Incidental Mutation 'R4791:Kdm5b'
| ID |
368532 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kdm5b
|
| Ensembl Gene |
ENSMUSG00000042207 |
| Gene Name |
lysine (K)-specific demethylase 5B |
| Synonyms |
Jarid1b, Plu1, Rb-Bp2, 2210016I17Rik, 2010009J12Rik, PLU-1, D1Ertd202e |
| MMRRC Submission |
041976-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.268)
|
| Stock # |
R4791 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
134560171-134635285 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 134630800 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 1515
(E1515G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000107817
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047714]
[ENSMUST00000112198]
|
| AlphaFold |
Q80Y84 |
| PDB Structure |
Solution structure of the ARID domain of Jarid1b protein [SOLUTION NMR]
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000047714
|
| SMART Domains |
Protein: ENSMUSP00000038138
Gene: ENSMUSG00000042207
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
30 |
N/A |
INTRINSIC |
|
JmjN
|
31 |
72 |
2.87e-20 |
SMART |
|
ARID
|
94 |
183 |
7.39e-32 |
SMART |
|
BRIGHT
|
98 |
188 |
1.51e-35 |
SMART |
|
low complexity region
|
228 |
239 |
N/A |
INTRINSIC |
|
PHD
|
311 |
357 |
6.15e-14 |
SMART |
|
JmjC
|
453 |
619 |
2.33e-67 |
SMART |
|
Pfam:zf-C5HC2
|
692 |
744 |
2.2e-17 |
PFAM |
|
Pfam:PLU-1
|
757 |
1088 |
5.6e-92 |
PFAM |
|
low complexity region
|
1097 |
1109 |
N/A |
INTRINSIC |
|
PHD
|
1178 |
1222 |
6.2e-10 |
SMART |
|
low complexity region
|
1225 |
1236 |
N/A |
INTRINSIC |
|
low complexity region
|
1406 |
1417 |
N/A |
INTRINSIC |
|
low complexity region
|
1470 |
1484 |
N/A |
INTRINSIC |
|
PHD
|
1486 |
1536 |
1.18e-6 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000112198
AA Change: E1515G
PolyPhen 2
Score 0.816 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000107817
Gene: ENSMUSG00000042207
AA Change: E1515G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
30 |
N/A |
INTRINSIC |
|
JmjN
|
31 |
72 |
2.87e-20 |
SMART |
|
ARID
|
94 |
183 |
7.39e-32 |
SMART |
|
BRIGHT
|
98 |
188 |
1.51e-35 |
SMART |
|
low complexity region
|
228 |
239 |
N/A |
INTRINSIC |
|
PHD
|
311 |
357 |
6.15e-14 |
SMART |
|
JmjC
|
453 |
619 |
2.33e-67 |
SMART |
|
Pfam:zf-C5HC2
|
692 |
745 |
6.7e-21 |
PFAM |
|
Pfam:PLU-1
|
756 |
1088 |
6e-94 |
PFAM |
|
low complexity region
|
1097 |
1109 |
N/A |
INTRINSIC |
|
PHD
|
1178 |
1222 |
6.2e-10 |
SMART |
|
low complexity region
|
1225 |
1236 |
N/A |
INTRINSIC |
|
low complexity region
|
1406 |
1417 |
N/A |
INTRINSIC |
|
low complexity region
|
1470 |
1484 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000191572
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 94.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Homozygous mutant mice display decreased body weight, decreased female fertility, lower uterine weight, and a delay in mammary development. Knockout of this gene has also been associated with embryonic lethality. [provided by RefSeq, Dec 2016]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit decreased body weight, background-sensitive premature mortality, decreased female fertility, delayed mammary gland development, decreased serum estradiol levels, and reduced mammary epithelial cell proliferation in early puberty. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 97 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4921507P07Rik |
