503,529 (GRCm38)	missense	probably benign	0.09
R1693:Lrp2	UTSW	2	69,510,418 (GRCm38)	missense	probably damaging	1.00
R1753:Lrp2	UTSW	2	69,496,489 (GRCm38)	missense	possibly damaging	0.87
R1799:Lrp2	UTSW	2	69,503,530 (GRCm38)	missense	probably benign	0.04
R1834:Lrp2	UTSW	2	69,466,880 (GRCm38)	missense	probably benign	0.01
R1921:Lrp2	UTSW	2	69,523,287 (GRCm38)	missense	probably damaging	1.00
R2000:Lrp2	UTSW	2	69,467,090 (GRCm38)	missense	probably damaging	1.00
R2077:Lrp2	UTSW	2	69,507,843 (GRCm38)	missense	probably damaging	1.00
R2092:Lrp2	UTSW	2	69,536,021 (GRCm38)	missense	probably benign	0.25
R2093:Lrp2	UTSW	2	69,536,021 (GRCm38)	missense	probably benign	0.25
R2108:Lrp2	UTSW	2	69,506,624 (GRCm38)	missense	possibly damaging	0.75
R2117:Lrp2	UTSW	2	69,483,385 (GRCm38)	missense	probably benign	0.05
R2122:Lrp2	UTSW	2	69,483,707 (GRCm38)	missense	probably damaging	1.00
R2134:Lrp2	UTSW	2	69,511,067 (GRCm38)	missense	probably damaging	1.00
R2207:Lrp2	UTSW	2	69,467,028 (GRCm38)	missense	possibly damaging	0.94
R2248:Lrp2	UTSW	2	69,511,010 (GRCm38)	missense	probably damaging	1.00
R2264:Lrp2	UTSW	2	69,482,366 (GRCm38)	missense	possibly damaging	0.88
R2316:Lrp2	UTSW	2	69,491,847 (GRCm38)	missense	possibly damaging	0.75
R2513:Lrp2	UTSW	2	69,506,374 (GRCm38)	splice site	probably null
R2984:Lrp2	UTSW	2	69,425,814 (GRCm38)	splice site	probably null
R3085:Lrp2	UTSW	2	69,467,135 (GRCm38)	missense	probably benign	0.05
R3103:Lrp2	UTSW	2	69,431,984 (GRCm38)	missense	probably benign	0.00
R3727:Lrp2	UTSW	2	69,510,429 (GRCm38)	missense	probably damaging	1.00
R3730:Lrp2	UTSW	2	69,534,907 (GRCm38)	critical splice donor site	probably null
R3730:Lrp2	UTSW	2	69,464,579 (GRCm38)	missense	probably damaging	0.99
R3731:Lrp2	UTSW	2	69,464,579 (GRCm38)	missense	probably damaging	0.99
R3731:Lrp2	UTSW	2	69,534,907 (GRCm38)	critical splice donor site	probably null
R3764:Lrp2	UTSW	2	69,496,336 (GRCm38)	missense	probably damaging	1.00
R3768:Lrp2	UTSW	2	69,505,105 (GRCm38)	missense	probably benign	0.34
R3778:Lrp2	UTSW	2	69,509,204 (GRCm38)	missense	probably benign	0.00
R3808:Lrp2	UTSW	2	69,501,548 (GRCm38)	missense	probably damaging	1.00
R3809:Lrp2	UTSW	2	69,501,548 (GRCm38)	missense	probably damaging	1.00
R3813:Lrp2	UTSW	2	69,464,579 (GRCm38)	missense	probably damaging	0.99
R3828:Lrp2	UTSW	2	69,426,012 (GRCm38)	missense	probably benign	0.03
R3852:Lrp2	UTSW	2	69,537,565 (GRCm38)	missense	probably damaging	0.96
R3877:Lrp2	UTSW	2	69,459,472 (GRCm38)	critical splice donor site	probably null
R3877:Lrp2	UTSW	2	69,549,047 (GRCm38)	missense	probably damaging	1.00
R3922:Lrp2	UTSW	2	69,506,376 (GRCm38)	missense	probably benign
R4081:Lrp2	UTSW	2	69,513,273 (GRCm38)	missense	probably damaging	0.98
