Incidental Mutation 'R4792:Lgr6'
| ID |
368641 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lgr6
|
| Ensembl Gene |
ENSMUSG00000042793 |
| Gene Name |
leucine-rich repeat-containing G protein-coupled receptor 6 |
| Synonyms |
A530037C04Rik |
| MMRRC Submission |
042419-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4792 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
134911039-135033014 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 134949544 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Cysteine
at position 229
(S229C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000035444
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044828]
[ENSMUST00000137968]
|
| AlphaFold |
Q3UVD5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000044828
AA Change: S229C
PolyPhen 2
Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000035444
Gene: ENSMUSG00000042793
AA Change: S229C
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
LRRNT
|
34 |
70 |
5.19e-3 |
SMART |
|
LRR
|
64 |
88 |
1.03e1 |
SMART |
|
LRR_TYP
|
89 |
112 |
6.52e-5 |
SMART |
|
LRR_TYP
|
113 |
136 |
2.71e-2 |
SMART |
|
LRR_TYP
|
137 |
160 |
4.79e-3 |
SMART |
|
LRR_TYP
|
161 |
184 |
1.58e-3 |
SMART |
|
LRR_TYP
|
185 |
208 |
2.36e-2 |
SMART |
|
LRR_TYP
|
209 |
232 |
3.39e-3 |
SMART |
|
LRR
|
233 |
255 |
8.97e0 |
SMART |
|
LRR_TYP
|
256 |
279 |
1.36e-2 |
SMART |
|
Blast:LRR
|
281 |
303 |
6e-7 |
BLAST |
|
LRR
|
327 |
350 |
9.24e1 |
SMART |
|
LRR
|
351 |
373 |
1.41e0 |
SMART |
|
LRR
|
374 |
396 |
4.84e1 |
SMART |
|
LRR_TYP
|
397 |
420 |
4.54e-4 |
SMART |
|
LRR_TYP
|
421 |
444 |
7.15e-2 |
SMART |
|
transmembrane domain
|
568 |
590 |
N/A |
INTRINSIC |
|
transmembrane domain
|
599 |
621 |
N/A |
INTRINSIC |
|
transmembrane domain
|
643 |
665 |
N/A |
INTRINSIC |
|
transmembrane domain
|
686 |
708 |
N/A |
INTRINSIC |
|
transmembrane domain
|
728 |
750 |
N/A |
INTRINSIC |
|
transmembrane domain
|
776 |
798 |
N/A |
INTRINSIC |
|
transmembrane domain
|
808 |
830 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000137968
|
| SMART Domains |
Protein: ENSMUSP00000122334
Gene: ENSMUSG00000042793
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:LRR
|
4 |
26 |
2e-7 |
BLAST |
|
LRR
|
50 |
73 |
9.24e1 |
SMART |
|
LRR
|
74 |
96 |
1.41e0 |
SMART |
|
LRR
|
97 |
119 |
4.84e1 |
SMART |
|
LRR_TYP
|
120 |
143 |
4.54e-4 |
SMART |
|
LRR_TYP
|
144 |
167 |
7.15e-2 |
SMART |
|
Pfam:7tm_1
|
301 |
550 |
3.6e-9 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000139369
|
| Meta Mutation Damage Score |
0.0731 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.6%
- 20x: 93.3%
|
| Validation Efficiency |
97% (89/92) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a reporter/null allele are viable and fertile with no apparent abnormal phenotype. Similarly, mice homozygous for a knock-in allele are healthy and fertile. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 82 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310061N02Rik |
A |
G |
16: 88,504,651 (GRCm39) |
S49P |
possibly damaging |
Het |
| Abcb1a |
T |
C |
5: 8,796,657 (GRCm39) |
|
probably null |
Het |
| Adgb |
G |
A |
10: 10,274,647 (GRCm39) |
T770I |
probably damaging |
Het |
| Adgre4 |
A |
T |
17: 56,098,491 (GRCm39) |
T134S |
probably benign |
Het |
| Aldh1a1 |
A |
G |
19: 20,597,349 (GRCm39) |
N110S |
probably damaging |
Het |
| Alox5 |
C |
A |
6: 116,437,964 (GRCm39) |
V8L |
possibly damaging |
Het |
| Ambra1 |
A |
G |
2: 91,603,191 (GRCm39) |
T392A |
possibly damaging |
Het |
| Apob |
A |
G |
12: 8,058,051 (GRCm39) |
