Incidental Mutation 'R4158:Zfp981'
ID 368310
Institutional Source Beutler Lab
Gene Symbol Zfp981
Ensembl Gene ENSMUSG00000056300
Gene Name zinc finger protein 981
Synonyms Gm13247
MMRRC Submission 041001-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.094) question?
Stock # R4158 (G1)
Quality Score 34
Status Validated
Chromosome 4
Chromosomal Location 146586484-146623852 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 146622080 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Glutamine at position 335 (P335Q)
Ref Sequence ENSEMBL: ENSMUSP00000136739 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105735] [ENSMUST00000140089] [ENSMUST00000179175]
AlphaFold A2A8V7
Predicted Effect probably benign
Transcript: ENSMUST00000105735
AA Change: P335Q

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000101361
Gene: ENSMUSG00000056300
AA Change: P335Q

DomainStartEndE-ValueType
KRAB 13 73 2.34e-15 SMART
ZnF_C2H2 239 261 7.9e-4 SMART
ZnF_C2H2 267 289 8.6e-5 SMART
ZnF_C2H2 295 317 8.6e-5 SMART
ZnF_C2H2 323 345 1.36e-2 SMART
ZnF_C2H2 351 373 6.32e-3 SMART
ZnF_C2H2 379 401 8.6e-5 SMART
ZnF_C2H2 407 429 3.11e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000140089
SMART Domains Protein: ENSMUSP00000115886
Gene: ENSMUSG00000056300

DomainStartEndE-ValueType
KRAB 13 73 2.34e-15 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145269
Predicted Effect probably benign
Transcript: ENSMUST00000179175
AA Change: P335Q

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000136739
Gene: ENSMUSG00000056300
AA Change: P335Q

