Incidental Mutation 'R4791:Nin'
| ID |
368609 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nin
|
| Ensembl Gene |
ENSMUSG00000021068 |
| Gene Name |
ninein |
| Synonyms |
3110068G20Rik |
| MMRRC Submission |
041976-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4791 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
12 |
| Chromosomal Location |
70011435-70113717 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 70043807 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Glycine
at position 945
(R945G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000152240
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021468]
[ENSMUST00000085314]
[ENSMUST00000095666]
[ENSMUST00000169074]
[ENSMUST00000220689]
[ENSMUST00000222237]
[ENSMUST00000222835]
[ENSMUST00000223257]
|
| AlphaFold |
Q61043 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000021468
AA Change: R945G
PolyPhen 2
Score 0.886 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000021468
Gene: ENSMUSG00000021068
AA Change: R945G
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1980 |
2013 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000085314
AA Change: R945G
PolyPhen 2
Score 0.945 (Sensitivity: 0.80; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000082422
Gene: ENSMUSG00000021068
AA Change: R945G
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
4.15e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
4.15e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1971 |
2045 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000095666
AA Change: R945G
PolyPhen 2
Score 0.886 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000093327
Gene: ENSMUSG00000021068
AA Change: R945G
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1980 |
2013 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000169074
AA Change: R945G
PolyPhen 2
Score 0.886 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000129648
Gene: ENSMUSG00000021068
AA Change: R945G
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1980 |
2013 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000220689
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000221486
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000222237
AA Change: R945G
PolyPhen 2
Score 0.945 (Sensitivity: 0.80; Specificity: 0.95)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000222835
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000223257
AA Change: R945G
PolyPhen 2
Score 0.810 (Sensitivity: 0.84; Specificity: 0.93)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000223316
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 94.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 97 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4921507P07Rik |
G |
T |
6: 50,595,837 (GRCm38) |
P32Q |
probably damaging |
Het |
| Abcc6 |
C |
T |
7: 45,982,160 (GRCm38) |
V1231M |
probably benign |
Het |
| Agl |
A |
G |
3: 116,786,528 (GRCm38) |
|
probably null |
Het |
| Ak7 |
T |
C |
12: 105,710,145 (GRCm38) |
F35L |
probably benign |
Het |
| Aldh1a1 |
A |
G |
19: 20,619,985 (GRCm38) |
N110S |
probably damaging |
Het |
| Arhgef5 |
C |
T |
6: 43,283,183 (GRCm38) |
L1368F |
probably damaging |
Het |
| Atp5j2 |
T |
C |
5: 145,184,555 (GRCm38) |
Y72C |
possibly damaging |
Het |
| Atp6v0a2 |
T |
G |
5: 124,646,727 (GRCm38) |
F317V |
probably benign |
Het |
| Bank1 |
A |
T |
3: 136,254,929 (GRCm38) |
S56T |
probably benign |
Het |
| BC080695 |
A |
G |
4: 143,570,989 (GRCm38) |
|
probably benign |
Het |
| Cachd1 |
T |
A |
4: 100,918,085 (GRCm38) |
C166S |
probably damaging |
Het |
| Cand1 |
A |
G |
10: 119,210,702 (GRCm38) |
I961T |
probably benign |
Het |
| Ccdc73 |
G |
A |
2: 104,981,105 (GRCm38) |
|
