Incidental Mutation 'R4790:Myh8'
| ID |
368485 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myh8
|
| Ensembl Gene |
ENSMUSG00000055775 |
| Gene Name |
myosin, heavy polypeptide 8, skeletal muscle, perinatal |
| Synonyms |
Myhsp, 4832426G23Rik, MyHC-pn, Myhs-p |
| MMRRC Submission |
042418-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.818)
|
| Stock # |
R4790 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
67277124-67308634 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 67279963 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Threonine
at position 95
(M95T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000104325
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000019625]
[ENSMUST00000108685]
|
| AlphaFold |
P13542 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000019625
AA Change: M95T
PolyPhen 2
Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000019625
Gene: ENSMUSG00000055775
AA Change: M95T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_N
|
37 |
76 |
2.1e-13 |
PFAM |
|
MYSc
|
82 |
782 |
N/A |
SMART |
|
IQ
|
783 |
805 |
5.44e-3 |
SMART |
|
Pfam:Myosin_tail_1
|
846 |
1927 |
2.4e-164 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000108685
AA Change: M95T
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000104325
Gene: ENSMUSG00000055775
AA Change: M95T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_N
|
37 |
78 |
3.8e-17 |
PFAM |
|
Pfam:Myosin_head
|
90 |
172 |
1.7e-31 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000108686
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000139052
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.5%
- 20x: 93.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes a myosin heavy chain. The encoded protein forms a hexamer with two heavy chains, two alkali light chains, and two regulatory light chain components. This complex functions in muscle contraction. This gene is located in a cluster of related genes on chromosome 11. [provided by RefSeq, Jun 2013]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 118 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1600015I10Rik |
T |
A |
6: 48,930,552 (GRCm38) |
I162N |
probably damaging |
Het |
| Abca5 |
T |
G |
11: 110,311,410 (GRCm38) |
T390P |
possibly damaging |
Het |
| Acss3 |
A |
T |
10: 107,023,702 (GRCm38) |
Y345* |
probably null |
Het |
| Adam26b |
A |
T |
8: 43,520,727 (GRCm38) |
S413T |
probably benign |
Het |
| Angpt2 |
T |
A |
8: 18,714,082 (GRCm38) |
Q148L |
probably damaging |
Het |
| Ank3 |
T |
A |
10: 69,988,151 (GRCm38) |
Y883* |
probably null |
Het |
| Ankrd52 |
A |
G |
10: 128,380,945 (GRCm38) |
K190E |
possibly damaging |
Het |
| Anks1b |
A |
G |
10: 90,163,275 (GRCm38) |
R415G |
probably damaging |
Het |
| Ano3 |
T |
A |
2: 110,884,919 (GRCm38) |
Q58L |
probably benign |
Het |
| Arhgap39 |
A |
T |
15: 76,726,731 (GRCm38) |
M924K |
possibly damaging |
Het |
| AU040320 |
A |
G |
4: 126,847,215 (GRCm38) |
M910V |
possibly damaging |
Het |
| BC051019 |
T |
A |
7: 109,716,346 (GRCm38) |
H86L |
probably benign |
Het |
| C1qbp |
G |
A |
11: 70,980,030 (GRCm38) |
Q151* |
probably null |
Het |
| C4b |
G |
T |
17: 34,734,143 (GRCm38) |
D1069E |
probably benign |
Het |
| C77080 |
C |
A |
4: 129,223,302 (GRCm38) |
R523L |
probably damaging |
Het |
| Casp1 |
C |
T |
9: 5,303,020 (GRCm38) |
T158I |
probably benign |
Het |
