Incidental Mutation 'R4791:Olfr847'
ID 368586
Institutional Source Beutler Lab
Gene Symbol Olfr847
Ensembl Gene ENSMUSG00000059821
Gene Name olfactory receptor 847
Synonyms MOR149-2, GA_x6K02T2PVTD-13113073-13112135
MMRRC Submission 041976-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.144) question?
Stock # R4791 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 19373668-19378669 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 19375809 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 24 (E24G)
Ref Sequence ENSEMBL: ENSMUSP00000151112 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079620] [ENSMUST00000216839]
AlphaFold Q8VFF4
Predicted Effect probably benign
Transcript: ENSMUST00000079620
AA Change: E24G

PolyPhen 2 Score 0.280 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000078568
Gene: ENSMUSG00000059821
AA Change: E24G

Pfam:7tm_4 31 308 1.9e-56 PFAM
Pfam:7tm_1 41 290 2.1e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212306
AA Change: E24G
Predicted Effect probably benign
Transcript: ENSMUST00000216839
AA Change: E24G

PolyPhen 2 Score 0.280 (Sensitivity: 0.91; Specificity: 0.88)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 97 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921507P07Rik G T 6: 50,595,837 (GRCm38) P32Q probably damaging Het
Abcc6 C T 7: 45,982,160 (GRCm38) V1231M probably benign Het
Agl A G 3: 116,786,528 (GRCm38) probably null Het
Ak7 T C 12: 105,710,145 (GRCm38) F35L probably benign Het
Aldh1a1 A G 19: 20,619,985 (GRCm38) N110S probably damaging Het
Arhgef5 C T 6: 43,283,183 (GRCm38) L1368F probably damaging Het
Atp5j2 T C 5: 145,184,555 (GRCm38) Y72C possibly damaging Het
Atp6v0a2 T G 5: 124,646,727 (GRCm38) F317V probably benign Het
Bank1 A T 3: 136,254,929 (GRCm38) S56T probably benign Het
BC080695 A G 4: 143,570,989 (GRCm38) probably benign Het
Cachd1 T A 4: 100,918,085 (GRCm38) C166S probably damaging Het
Cand1 A G 10: 119,210,702 (GRCm38) I961T probably benign Het
Ccdc73 G A 2: 104,981,105 (GRCm38) probably null Het
Cct6b A T 11: 82,742,004 (GRCm38) probably null Het
Chd2 A C 7: 73,468,577 (GRCm38) S1098A probably benign Het
Col6a4 A T 9: 106,080,202 (GRCm38) V141E possibly damaging Het
Col6a5 T C 9: 105,930,784 (GRCm38) T1022A unknown Het
Cr2 A T 1: 195,155,935 (GRCm38) C698S probably damaging Het
Diexf G A 1: 193,128,267 (GRCm38) H143Y probably benign Het
Dnaaf5 C A 5: 139,184,650 (GRCm38) Q786K possibly damaging Het
Dnah6 T C 6: 73,095,074 (GRCm38) D2423G probably benign Het
Dnhd1 T C 7: 105,721,117 (GRCm38) F4583S probably damaging Het
Duoxa2 A T 2: 122,301,198 (GRCm38) T123S probably damaging Het
Edem1 T G 6: 108,841,634 (GRCm38) V201G probably damaging Het
Eef1d C T 15: 75,903,682 (GRCm38) A43T possibly damaging Het
Elavl3 T C 9: 22,024,678 (GRCm38) K249E probably damaging Het
Epg5 G T 18: 77,948,996 (GRCm38) E303* probably null Het
Fam83h T C 15: 76,002,368 (GRCm38) D1040G probably damaging Het
Fndc7 A T 3: 108,876,659 (GRCm38) F211L probably benign Het