probably null |
Het |
| Cct6b |
A |
T |
11: 82,742,004 (GRCm38) |
|
probably null |
Het |
| Chd2 |
A |
C |
7: 73,468,577 (GRCm38) |
S1098A |
probably benign |
Het |
| Col6a4 |
A |
T |
9: 106,080,202 (GRCm38) |
V141E |
possibly damaging |
Het |
| Col6a5 |
T |
C |
9: 105,930,784 (GRCm38) |
T1022A |
unknown |
Het |
| Cr2 |
A |
T |
1: 195,155,935 (GRCm38) |
C698S |
probably damaging |
Het |
| Diexf |
G |
A |
1: 193,128,267 (GRCm38) |
H143Y |
probably benign |
Het |
| Dnaaf5 |
C |
A |
5: 139,184,650 (GRCm38) |
Q786K |
possibly damaging |
Het |
| Dnah6 |
T |
C |
6: 73,095,074 (GRCm38) |
D2423G |
probably benign |
Het |
| Dnhd1 |
T |
C |
7: 105,721,117 (GRCm38) |
F4583S |
probably damaging |
Het |
| Duoxa2 |
A |
T |
2: 122,301,198 (GRCm38) |
T123S |
probably damaging |
Het |
| Edem1 |
T |
G |
6: 108,841,634 (GRCm38) |
V201G |
probably damaging |
Het |
| Eef1d |
C |
T |
15: 75,903,682 (GRCm38) |
A43T |
possibly damaging |
Het |
| Elavl3 |
T |
C |
9: 22,024,678 (GRCm38) |
K249E |
probably damaging |
Het |
| Epg5 |
G |
T |
18: 77,948,996 (GRCm38) |
E303* |
probably null |
Het |
| Fam83h |
T |
C |
15: 76,002,368 (GRCm38) |
D1040G |
probably damaging |
Het |
| Fndc7 |
A |
T |
3: 108,876,659 (GRCm38) |
F211L |
probably benign |
Het |
| Fsip2 |
A |
G |
2: 82,982,108 (GRCm38) |
T2924A |
possibly damaging |
Het |
| Gm5616 |
T |
C |
9: 48,450,683 (GRCm38) |
|
noncoding transcript |
Het |
| Gpr135 |
T |
A |
12: 72,069,868 (GRCm38) |
D375V |
probably benign |
Het |
| Hgd |
A |
G |
16: 37,631,825 (GRCm38) |
*446W |
probably null |
Het |
| Hivep2 |
C |
A |
10: 14,128,969 (GRCm38) |
T437K |
probably benign |
Het |
| Htra2 |
A |
G |
6: 83,051,817 (GRCm38) |
L379P |
probably damaging |
Het |
| Hypk |
G |
T |
2: 121,457,655 (GRCm38) |
|
probably null |
Het |
| Ica1l |
A |
G |
1: 60,010,201 (GRCm38) |
F198L |
probably damaging |
Het |
| Igsf11 |
G |
A |
16: 39,024,864 (GRCm38) |
S319N |
probably damaging |
Het |
| Il12rb1 |
T |
C |
8: 70,813,368 (GRCm38) |
S213P |
possibly damaging |
Het |
| Katnal1 |
C |
T |
5: 148,904,650 (GRCm38) |
V135M |
probably damaging |
Het |
| Kcnc4 |
G |
A |
3: 107,447,543 (GRCm38) |
P530S |
probably benign |
Het |
| Kcnu1 |
T |
C |
8: 25,913,752 (GRCm38) |
Y24H |
probably damaging |
Het |
| Kdm5b |
A |
G |
1: 134,630,800 (GRCm38) |
E1515G |
possibly damaging |
Het |
| Kif18a |
A |
T |
2: 109,287,875 (GRCm38) |
M12L |
probably benign |
Het |
| Klre1 |
T |
C |
6: 129,584,155 (GRCm38) |
S160P |
probably damaging |
Het |
| Lama2 |
A |
T |
10: 27,467,271 (GRCm38) |
H68Q |
probably damaging |
Het |
| Lgals8 |
T |
C |
13: 12,453,322 (GRCm38) |
K49R |
possibly damaging |
Het |
| Lmf1 |
G |
A |
17: 25,654,471 (GRCm38) |
V317M |
probably damaging |
Het |
| Lsr |
T |
C |
7: 30,958,552 (GRCm38) |
T328A |
probably damaging |
Het |
| Mark4 |
C |
T |
7: 19,451,657 (GRCm38) |
E51K |
probably benign |
Het |
| Mindy2 |
T |
C |
9: 70,634,001 (GRCm38) |
|
probably null |
Het |
| Mkks |
G |
A |
2: 136,876,162 (GRCm38) |
T400I |
probably benign |
Het |
| Mon2 |
T |
A |
10: 123,006,057 (GRCm38) |
M1544L |
probably benign |
Het |
| Mrc2 |
G |
A |
11: 105,348,431 (GRCm38) |
|
probably null |
Het |
| Myo5c |
T |
G |
9: 75,290,916 (GRCm38) |
L1341R |
probably damaging |
Het |
| Nox4 |
T |
C |
7: 87,304,847 (GRCm38) |
V120A |
probably benign |
Het |
| Olfr1196 |
C |
T |
2: 88,700,898 (GRCm38) |
V144I |
probably benign |
Het |
| Olfr1496 |
T |
A |
19: 13,781,342 (GRCm38) |
C243* |
probably null |
Het |
| Olfr169 |
G |
T |
16: 19,566,663 (GRCm38) |
H73Q |
possibly damaging |
Het |
| Olfr30 |
A |
T |
11: 58,455,544 (GRCm38) |
V135E |
possibly damaging |
Het |
| Olfr847 |
T |
C |
9: 19,375,809 (GRCm38) |
E24G |
probably benign |
Het |
| Plekha2 |
T |
A |
8: 25,042,762 (GRCm38) |
R398W |