R4082:Lrp2	UTSW	2	69,513,273 (GRCm38)	missense	probably damaging	0.98
R4118:Lrp2	UTSW	2	69,430,262 (GRCm38)	critical splice donor site	probably null
R4193:Lrp2	UTSW	2	69,467,143 (GRCm38)	missense	probably damaging	1.00
R4284:Lrp2	UTSW	2	69,480,094 (GRCm38)	missense	possibly damaging	0.95
R4322:Lrp2	UTSW	2	69,425,991 (GRCm38)	nonsense	probably null
R4352:Lrp2	UTSW	2	69,432,182 (GRCm38)	critical splice donor site	probably null
R4407:Lrp2	UTSW	2	69,502,517 (GRCm38)	missense	probably damaging	1.00
R4408:Lrp2	UTSW	2	69,467,169 (GRCm38)	missense	probably benign	0.09
R4416:Lrp2	UTSW	2	69,527,231 (GRCm38)	missense	probably benign	0.18
R4426:Lrp2	UTSW	2	69,506,348 (GRCm38)	missense	probably benign	0.00
R4510:Lrp2	UTSW	2	69,480,062 (GRCm38)	missense	possibly damaging	0.58
R4511:Lrp2	UTSW	2	69,480,062 (GRCm38)	missense	possibly damaging	0.58
R4553:Lrp2	UTSW	2	69,513,285 (GRCm38)	missense	probably benign	0.13
R4591:Lrp2	UTSW	2	69,536,075 (GRCm38)	missense	probably damaging	1.00
R4612:Lrp2	UTSW	2	69,458,427 (GRCm38)	nonsense	probably null
R4622:Lrp2	UTSW	2	69,460,349 (GRCm38)	missense	possibly damaging	0.87
R4632:Lrp2	UTSW	2	69,489,129 (GRCm38)	splice site	probably null
R4633:Lrp2	UTSW	2	69,461,417 (GRCm38)	missense	probably benign	0.16
R4636:Lrp2	UTSW	2	69,436,639 (GRCm38)	missense	possibly damaging	0.93
R4657:Lrp2	UTSW	2	69,466,993 (GRCm38)	missense	probably damaging	1.00
R4667:Lrp2	UTSW	2	69,489,298 (GRCm38)	missense	probably benign	0.02
R4712:Lrp2	UTSW	2	69,506,551 (GRCm38)	missense	probably damaging	1.00
R4713:Lrp2	UTSW	2	69,487,966 (GRCm38)	missense	probably damaging	1.00
R4720:Lrp2	UTSW	2	69,481,173 (GRCm38)	missense	probably damaging	0.99
R4732:Lrp2	UTSW	2	69,533,555 (GRCm38)	missense	probably benign
R4733:Lrp2	UTSW	2	69,533,555 (GRCm38)	missense	probably benign
R4777:Lrp2	UTSW	2	69,482,264 (GRCm38)	missense	probably damaging	1.00
R4786:Lrp2	UTSW	2	69,537,956 (GRCm38)	missense	probably damaging	1.00
R4842:Lrp2	UTSW	2	69,469,411 (GRCm38)	missense	probably benign	0.06
R4845:Lrp2	UTSW	2	69,509,241 (GRCm38)	missense	possibly damaging	0.71
R4846:Lrp2	UTSW	2	69,479,113 (GRCm38)	missense	probably damaging	1.00
R4938:Lrp2	UTSW	2	69,472,368 (GRCm38)	missense	probably damaging	0.98
R4951:Lrp2	UTSW	2	69,535,988 (GRCm38)	missense	probably damaging	1.00
R4990:Lrp2	UTSW	2	69,481,388 (GRCm38)	missense	probably benign	0.01
R5075:Lrp2	UTSW	2	69,465,758 (GRCm38)	missense	probably benign	0.00
R5078:Lrp2	UTSW	2	69,501,530 (GRCm38)	missense	possibly damaging	0.93
R5102:Lrp2	UTSW	2	69,489,158 (GRCm38)	missense	probably damaging	0.98
R5124:Lrp2	UTSW	2	69,501,490 (GRCm38)	missense	probably damaging	0.97
R5131:Lrp2	UTSW	2	69,430,342 (GRCm38)	missense	possibly damaging	0.74
