Incidental Mutation 'R4792:Herc1'
ID 368686
Institutional Source Beutler Lab
Gene Symbol Herc1
Ensembl Gene ENSMUSG00000038664
Gene Name HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms tbl, D130015N03Rik, 2810449H11Rik
MMRRC Submission 042419-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4792 (G1)
Quality Score 186
Status Validated
Chromosome 9
Chromosomal Location 66257732-66416057 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 66403266 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 4395 (V4395E)
Ref Sequence ENSEMBL: ENSMUSP00000044801 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042824]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000042824
AA Change: V4395E

PolyPhen 2 Score 0.674 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000044801
Gene: ENSMUSG00000038664
AA Change: V4395E

DomainStartEndE-ValueType
low complexity region 79 90 N/A INTRINSIC
low complexity region 136 147 N/A INTRINSIC
Pfam:RCC1 476 526 5.4e-15 PFAM
Pfam:RCC1_2 513 542 1.3e-9 PFAM
Pfam:RCC1 529 576 5.5e-16 PFAM
Pfam:RCC1 579 629 1.5e-10 PFAM
Pfam:RCC1 632 680 3.6e-9 PFAM
Pfam:RCC1_2 667 696 2.2e-11 PFAM
Pfam:RCC1 683 733 1.2e-14 PFAM
low complexity region 787 807 N/A INTRINSIC
low complexity region 852 864 N/A INTRINSIC
low complexity region 1014 1025 N/A INTRINSIC
low complexity region 1080 1100 N/A INTRINSIC
low complexity region 1348 1378 N/A INTRINSIC
low complexity region 1659 1676 N/A INTRINSIC
low complexity region 1865 1874 N/A INTRINSIC
low complexity region 2002 2030 N/A INTRINSIC
SPRY 2067 2188 1.8e-30 SMART
coiled coil region 2251 2280 N/A INTRINSIC
low complexity region 2410 2423 N/A INTRINSIC
low complexity region 2613 2629 N/A INTRINSIC
low complexity region 2633 2648 N/A INTRINSIC
low complexity region 2650 2667 N/A INTRINSIC
low complexity region 2736 2749 N/A INTRINSIC
low complexity region 2882 2896 N/A INTRINSIC
low complexity region 2924 2935 N/A INTRINSIC
low complexity region 2971 2987 N/A INTRINSIC
low complexity region 3045 3051 N/A INTRINSIC
low complexity region 3168 3186 N/A INTRINSIC
low complexity region 3191 3213 N/A INTRINSIC
low complexity region 3364 3379 N/A INTRINSIC
WD40 3415 3454 1.68e-6 SMART
WD40 3570 3608 3.68e1 SMART
WD40 3613 3652 4.3e-1 SMART
WD40 3657 3702 3.17e-2 SMART
WD40 3734 3773 8.29e-6 SMART
low complexity region 3950 3964 N/A INTRINSIC
Pfam:RCC1_2 4079 4111 7.3e-9 PFAM
Pfam:RCC1 4098 4147 3.4e-16 PFAM
Pfam:RCC1_2 4134 4163 1.8e-7 PFAM
Pfam:RCC1 4150 4199 7.2e-16 PFAM
Pfam:RCC1 4204 4252 6.1e-12 PFAM
Pfam:RCC1 4255 4304 2.4e-7 PFAM
Pfam:RCC1_2 4291 4320 5.8e-12 PFAM
Pfam:RCC1 4307 4356 8.9e-16 PFAM
Blast:HECTc 4389 4423 2e-11 BLAST
HECTc 4497 4846 8.2e-148 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130854
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135600
Meta Mutation Damage Score 0.1436 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.3%
Validation Efficiency 97% (89/92)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gen encodes a member of the HERC protein family. This protein stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein may be involved in membrane transport processes. [provided by RefSeq, Mar 2012]
