Incidental Mutation 'R4087:Gpr108'
ID368220
Institutional Source Beutler Lab
Gene Symbol Gpr108
Ensembl Gene ENSMUSG00000005823
Gene NameG protein-coupled receptor 108
Synonyms1810015L19Rik
MMRRC Submission 040980-MU
Accession Numbers

Genbank: NM_030084.3; Ensembl: ENSMUST00000005975

Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R4087 (G1)
Quality Score225
Status Validated
Chromosome17
Chromosomal Location57234914-57247641 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 57237925 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Histidine at position 313 (Y313H)
Ref Sequence ENSEMBL: ENSMUSP00000005975 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000005975]
Predicted Effect probably damaging
Transcript: ENSMUST00000005975
AA Change: Y313H

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000005975
Gene: ENSMUSG00000005823
AA Change: Y313H

DomainStartEndE-ValueType
low complexity region 61 75 N/A INTRINSIC
low complexity region 86 103 N/A INTRINSIC
Pfam:Lung_7-TM_R 240 529 2.3e-98 PFAM
low complexity region 535 547 N/A INTRINSIC
Meta Mutation Damage Score 0.0821 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.7%
  • 20x: 96.3%
Validation Efficiency 96% (50/52)
Allele List at MGI

All alleles(3) : Targeted, other(2) Gene trapped(1)

Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A530064D06Rik A G 17: 48,166,510 S80P probably damaging Het
Acss3 T G 10: 107,053,452 Y169S probably damaging Het
Cep250 G A 2: 155,992,632 R2159K probably damaging Het
Cldn34c4 A T X: 127,721,388 V153E probably damaging Het
Col4a4 T A 1: 82,523,922 Y370F unknown Het
Col6a6 A T 9: 105,783,956 I318N possibly damaging Het
Csmd1 T A 8: 15,992,738 I2332F probably damaging Het
Dnajc28 G A 16: 91,616,867 T187M probably damaging Het
Dym T A 18: 75,230,101 Y559N probably damaging Het
Eif3g A G 9: 20,897,952 V59A possibly damaging Het
Fam171a1 G A 2: 3,226,296 R697Q probably damaging Het
Fermt3 T A 19: 7,003,577 probably null Het
Git2 A G 5: 114,764,405 Y189H probably damaging Het
Gkn3 C T 6: 87,383,525 A163T probably damaging Het
Gm7713 C T 15: 59,994,409 noncoding transcript Het
Kcnh8 T C 17: 52,803,400 I213T possibly damaging Het
Lpgat1 A T 1: 191,763,616 I306F possibly damaging Het
Mapk8 T C 14: 33,390,248 T228A probably benign Het
Med12l T C 3: 59,297,921 V2101A probably benign Het
Mettl13 T C 1: 162,548,202 K19E possibly damaging Het
Mta1 A G 12: 113,112,182 Y22C probably damaging Het
Notch3 T C 17: 32,158,113 T273A possibly damaging Het
Notch4 T C 17: 34,584,435 W1443R probably damaging Het
Npy5r T A 8: 66,682,045 D32V probably damaging Het
Olfr1083-ps C A 2: 86,606,953 *206L probably null Het
Rbm47 A G 5: 66,022,737 M409T probably benign Het
Rnf144a C T 12: 26,327,592 V51I probably damaging Het
Rxfp1 T A 3: 79,644,949 T682S probably damaging Het
Sertad2 GCCCC GCCCCC 11: 20,648,664 probably null Het
Sos1 A G 17: 80,449,352 V257A probably benign Het
Ssfa2 C T 2: 79,658,347 Q925* probably null Het
Tdrd9 C T 12: 112,013,486 Q256* probably null Het
Tmprss11d A T 5: 86,309,279 S174T probably damaging Het
Tor1b T A 2: 30,956,519 I238N probably damaging Het
Tppp2 T C 14: 51,919,500 probably null Het
Traf3ip3 A G 1: 193,181,320 V414A probably damaging Het
Trim14 T A 4: 46,523,709 T110S probably benign Het
Trim30d T C 7: 104,487,800 N66D probably damaging Het
Usp48 A G 4: 137,623,340 N46S possibly damaging Het
Vmn2r115 A C 17: 23,346,384 Q415P probably benign Het
Wbp2nl A G 15: 82,308,561 M149V probably benign Het
Zfp106 T C 2: 120,526,899 probably null Het
Zfp281 T A 1: 136,626,121 I279N probably damaging Het
Other mutations in Gpr108
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01982:Gpr108 APN 17 57237877 missense probably damaging 1.00
IGL02486:Gpr108 APN 17 57235977 missense probably damaging 1.00
IGL02810:Gpr108 APN 17 57242742 missense probably benign 0.39
IGL03233:Gpr108 APN 17 57245042 missense probably benign 0.00
1mM(1):Gpr108 UTSW 17 57245352 unclassified probably benign
IGL02799:Gpr108 UTSW 17 57237482 missense probably damaging 1.00
PIT4468001:Gpr108 UTSW 17 57247563 missense probably null 0.09
R0391:Gpr108 UTSW 17 57243101 missense probably benign 0.02
R0469:Gpr108 UTSW 17 57235358 missense possibly damaging 0.65
R0510:Gpr108 UTSW 17 57235358 missense possibly damaging 0.65
R0613:Gpr108 UTSW 17 57238174 splice site probably benign
R1034:Gpr108 UTSW 17 57235995 missense probably damaging 1.00
R1141:Gpr108 UTSW 17 57237219 missense probably damaging 1.00
R1748:Gpr108 UTSW 17 57236217 missense probably damaging 0.99
R2000:Gpr108 UTSW 17 57236712 missense probably benign 0.03
R3036:Gpr108 UTSW 17 57245323 missense probably benign 0.01
R4089:Gpr108 UTSW 17 57237925 missense probably damaging 1.00
R5071:Gpr108 UTSW 17 57235335 missense probably damaging 1.00
R5566:Gpr108 UTSW 17 57236919 missense probably damaging 1.00
R6889:Gpr108 UTSW 17 57236990 missense probably damaging 1.00
R7352:Gpr108 UTSW 17 57236944 missense probably damaging 1.00
R7587:Gpr108 UTSW 17 57236732 missense probably damaging 1.00
R7642:Gpr108 UTSW 17 57236228 nonsense probably null
Z1177:Gpr108 UTSW 17 57237316 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACTGACTGGGCCAATGGATG -3'
(R):5'- AAACTCTACCTGATCATGTCTGC -3'

Sequencing Primer
(F):5'- ACTGGGCCAATGGATGTTCCTG -3'
(R):5'- GATCATGTCTGCCTGCTTTCTGG -3'
Posted On2016-01-06