| Casq1 |
T |
C |
1: 172,216,837 (GRCm38) |
D141G |
probably damaging |
Het |
| Ccdc33 |
T |
A |
9: 58,029,957 (GRCm38) |
E653V |
probably damaging |
Het |
| Cd180 |
C |
T |
13: 102,702,822 (GRCm38) |
T71M |
probably damaging |
Het |
| Cdk4 |
T |
C |
10: 127,064,701 (GRCm38) |
L112P |
probably damaging |
Het |
| Celf2 |
A |
G |
2: 6,549,903 (GRCm38) |
F425S |
probably damaging |
Het |
| Chrm3 |
A |
T |
13: 9,877,662 (GRCm38) |
V446E |
probably benign |
Het |
| Chst9 |
A |
T |
18: 15,453,050 (GRCm38) |
L152H |
probably damaging |
Het |
| Cib2 |
A |
G |
9: 54,549,803 (GRCm38) |
|
probably null |
Het |
| Clec18a |
T |
C |
8: 111,072,085 (GRCm38) |
S366G |
probably damaging |
Het |
| Crebbp |
A |
G |
16: 4,180,119 (GRCm38) |
F34L |
probably damaging |
Het |
| Dapk1 |
AT |
A |
13: 60,723,105 (GRCm38) |
|
probably null |
Het |
| Ddi1 |
T |
A |
9: 6,265,761 (GRCm38) |
M203L |
probably benign |
Het |
| Ddx20 |
G |
T |
3: 105,683,169 (GRCm38) |
S270R |
probably benign |
Het |
| Epp13 |
A |
T |
7: 6,266,318 (GRCm38) |
K31* |
probably null |
Het |
| Espnl |
A |
T |
1: 91,344,424 (GRCm38) |
E458V |
probably damaging |
Het |
| Fat3 |
T |
C |
9: 15,998,484 (GRCm38) |
D2074G |
probably damaging |
Het |
| Fcf1 |
A |
G |
12: 84,974,128 (GRCm38) |
T61A |
probably benign |
Het |
| Fkbp15 |
T |
C |
4: 62,307,997 (GRCm38) |
R772G |
probably benign |
Het |
| Flnb |
T |
C |
14: 7,905,661 (GRCm38) |
V1137A |
probably benign |
Het |
| Fosb |
C |
A |
7: 19,309,388 (GRCm38) |
C15F |
probably damaging |
Het |
| Frem2 |
A |
T |
3: 53,516,741 (GRCm38) |
W3092R |
probably benign |
Het |
| Gm3248 |
T |
C |
14: 5,945,831 (GRCm38) |
I28V |
probably damaging |
Het |
| Gm4922 |
G |
T |
10: 18,784,168 (GRCm38) |
L269I |
possibly damaging |
Het |
| Gucy2e |
G |
A |
11: 69,228,448 (GRCm38) |
R627W |
probably damaging |
Het |
| Hephl1 |
T |
A |
9: 15,059,171 (GRCm38) |
E1009V |
probably damaging |
Het |
| Hsf4 |
A |
T |
8: 105,270,605 (GRCm38) |
Q61L |
probably damaging |
Het |
| Itgam |
T |
A |
7: 128,116,273 (GRCm38) |
N1046K |
probably benign |
Het |
| Itgav |
G |
A |
2: 83,755,810 (GRCm38) |
C138Y |
probably damaging |
Het |
| Itih4 |
A |
T |
14: 30,889,910 (GRCm38) |
Y157F |
probably damaging |
Het |
| Kcnt2 |
C |
T |
1: 140,354,516 (GRCm38) |
R80C |
probably damaging |
Het |
| Kdm4b |
G |
A |
17: 56,401,618 (GRCm38) |
V986M |
probably damaging |
Het |
| Lamb3 |
T |
A |
1: 193,339,886 (GRCm38) |
V1014D |
probably damaging |
Het |
| Lrrc74b |
G |
T |
16: 17,549,853 (GRCm38) |
N282K |
probably damaging |
Het |
| Map3k20 |
T |
A |
2: 72,441,704 (GRCm38) |
H725Q |
probably benign |
Het |
| Mink1 |
A |
G |
11: 70,599,041 (GRCm38) |
N81S |
probably damaging |
Het |
| Mmp21 |
A |
G |
7: 133,675,030 (GRCm38) |
Y415H |
probably damaging |
Het |
| Mycbp2 |
A |
T |
14: 103,229,437 (GRCm38) |
W1297R |
probably damaging |
Het |
| Myo7b |
A |
T |
18: 32,000,105 (GRCm38) |
|
probably null |
Het |
| Nanog |
A |
G |
6: 122,707,915 (GRCm38) |
M20V |
probably benign |
Het |
| Ncapd3 |
A |
G |
9: 27,051,850 (GRCm38) |
I484V |
probably benign |
Het |
| Ndufa12 |
A |
T |
10: 94,220,758 (GRCm38) |
N116I |
probably benign |
Het |
| Nedd4l |
A |
G |
18: 65,203,945 (GRCm38) |
I668V |
possibly damaging |
Het |
| Nobox |
T |
C |
6: 43,305,546 (GRCm38) |
D309G |
probably benign |
Het |
| Npnt |
A |
G |
3: 132,890,762 (GRCm38) |
|
probably benign |
Het |
| Nrxn1 |