PHENOTYPE: Homozygotes for this spontaneous mutation exhibit an abnormal cerebellar Purkinje cell layer and Purkinje cell degeneration. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 82 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310061N02Rik A G 16: 88,504,651 (GRCm39) S49P possibly damaging Het
Abcb1a T C 5: 8,796,657 (GRCm39) probably null Het
Adgb G A 10: 10,274,647 (GRCm39) T770I probably damaging Het
Adgre4 A T 17: 56,098,491 (GRCm39) T134S probably benign Het
Aldh1a1 A G 19: 20,597,349 (GRCm39) N110S probably damaging Het
Alox5 C A 6: 116,437,964 (GRCm39) V8L possibly damaging Het
Ambra1 A G 2: 91,603,191 (GRCm39) T392A possibly damaging Het
Apob A G 12: 8,058,051 (GRCm39) I2145V probably benign Het
Arhgap39 A G 15: 76,625,717 (GRCm39) Y196H possibly damaging Het
Armh2 A G 13: 24,930,490 (GRCm39) probably benign Het
Carmil1 A G 13: 24,251,173 (GRCm39) L439S probably damaging Het
Carmil1 A T 13: 24,325,659 (GRCm39) S224T possibly damaging Het
Cfh G A 1: 140,028,561 (GRCm39) Q706* probably null Het
Chd2 A C 7: 73,118,325 (GRCm39) S1098A probably benign Het
Chrna5 A T 9: 54,911,985 (GRCm39) I158F probably damaging Het
Cilk1 A G 9: 78,060,975 (GRCm39) D207G probably damaging Het
Col6a5 T C 9: 105,807,983 (GRCm39) T1022A unknown Het
Cul7 T A 17: 46,967,976 (GRCm39) Y423* probably null Het
Cyp2e1 T C 7: 140,353,588 (GRCm39) Y342H probably benign Het
D630045J12Rik T C 6: 38,125,275 (GRCm39) K1580E probably damaging Het
Dnah6 A G 6: 73,066,651 (GRCm39) M2573T probably damaging Het
Dnai4 T C 4: 102,929,881 (GRCm39) K370R possibly damaging Het
Edem1 T A 6: 108,805,707 (GRCm39) probably benign Het
Erp29 C T 5: 121,585,237 (GRCm39) E86K probably benign Het
Esrp2 C A 8: 106,859,141 (GRCm39) R535L probably damaging Het
Gabrb2 C T 11: 42,420,330 (GRCm39) probably benign Het
Gpat3 C T 5: 101,005,039 (GRCm39) P58L probably benign Het
Hivep2 C A 10: 14,004,713 (GRCm39) T437K probably benign Het
Hmgb2 G A 8: 57,966,344 (GRCm39) C106Y probably damaging Het
Hoxa10 T C 6: 52,209,481 (GRCm39) probably benign Het
Hsd3b1 T A 3: 98,760,226 (GRCm39) Y255F probably benign Het
Ighd T C 12: 113,379,819 (GRCm39) K42E probably benign Het
Ighv1-26 T C 12: 114,752,191 (GRCm39) Y51C possibly damaging Het
Ighv5-2 C T 12: 113,542,419 (GRCm39) E19K possibly damaging Het
Ipo11 T C 13: 106,970,668 (GRCm39) probably benign Het
Itk C T 11: 46,235,658 (GRCm39) probably benign Het
Kat6a T A 8: 23,430,592 (GRCm39) H1982Q unknown Het
Kdm4d C T 9: 14,374,686 (GRCm39) V391I probably benign Het
Klk14 G A 7: 43,341,501 (GRCm39) C51Y probably damaging Het
Lgr6 T A 1: 134,949,544 (GRCm39) S229C probably benign Het
Lhx9 T A 1: 138,766,089 (GRCm39) Y233F possibly damaging Het
Lmf1 G A 17: 25,873,445 (GRCm39) V317M probably damaging Het
Mapk4 T C 18: 74,070,321 (GRCm39) T191A probably damaging Het
Mrc2 G A 11: 105,239,257 (GRCm39) probably null Het
Naglu C T 11: 100,961,932 (GRCm39) T135M probably damaging Het
Nomo1 T A 7: 45,693,643 (GRCm39) probably null Het
Nop56 T A 2: 130,119,784 (GRCm39) V75E possibly damaging Het
Nr1i3 G A 1: 171,046,164 (GRCm39) C283Y probably damaging Het