G |
T |
6: 50,595,837 (GRCm38) |
P32Q |
probably damaging |
Het |
| Abcc6 |
C |
T |
7: 45,982,160 (GRCm38) |
V1231M |
probably benign |
Het |
| Agl |
A |
G |
3: 116,786,528 (GRCm38) |
|
probably null |
Het |
| Ak7 |
T |
C |
12: 105,710,145 (GRCm38) |
F35L |
probably benign |
Het |
| Aldh1a1 |
A |
G |
19: 20,619,985 (GRCm38) |
N110S |
probably damaging |
Het |
| Arhgef5 |
C |
T |
6: 43,283,183 (GRCm38) |
L1368F |
probably damaging |
Het |
| Atp5j2 |
T |
C |
5: 145,184,555 (GRCm38) |
Y72C |
possibly damaging |
Het |
| Atp6v0a2 |
T |
G |
5: 124,646,727 (GRCm38) |
F317V |
probably benign |
Het |
| Bank1 |
A |
T |
3: 136,254,929 (GRCm38) |
S56T |
probably benign |
Het |
| BC080695 |
A |
G |
4: 143,570,989 (GRCm38) |
|
probably benign |
Het |
| Cachd1 |
T |
A |
4: 100,918,085 (GRCm38) |
C166S |
probably damaging |
Het |
| Cand1 |
A |
G |
10: 119,210,702 (GRCm38) |
I961T |
probably benign |
Het |
| Ccdc73 |
G |
A |
2: 104,981,105 (GRCm38) |
|
probably null |
Het |
| Cct6b |
A |
T |
11: 82,742,004 (GRCm38) |
|
probably null |
Het |
| Chd2 |
A |
C |
7: 73,468,577 (GRCm38) |
S1098A |
probably benign |
Het |
| Col6a4 |
A |
T |
9: 106,080,202 (GRCm38) |
V141E |
possibly damaging |
Het |
| Col6a5 |
T |
C |
9: 105,930,784 (GRCm38) |
T1022A |
unknown |
Het |
| Cr2 |
A |
T |
1: 195,155,935 (GRCm38) |
C698S |
probably damaging |
Het |
| Diexf |
G |
A |
1: 193,128,267 (GRCm38) |
H143Y |
probably benign |
Het |
| Dnaaf5 |
C |
A |
5: 139,184,650 (GRCm38) |
Q786K |
possibly damaging |
Het |
| Dnah6 |
T |
C |
6: 73,095,074 (GRCm38) |
D2423G |
probably benign |
Het |
| Dnhd1 |
T |
C |
7: 105,721,117 (GRCm38) |
F4583S |
probably damaging |
Het |
| Duoxa2 |
A |
T |
2: 122,301,198 (GRCm38) |
T123S |
probably damaging |
Het |
| Edem1 |
T |
G |
6: 108,841,634 (GRCm38) |
V201G |
probably damaging |
Het |
| Eef1d |
C |
T |
15: 75,903,682 (GRCm38) |
A43T |
possibly damaging |
Het |
| Elavl3 |
T |
C |
9: 22,024,678 (GRCm38) |
K249E |
probably damaging |
Het |
| Epg5 |
G |
T |
18: 77,948,996 (GRCm38) |
E303* |
probably null |
Het |
| Fam83h |
T |
C |
15: 76,002,368 (GRCm38) |
D1040G |
probably damaging |
Het |
| Fndc7 |
A |
T |
3: 108,876,659 (GRCm38) |
F211L |
probably benign |
Het |
| Fsip2 |
A |
G |
2: 82,982,108 (GRCm38) |
T2924A |
possibly damaging |
Het |
| Gm5616 |
T |
C |
9: 48,450,683 (GRCm38) |
|
noncoding transcript |
Het |
| Gpr135 |
T |
A |
12: 72,069,868 (GRCm38) |
D375V |
probably benign |
Het |
| Hgd |
A |
G |
16: 37,631,825 (GRCm38) |
*446W |
probably null |
Het |
| Hivep2 |
C |
A |
10: 14,128,969 (GRCm38) |
T437K |
probably benign |
Het |
| Htra2 |
A |
G |
6: 83,051,817 (GRCm38) |
L379P |
probably damaging |
Het |
| Hypk |
G |
T |
2: 121,457,655 (GRCm38) |
|
probably null |
Het |
| Ica1l |
A |
G |
1: 60,010,201 (GRCm38) |
F198L |
probably damaging |
Het |
| Igsf11 |
G |
A |
16: 39,024,864 (GRCm38) |
S319N |
probably damaging |
Het |
| Il12rb1 |
T |
C |
8: 70,813,368 (GRCm38) |
S213P |
possibly damaging |
Het |
| Katnal1 |
C |
T |
5: 148,904,650 (GRCm38) |
V135M |
probably damaging |
Het |
| Kcnc4 |
G |
A |
3: 107,447,543 (GRCm38) |
P530S |