A |
C |
17: 90,455,049 (GRCm38) |
Y2D |
possibly damaging |
Het |
| Obox6 |
G |
T |
7: 15,834,577 (GRCm38) |
P125T |
possibly damaging |
Het |
| Ofcc1 |
G |
A |
13: 40,015,388 (GRCm38) |
T841I |
probably damaging |
Het |
| Olfr1079 |
T |
C |
2: 86,538,880 (GRCm38) |
T10A |
possibly damaging |
Het |
| Olfr1193 |
T |
A |
2: 88,678,387 (GRCm38) |
N177K |
possibly damaging |
Het |
| Olfr1436 |
A |
G |
19: 12,298,941 (GRCm38) |
Y64H |
possibly damaging |
Het |
| Olfr202 |
A |
T |
16: 59,284,458 (GRCm38) |
V13D |
probably damaging |
Het |
| Olfr679 |
T |
C |
7: 105,086,637 (GRCm38) |
|
probably benign |
Het |
| Olfr697 |
C |
G |
7: 106,741,791 (GRCm38) |
V48L |
probably benign |
Het |
| Olfr761 |
T |
C |
17: 37,952,742 (GRCm38) |
Y94C |
probably damaging |
Het |
| Osm |
A |
T |
11: 4,238,435 (GRCm38) |
M21L |
probably benign |
Het |
| Otogl |
T |
A |
10: 107,822,033 (GRCm38) |
|
probably null |
Het |
| Otud4 |
T |
G |
8: 79,666,773 (GRCm38) |
S493A |
possibly damaging |
Het |
| Pars2 |
A |
G |
4: 106,651,111 (GRCm38) |
|
probably benign |
Het |
| Phlda3 |
T |
A |
1: 135,766,819 (GRCm38) |
V124E |
possibly damaging |
Het |
| Pias4 |
T |
C |
10: 81,157,492 (GRCm38) |
D199G |
probably damaging |
Het |
| Pm20d1 |
T |
C |
1: 131,812,039 (GRCm38) |
L375P |
probably benign |
Het |
| Pole2 |
T |
C |
12: 69,226,365 (GRCm38) |
I48V |
probably benign |
Het |
| Prrc2c |
T |
C |
1: 162,710,481 (GRCm38) |
R527G |
unknown |
Het |
| Rasgrf2 |
G |
T |
13: 91,988,016 (GRCm38) |
N592K |
probably damaging |
Het |
| Rbm7 |
A |
G |
9: 48,495,174 (GRCm38) |
L26P |
probably damaging |
Het |
| Rhag |
A |
G |
17: 40,831,290 (GRCm38) |
H208R |
probably benign |
Het |
| Rnf17 |
A |
G |
14: 56,434,355 (GRCm38) |
E268G |
probably damaging |
Het |
| Rnf220 |
A |
G |
4: 117,289,055 (GRCm38) |
V23A |
probably benign |
Het |
| Rnf7 |
A |
T |
9: 96,478,419 (GRCm38) |
V55D |
probably damaging |
Het |
| Sdr9c7 |
C |
A |
10: 127,903,579 (GRCm38) |
R188S |
possibly damaging |
Het |
| Senp6 |
T |
A |
9: 80,089,858 (GRCm38) |
N51K |
probably benign |
Het |
| Skint3 |
C |
A |
4: 112,255,898 (GRCm38) |
T235K |
possibly damaging |
Het |
| Slc10a5 |
A |
G |
3: 10,335,036 (GRCm38) |
F188S |
probably damaging |
Het |
| Slc41a1 |
G |
A |
1: 131,830,952 (GRCm38) |
G111R |
probably damaging |
Het |
| Smarca1 |
T |
C |
X: 47,884,067 (GRCm38) |
D132G |
probably null |
Het |
| Snrnp48 |
C |
T |
13: 38,221,323 (GRCm38) |
R299W |
probably damaging |
Het |
| Sspo |
G |
A |
6: 48,460,771 (GRCm38) |
G1413D |
probably benign |
Het |
| Star |
T |
A |
8: 25,808,616 (GRCm38) |
H16Q |
probably damaging |
Het |
| Strc |
T |
C |
2: 121,375,594 (GRCm38) |
D779G |
probably benign |
Het |
| Sulf2 |
T |
C |
2: 166,089,295 (GRCm38) |
Y264C |
probably damaging |
Het |
| Supt7l |
A |
G |
5: 31,522,904 (GRCm38) |
S6P |
possibly damaging |
Het |
| Syne2 |
A |
G |
12: 76,020,391 (GRCm38) |
D4289G |
probably benign |
Het |
| Szrd1 |
A |
T |
4: 141,139,690 (GRCm38) |
|
probably null |
Het |
| Tada1 |
T |
C |
1: 166,391,954 (GRCm38) |
V275A |
possibly damaging |
Het |
| Tbr1 |
A |
T |
2: 61,811,588 (GRCm38) |
Y136F |
probably benign |
Het |
| Tbx20 |
T |
A |
9: 24,725,714 (GRCm38) |
H359L |
probably benign |
Het |
| Thbs4 |
G |
T |
13: 92,762,806 (GRCm38) |
D560E |
probably damaging |
Het |
| Tnfsf14 |
T |
C |
17: 57,190,740 (GRCm38) |
H164R |
probably damaging |
Het |
| Trmu |
T |