probably damaging |
Het |
| Pradc1 |
A |
G |
6: 85,447,191 (GRCm38) |
W58R |
probably damaging |
Het |
| Prrc2b |
A |
G |
2: 32,217,339 (GRCm38) |
|
probably null |
Het |
| Psg19 |
T |
A |
7: 18,794,146 (GRCm38) |
N224I |
probably damaging |
Het |
| Ranbp17 |
A |
C |
11: 33,487,746 (GRCm38) |
V164G |
probably benign |
Het |
| Rasgrp3 |
A |
G |
17: 75,500,173 (GRCm38) |
S211G |
probably benign |
Het |
| Rcc1l |
G |
A |
5: 134,163,776 (GRCm38) |
P270S |
possibly damaging |
Het |
| Rfx6 |
T |
A |
10: 51,719,944 (GRCm38) |
|
probably null |
Het |
| Rnf222 |
A |
T |
11: 68,893,019 (GRCm38) |
E137D |
probably damaging |
Het |
| Selenof |
T |
G |
3: 144,596,823 (GRCm38) |
Y120D |
probably damaging |
Het |
| Sema3b |
G |
T |
9: 107,603,813 (GRCm38) |
D108E |
probably damaging |
Het |
| Shank3 |
T |
A |
15: 89,500,354 (GRCm38) |
L143Q |
probably damaging |
Het |
| Shtn1 |
G |
C |
19: 59,050,873 (GRCm38) |
R45G |
probably damaging |
Het |
| Sirt4 |
T |
C |
5: 115,480,314 (GRCm38) |
T234A |
possibly damaging |
Het |
| Slc25a30 |
C |
A |
14: 75,763,366 (GRCm38) |
W266L |
probably benign |
Het |
| Spata20 |
A |
T |
11: 94,484,586 (GRCm38) |
N127K |
probably damaging |
Het |
| St14 |
C |
T |
9: 31,095,622 (GRCm38) |
G636D |
probably benign |
Het |
| Stat5a |
G |
A |
11: 100,865,463 (GRCm38) |
E170K |
probably damaging |
Het |
| Sugp2 |
C |
T |
8: 70,242,790 (GRCm38) |
R138C |
probably damaging |
Het |
| Sult1e1 |
C |
A |
5: 87,586,730 (GRCm38) |
W119L |
possibly damaging |
Het |
| Sv2a |
T |
C |
3: 96,192,558 (GRCm38) |
V608A |
possibly damaging |
Het |
| Syne2 |
T |
C |
12: 75,909,244 (GRCm38) |
Y575H |
possibly damaging |
Het |
| Taok2 |
G |
A |
7: 126,868,132 (GRCm38) |
S167L |
possibly damaging |
Het |
| Thoc6 |
T |
C |
17: 23,670,067 (GRCm38) |
H151R |
possibly damaging |
Het |
| Tm9sf2 |
T |
C |
14: 122,139,650 (GRCm38) |
S197P |
probably benign |
Het |
| Tmem260 |
CAGGGACCGGCATAG |
CAG |
14: 48,511,994 (GRCm38) |
|
probably benign |
Het |
| Tmx2 |
G |
A |
2: 84,677,996 (GRCm38) |
P15L |
probably damaging |
Het |
| Top1mt |
C |
T |
15: 75,668,625 (GRCm38) |
|
probably null |
Het |
| Trpm6 |
T |
A |
19: 18,867,981 (GRCm38) |
S1682T |
probably benign |
Het |
| Trrap |
C |
T |
5: 144,803,277 (GRCm38) |
R1171W |
probably damaging |
Het |
| Ugt3a2 |
A |
G |
15: 9,361,579 (GRCm38) |
D147G |
probably damaging |
Het |
| Vnn3 |
A |
G |
10: 23,864,621 (GRCm38) |
H274R |
probably benign |
Het |
| Vwf |
C |
A |
6: 125,643,363 (GRCm38) |
T1668K |
|
Het |
| Zfp568 |
T |
C |
7: 30,015,183 (GRCm38) |
S162P |
probably damaging |
Het |
| Zfp658 |
T |
A |
7: 43,574,466 (GRCm38) |
C722S |
possibly damaging |
Het |
| Zfp808 |
T |
A |
13: 62,171,231 (GRCm38) |
H91Q |
probably damaging |
Het |
|
| Other mutations in Nin |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00472:Nin
|
APN |
12 |
70,030,088 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL00677:Nin
|
APN |
12 |
70,026,860 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00823:Nin
|
APN |
12 |
70,014,793 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL01103:Nin
|
APN |
12 |
70,056,758 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01113:Nin
|
APN |
12 |
70,031,779 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01420:Nin
|
APN |
12 |
70,045,414 (GRCm38) |
missense |
probably benign |
0.08 |
|
IGL01556:Nin
|
APN |
12 |
70,043,188 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL01663:Nin
|
APN |
12 |
70,043,665 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
IGL02002:Nin
|
APN |
12 |
70,062,699 (GRCm38) |
nonsense |
probably null |
|
|
IGL02030:Nin
|
APN |
12 |
70,045,268 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02202:Nin
|
APN |
12 |