DomainStartEndE-ValueType
KRAB 13 73 2.34e-15 SMART
ZnF_C2H2 239 261 7.9e-4 SMART
ZnF_C2H2 267 289 8.6e-5 SMART
ZnF_C2H2 295 317 8.6e-5 SMART
ZnF_C2H2 323 345 1.36e-2 SMART
ZnF_C2H2 351 373 6.32e-3 SMART
ZnF_C2H2 379 401 8.6e-5 SMART
ZnF_C2H2 407 429 3.11e-2 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181199
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 97% (38/39)
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam34 T C 8: 44,103,854 (GRCm39) H597R probably damaging Het
Adgrf4 G T 17: 42,978,568 (GRCm39) H258Q probably benign Het
Ankrd1 T A 19: 36,095,273 (GRCm39) K138N probably damaging Het
Arg1 T C 10: 24,798,575 (GRCm39) E25G probably damaging Het
Arhgef19 T C 4: 140,973,660 (GRCm39) I49T possibly damaging Het
Bsn A G 9: 107,990,145 (GRCm39) V1869A possibly damaging Het
Cep350 G A 1: 155,808,621 (GRCm39) R652W probably damaging Het
Cyp19a1 G A 9: 54,093,980 (GRCm39) T94I probably damaging Het
Dnajc13 G A 9: 104,067,641 (GRCm39) L1173F probably damaging Het
Dse A G 10: 34,029,330 (GRCm39) F587L probably damaging Het
Efcab14 A C 4: 115,597,594 (GRCm39) D63A probably damaging Het
Eomes A G 9: 118,308,031 (GRCm39) T35A probably benign Het
Fbxl20 T C 11: 97,986,220 (GRCm39) probably benign Het
Flcn T C 11: 59,691,947 (GRCm39) N234S probably benign Het
Gm20939 A T 17: 95,184,162 (GRCm39) Y270F possibly damaging Het
Ikzf4 A T 10: 128,479,605 (GRCm39) probably benign Het
Il22b T C 10: 118,129,037 (GRCm39) T151A probably damaging Het
Kcne4 A G 1: 78,795,819 (GRCm39) N156D probably benign Het
Kcnh8 GAGACCAACGAGCAGCTGATGCTTCAGA GAGA 17: 53,032,934 (GRCm39) 74 probably benign Het
Lrrc45 A T 11: 120,609,272 (GRCm39) D377V possibly damaging Het
Magi3 T C 3: 103,958,277 (GRCm39) K603E probably damaging Het
Mocos T C 18: 24,807,303 (GRCm39) I345T probably damaging Het
Nox4 A T 7: 87,046,032 (GRCm39) H557L possibly damaging Het
Oasl1 A G 5: 115,075,073 (GRCm39) K378E possibly damaging Het
Pla2r1 A T 2: 60,252,966 (GRCm39) I1375K probably damaging Het
Ppp6r3 T A 19: 3,562,037 (GRCm39) H208L probably damaging Het
Ptprz1 A T 6: 23,001,683 (GRCm39) K1258* probably null Het
Ptprz1 T C 6: 23,022,204 (GRCm39) I844T possibly damaging Het
Sdk1 A G 5: 142,100,154 (GRCm39) I1395V probably benign Het
Sec31b T C 19: 44,513,625 (GRCm39) N470S probably benign Het
Slc26a7 T C 4: 14,544,197 (GRCm39) T369A probably benign Het
Tex14 T G 11: 87,407,595 (GRCm39) S900R probably benign Het
Ush2a G A 1: 188,460,907 (GRCm39) V2723M probably damaging Het
Vat1l T A 8: 115,098,469 (GRCm39) M413K probably benign Het
Other mutations in Zfp981
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02647:Zfp981 APN 4 146,621,709 (GRCm39) nonsense probably null
R0003:Zfp981 UTSW 4 146,622,217 (GRCm39) missense probably damaging 1.00
R1172:Zfp981 UTSW 4 146,622,221 (GRCm39) missense probably benign
R2989:Zfp981 UTSW 4 146,622,347 (GRCm39) missense probably benign 0.40
R4158:Zfp981 UTSW 4 146,622,339 (GRCm39) missense probably benign 0.07
R4778:Zfp981 UTSW 4 146,622,112 (GRCm39) missense probably benign
R5148:Zfp981 UTSW 4 146,621,357 (GRCm39) missense possibly damaging 0.86
R5352:Zfp981 UTSW 4 146,621,462 (GRCm39) missense probably benign 0.29
R6252:Zfp981 UTSW 4 146,621,970 (GRCm39) missense probably benign 0.22
R6674:Zfp981 UTSW 4 146,619,950 (GRCm39) missense probably damaging 0.98
R6765:Zfp981 UTSW 4 146,622,363 (GRCm39) missense probably benign 0.34
R7288:Zfp981 UTSW 4 146,622,100 (GRCm39) missense probably benign 0.32
R7816:Zfp981 UTSW 4 146,622,100 (GRCm39) missense probably benign 0.32
R7835:Zfp981 UTSW 4 146,622,333 (GRCm39) missense probably benign 0.01
R8020:Zfp981 UTSW 4 146,621,825 (GRCm39) missense possibly damaging 0.91
R8797:Zfp981 UTSW 4 146,619,906 (GRCm39) nonsense probably null
R8805:Zfp981 UTSW 4 146,622,410 (GRCm39) missense possibly damaging 0.86
R9145:Zfp981 UTSW 4 146,622,410 (GRCm39) missense possibly damaging 0.72
R9324:Zfp981 UTSW 4 146,619,884 (GRCm39) missense possibly damaging 0.95
R9471:Zfp981 UTSW 4 146,622,080 (GRCm39) missense probably benign
Z1176:Zfp981 UTSW 4 146,621,547 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- ACAGTCTTCAAAGTCAGCAGAG -3'
(R):5'- GAACTCTCAGATAGCCTTTGTCAG -3'

Sequencing Primer
(F):5'- CCTTACAAATGCAGTGAGTGTGAC -3'
(R):5'- CTCAGATAGCCTTTGTCAGTAAAGC -3'
Posted On 2016-01-25