C |
15: 85,882,805 (GRCm38) |
S72P |
probably damaging |
Het |
| Tsnaxip1 |
C |
A |
8: 105,833,523 (GRCm38) |
Q36K |
probably benign |
Het |
| Ttc28 |
T |
A |
5: 111,224,217 (GRCm38) |
M844K |
possibly damaging |
Het |
| Tubgcp2 |
T |
C |
7: 139,999,288 (GRCm38) |
Y695C |
probably damaging |
Het |
| Ugt1a10 |
T |
A |
1: 88,056,287 (GRCm38) |
M269K |
probably damaging |
Het |
| Urb1 |
A |
T |
16: 90,769,555 (GRCm38) |
L1448* |
probably null |
Het |
| Vmn2r124 |
A |
T |
17: 18,049,593 (GRCm38) |
H37L |
probably damaging |
Het |
| Vmn2r44 |
T |
C |
7: 8,367,950 (GRCm38) |
N699S |
probably damaging |
Het |
| Vps35 |
A |
T |
8: 85,278,857 (GRCm38) |
|
probably null |
Het |
| Yipf1 |
G |
T |
4: 107,336,199 (GRCm38) |
|
probably null |
Het |
| Zfp395 |
A |
G |
14: 65,386,541 (GRCm38) |
N153S |
possibly damaging |
Het |
| Zfp395 |
A |
G |
14: 65,393,207 (GRCm38) |
D402G |
probably damaging |
Het |
| Zfp652 |
T |
C |
11: 95,749,609 (GRCm38) |
V120A |
probably damaging |
Het |
| Zp3r |
T |
C |
1: 130,582,892 (GRCm38) |
I364M |
probably damaging |
Het |
|
| Other mutations in Myh8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00236:Myh8
|
APN |
11 |
67,283,818 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL01020:Myh8
|
APN |
11 |
67,283,403 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01348:Myh8
|
APN |
11 |
67,297,780 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01382:Myh8
|
APN |
11 |
67,301,973 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01454:Myh8
|
APN |
11 |
67,283,596 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01457:Myh8
|
APN |
11 |
67,292,679 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01472:Myh8
|
APN |
11 |
67,288,379 (GRCm38) |
splice site |
probably benign |
|
|
IGL01473:Myh8
|
APN |
11 |
67,301,825 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL01613:Myh8
|
APN |
11 |
67,301,710 (GRCm38) |
missense |
probably benign |
0.11 |
|
IGL01763:Myh8
|
APN |
11 |
67,286,419 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL01828:Myh8
|
APN |
11 |
67,303,826 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
IGL01862:Myh8
|
APN |
11 |
67,289,694 (GRCm38) |
nonsense |
probably null |
|
|
IGL01905:Myh8
|
APN |
11 |
67,284,651 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
IGL02280:Myh8
|
APN |
11 |
67,283,372 (GRCm38) |
unclassified |
probably benign |
|
|
IGL02386:Myh8
|
APN |
11 |
67,294,440 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02449:Myh8
|
APN |
11 |
67,294,614 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL02500:Myh8
|
APN |
11 |
67,305,710 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02745:Myh8
|
APN |
11 |
67,297,501 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
IGL02799:Myh8
|
APN |
11 |
67,301,592 (GRCm38) |
splice site |
probably benign |
|
|
IGL03063:Myh8
|
APN |
11 |
67,288,205 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL03223:Myh8
|
APN |
11 |
67,283,818 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL03336:Myh8
|
APN |
11 |
67,284,702 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03338:Myh8
|
APN |
11 |
67,298,346 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03351:Myh8
|
APN |
11 |
67,303,913 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
IGL03392:Myh8
|
APN |
11 |
67,294,418 (GRCm38) |
missense |
probably damaging |
1.00 |
|
BB003:Myh8
|
UTSW |