Or4x6 T A 2: 89,949,174 (GRCm39) Y256F possibly damaging Het
Or51d1 G A 7: 102,347,933 (GRCm39) G163R probably damaging Het
Or6c38 T G 10: 128,929,489 (GRCm39) Y118S probably damaging Het
Pcdhga2 A G 18: 37,802,452 (GRCm39) S99G probably benign Het
Pcnx1 T A 12: 81,965,925 (GRCm39) D697E probably damaging Het
Plxnb1 G A 9: 108,939,716 (GRCm39) D1462N probably damaging Het
Pnn G T 12: 59,118,991 (GRCm39) V525F possibly damaging Het
Prrc2a A T 17: 35,375,463 (GRCm39) D1062E probably damaging Het
Prss35 T A 9: 86,637,722 (GRCm39) V164E probably damaging Het
Psapl1 T C 5: 36,362,547 (GRCm39) S380P probably benign Het
Rnf222 A T 11: 68,783,845 (GRCm39) E137D probably damaging Het
Rsph10b A G 5: 143,874,135 (GRCm39) T79A probably damaging Het
Sbf2 T C 7: 109,950,817 (GRCm39) Q1164R probably damaging Het
Scn7a T C 2: 66,556,592 (GRCm39) D331G probably damaging Het
Shtn1 G C 19: 59,039,305 (GRCm39) R45G probably damaging Het
Sspo G A 6: 48,438,519 (GRCm39) S1529N probably benign Het
St8sia3 T A 18: 64,398,634 (GRCm39) V31E probably benign Het
Sult1b1 A T 5: 87,662,906 (GRCm39) W265R probably damaging Het
Supt5 G T 7: 28,015,754 (GRCm39) Q863K probably benign Het
Tbc1d31 A G 15: 57,804,124 (GRCm39) R380G probably benign Het
Tdpoz1 T A 3: 93,577,845 (GRCm39) D313V possibly damaging Het
Tmem260 CAGGGACCGGCATAG CAG 14: 48,749,451 (GRCm39) probably benign Het
Tpx2 A T 2: 152,727,016 (GRCm39) T428S probably damaging Het
Trip11 A T 12: 101,851,705 (GRCm39) H786Q probably benign Het
Trpc6 A T 9: 8,626,615 (GRCm39) M322L probably benign Het
Try10 T C 6: 41,332,386 (GRCm39) V14A probably benign Het
Unc13d A T 11: 115,961,108 (GRCm39) F416L probably damaging Het
Vmn2r75 A T 7: 85,812,378 (GRCm39) M547K possibly damaging Het
Zbp1 A G 2: 173,051,006 (GRCm39) F288S probably damaging Het
Zc3h11a T A 1: 133,568,436 (GRCm39) Q71L probably damaging Het
Zfp40 G A 17: 23,396,008 (GRCm39) T193I possibly damaging Het
Zfp607a T C 7: 27,578,078 (GRCm39) Y383H probably benign Het
Zfp622 T A 15: 25,987,128 (GRCm39) Y82* probably null Het
Zfp964 T C 8: 70,116,665 (GRCm39) F422L probably benign Het
Other mutations in Herc1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00092:Herc1 APN 9 66,391,248 (GRCm39) missense probably benign 0.02
IGL00159:Herc1 APN 9 66,344,964 (GRCm39) missense possibly damaging 0.94
IGL00486:Herc1 APN 9 66,383,402 (GRCm39) missense probably benign
IGL00717:Herc1 APN 9 66,392,284 (GRCm39) missense probably damaging 1.00
IGL00766:Herc1 APN 9 66,358,023 (GRCm39) missense probably damaging 1.00
IGL00776:Herc1 APN 9 66,328,320 (GRCm39) missense probably benign
IGL00987:Herc1 APN 9 66,315,334 (GRCm39) missense probably benign 0.07
IGL01090:Herc1 APN 9 66,376,457 (GRCm39) nonsense probably null
IGL01098:Herc1 APN 9 66,369,204 (GRCm39) critical splice donor site probably null
IGL01106:Herc1 APN 9 66,383,720 (GRCm39) splice site probably benign
IGL01120:Herc1 APN 9 66,336,162 (GRCm39) missense probably benign
IGL01359:Herc1 APN 9 66,346,550 (GRCm39) missense probably benign 0.01
IGL01360:Herc1 APN 9 66,390,981 (GRCm39) missense probably benign
IGL01364:Herc1 APN 9 66,306,643 (GRCm39) missense probably benign 0.00