I2145V |
probably benign |
Het |
| Arhgap39 |
A |
G |
15: 76,625,717 (GRCm39) |
Y196H |
possibly damaging |
Het |
| Armh2 |
A |
G |
13: 24,930,490 (GRCm39) |
|
probably benign |
Het |
| Carmil1 |
A |
G |
13: 24,251,173 (GRCm39) |
L439S |
probably damaging |
Het |
| Carmil1 |
A |
T |
13: 24,325,659 (GRCm39) |
S224T |
possibly damaging |
Het |
| Cfh |
G |
A |
1: 140,028,561 (GRCm39) |
Q706* |
probably null |
Het |
| Chd2 |
A |
C |
7: 73,118,325 (GRCm39) |
S1098A |
probably benign |
Het |
| Chrna5 |
A |
T |
9: 54,911,985 (GRCm39) |
I158F |
probably damaging |
Het |
| Cilk1 |
A |
G |
9: 78,060,975 (GRCm39) |
D207G |
probably damaging |
Het |
| Col6a5 |
T |
C |
9: 105,807,983 (GRCm39) |
T1022A |
unknown |
Het |
| Cul7 |
T |
A |
17: 46,967,976 (GRCm39) |
Y423* |
probably null |
Het |
| Cyp2e1 |
T |
C |
7: 140,353,588 (GRCm39) |
Y342H |
probably benign |
Het |
| D630045J12Rik |
T |
C |
6: 38,125,275 (GRCm39) |
K1580E |
probably damaging |
Het |
| Dnah6 |
A |
G |
6: 73,066,651 (GRCm39) |
M2573T |
probably damaging |
Het |
| Dnai4 |
T |
C |
4: 102,929,881 (GRCm39) |
K370R |
possibly damaging |
Het |
| Edem1 |
T |
A |
6: 108,805,707 (GRCm39) |
|
probably benign |
Het |
| Erp29 |
C |
T |
5: 121,585,237 (GRCm39) |
E86K |
probably benign |
Het |
| Esrp2 |
C |
A |
8: 106,859,141 (GRCm39) |
R535L |
probably damaging |
Het |
| Gabrb2 |
C |
T |
11: 42,420,330 (GRCm39) |
|
probably benign |
Het |
| Gpat3 |
C |
T |
5: 101,005,039 (GRCm39) |
P58L |
probably benign |
Het |
| Herc1 |
T |
A |
9: 66,403,266 (GRCm39) |
V4395E |
possibly damaging |
Het |
| Hivep2 |
C |
A |
10: 14,004,713 (GRCm39) |
T437K |
probably benign |
Het |
| Hmgb2 |
G |
A |
8: 57,966,344 (GRCm39) |
C106Y |
probably damaging |
Het |
| Hoxa10 |
T |
C |
6: 52,209,481 (GRCm39) |
|
probably benign |
Het |
| Hsd3b1 |
T |
A |
3: 98,760,226 (GRCm39) |
Y255F |
probably benign |
Het |
| Ighd |
T |
C |
12: 113,379,819 (GRCm39) |
K42E |
probably benign |
Het |
| Ighv1-26 |
T |
C |
12: 114,752,191 (GRCm39) |
Y51C |
possibly damaging |
Het |
| Ighv5-2 |
C |
T |
12: 113,542,419 (GRCm39) |
E19K |
possibly damaging |
Het |
| Ipo11 |
T |
C |
13: 106,970,668 (GRCm39) |
|
probably benign |
Het |
| Itk |
C |
T |
11: 46,235,658 (GRCm39) |
|
probably benign |
Het |
| Kat6a |
T |
A |
8: 23,430,592 (GRCm39) |
H1982Q |
unknown |
Het |
| Kdm4d |
C |
T |
9: 14,374,686 (GRCm39) |
V391I |
probably benign |
Het |
| Klk14 |
G |
A |
7: 43,341,501 (GRCm39) |
C51Y |
probably damaging |
Het |
| Lhx9 |
T |
A |
1: 138,766,089 (GRCm39) |
Y233F |
possibly damaging |
Het |
| Lmf1 |
G |
A |
17: 25,873,445 (GRCm39) |
V317M |
probably damaging |
Het |
| Mapk4 |
T |
C |
18: 74,070,321 (GRCm39) |
T191A |
probably damaging |
Het |
| Mrc2 |
G |
A |
11: 105,239,257 (GRCm39) |
|
probably null |
Het |
| Naglu |
C |
T |
11: 100,961,932 (GRCm39) |
T135M |
probably damaging |
Het |
| Nomo1 |
T |
A |
7: 45,693,643 (GRCm39) |
|
probably null |
Het |
| Nop56 |
T |
A |
2: 130,119,784 (GRCm39) |
V75E |
possibly damaging |
Het |
| Nr1i3 |
G |
A |
1: 171,046,164 (GRCm39) |
C283Y |
probably damaging |
Het |
| Or4x6 |
T |
A |
2: 89,949,174 (GRCm39) |
Y256F |
possibly damaging |
Het |
| Or51d1 |
G |
A |
7: 102,347,933 (GRCm39) |
G163R |
probably damaging |
Het |
| Or6c38 |
T |
G |
10: 128,929,489 (GRCm39) |
Y118S |
probably damaging |
Het |
| Pcdhga2 |
A |
G |
18: 37,802,452 (GRCm39) |
S99G |
probably benign |
Het |
| Pcnx1 |
T |
A |
12: 81,965,925 (GRCm39) |
D697E |
probably damaging |
Het |
| Plxnb1 |
G |
A |
9: 108,939,716 (GRCm39) |
D1462N |
probably damaging |
