Incidental Mutation 'R4158:Zfp981'
ID |
368311 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zfp981
|
Ensembl Gene |
ENSMUSG00000056300 |
Gene Name |
zinc finger protein 981 |
Synonyms |
Gm13247 |
MMRRC Submission |
041001-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.094)
|
Stock # |
R4158 (G1)
|
Quality Score |
44 |
Status
|
Validated
|
Chromosome |
4 |
Chromosomal Location |
146586484-146623852 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 146622339 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Histidine to Glutamine
at position 421
(H421Q)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000136739
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000105735]
[ENSMUST00000140089]
[ENSMUST00000179175]
|
AlphaFold |
A2A8V7 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000105735
AA Change: H421Q
PolyPhen 2
Score 0.066 (Sensitivity: 0.94; Specificity: 0.84)
|
SMART Domains |
Protein: ENSMUSP00000101361 Gene: ENSMUSG00000056300 AA Change: H421Q
Domain | Start | End | E-Value | Type |
KRAB
|
13 |
73 |
2.34e-15 |
SMART |
ZnF_C2H2
|
239 |
261 |
7.9e-4 |
SMART |
ZnF_C2H2
|
267 |
289 |
8.6e-5 |
SMART |
ZnF_C2H2
|
295 |
317 |
8.6e-5 |
SMART |
ZnF_C2H2
|
323 |
345 |
1.36e-2 |
SMART |
ZnF_C2H2
|
351 |
373 |
6.32e-3 |
SMART |
ZnF_C2H2
|
379 |
401 |
8.6e-5 |
SMART |
ZnF_C2H2
|
407 |
429 |
3.11e-2 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000140089
|
SMART Domains |
Protein: ENSMUSP00000115886 Gene: ENSMUSG00000056300
Domain | Start | End | E-Value | Type |
KRAB
|
13 |
73 |
2.34e-15 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000145269
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000179175
AA Change: H421Q
PolyPhen 2
Score 0.066 (Sensitivity: 0.94; Specificity: 0.84)
|
SMART Domains |
Protein: ENSMUSP00000136739 Gene: ENSMUSG00000056300 AA Change: H421Q
Domain | Start | End | E-Value | Type |
KRAB
|
13 |
73 |
2.34e-15 |
SMART |
ZnF_C2H2
|
239 |
261 |
7.9e-4 |
SMART |
ZnF_C2H2
|
267 |
289 |
8.6e-5 |
SMART |
ZnF_C2H2
|
295 |
317 |
8.6e-5 |
SMART |
ZnF_C2H2
|
323 |
345 |
1.36e-2 |
SMART |
ZnF_C2H2
|
351 |
373 |
6.32e-3 |
SMART |
ZnF_C2H2
|
379 |
401 |
8.6e-5 |
SMART |
ZnF_C2H2
|
407 |
429 |
3.11e-2 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000181199
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.5%
|
Validation Efficiency |
97% (38/39) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 34 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adam34 |
T |
C |
8: 44,103,854 (GRCm39) |
H597R |
probably damaging |
Het |
Adgrf4 |
G |
T |
17: 42,978,568 (GRCm39) |
H258Q |
probably benign |
Het |
Ankrd1 |
T |
A |
19: 36,095,273 (GRCm39) |
K138N |
probably damaging |
Het |
Arg1 |
T |
C |
10: 24,798,575 (GRCm39) |
E25G |
probably damaging |
Het |
Arhgef19 |
T |
C |
4: 140,973,660 (GRCm39) |
I49T |
possibly damaging |
Het |
Bsn |
A |
G |
9: 107,990,145 (GRCm39) |
V1869A |
possibly damaging |
Het |
Cep350 |
G |
A |
1: 155,808,621 (GRCm39) |
R652W |
probably damaging |
Het |
Cyp19a1 |
G |
A |
9: 54,093,980 (GRCm39) |
T94I |
probably damaging |
Het |
Dnajc13 |
G |
A |
9: 104,067,641 (GRCm39) |
L1173F |
probably damaging |
Het |
Dse |
A |
G |
10: 34,029,330 (GRCm39) |
F587L |
probably damaging |
Het |
Efcab14 |
A |
C |
4: 115,597,594 (GRCm39) |
D63A |
probably damaging |
Het |
Eomes |
A |
G |
9: 118,308,031 (GRCm39) |
T35A |
probably benign |
Het |
Fbxl20 |
T |
C |
11: 97,986,220 (GRCm39) |
|
probably benign |
Het |
Flcn |
T |
C |
11: 59,691,947 (GRCm39) |
N234S |
probably benign |
Het |
Gm20939 |
A |
T |
17: 95,184,162 (GRCm39) |