probably benign |
Het |
| Kcnu1 |
T |
C |
8: 25,913,752 (GRCm38) |
Y24H |
probably damaging |
Het |
| Kif18a |
A |
T |
2: 109,287,875 (GRCm38) |
M12L |
probably benign |
Het |
| Klre1 |
T |
C |
6: 129,584,155 (GRCm38) |
S160P |
probably damaging |
Het |
| Lama2 |
A |
T |
10: 27,467,271 (GRCm38) |
H68Q |
probably damaging |
Het |
| Lgals8 |
T |
C |
13: 12,453,322 (GRCm38) |
K49R |
possibly damaging |
Het |
| Lmf1 |
G |
A |
17: 25,654,471 (GRCm38) |
V317M |
probably damaging |
Het |
| Lsr |
T |
C |
7: 30,958,552 (GRCm38) |
T328A |
probably damaging |
Het |
| Mark4 |
C |
T |
7: 19,451,657 (GRCm38) |
E51K |
probably benign |
Het |
| Mindy2 |
T |
C |
9: 70,634,001 (GRCm38) |
|
probably null |
Het |
| Mkks |
G |
A |
2: 136,876,162 (GRCm38) |
T400I |
probably benign |
Het |
| Mon2 |
T |
A |
10: 123,006,057 (GRCm38) |
M1544L |
probably benign |
Het |
| Mrc2 |
G |
A |
11: 105,348,431 (GRCm38) |
|
probably null |
Het |
| Myo5c |
T |
G |
9: 75,290,916 (GRCm38) |
L1341R |
probably damaging |
Het |
| Nin |
T |
C |
12: 70,043,807 (GRCm38) |
R945G |
possibly damaging |
Het |
| Nox4 |
T |
C |
7: 87,304,847 (GRCm38) |
V120A |
probably benign |
Het |
| Olfr1196 |
C |
T |
2: 88,700,898 (GRCm38) |
V144I |
probably benign |
Het |
| Olfr1496 |
T |
A |
19: 13,781,342 (GRCm38) |
C243* |
probably null |
Het |
| Olfr169 |
G |
T |
16: 19,566,663 (GRCm38) |
H73Q |
possibly damaging |
Het |
| Olfr30 |
A |
T |
11: 58,455,544 (GRCm38) |
V135E |
possibly damaging |
Het |
| Olfr847 |
T |
C |
9: 19,375,809 (GRCm38) |
E24G |
probably benign |
Het |
| Plekha2 |
T |
A |
8: 25,042,762 (GRCm38) |
R398W |
probably damaging |
Het |
| Pradc1 |
A |
G |
6: 85,447,191 (GRCm38) |
W58R |
probably damaging |
Het |
| Prrc2b |
A |
G |
2: 32,217,339 (GRCm38) |
|
probably null |
Het |
| Psg19 |
T |
A |
7: 18,794,146 (GRCm38) |
N224I |
probably damaging |
Het |
| Ranbp17 |
A |
C |
11: 33,487,746 (GRCm38) |
V164G |
probably benign |
Het |
| Rasgrp3 |
A |
G |
17: 75,500,173 (GRCm38) |
S211G |
probably benign |
Het |
| Rcc1l |
G |
A |
5: 134,163,776 (GRCm38) |
P270S |
possibly damaging |
Het |
| Rfx6 |
T |
A |
10: 51,719,944 (GRCm38) |
|
probably null |
Het |
| Rnf222 |
A |
T |
11: 68,893,019 (GRCm38) |
E137D |
probably damaging |
Het |
| Selenof |
T |
G |
3: 144,596,823 (GRCm38) |
Y120D |
probably damaging |
Het |
| Sema3b |
G |
T |
9: 107,603,813 (GRCm38) |
D108E |
probably damaging |
Het |
| Shank3 |
T |
A |
15: 89,500,354 (GRCm38) |
L143Q |
probably damaging |
Het |
| Shtn1 |
G |
C |
19: 59,050,873 (GRCm38) |
R45G |
probably damaging |
Het |
| Sirt4 |
T |
C |
5: 115,480,314 (GRCm38) |
T234A |
possibly damaging |
Het |
| Slc25a30 |
C |
A |
14: 75,763,366 (GRCm38) |
W266L |
probably benign |
Het |
| Spata20 |
A |
T |
11: 94,484,586 (GRCm38) |
N127K |
probably damaging |
Het |
| St14 |
C |
T |
9: 31,095,622 (GRCm38) |
G636D |
probably benign |
Het |
| Stat5a |
G |
A |
11: 100,865,463 (GRCm38) |
E170K |
probably damaging |
Het |
| Sugp2 |
C |
T |
8: 70,242,790 (GRCm38) |
R138C |
probably damaging |
Het |
| Sult1e1 |
C |
A |
5: 87,586,730 (GRCm38) |
W119L |
possibly damaging |
Het |
| Sv2a |
T |
C |
3: 96,192,558 (GRCm38) |
V608A |
possibly damaging |
Het |
| Syne2 |
T |
C |
12: 75,909,244 (GRCm38) |
Y575H |
possibly damaging |
Het |
| Taok2 |
G |
A |