Het |
| Pnn |
G |
T |
12: 59,118,991 (GRCm39) |
V525F |
possibly damaging |
Het |
| Prrc2a |
A |
T |
17: 35,375,463 (GRCm39) |
D1062E |
probably damaging |
Het |
| Prss35 |
T |
A |
9: 86,637,722 (GRCm39) |
V164E |
probably damaging |
Het |
| Psapl1 |
T |
C |
5: 36,362,547 (GRCm39) |
S380P |
probably benign |
Het |
| Rnf222 |
A |
T |
11: 68,783,845 (GRCm39) |
E137D |
probably damaging |
Het |
| Rsph10b |
A |
G |
5: 143,874,135 (GRCm39) |
T79A |
probably damaging |
Het |
| Sbf2 |
T |
C |
7: 109,950,817 (GRCm39) |
Q1164R |
probably damaging |
Het |
| Scn7a |
T |
C |
2: 66,556,592 (GRCm39) |
D331G |
probably damaging |
Het |
| Shtn1 |
G |
C |
19: 59,039,305 (GRCm39) |
R45G |
probably damaging |
Het |
| Sspo |
G |
A |
6: 48,438,519 (GRCm39) |
S1529N |
probably benign |
Het |
| St8sia3 |
T |
A |
18: 64,398,634 (GRCm39) |
V31E |
probably benign |
Het |
| Sult1b1 |
A |
T |
5: 87,662,906 (GRCm39) |
W265R |
probably damaging |
Het |
| Supt5 |
G |
T |
7: 28,015,754 (GRCm39) |
Q863K |
probably benign |
Het |
| Tbc1d31 |
A |
G |
15: 57,804,124 (GRCm39) |
R380G |
probably benign |
Het |
| Tdpoz1 |
T |
A |
3: 93,577,845 (GRCm39) |
D313V |
possibly damaging |
Het |
| Tmem260 |
CAGGGACCGGCATAG |
CAG |
14: 48,749,451 (GRCm39) |
|
probably benign |
Het |
| Tpx2 |
A |
T |
2: 152,727,016 (GRCm39) |
T428S |
probably damaging |
Het |
| Trip11 |
A |
T |
12: 101,851,705 (GRCm39) |
H786Q |
probably benign |
Het |
| Trpc6 |
A |
T |
9: 8,626,615 (GRCm39) |
M322L |
probably benign |
Het |
| Try10 |
T |
C |
6: 41,332,386 (GRCm39) |
V14A |
probably benign |
Het |
| Unc13d |
A |
T |
11: 115,961,108 (GRCm39) |
F416L |
probably damaging |
Het |
| Vmn2r75 |
A |
T |
7: 85,812,378 (GRCm39) |
M547K |
possibly damaging |
Het |
| Zbp1 |
A |
G |
2: 173,051,006 (GRCm39) |
F288S |
probably damaging |
Het |
| Zc3h11a |
T |
A |
1: 133,568,436 (GRCm39) |
Q71L |
probably damaging |
Het |
| Zfp40 |
G |
A |
17: 23,396,008 (GRCm39) |
T193I |
possibly damaging |
Het |
| Zfp607a |
T |
C |
7: 27,578,078 (GRCm39) |
Y383H |
probably benign |
Het |
| Zfp622 |
T |
A |
15: 25,987,128 (GRCm39) |
Y82* |
probably null |
Het |
| Zfp964 |
T |
C |
8: 70,116,665 (GRCm39) |
F422L |
probably benign |
Het |
|
| Other mutations in Lgr6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02481:Lgr6
|
APN |
1 |
134,929,429 (GRCm39) |
splice site |
probably benign |
|
|
IGL02483:Lgr6
|
APN |
1 |
134,929,429 (GRCm39) |
splice site |
probably benign |
|
|
IGL03270:Lgr6
|
APN |
1 |
134,925,442 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0002:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0294:Lgr6
|
UTSW |
1 |
135,032,799 (GRCm39) |
missense |
unknown |
|
|
R0294:Lgr6
|
UTSW |
1 |
134,915,629 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0361:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0390:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0731:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0734:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0741:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0742:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0765:Lgr6
|
UTSW |
1 |
134,921,624 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0903:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0904:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0905:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0906:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0907:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0908:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0967:Lgr6