70,055,436 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02207:Nin
|
APN |
12 |
70,056,657 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02257:Nin
|
APN |
12 |
70,102,691 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
IGL02394:Nin
|
APN |
12 |
70,044,031 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02531:Nin
|
APN |
12 |
70,020,932 (GRCm38) |
missense |
probably benign |
0.02 |
|
IGL03028:Nin
|
APN |
12 |
70,035,270 (GRCm38) |
missense |
probably benign |
0.13 |
|
IGL03155:Nin
|
APN |
12 |
70,031,770 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03197:Nin
|
APN |
12 |
70,026,810 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL02835:Nin
|
UTSW |
12 |
70,056,738 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0131:Nin
|
UTSW |
12 |
70,051,141 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0131:Nin
|
UTSW |
12 |
70,051,141 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0132:Nin
|
UTSW |
12 |
70,051,141 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0211:Nin
|
UTSW |
12 |
70,014,875 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0211:Nin
|
UTSW |
12 |
70,014,875 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0734:Nin
|
UTSW |
12 |
70,030,113 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0947:Nin
|
UTSW |
12 |
70,061,186 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1085:Nin
|
UTSW |
12 |
70,020,962 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R1367:Nin
|
UTSW |
12 |
70,043,929 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1452:Nin
|
UTSW |
12 |
70,017,650 (GRCm38) |
nonsense |
probably null |
|
|
R1477:Nin
|
UTSW |
12 |
70,044,184 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R1518:Nin
|
UTSW |
12 |
70,014,773 (GRCm38) |
missense |
probably benign |
0.27 |
|
R1566:Nin
|
UTSW |
12 |
70,054,479 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1572:Nin
|
UTSW |
12 |
70,038,750 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1583:Nin
|
UTSW |
12 |
70,031,738 (GRCm38) |
missense |
probably benign |
|
|
R1584:Nin
|
UTSW |
12 |
70,042,669 (GRCm38) |
missense |
probably benign |
0.03 |
|
R1699:Nin
|
UTSW |
12 |
70,045,563 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R1699:Nin
|
UTSW |
12 |
70,030,938 (GRCm38) |
missense |
probably benign |
0.40 |
|
R1765:Nin
|
UTSW |
12 |
70,042,891 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1794:Nin
|
UTSW |
12 |
70,043,795 (GRCm38) |
nonsense |
probably null |
|
|
R1952:Nin
|
UTSW |
12 |
70,030,926 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2004:Nin
|
UTSW |
12 |
70,025,477 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2025:Nin
|
UTSW |
12 |
70,030,008 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2060:Nin
|
UTSW |
12 |
70,042,418 (GRCm38) |
missense |
possibly damaging |
0.64 |
|
R2213:Nin
|
UTSW |
12 |
70,045,354 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2224:Nin
|
UTSW |
12 |
70,061,230 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2247:Nin
|
UTSW |
12 |
70,054,545 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2972:Nin
|
UTSW |
12 |
70,062,713 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3776:Nin
|
UTSW |
12 |
70,038,682 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R3881:Nin
|
UTSW |
12 |
70,042,541 (GRCm38) |
missense |
probably benign |
0.00 |
|
R3930:Nin
|
UTSW |
12 |
70,078,242 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3959:Nin
|
UTSW |
12 |
70,050,752 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4229:Nin
|
UTSW |
12 |
70,051,210 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4359:Nin
|
UTSW |
12 |
70,014,938 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4423:Nin
|
UTSW |
12 |
70,042,978 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4461:Nin