7: 126,868,132 (GRCm38) |
S167L |
possibly damaging |
Het |
| Thoc6 |
T |
C |
17: 23,670,067 (GRCm38) |
H151R |
possibly damaging |
Het |
| Tm9sf2 |
T |
C |
14: 122,139,650 (GRCm38) |
S197P |
probably benign |
Het |
| Tmem260 |
CAGGGACCGGCATAG |
CAG |
14: 48,511,994 (GRCm38) |
|
probably benign |
Het |
| Tmx2 |
G |
A |
2: 84,677,996 (GRCm38) |
P15L |
probably damaging |
Het |
| Top1mt |
C |
T |
15: 75,668,625 (GRCm38) |
|
probably null |
Het |
| Trpm6 |
T |
A |
19: 18,867,981 (GRCm38) |
S1682T |
probably benign |
Het |
| Trrap |
C |
T |
5: 144,803,277 (GRCm38) |
R1171W |
probably damaging |
Het |
| Ugt3a2 |
A |
G |
15: 9,361,579 (GRCm38) |
D147G |
probably damaging |
Het |
| Vnn3 |
A |
G |
10: 23,864,621 (GRCm38) |
H274R |
probably benign |
Het |
| Vwf |
C |
A |
6: 125,643,363 (GRCm38) |
T1668K |
|
Het |
| Zfp568 |
T |
C |
7: 30,015,183 (GRCm38) |
S162P |
probably damaging |
Het |
| Zfp658 |
T |
A |
7: 43,574,466 (GRCm38) |
C722S |
possibly damaging |
Het |
| Zfp808 |
T |
A |
13: 62,171,231 (GRCm38) |
H91Q |
probably damaging |
Het |
|
| Other mutations in Kdm5b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00230:Kdm5b
|
APN |
1 |
134,620,955 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01458:Kdm5b
|
APN |
1 |
134,621,986 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
IGL01567:Kdm5b
|
APN |
1 |
134,602,540 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01625:Kdm5b
|
APN |
1 |
134,617,968 (GRCm38) |
missense |
possibly damaging |
0.74 |
|
IGL01970:Kdm5b
|
APN |
1 |
134,600,727 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02183:Kdm5b
|
APN |
1 |
134,624,931 (GRCm38) |
missense |
probably benign |
0.09 |
|
IGL02592:Kdm5b
|
APN |
1 |
134,624,853 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02695:Kdm5b
|
APN |
1 |
134,604,485 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
IGL02697:Kdm5b
|
APN |
1 |
134,588,773 (GRCm38) |
splice site |
probably benign |
|
|
IGL03036:Kdm5b
|
APN |
1 |
134,608,937 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03056:Kdm5b
|
APN |
1 |
134,587,979 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03206:Kdm5b
|
APN |
1 |
134,627,317 (GRCm38) |
missense |
probably benign |
|
|
IGL03342:Kdm5b
|
APN |
1 |
134,602,576 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL03388:Kdm5b
|
APN |
1 |
134,627,322 (GRCm38) |
missense |
probably benign |
|
|
amaryllis
|
UTSW |
1 |
134,609,061 (GRCm38) |
critical splice donor site |
probably null |
|
|
PIT4486001:Kdm5b
|
UTSW |
1 |
134,628,685 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0233:Kdm5b
|
UTSW |
1 |
134,604,634 (GRCm38) |
splice site |
probably benign |
|
|
R0334:Kdm5b
|
UTSW |
1 |
134,604,522 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0504:Kdm5b
|
UTSW |
1 |
134,621,023 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0505:Kdm5b
|
UTSW |
1 |
134,602,571 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R0521:Kdm5b
|
UTSW |
1 |
134,618,033 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R1004:Kdm5b
|
UTSW |
1 |
134,588,904 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R1087:Kdm5b
|
UTSW |
1 |
134,600,637 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1126:Kdm5b
|
UTSW |
1 |
134,613,991 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R1221:Kdm5b