R5141:Lrp2	UTSW	2	69,552,349 (GRCm38)	splice site	probably null
R5223:Lrp2	UTSW	2	69,524,053 (GRCm38)	missense	probably damaging	0.99
R5236:Lrp2	UTSW	2	69,456,819 (GRCm38)	splice site	probably null
R5267:Lrp2	UTSW	2	69,548,978 (GRCm38)	missense	possibly damaging	0.83
R5290:Lrp2	UTSW	2	69,513,354 (GRCm38)	missense	probably damaging	1.00
R5333:Lrp2	UTSW	2	69,525,228 (GRCm38)	missense	probably benign	0.01
R5355:Lrp2	UTSW	2	69,454,838 (GRCm38)	nonsense	probably null
R5356:Lrp2	UTSW	2	69,464,708 (GRCm38)	missense	possibly damaging	0.74
R5369:Lrp2	UTSW	2	69,459,560 (GRCm38)	missense	probably benign	0.04
R5486:Lrp2	UTSW	2	69,437,465 (GRCm38)	missense	probably benign	0.04
R5554:Lrp2	UTSW	2	69,552,424 (GRCm38)	missense	possibly damaging	0.92
R5584:Lrp2	UTSW	2	69,451,288 (GRCm38)	missense	probably damaging	1.00
R5585:Lrp2	UTSW	2	69,464,624 (GRCm38)	missense	possibly damaging	0.77
R5587:Lrp2	UTSW	2	69,499,263 (GRCm38)	missense	probably benign
R5605:Lrp2	UTSW	2	69,523,299 (GRCm38)	missense	probably damaging	1.00
R5637:Lrp2	UTSW	2	69,472,418 (GRCm38)	missense	probably damaging	1.00
R5647:Lrp2	UTSW	2	69,519,914 (GRCm38)	missense	probably null	0.80
R5686:Lrp2	UTSW	2	69,511,061 (GRCm38)	missense	possibly damaging	0.88
R5691:Lrp2	UTSW	2	69,502,553 (GRCm38)	missense	probably damaging	1.00
R5724:Lrp2	UTSW	2	69,451,382 (GRCm38)	missense	probably damaging	0.99
R5726:Lrp2	UTSW	2	69,509,147 (GRCm38)	missense	probably damaging	1.00
R5743:Lrp2	UTSW	2	69,466,877 (GRCm38)	missense	probably damaging	1.00
R5777:Lrp2	UTSW	2	69,455,525 (GRCm38)	missense	probably damaging	1.00
R5841:Lrp2	UTSW	2	69,480,153 (GRCm38)	missense	probably benign	0.00
R5892:Lrp2	UTSW	2	69,442,776 (GRCm38)	missense	probably benign
R5951:Lrp2	UTSW	2	69,496,323 (GRCm38)	splice site	probably null
R5974:Lrp2	UTSW	2	69,459,548 (GRCm38)	missense	probably damaging	1.00
R5980:Lrp2	UTSW	2	69,535,005 (GRCm38)	missense	probably damaging	1.00
R6046:Lrp2	UTSW	2	69,506,754 (GRCm38)	missense	probably damaging	1.00
R6113:Lrp2	UTSW	2	69,483,557 (GRCm38)	missense	possibly damaging	0.76
R6146:Lrp2	UTSW	2	69,511,001 (GRCm38)	missense	probably benign	0.00
R6177:Lrp2	UTSW	2	69,510,419 (GRCm38)	frame shift	probably null
R6180:Lrp2	UTSW	2	69,503,524 (GRCm38)	missense	possibly damaging	0.85
R6219:Lrp2	UTSW	2	69,469,478 (GRCm38)	missense	probably damaging	1.00
R6228:Lrp2	UTSW	2	69,482,366 (GRCm38)	missense	possibly damaging	0.88
R6265:Lrp2	UTSW	2	69,466,340 (GRCm38)	missense	probably damaging	1.00
R6312:Lrp2	UTSW	2	69,436,681 (GRCm38)	missense	probably damaging	1.00
R6337:Lrp2	UTSW	2	69,438,467 (GRCm38)	missense	probably damaging	1.00
R6376:Lrp2	UTSW	2	69,483,443 (GRCm38)	missense	probably benign	0.02