|
UTSW |
12 |
70,042,585 (GRCm38) |
missense |
probably benign |
0.37 |
|
R4639:Nin
|
UTSW |
12 |
70,038,601 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4839:Nin
|
UTSW |
12 |
70,090,551 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R4912:Nin
|
UTSW |
12 |
70,044,063 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5712:Nin
|
UTSW |
12 |
70,042,769 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5726:Nin
|
UTSW |
12 |
70,078,179 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5804:Nin
|
UTSW |
12 |
70,045,601 (GRCm38) |
missense |
possibly damaging |
0.58 |
|
R5874:Nin
|
UTSW |
12 |
70,030,918 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R5992:Nin
|
UTSW |
12 |
70,045,524 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R6077:Nin
|
UTSW |
12 |
70,019,232 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6184:Nin
|
UTSW |
12 |
70,043,737 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6307:Nin
|
UTSW |
12 |
70,014,857 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R6315:Nin
|
UTSW |
12 |
70,045,615 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6326:Nin
|
UTSW |
12 |
70,045,181 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R6492:Nin
|
UTSW |
12 |
70,054,534 (GRCm38) |
missense |
probably benign |
0.22 |
|
R6562:Nin
|
UTSW |
12 |
70,055,954 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6578:Nin
|
UTSW |
12 |
70,061,194 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6613:Nin
|
UTSW |
12 |
70,030,954 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7112:Nin
|
UTSW |
12 |
70,102,799 (GRCm38) |
missense |
|
|
|
R7170:Nin
|
UTSW |
12 |
70,044,239 (GRCm38) |
missense |
|
|
|
R7324:Nin
|
UTSW |
12 |
70,043,734 (GRCm38) |
missense |
|
|
|
R7338:Nin
|
UTSW |
12 |
70,044,064 (GRCm38) |
missense |
|
|
|
R7372:Nin
|
UTSW |
12 |
70,056,029 (GRCm38) |
missense |
|
|
|
R7431:Nin
|
UTSW |
12 |
70,078,223 (GRCm38) |
missense |
|
|
|
R7577:Nin
|
UTSW |
12 |
70,062,706 (GRCm38) |
missense |
|
|
|
R7655:Nin
|
UTSW |
12 |
70,042,768 (GRCm38) |
missense |
|
|
|
R7656:Nin
|
UTSW |
12 |
70,042,768 (GRCm38) |
missense |
|
|
|
R7683:Nin
|
UTSW |
12 |
70,078,182 (GRCm38) |
missense |
|
|
|
R7769:Nin
|
UTSW |
12 |
70,043,230 (GRCm38) |
missense |
|
|
|
R7981:Nin
|
UTSW |
12 |
70,042,817 (GRCm38) |
missense |
|
|
|
R8138:Nin
|
UTSW |
12 |
70,042,898 (GRCm38) |
missense |
|
|
|
R8141:Nin
|
UTSW |
12 |
70,030,021 (GRCm38) |
missense |
|
|
|
R8754:Nin
|
UTSW |
12 |
70,031,013 (GRCm38) |
intron |
probably benign |
|
|
R8790:Nin
|
UTSW |
12 |
70,021,019 (GRCm38) |
missense |
|
|
|
R8899:Nin
|
UTSW |
12 |
70,030,936 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8974:Nin
|
UTSW |
12 |
70,078,158 (GRCm38) |
missense |
|
|
|
R9085:Nin
|
UTSW |
12 |
70,030,012 (GRCm38) |
nonsense |
probably null |
|
|
R9143:Nin
|
UTSW |
12 |
70,090,575 (GRCm38) |
missense |
|
|
|
R9380:Nin
|
UTSW |
12 |
70,028,031 (GRCm38) |
missense |
|
|
|
R9496:Nin
|
UTSW |
12 |
70,055,988 (GRCm38) |
missense |
|
|
|
R9638:Nin
|
UTSW |
12 |
70,020,844 (GRCm38) |
missense |
|
|
|
R9709:Nin
|
UTSW |
12 |
70,102,694 (GRCm38) |
missense |
|
|
|
R9745:Nin
|
UTSW |
12 |
70,043,125 (GRCm38) |
missense |
|
|
|
R9792:Nin
|
UTSW |
12 |
70,047,235 (GRCm38) |
missense |
|
|
|
Z1176:Nin
|
UTSW |
12 |
70,049,164 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
Z1177:Nin
|
UTSW |
12 |
70,054,426 (GRCm38) |
missense |
|
|
|
Z1177:Nin
|
UTSW |
12 |
70,044,095 (GRCm38) |
missense |
|
|
|
| Predicted Primers |
PCR Primer
(F):5'- CACCCTGAAGCATCAAGAGA -3'
(R):5'- CGGCCATGAAGCAGGAACAG -3'
Sequencing Primer
(F):5'- ACTGTATTCTGAAGCCTGCAG -3'
(R):5'- CAGGAGATACTGGAGAGGACATAC -3'
|
| Posted On |
2016-02-04 |
Incidental Mutation