Y270F |
possibly damaging |
Het |
Ikzf4 |
A |
T |
10: 128,479,605 (GRCm39) |
|
probably benign |
Het |
Il22b |
T |
C |
10: 118,129,037 (GRCm39) |
T151A |
probably damaging |
Het |
Kcne4 |
A |
G |
1: 78,795,819 (GRCm39) |
N156D |
probably benign |
Het |
Kcnh8 |
GAGACCAACGAGCAGCTGATGCTTCAGA |
GAGA |
17: 53,032,934 (GRCm39) |
74 |
probably benign |
Het |
Lrrc45 |
A |
T |
11: 120,609,272 (GRCm39) |
D377V |
possibly damaging |
Het |
Magi3 |
T |
C |
3: 103,958,277 (GRCm39) |
K603E |
probably damaging |
Het |
Mocos |
T |
C |
18: 24,807,303 (GRCm39) |
I345T |
probably damaging |
Het |
Nox4 |
A |
T |
7: 87,046,032 (GRCm39) |
H557L |
possibly damaging |
Het |
Oasl1 |
A |
G |
5: 115,075,073 (GRCm39) |
K378E |
possibly damaging |
Het |
Pla2r1 |
A |
T |
2: 60,252,966 (GRCm39) |
I1375K |
probably damaging |
Het |
Ppp6r3 |
T |
A |
19: 3,562,037 (GRCm39) |
H208L |
probably damaging |
Het |
Ptprz1 |
A |
T |
6: 23,001,683 (GRCm39) |
K1258* |
probably null |
Het |
Ptprz1 |
T |
C |
6: 23,022,204 (GRCm39) |
I844T |
possibly damaging |
Het |
Sdk1 |
A |
G |
5: 142,100,154 (GRCm39) |
I1395V |
probably benign |
Het |
Sec31b |
T |
C |
19: 44,513,625 (GRCm39) |
N470S |
probably benign |
Het |
Slc26a7 |
T |
C |
4: 14,544,197 (GRCm39) |
T369A |
probably benign |
Het |
Tex14 |
T |
G |
11: 87,407,595 (GRCm39) |
S900R |
probably benign |
Het |
Ush2a |
G |
A |
1: 188,460,907 (GRCm39) |
V2723M |
probably damaging |
Het |
Vat1l |
T |
A |
8: 115,098,469 (GRCm39) |
M413K |
probably benign |
Het |
|
Other mutations in Zfp981 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL02647:Zfp981
|
APN |
4 |
146,621,709 (GRCm39) |
nonsense |
probably null |
|
R0003:Zfp981
|
UTSW |
4 |
146,622,217 (GRCm39) |
missense |
probably damaging |
1.00 |
R1172:Zfp981
|
UTSW |
4 |
146,622,221 (GRCm39) |
missense |
probably benign |
|
R2989:Zfp981
|
UTSW |
4 |
146,622,347 (GRCm39) |
missense |
probably benign |
0.40 |
R4158:Zfp981
|
UTSW |
4 |
146,622,080 (GRCm39) |
missense |
probably benign |
|
R4778:Zfp981
|
UTSW |
4 |
146,622,112 (GRCm39) |
missense |
probably benign |
|
R5148:Zfp981
|
UTSW |
4 |
146,621,357 (GRCm39) |
missense |
possibly damaging |
0.86 |
R5352:Zfp981
|
UTSW |
4 |
146,621,462 (GRCm39) |
missense |
probably benign |
0.29 |
R6252:Zfp981
|
UTSW |
4 |
146,621,970 (GRCm39) |
missense |
probably benign |
0.22 |
R6674:Zfp981
|
UTSW |
4 |
146,619,950 (GRCm39) |
missense |
probably damaging |
0.98 |
R6765:Zfp981
|
UTSW |
4 |
146,622,363 (GRCm39) |
missense |
probably benign |
0.34 |
R7288:Zfp981
|
UTSW |
4 |
146,622,100 (GRCm39) |
missense |
probably benign |
0.32 |
R7816:Zfp981
|
UTSW |
4 |
146,622,100 (GRCm39) |
missense |
probably benign |
0.32 |
R7835:Zfp981
|
UTSW |
4 |
146,622,333 (GRCm39) |
missense |
probably benign |
0.01 |
R8020:Zfp981
|
UTSW |
4 |
146,621,825 (GRCm39) |
missense |
possibly damaging |
0.91 |
R8797:Zfp981
|
UTSW |
4 |
146,619,906 (GRCm39) |
nonsense |
probably null |
|
R8805:Zfp981
|
UTSW |
4 |
146,622,410 (GRCm39) |
missense |
possibly damaging |
0.86 |
R9145:Zfp981
|
UTSW |
4 |
146,622,410 (GRCm39) |
missense |
possibly damaging |
0.72 |
R9324:Zfp981
|
UTSW |
4 |
146,619,884 (GRCm39) |
missense |
possibly damaging |
0.95 |
R9471:Zfp981
|
UTSW |
4 |
146,622,080 (GRCm39) |
missense |
probably benign |
|
Z1176:Zfp981
|
UTSW |
4 |
146,621,547 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Predicted Primers |
PCR Primer
(F):5'- CCTTACAAATGCAGTGAGTGTGA -3'
(R):5'- ACATTTGTAAGAATTCTCCCCTGT -3'
Sequencing Primer
(F):5'- CAGTGAGTGTGACAAATGCTTTACCC -3'
(R):5'- CTCTGATGCCTTCTCAGAGTGAG -3'
|
Posted On |
2016-01-25 |