11 |
67,278,906 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
BB009:Myh8
|
UTSW |
11 |
67,294,604 (GRCm38) |
missense |
probably benign |
0.00 |
|
BB013:Myh8
|
UTSW |
11 |
67,278,906 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
BB019:Myh8
|
UTSW |
11 |
67,294,604 (GRCm38) |
missense |
probably benign |
0.00 |
|
PIT4354001:Myh8
|
UTSW |
11 |
67,289,630 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0012:Myh8
|
UTSW |
11 |
67,300,021 (GRCm38) |
missense |
probably benign |
0.02 |
|
R0016:Myh8
|
UTSW |
11 |
67,298,525 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0016:Myh8
|
UTSW |
11 |
67,298,525 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0115:Myh8
|
UTSW |
11 |
67,306,264 (GRCm38) |
splice site |
probably benign |
|
|
R0131:Myh8
|
UTSW |
11 |
67,292,188 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R0131:Myh8
|
UTSW |
11 |
67,292,188 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R0132:Myh8
|
UTSW |
11 |
67,292,188 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R0238:Myh8
|
UTSW |
11 |
67,301,692 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0238:Myh8
|
UTSW |
11 |
67,301,692 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0239:Myh8
|
UTSW |
11 |
67,301,692 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0239:Myh8
|
UTSW |
11 |
67,301,692 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0393:Myh8
|
UTSW |
11 |
67,306,017 (GRCm38) |
splice site |
probably benign |
|
|
R0453:Myh8
|
UTSW |
11 |
67,292,905 (GRCm38) |
missense |
probably benign |
0.03 |
|
R0454:Myh8
|
UTSW |
11 |
67,303,765 (GRCm38) |
nonsense |
probably null |
|
|
R0466:Myh8
|
UTSW |
11 |
67,298,579 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0487:Myh8
|
UTSW |
11 |
67,302,011 (GRCm38) |
missense |
probably benign |
|
|
R0511:Myh8
|
UTSW |
11 |
67,284,507 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0557:Myh8
|
UTSW |
11 |
67,301,798 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R0589:Myh8
|
UTSW |
11 |
67,298,627 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0658:Myh8
|
UTSW |
11 |
67,284,532 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0782:Myh8
|
UTSW |
11 |
67,289,754 (GRCm38) |
missense |
probably benign |
0.16 |
|
R0829:Myh8
|
UTSW |
11 |
67,283,500 (GRCm38) |
unclassified |
probably benign |
|
|
R0845:Myh8
|
UTSW |
11 |
67,286,264 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0930:Myh8
|
UTSW |
11 |
67,305,998 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R0972:Myh8
|
UTSW |
11 |
67,297,759 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1132:Myh8
|
UTSW |
11 |
67,297,131 (GRCm38) |
nonsense |
probably null |
|
|
R1417:Myh8
|
UTSW |
11 |
67,306,185 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1478:Myh8
|
UTSW |
11 |
67,292,725 (GRCm38) |
missense |
probably benign |
0.23 |
|
R1497:Myh8
|
UTSW |
11 |
67,289,812 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1605:Myh8
|
UTSW |
11 |
67,301,671 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1701:Myh8
|
UTSW |
11 |
67,280,138 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1950:Myh8
|
UTSW |
11 |
67,279,004 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
R1989:Myh8
|
UTSW |
11 |
67,292,724 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2010:Myh8
|
UTSW |
11 |
67,297,164 (GRCm38) |
nonsense |
probably null |
|
|
R2095:Myh8