|
UTSW |
1 |
134,921,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1078:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1079:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1131:Lgr6
|
UTSW |
1 |
134,915,042 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1440:Lgr6
|
UTSW |
1 |
134,915,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1533:Lgr6
|
UTSW |
1 |
135,032,670 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R1728:Lgr6
|
UTSW |
1 |
134,931,214 (GRCm39) |
missense |
probably benign |
|
|
R1728:Lgr6
|
UTSW |
1 |
134,918,373 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1728:Lgr6
|
UTSW |
1 |
134,914,826 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1729:Lgr6
|
UTSW |
1 |
134,918,373 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1729:Lgr6
|
UTSW |
1 |
134,915,747 (GRCm39) |
missense |
probably benign |
|
|
R1729:Lgr6
|
UTSW |
1 |
134,914,826 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1729:Lgr6
|
UTSW |
1 |
134,931,214 (GRCm39) |
missense |
probably benign |
|
|
R1730:Lgr6
|
UTSW |
1 |
134,915,747 (GRCm39) |
missense |
probably benign |
|
|
R1730:Lgr6
|
UTSW |
1 |
134,914,826 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1730:Lgr6
|
UTSW |
1 |
134,931,214 (GRCm39) |
missense |
probably benign |
|
|
R1730:Lgr6
|
UTSW |
1 |
134,918,373 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1739:Lgr6
|
UTSW |
1 |
134,931,214 (GRCm39) |
missense |
probably benign |
|
|
R1739:Lgr6
|
UTSW |
1 |
134,914,826 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1739:Lgr6
|
UTSW |
1 |
134,915,747 (GRCm39) |
missense |
probably benign |
|
|
R1739:Lgr6
|
UTSW |
1 |
134,918,373 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1762:Lgr6
|
UTSW |
1 |
134,931,214 (GRCm39) |
missense |
probably benign |
|
|
R1762:Lgr6
|
UTSW |
1 |
134,914,826 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1762:Lgr6
|
UTSW |
1 |
134,915,747 (GRCm39) |
missense |
probably benign |
|
|
R1762:Lgr6
|
UTSW |
1 |
134,918,373 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1782:Lgr6
|
UTSW |
1 |
134,915,717 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1783:Lgr6
|
UTSW |
1 |
134,915,747 (GRCm39) |
missense |
probably benign |
|
|
R1783:Lgr6
|
UTSW |
1 |
134,918,373 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1783:Lgr6
|
UTSW |
1 |
134,931,214 (GRCm39) |
missense |
probably benign |
|
|
R1783:Lgr6
|
UTSW |
1 |
134,914,826 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1784:Lgr6
|
UTSW |
1 |
134,931,214 (GRCm39) |
missense |
probably benign |
|
|
R1784:Lgr6
|
UTSW |
1 |
134,914,826 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1784:Lgr6
|
UTSW |
1 |
134,915,747 (GRCm39) |
missense |
probably benign |
|
|
R1784:Lgr6
|
UTSW |
1 |
134,918,373 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1785:Lgr6
|
UTSW |
1 |
134,915,747 (GRCm39) |
missense |
probably benign |
|
|
R1785:Lgr6
|
UTSW |
1 |
134,914,826 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1785:Lgr6
|
UTSW |
1 |
134,931,214 (GRCm39) |
missense |
probably benign |
|
|
R1785:Lgr6
|
UTSW |
1 |
134,918,373 (GRCm39) |
missense |
probably benign |
0.18 |
|
R2020:Lgr6
|
UTSW |
1 |
135,003,013 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3104:Lgr6
|
UTSW |
1 |
134,928,210 (GRCm39) |
splice site |
probably null |
|
|
R4629:Lgr6
|
UTSW |
1 |
135,032,670 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5001:Lgr6
|
UTSW |
1 |