|
UTSW |
1 |
134,599,091 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R1230:Kdm5b
|
UTSW |
1 |
134,613,254 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1345:Kdm5b
|
UTSW |
1 |
134,630,550 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R1482:Kdm5b
|
UTSW |
1 |
134,624,897 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1582:Kdm5b
|
UTSW |
1 |
134,624,853 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1653:Kdm5b
|
UTSW |
1 |
134,602,481 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1693:Kdm5b
|
UTSW |
1 |
134,597,576 (GRCm38) |
splice site |
probably benign |
|
|
R1721:Kdm5b
|
UTSW |
1 |
134,613,181 (GRCm38) |
splice site |
probably benign |
|
|
R1741:Kdm5b
|
UTSW |
1 |
134,618,017 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R1762:Kdm5b
|
UTSW |
1 |
134,604,467 (GRCm38) |
nonsense |
probably null |
|
|
R1820:Kdm5b
|
UTSW |
1 |
134,597,670 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R1872:Kdm5b
|
UTSW |
1 |
134,624,994 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1966:Kdm5b
|
UTSW |
1 |
134,613,873 (GRCm38) |
splice site |
probably null |
|
|
R2056:Kdm5b
|
UTSW |
1 |
134,613,214 (GRCm38) |
missense |
probably benign |
0.05 |
|
R2059:Kdm5b
|
UTSW |
1 |
134,613,214 (GRCm38) |
missense |
probably benign |
0.05 |
|
R2405:Kdm5b
|
UTSW |
1 |
134,609,016 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3417:Kdm5b
|
UTSW |
1 |
134,587,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3771:Kdm5b
|
UTSW |
1 |
134,613,345 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3783:Kdm5b
|
UTSW |
1 |
134,630,542 (GRCm38) |
missense |
probably benign |
|
|
R3803:Kdm5b
|
UTSW |
1 |
134,615,941 (GRCm38) |
missense |
probably benign |
0.07 |
|
R3980:Kdm5b
|
UTSW |
1 |
134,619,670 (GRCm38) |
missense |
probably benign |
0.11 |
|
R3983:Kdm5b
|
UTSW |
1 |
134,631,304 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R4013:Kdm5b
|
UTSW |
1 |
134,627,329 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R4162:Kdm5b
|
UTSW |
1 |
134,625,161 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4701:Kdm5b
|
UTSW |
1 |
134,606,012 (GRCm38) |
intron |
probably benign |
|
|
R4836:Kdm5b
|
UTSW |
1 |
134,593,315 (GRCm38) |
splice site |
probably null |
|
|
R4924:Kdm5b
|
UTSW |
1 |
134,631,351 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5135:Kdm5b
|
UTSW |
1 |
134,588,746 (GRCm38) |
intron |
probably benign |
|
|
R5248:Kdm5b
|
UTSW |
1 |
134,620,997 (GRCm38) |
missense |
probably benign |
0.11 |
|
R5290:Kdm5b
|
UTSW |
1 |
134,622,099 (GRCm38) |
splice site |
probably null |
|
|
R5358:Kdm5b
|
UTSW |
1 |
134,607,694 (GRCm38) |
nonsense |
probably null |
|
|
R5388:Kdm5b
|
UTSW |
1 |
134,608,897 (GRCm38) |
nonsense |
probably null |
|
|
R5396:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5397:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5398:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5399:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5529:Kdm5b
|
UTSW |
1 |
134,588,003 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5540:Kdm5b
|
UTSW |
1 |
134,631,241 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5661:Kdm5b
|
UTSW |
1 |
134,599,073 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5663:Kdm5b