R6385:Lrp2	UTSW	2	69,495,784 (GRCm38)	missense	probably benign	0.22
R6429:Lrp2	UTSW	2	69,461,287 (GRCm38)	missense	probably damaging	1.00
R6458:Lrp2	UTSW	2	69,505,156 (GRCm38)	missense	probably benign	0.00
R6524:Lrp2	UTSW	2	69,436,639 (GRCm38)	missense	possibly damaging	0.93
R6555:Lrp2	UTSW	2	69,509,303 (GRCm38)	missense	probably benign	0.00
R6594:Lrp2	UTSW	2	69,439,923 (GRCm38)	missense	possibly damaging	0.58
R6599:Lrp2	UTSW	2	69,469,405 (GRCm38)	missense	probably damaging	1.00
R6655:Lrp2	UTSW	2	69,453,858 (GRCm38)	missense	probably benign	0.01
R6718:Lrp2	UTSW	2	69,483,780 (GRCm38)	missense	probably benign	0.09
R6736:Lrp2	UTSW	2	69,448,211 (GRCm38)	missense	probably benign	0.02
R6738:Lrp2	UTSW	2	69,458,488 (GRCm38)	missense	probably damaging	0.97
R6799:Lrp2	UTSW	2	69,483,904 (GRCm38)	missense	probably damaging	1.00
R6846:Lrp2	UTSW	2	69,518,443 (GRCm38)	missense	probably damaging	1.00
R6856:Lrp2	UTSW	2	69,513,268 (GRCm38)	missense	probably damaging	1.00
R6861:Lrp2	UTSW	2	69,513,377 (GRCm38)	missense	possibly damaging	0.77
R6888:Lrp2	UTSW	2	69,524,141 (GRCm38)	missense	probably damaging	0.98
R6897:Lrp2	UTSW	2	69,510,502 (GRCm38)	missense	probably benign
R6902:Lrp2	UTSW	2	69,459,503 (GRCm38)	missense	probably damaging	1.00
R6908:Lrp2	UTSW	2	69,472,365 (GRCm38)	missense	probably damaging	1.00
R6918:Lrp2	UTSW	2	69,489,305 (GRCm38)	missense	probably damaging	1.00
R6989:Lrp2	UTSW	2	69,472,455 (GRCm38)	missense	probably damaging	1.00
R7022:Lrp2	UTSW	2	69,483,208 (GRCm38)	missense	probably damaging	1.00
R7025:Lrp2	UTSW	2	69,483,028 (GRCm38)	missense	possibly damaging	0.90
R7026:Lrp2	UTSW	2	69,521,787 (GRCm38)	missense	probably damaging	0.97
R7138:Lrp2	UTSW	2	69,465,745 (GRCm38)	missense	possibly damaging	0.94
R7145:Lrp2	UTSW	2	69,454,808 (GRCm38)	critical splice donor site	probably null
R7150:Lrp2	UTSW	2	69,488,051 (GRCm38)	missense	probably damaging	0.99
R7165:Lrp2	UTSW	2	69,506,573 (GRCm38)	missense	probably damaging	0.99
R7174:Lrp2	UTSW	2	69,433,072 (GRCm38)	missense	probably benign	0.11
R7204:Lrp2	UTSW	2	69,472,533 (GRCm38)	missense	probably benign	0.25
R7275:Lrp2	UTSW	2	69,459,531 (GRCm38)	nonsense	probably null
R7278:Lrp2	UTSW	2	69,486,352 (GRCm38)	missense	probably damaging	1.00
R7296:Lrp2	UTSW	2	69,482,381 (GRCm38)	missense	probably benign	0.04
R7315:Lrp2	UTSW	2	69,491,822 (GRCm38)	missense	probably damaging	0.98
R7342:Lrp2	UTSW	2	69,479,290 (GRCm38)	missense	possibly damaging	0.95
R7351:Lrp2	UTSW	2	69,448,142 (GRCm38)	missense	probably damaging	1.00
R7352:Lrp2	UTSW	2	69,472,397 (GRCm38)	missense	probably benign	0.04
R7366:Lrp2	UTSW	2	69,483,806 (GRCm38)	missense	probably damaging	1.00
R7373:Lrp2	UTSW	2	69,500,692 (GRCm38)	missense	probably damaging	1.00