IGL01470:Herc1 APN 9 66,404,918 (GRCm39) missense possibly damaging 0.94
IGL01670:Herc1 APN 9 66,394,342 (GRCm39) missense probably damaging 1.00
IGL01825:Herc1 APN 9 66,307,089 (GRCm39) missense probably benign 0.00
IGL01903:Herc1 APN 9 66,294,154 (GRCm39) nonsense probably null
IGL01988:Herc1 APN 9 66,395,357 (GRCm39) splice site probably benign
IGL02074:Herc1 APN 9 66,358,265 (GRCm39) missense probably benign
IGL02089:Herc1 APN 9 66,388,151 (GRCm39) missense probably damaging 1.00
IGL02177:Herc1 APN 9 66,341,793 (GRCm39) missense probably benign
IGL02300:Herc1 APN 9 66,383,645 (GRCm39) missense probably benign 0.01
IGL02304:Herc1 APN 9 66,383,696 (GRCm39) missense probably benign 0.06
IGL02369:Herc1 APN 9 66,399,293 (GRCm39) nonsense probably null
IGL02445:Herc1 APN 9 66,340,764 (GRCm39) missense possibly damaging 0.95
IGL02447:Herc1 APN 9 66,404,610 (GRCm39) missense possibly damaging 0.59
IGL02549:Herc1 APN 9 66,307,183 (GRCm39) missense probably damaging 0.98
IGL02571:Herc1 APN 9 66,341,887 (GRCm39) splice site probably benign
IGL02709:Herc1 APN 9 66,404,962 (GRCm39) missense probably damaging 0.97
IGL02717:Herc1 APN 9 66,279,203 (GRCm39) nonsense probably null
IGL02726:Herc1 APN 9 66,349,270 (GRCm39) missense probably benign 0.37
IGL02733:Herc1 APN 9 66,358,274 (GRCm39) missense probably benign
IGL02963:Herc1 APN 9 66,296,105 (GRCm39) missense probably damaging 0.99
IGL03101:Herc1 APN 9 66,395,279 (GRCm39) missense probably benign
IGL03193:Herc1 APN 9 66,309,962 (GRCm39) missense probably benign
IGL03203:Herc1 APN 9 66,296,182 (GRCm39) critical splice donor site probably null
IGL03216:Herc1 APN 9 66,386,228 (GRCm39) missense probably benign 0.06
IGL03282:Herc1 APN 9 66,358,741 (GRCm39) missense probably benign 0.05
IGL03295:Herc1 APN 9 66,303,985 (GRCm39) missense possibly damaging 0.56
cradle UTSW 9 66,391,148 (GRCm39) splice site probably null
miracles UTSW 9 66,370,119 (GRCm39) nonsense probably null
newton UTSW 9 66,375,085 (GRCm39) missense probably damaging 1.00
R0907_Herc1_362 UTSW 9 66,340,710 (GRCm39) missense possibly damaging 0.94
R4427_Herc1_231 UTSW 9 66,403,287 (GRCm39) missense probably damaging 1.00
R5026_Herc1_363 UTSW 9 66,393,408 (GRCm39) missense probably benign 0.03
stables UTSW 9 66,386,735 (GRCm39) missense probably benign 0.13
strangle UTSW 9 66,408,470 (GRCm39) frame shift probably null
IGL03134:Herc1 UTSW 9 66,341,345 (GRCm39) critical splice acceptor site probably benign
PIT4243001:Herc1 UTSW 9 66,279,489 (GRCm39) missense probably benign 0.00
PIT4486001:Herc1 UTSW 9 66,279,671 (GRCm39) missense probably damaging 1.00
PIT4696001:Herc1 UTSW 9 66,386,291 (GRCm39) missense probably damaging 1.00
R0044:Herc1 UTSW 9 66,355,457 (GRCm39) missense probably benign 0.04
R0044:Herc1 UTSW 9 66,355,457 (GRCm39) missense probably benign 0.04
R0052:Herc1 UTSW 9 66,307,438 (GRCm39) missense probably damaging 0.99
R0114:Herc1 UTSW 9 66,369,128 (GRCm39) missense probably damaging 0.99
R0129:Herc1 UTSW 9 66,355,357 (GRCm39) missense probably damaging 1.00
R0131:Herc1 UTSW 9 66,388,192 (GRCm39) missense probably benign 0.00
R0131:Herc1 UTSW 9 66,388,192 (GRCm39) missense probably benign 0.00