|
UTSW |
1 |
134,630,635 (GRCm38) |
missense |
probably benign |
|
|
R5822:Kdm5b
|
UTSW |
1 |
134,588,773 (GRCm38) |
splice site |
probably benign |
|
|
R6226:Kdm5b
|
UTSW |
1 |
134,608,878 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6368:Kdm5b
|
UTSW |
1 |
134,599,207 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6681:Kdm5b
|
UTSW |
1 |
134,613,269 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R6715:Kdm5b
|
UTSW |
1 |
134,609,061 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7132:Kdm5b
|
UTSW |
1 |
134,599,106 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7202:Kdm5b
|
UTSW |
1 |
134,624,759 (GRCm38) |
missense |
probably benign |
|
|
R7258:Kdm5b
|
UTSW |
1 |
134,621,021 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7335:Kdm5b
|
UTSW |
1 |
134,560,439 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7420:Kdm5b
|
UTSW |
1 |
134,604,497 (GRCm38) |
missense |
probably benign |
0.14 |
|
R7426:Kdm5b
|
UTSW |
1 |
134,595,833 (GRCm38) |
missense |
probably benign |
0.02 |
|
R7452:Kdm5b
|
UTSW |
1 |
134,624,948 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7595:Kdm5b
|
UTSW |
1 |
134,608,966 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7612:Kdm5b
|
UTSW |
1 |
134,624,918 (GRCm38) |
nonsense |
probably null |
|
|
R7704:Kdm5b
|
UTSW |
1 |
134,587,931 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7846:Kdm5b
|
UTSW |
1 |
134,617,840 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8115:Kdm5b
|
UTSW |
1 |
134,619,673 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R8146:Kdm5b
|
UTSW |
1 |
134,625,126 (GRCm38) |
missense |
probably benign |
0.05 |
|
R8160:Kdm5b
|
UTSW |
1 |
134,613,919 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8527:Kdm5b
|
UTSW |
1 |
134,605,774 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R8542:Kdm5b
|
UTSW |
1 |
134,605,774 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R8930:Kdm5b
|
UTSW |
1 |
134,616,272 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8932:Kdm5b
|
UTSW |
1 |
134,616,272 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8950:Kdm5b
|
UTSW |
1 |
134,613,926 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R9089:Kdm5b
|
UTSW |
1 |
134,607,768 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R9109:Kdm5b
|
UTSW |
1 |
134,600,755 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9133:Kdm5b
|
UTSW |
1 |
134,602,585 (GRCm38) |
missense |
probably benign |
|
|
R9298:Kdm5b
|
UTSW |
1 |
134,600,755 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9423:Kdm5b
|
UTSW |
1 |
134,587,967 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R9630:Kdm5b
|
UTSW |
1 |
134,585,233 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9670:Kdm5b
|
UTSW |
1 |
134,630,502 (GRCm38) |
nonsense |
probably null |
|
|
X0063:Kdm5b
|
UTSW |
1 |
134,588,876 (GRCm38) |
missense |
probably benign |
0.07 |
|
Z1176:Kdm5b
|
UTSW |
1 |
134,625,035 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1177:Kdm5b
|
UTSW |
1 |
134,595,798 (GRCm38) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CTATGACTTAGTGCGTAATGCTG -3'
(R):5'- AAGGGCACTCACTCCATCAG -3'
Sequencing Primer
(F):5'- GTGCGTAATGCTGAAACTCATTCC -3'
(R):5'- CCACCTTCTGAGCGCCG -3'
|
| Posted On |
2016-02-04 |
Incidental Mutation