|
UTSW |
11 |
67,286,224 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2132:Myh8
|
UTSW |
11 |
67,292,876 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2152:Myh8
|
UTSW |
11 |
67,294,469 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2229:Myh8
|
UTSW |
11 |
67,308,348 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R2302:Myh8
|
UTSW |
11 |
67,286,239 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2364:Myh8
|
UTSW |
11 |
67,294,518 (GRCm38) |
missense |
probably benign |
0.03 |
|
R2429:Myh8
|
UTSW |
11 |
67,303,897 (GRCm38) |
missense |
probably benign |
0.21 |
|
R2880:Myh8
|
UTSW |
11 |
67,297,264 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3692:Myh8
|
UTSW |
11 |
67,301,918 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R3756:Myh8
|
UTSW |
11 |
67,284,617 (GRCm38) |
unclassified |
probably benign |
|
|
R3924:Myh8
|
UTSW |
11 |
67,297,137 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4172:Myh8
|
UTSW |
11 |
67,292,421 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4255:Myh8
|
UTSW |
11 |
67,299,734 (GRCm38) |
missense |
probably benign |
|
|
R4621:Myh8
|
UTSW |
11 |
67,286,258 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4623:Myh8
|
UTSW |
11 |
67,286,258 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4914:Myh8
|
UTSW |
11 |
67,292,684 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5074:Myh8
|
UTSW |
11 |
67,305,916 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
R5119:Myh8
|
UTSW |
11 |
67,298,358 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5159:Myh8
|
UTSW |
11 |
67,288,353 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5229:Myh8
|
UTSW |
11 |
67,284,484 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R5320:Myh8
|
UTSW |
11 |
67,286,263 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5455:Myh8
|
UTSW |
11 |
67,301,418 (GRCm38) |
missense |
possibly damaging |
0.59 |
|
R5523:Myh8
|
UTSW |
11 |
67,305,962 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R5540:Myh8
|
UTSW |
11 |
67,286,440 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5726:Myh8
|
UTSW |
11 |
67,294,566 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
R5770:Myh8
|
UTSW |
11 |
67,297,200 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6135:Myh8
|
UTSW |
11 |
67,297,500 (GRCm38) |
missense |
possibly damaging |
0.51 |
|
R6253:Myh8
|
UTSW |
11 |
67,301,967 (GRCm38) |
missense |
probably benign |
0.06 |
|
R6318:Myh8
|
UTSW |
11 |
67,299,341 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6432:Myh8
|
UTSW |
11 |
67,298,579 (GRCm38) |
missense |
probably benign |
0.01 |
|
R6452:Myh8
|
UTSW |
11 |
67,305,739 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R6452:Myh8
|
UTSW |
11 |
67,292,449 (GRCm38) |
missense |
probably benign |
0.27 |
|
R6512:Myh8
|
UTSW |
11 |
67,289,662 (GRCm38) |
nonsense |
probably null |
|
|
R6714:Myh8
|
UTSW |
11 |
67,306,949 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6842:Myh8
|
UTSW |
11 |
67,284,655 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7007:Myh8
|
UTSW |
11 |
67,288,316 (GRCm38) |
missense |
probably benign |
0.03 |
|
R7025:Myh8
|
UTSW |
11 |
67,297,539 (GRCm38) |
missense |
probably benign |
0.02 |
|
R7086:Myh8
|
UTSW |
11 |
67,292,627 (GRCm38) |
splice site |
probably null |
|
|
R7098:Myh8
|
UTSW |
11 |
67,279,053 (GRCm38) |
missense |