Fsip2 A G 2: 82,982,108 (GRCm38) T2924A possibly damaging Het
Gm5616 T C 9: 48,450,683 (GRCm38) noncoding transcript Het
Gpr135 T A 12: 72,069,868 (GRCm38) D375V probably benign Het
Hgd A G 16: 37,631,825 (GRCm38) *446W probably null Het
Hivep2 C A 10: 14,128,969 (GRCm38) T437K probably benign Het
Htra2 A G 6: 83,051,817 (GRCm38) L379P probably damaging Het
Hypk G T 2: 121,457,655 (GRCm38) probably null Het
Ica1l A G 1: 60,010,201 (GRCm38) F198L probably damaging Het
Igsf11 G A 16: 39,024,864 (GRCm38) S319N probably damaging Het
Il12rb1 T C 8: 70,813,368 (GRCm38) S213P possibly damaging Het
Katnal1 C T 5: 148,904,650 (GRCm38) V135M probably damaging Het
Kcnc4 G A 3: 107,447,543 (GRCm38) P530S probably benign Het
Kcnu1 T C 8: 25,913,752 (GRCm38) Y24H probably damaging Het
Kdm5b A G 1: 134,630,800 (GRCm38) E1515G possibly damaging Het
Kif18a A T 2: 109,287,875 (GRCm38) M12L probably benign Het
Klre1 T C 6: 129,584,155 (GRCm38) S160P probably damaging Het
Lama2 A T 10: 27,467,271 (GRCm38) H68Q probably damaging Het
Lgals8 T C 13: 12,453,322 (GRCm38) K49R possibly damaging Het
Lmf1 G A 17: 25,654,471 (GRCm38) V317M probably damaging Het
Lsr T C 7: 30,958,552 (GRCm38) T328A probably damaging Het
Mark4 C T 7: 19,451,657 (GRCm38) E51K probably benign Het
Mindy2 T C 9: 70,634,001 (GRCm38) probably null Het
Mkks G A 2: 136,876,162 (GRCm38) T400I probably benign Het
Mon2 T A 10: 123,006,057 (GRCm38) M1544L probably benign Het
Mrc2 G A 11: 105,348,431 (GRCm38) probably null Het
Myo5c T G 9: 75,290,916 (GRCm38) L1341R probably damaging Het
Nin T C 12: 70,043,807 (GRCm38) R945G possibly damaging Het
Nox4 T C 7: 87,304,847 (GRCm38) V120A probably benign Het
Olfr1196 C T 2: 88,700,898 (GRCm38) V144I probably benign Het
Olfr1496 T A 19: 13,781,342 (GRCm38) C243* probably null Het
Olfr169 G T 16: 19,566,663 (GRCm38) H73Q possibly damaging Het
Olfr30 A T 11: 58,455,544 (GRCm38) V135E possibly damaging Het
Plekha2 T A 8: 25,042,762 (GRCm38) R398W probably damaging Het
Pradc1 A G 6: 85,447,191 (GRCm38) W58R probably damaging Het
Prrc2b A G 2: 32,217,339 (GRCm38) probably null Het
Psg19 T A 7: 18,794,146 (GRCm38) N224I probably damaging Het
Ranbp17 A C 11: 33,487,746 (GRCm38) V164G probably benign Het
Rasgrp3 A G 17: 75,500,173 (GRCm38) S211G probably benign Het
Rcc1l G A 5: 134,163,776 (GRCm38) P270S possibly damaging Het
Rfx6 T A 10: 51,719,944 (GRCm38) probably null Het
Rnf222 A T 11: 68,893,019 (GRCm38) E137D probably damaging Het
Selenof T G 3: 144,596,823 (GRCm38) Y120D probably damaging Het
Sema3b G T 9: 107,603,813 (GRCm38) D108E probably damaging Het
Shank3 T A 15: 89,500,354 (GRCm38) L143Q probably damaging Het
Shtn1 G C 19: 59,050,873 (GRCm38) R45G probably damaging Het
Sirt4 T C 5: 115,480,314 (GRCm38) T234A possibly damaging Het
Slc25a30 C A 14: 75,763,366 (GRCm38) W266L probably benign Het
Spata20 A T 11: 94,484,586 (GRCm38) N127K probably damaging Het
St14 C T 9: 31,095,622 (GRCm38) G636D probably benign Het