R7446:Lrp2	UTSW	2	69,432,213 (GRCm38)	missense	probably damaging	1.00
R7446:Lrp2	UTSW	2	69,459,674 (GRCm38)	missense	probably damaging	0.99
R7451:Lrp2	UTSW	2	69,513,333 (GRCm38)	missense	probably damaging	1.00
R7492:Lrp2	UTSW	2	69,537,581 (GRCm38)	missense	probably damaging	0.99
R7571:Lrp2	UTSW	2	69,516,403 (GRCm38)	missense	probably damaging	1.00
R7638:Lrp2	UTSW	2	69,477,008 (GRCm38)	critical splice donor site	probably null
R7664:Lrp2	UTSW	2	69,506,732 (GRCm38)	missense	probably damaging	1.00
R7686:Lrp2	UTSW	2	69,489,237 (GRCm38)	missense	probably damaging	1.00
R7711:Lrp2	UTSW	2	69,479,343 (GRCm38)	critical splice acceptor site	probably null
R7737:Lrp2	UTSW	2	69,496,438 (GRCm38)	missense	possibly damaging	0.77
R7763:Lrp2	UTSW	2	69,503,388 (GRCm38)	missense	probably damaging	0.99
R7775:Lrp2	UTSW	2	69,501,539 (GRCm38)	missense	possibly damaging	0.74
R7824:Lrp2	UTSW	2	69,501,539 (GRCm38)	missense	possibly damaging	0.74
R7840:Lrp2	UTSW	2	69,464,784 (GRCm38)	missense	probably damaging	0.98
R7878:Lrp2	UTSW	2	69,507,809 (GRCm38)	missense	probably damaging	1.00
R7878:Lrp2	UTSW	2	69,507,810 (GRCm38)	missense	probably damaging	1.00
R7895:Lrp2	UTSW	2	69,458,479 (GRCm38)	missense	probably damaging	0.97
R7898:Lrp2	UTSW	2	69,441,366 (GRCm38)	missense	probably benign	0.00
R7912:Lrp2	UTSW	2	69,428,672 (GRCm38)	missense	probably benign	0.03
R7923:Lrp2	UTSW	2	69,438,388 (GRCm38)	missense	possibly damaging	0.75
R7932:Lrp2	UTSW	2	69,426,027 (GRCm38)	missense	probably benign	0.00
R7940:Lrp2	UTSW	2	69,432,197 (GRCm38)	missense	possibly damaging	0.91
R7954:Lrp2	UTSW	2	69,503,523 (GRCm38)	missense	possibly damaging	0.61
R8007:Lrp2	UTSW	2	69,506,505 (GRCm38)	missense	probably benign	0.02
R8084:Lrp2	UTSW	2	69,509,369 (GRCm38)	missense	probably damaging	0.97
R8087:Lrp2	UTSW	2	69,448,129 (GRCm38)	missense	probably damaging	1.00
R8090:Lrp2	UTSW	2	69,464,745 (GRCm38)	missense	possibly damaging	0.94
R8110:Lrp2	UTSW	2	69,506,453 (GRCm38)	missense	probably benign
R8129:Lrp2	UTSW	2	69,430,280 (GRCm38)	missense	possibly damaging	0.75
R8155:Lrp2	UTSW	2	69,482,998 (GRCm38)	missense	possibly damaging	0.74
R8182:Lrp2	UTSW	2	69,489,329 (GRCm38)	missense	probably damaging	1.00
R8239:Lrp2	UTSW	2	69,481,267 (GRCm38)	nonsense	probably null
R8247:Lrp2	UTSW	2	69,431,087 (GRCm38)	missense	possibly damaging	0.76
R8327:Lrp2	UTSW	2	69,491,924 (GRCm38)	missense	probably damaging	1.00
R8355:Lrp2	UTSW	2	69,516,484 (GRCm38)	missense	probably damaging	0.99
R8404:Lrp2	UTSW	2	69,514,241 (GRCm38)	nonsense	probably null
R8427:Lrp2	UTSW	2	69,451,297 (GRCm38)	missense	probably damaging	0.97
R8463:Lrp2	UTSW	2	69,491,906 (GRCm38)	missense	probably damaging	1.00
R8502:Lrp2	UTSW	2	69,514,241 (GRCm38)	nonsense	probably null