probably benign |
0.03 |
|
R7498:Myh8
|
UTSW |
11 |
67,283,437 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
R7716:Myh8
|
UTSW |
11 |
67,298,652 (GRCm38) |
missense |
possibly damaging |
0.51 |
|
R7765:Myh8
|
UTSW |
11 |
67,303,655 (GRCm38) |
missense |
probably benign |
0.44 |
|
R7825:Myh8
|
UTSW |
11 |
67,303,712 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R7921:Myh8
|
UTSW |
11 |
67,283,818 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R7926:Myh8
|
UTSW |
11 |
67,278,906 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R7932:Myh8
|
UTSW |
11 |
67,294,604 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8003:Myh8
|
UTSW |
11 |
67,299,760 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8028:Myh8
|
UTSW |
11 |
67,303,676 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R8121:Myh8
|
UTSW |
11 |
67,289,821 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8125:Myh8
|
UTSW |
11 |
67,299,772 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R8170:Myh8
|
UTSW |
11 |
67,288,266 (GRCm38) |
missense |
probably benign |
0.30 |
|
R8277:Myh8
|
UTSW |
11 |
67,292,909 (GRCm38) |
missense |
probably benign |
0.10 |
|
R8304:Myh8
|
UTSW |
11 |
67,304,336 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R8431:Myh8
|
UTSW |
11 |
67,283,614 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R8535:Myh8
|
UTSW |
11 |
67,278,915 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8795:Myh8
|
UTSW |
11 |
67,283,377 (GRCm38) |
critical splice acceptor site |
probably benign |
|
|
R8858:Myh8
|
UTSW |
11 |
67,301,994 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R8927:Myh8
|
UTSW |
11 |
67,283,255 (GRCm38) |
missense |
probably benign |
0.10 |
|
R8928:Myh8
|
UTSW |
11 |
67,283,255 (GRCm38) |
missense |
probably benign |
0.10 |
|
R9031:Myh8
|
UTSW |
11 |
67,299,315 (GRCm38) |
missense |
possibly damaging |
0.49 |
|
R9172:Myh8
|
UTSW |
11 |
67,292,434 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R9252:Myh8
|
UTSW |
11 |
67,286,476 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9365:Myh8
|
UTSW |
11 |
67,283,806 (GRCm38) |
missense |
probably benign |
0.42 |
|
R9468:Myh8
|
UTSW |
11 |
67,306,904 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9564:Myh8
|
UTSW |
11 |
67,286,389 (GRCm38) |
missense |
probably benign |
0.40 |
|
R9565:Myh8
|
UTSW |
11 |
67,286,389 (GRCm38) |
missense |
probably benign |
0.40 |
|
T0722:Myh8
|
UTSW |
11 |
67,304,436 (GRCm38) |
missense |
probably benign |
0.41 |
|
Z1088:Myh8
|
UTSW |
11 |
67,298,592 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1176:Myh8
|
UTSW |
11 |
67,303,674 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1177:Myh8
|
UTSW |
11 |
67,308,355 (GRCm38) |
missense |
possibly damaging |
0.64 |
|
Z1177:Myh8
|
UTSW |
11 |
67,301,424 (GRCm38) |
missense |
probably damaging |
0.99 |
|
Z1187:Myh8
|
UTSW |
11 |
67,297,486 (GRCm38) |
missense |
probably benign |
|
|
Z1188:Myh8
|
UTSW |
11 |
67,297,486 (GRCm38) |
missense |
probably benign |
|
|
Z1190:Myh8
|
UTSW |
11 |
67,297,486 (GRCm38) |
missense |
probably benign |
|
|
Z1191:Myh8
|
UTSW |
11 |
67,297,486 (GRCm38) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCAGGCCTTTAAAAGTCACCGAATAAC -3'
(R):5'- AGCCACTTGTAGGGGTTGAC -3'
Sequencing Primer
(F):5'- CCATACGAAGCAAACAAAGTGTG -3'
(R):5'- TAGGGGTTGACGGTGACAC -3'
|
| Posted On |
2016-02-04 |
Incidental Mutation