134,918,370 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5191:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5194:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5195:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5196:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5197:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5228:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5230:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5243:Lgr6
|
UTSW |
1 |
135,037,010 (GRCm39) |
unclassified |
probably benign |
|
|
R5299:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5300:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5417:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5419:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5601:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5603:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5636:Lgr6
|
UTSW |
1 |
134,914,816 (GRCm39) |
missense |
probably benign |
0.28 |
|
R5699:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5748:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5767:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5825:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5971:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6078:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6079:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6138:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6258:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6259:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6260:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6740:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6871:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6984:Lgr6
|
UTSW |
1 |
134,915,740 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R6986:Lgr6
|
UTSW |
1 |
134,921,694 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7233:Lgr6
|
UTSW |
1 |
134,928,214 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7699:Lgr6
|
UTSW |
1 |
134,923,770 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7700:Lgr6
|
UTSW |
1 |
134,923,770 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7734:Lgr6
|
UTSW |
1 |
134,930,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7849:Lgr6
|
UTSW |
1 |
134,915,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7970:Lgr6
|
UTSW |
1 |
134,921,723 (GRCm39) |
missense |
probably benign |
|
|
R8068:Lgr6
|
UTSW |
1 |
134,991,402 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8252:Lgr6
|
UTSW |
1 |
134,931,215 (GRCm39) |
missense |
probably null |
0.78 |
|
R8516:Lgr6
|
UTSW |
1 |
135,003,021 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8771:Lgr6
|
UTSW |
1 |
134,933,429 (GRCm39) |
nonsense |
probably null |
|
|
R8858:Lgr6
|
UTSW |
1 |
134,923,849 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8885:Lgr6
|
UTSW |
1 |
134,915,342 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9014:Lgr6
|
UTSW |
1 |
134,931,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9277:Lgr6
|
UTSW |
1 |
134,915,217 (GRCm39) |
nonsense |
probably null |
|
|
R9660:Lgr6
|
UTSW |
1 |
134,915,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9728:Lgr6
|
UTSW |
1 |
134,915,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Lgr6
|
UTSW |
1 |
134,915,809 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
Z1191:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTTGCTGAGTGACATCTTAGAG -3'
(R):5'- CGTGGCTTCAGAAATGGGTC -3'
Sequencing Primer
(F):5'- GTGACATCTTAGAGAAGAGTCCC -3'
(R):5'- TGCTTGTCCCTGGAGAAAAG -3'
|
| Posted On |
2016-02-04 |
Incidental Mutation