Stat5a G A 11: 100,865,463 (GRCm38) E170K probably damaging Het
Sugp2 C T 8: 70,242,790 (GRCm38) R138C probably damaging Het
Sult1e1 C A 5: 87,586,730 (GRCm38) W119L possibly damaging Het
Sv2a T C 3: 96,192,558 (GRCm38) V608A possibly damaging Het
Syne2 T C 12: 75,909,244 (GRCm38) Y575H possibly damaging Het
Taok2 G A 7: 126,868,132 (GRCm38) S167L possibly damaging Het
Thoc6 T C 17: 23,670,067 (GRCm38) H151R possibly damaging Het
Tm9sf2 T C 14: 122,139,650 (GRCm38) S197P probably benign Het
Tmem260 CAGGGACCGGCATAG CAG 14: 48,511,994 (GRCm38) probably benign Het
Tmx2 G A 2: 84,677,996 (GRCm38) P15L probably damaging Het
Top1mt C T 15: 75,668,625 (GRCm38) probably null Het
Trpm6 T A 19: 18,867,981 (GRCm38) S1682T probably benign Het
Trrap C T 5: 144,803,277 (GRCm38) R1171W probably damaging Het
Ugt3a2 A G 15: 9,361,579 (GRCm38) D147G probably damaging Het
Vnn3 A G 10: 23,864,621 (GRCm38) H274R probably benign Het
Vwf C A 6: 125,643,363 (GRCm38) T1668K Het
Zfp568 T C 7: 30,015,183 (GRCm38) S162P probably damaging Het
Zfp658 T A 7: 43,574,466 (GRCm38) C722S possibly damaging Het
Zfp808 T A 13: 62,171,231 (GRCm38) H91Q probably damaging Het
Other mutations in Olfr847
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01150:Olfr847 APN 9 19,375,239 (GRCm38) missense probably damaging 1.00
IGL01293:Olfr847 APN 9 19,375,336 (GRCm38) missense probably benign 0.23
IGL01879:Olfr847 APN 9 19,375,407 (GRCm38) nonsense probably null
IGL03298:Olfr847 APN 9 19,375,062 (GRCm38) missense probably damaging 1.00
R1350:Olfr847 UTSW 9 19,375,414 (GRCm38) missense possibly damaging 0.94
R1400:Olfr847 UTSW 9 19,375,062 (GRCm38) missense probably damaging 0.98
R2894:Olfr847 UTSW 9 19,375,292 (GRCm38) nonsense probably null
R4468:Olfr847 UTSW 9 19,375,648 (GRCm38) missense probably benign 0.00
R4694:Olfr847 UTSW 9 19,375,398 (GRCm38) missense probably damaging 1.00
R4794:Olfr847 UTSW 9 19,375,545 (GRCm38) missense probably benign 0.00
R5517:Olfr847 UTSW 9 19,375,767 (GRCm38) missense probably damaging 1.00
R5599:Olfr847 UTSW 9 19,375,629 (GRCm38) missense possibly damaging 0.77
R5777:Olfr847 UTSW 9 19,375,718 (GRCm38) missense probably benign 0.29
R6505:Olfr847 UTSW 9 19,374,941 (GRCm38) makesense probably null
R6509:Olfr847 UTSW 9 19,375,143 (GRCm38) missense probably benign
R7246:Olfr847 UTSW 9 19,375,465 (GRCm38) nonsense probably null
R7659:Olfr847 UTSW 9 19,375,558 (GRCm38) missense probably benign 0.03
R7789:Olfr847 UTSW 9 19,375,065 (GRCm38) missense probably benign 0.33
R7886:Olfr847 UTSW 9 19,375,906 (GRCm38) splice site probably null
R8948:Olfr847 UTSW 9 19,374,966 (GRCm38) missense probably benign 0.03
R9326:Olfr847 UTSW 9 19,375,050 (GRCm38) missense probably damaging 1.00
R9612:Olfr847 UTSW 9 19,375,381 (GRCm38) missense possibly damaging 0.69
R9784:Olfr847 UTSW 9 19,375,820 (GRCm38) missense probably damaging 0.99
R9798:Olfr847 UTSW 9 19,375,281 (GRCm38) missense probably benign 0.30
Z1088:Olfr847 UTSW 9 19,375,684 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2016-02-04