R8529:Lrp2	UTSW	2	69,500,642 (GRCm38)	missense	probably damaging	0.96
R8673:Lrp2	UTSW	2	69,472,460 (GRCm38)	missense	probably damaging	1.00
R8698:Lrp2	UTSW	2	69,448,239 (GRCm38)	missense	probably benign	0.39
R8698:Lrp2	UTSW	2	69,458,423 (GRCm38)	missense	probably benign	0.37
R8708:Lrp2	UTSW	2	69,459,613 (GRCm38)	missense	probably damaging	1.00
R8716:Lrp2	UTSW	2	69,443,794 (GRCm38)	missense	probably benign	0.04
R8723:Lrp2	UTSW	2	69,486,304 (GRCm38)	missense	probably damaging	1.00
R8787:Lrp2	UTSW	2	69,552,401 (GRCm38)	missense	probably damaging	1.00
R8903:Lrp2	UTSW	2	69,549,038 (GRCm38)	missense	possibly damaging	0.68
R8944:Lrp2	UTSW	2	69,511,004 (GRCm38)	missense	probably damaging	1.00
R9069:Lrp2	UTSW	2	69,501,652 (GRCm38)	missense	probably damaging	1.00
R9076:Lrp2	UTSW	2	69,519,916 (GRCm38)	missense	probably benign	0.01
R9155:Lrp2	UTSW	2	69,461,369 (GRCm38)	nonsense	probably null
R9173:Lrp2	UTSW	2	69,469,387 (GRCm38)	missense	probably damaging	1.00
R9254:Lrp2	UTSW	2	69,503,547 (GRCm38)	missense	probably benign	0.09
R9256:Lrp2	UTSW	2	69,510,959 (GRCm38)	missense	probably benign	0.03
R9291:Lrp2	UTSW	2	69,480,035 (GRCm38)	missense	probably damaging	1.00
R9335:Lrp2	UTSW	2	69,428,639 (GRCm38)	missense	probably benign	0.01
R9357:Lrp2	UTSW	2	69,506,573 (GRCm38)	missense	probably damaging	0.99
R9368:Lrp2	UTSW	2	69,527,635 (GRCm38)	missense	probably damaging	0.99
R9453:Lrp2	UTSW	2	69,458,488 (GRCm38)	missense	probably damaging	1.00
R9546:Lrp2	UTSW	2	69,456,821 (GRCm38)	critical splice donor site	probably null
R9554:Lrp2	UTSW	2	69,431,153 (GRCm38)	missense	probably damaging	1.00
R9597:Lrp2	UTSW	2	69,430,359 (GRCm38)	missense	probably benign	0.02
R9601:Lrp2	UTSW	2	69,459,584 (GRCm38)	missense	probably damaging	1.00
R9623:Lrp2	UTSW	2	69,477,079 (GRCm38)	missense	probably benign	0.09
RF016:Lrp2	UTSW	2	69,509,205 (GRCm38)	missense	probably benign
X0011:Lrp2	UTSW	2	69,519,998 (GRCm38)	missense	probably damaging	1.00
X0023:Lrp2	UTSW	2	69,436,600 (GRCm38)	missense	probably damaging	0.99
Z1176:Lrp2	UTSW	2	69,507,881 (GRCm38)	missense	possibly damaging	0.88
Z1176:Lrp2	UTSW	2	69,480,042 (GRCm38)	missense	possibly damaging	0.66
Z1177:Lrp2	UTSW	2	69,451,280 (GRCm38)	missense	probably damaging	1.00
Z1177:Lrp2	UTSW	2	69,496,468 (GRCm38)	missense	probably damaging	1.00
Z1177:Lrp2	UTSW	2	69,501,641 (GRCm38)	missense	probably damaging	1.00
Z1177:Lrp2	UTSW	2	69,509,289 (GRCm38)	missense	probably benign	0.00
Z1177:Lrp2	UTSW	2	69,472,453 (GRCm38)	missense	probably benign	0.03

Predicted Primers

PCR Primer
(F):5'- GTCTACGTCACACTTCCAGC -3'
(R):5'- AAGGGCATGAACTCACAAGTC -3'

Sequencing Primer
(F):5'- ACACTTCCAGCTCTGCGG -3'
(R):5'- GCATGAACTCACAAGTCTGATAAAAG -3'

Posted On

2015-12-29