R0132:Herc1 UTSW 9 66,388,192 (GRCm39) missense probably benign 0.00
R0158:Herc1 UTSW 9 66,403,203 (GRCm39) nonsense probably null
R0333:Herc1 UTSW 9 66,371,981 (GRCm39) splice site probably null
R0384:Herc1 UTSW 9 66,388,332 (GRCm39) splice site probably benign
R0419:Herc1 UTSW 9 66,353,356 (GRCm39) splice site probably benign
R0453:Herc1 UTSW 9 66,307,054 (GRCm39) missense probably benign 0.20
R0458:Herc1 UTSW 9 66,383,663 (GRCm39) missense probably benign 0.12
R0490:Herc1 UTSW 9 66,392,281 (GRCm39) missense probably damaging 1.00
R0506:Herc1 UTSW 9 66,355,441 (GRCm39) missense probably damaging 0.99
R0513:Herc1 UTSW 9 66,352,927 (GRCm39) missense possibly damaging 0.96
R0628:Herc1 UTSW 9 66,358,163 (GRCm39) missense probably benign 0.35
R0666:Herc1 UTSW 9 66,392,170 (GRCm39) splice site probably benign
R0674:Herc1 UTSW 9 66,408,474 (GRCm39) missense probably damaging 0.99
R0682:Herc1 UTSW 9 66,389,263 (GRCm39) missense possibly damaging 0.95
R0690:Herc1 UTSW 9 66,294,120 (GRCm39) nonsense probably null
R0701:Herc1 UTSW 9 66,395,232 (GRCm39) missense probably damaging 1.00
R0766:Herc1 UTSW 9 66,412,122 (GRCm39) missense probably damaging 1.00
R0850:Herc1 UTSW 9 66,373,952 (GRCm39) missense probably damaging 1.00
R0907:Herc1 UTSW 9 66,340,710 (GRCm39) missense possibly damaging 0.94
R0972:Herc1 UTSW 9 66,279,427 (GRCm39) missense probably damaging 1.00
R0976:Herc1 UTSW 9 66,347,160 (GRCm39) missense possibly damaging 0.74
R1027:Herc1 UTSW 9 66,363,250 (GRCm39) missense probably benign
R1200:Herc1 UTSW 9 66,393,406 (GRCm39) missense probably damaging 1.00
R1226:Herc1 UTSW 9 66,323,545 (GRCm39) missense probably benign 0.00
R1364:Herc1 UTSW 9 66,307,375 (GRCm39) missense probably damaging 1.00
R1395:Herc1 UTSW 9 66,346,463 (GRCm39) missense probably benign 0.13
R1432:Herc1 UTSW 9 66,372,751 (GRCm39) missense probably benign 0.13
R1440:Herc1 UTSW 9 66,375,085 (GRCm39) missense probably damaging 1.00
R1476:Herc1 UTSW 9 66,415,548 (GRCm39) missense probably damaging 1.00
R1590:Herc1 UTSW 9 66,399,235 (GRCm39) splice site probably benign
R1634:Herc1 UTSW 9 66,380,820 (GRCm39) missense possibly damaging 0.51
R1700:Herc1 UTSW 9 66,357,960 (GRCm39) splice site probably null
R1753:Herc1 UTSW 9 66,409,366 (GRCm39) critical splice donor site probably null
R1753:Herc1 UTSW 9 66,376,292 (GRCm39) missense probably damaging 1.00
R1796:Herc1 UTSW 9 66,296,138 (GRCm39) nonsense probably null
R1830:Herc1 UTSW 9 66,404,881 (GRCm39) missense possibly damaging 0.95
R1855:Herc1 UTSW 9 66,298,708 (GRCm39) missense possibly damaging 0.95
R1866:Herc1 UTSW 9 66,358,073 (GRCm39) missense probably damaging 1.00
R1894:Herc1 UTSW 9 66,386,743 (GRCm39) missense probably damaging 1.00
R1918:Herc1 UTSW 9 66,383,408 (GRCm39) splice site probably null
R1999:Herc1 UTSW 9 66,393,360 (GRCm39) missense probably benign 0.07
R2034:Herc1 UTSW 9 66,349,254 (GRCm39) missense probably benign 0.01
R2138:Herc1 UTSW 9 66,377,589 (GRCm39) missense possibly damaging 0.94
R2186:Herc1 UTSW 9 66,347,183 (GRCm39) missense probably benign 0.45
R2192:Herc1 UTSW 9 66,372,688 (GRCm39) missense probably damaging 0.99
R2312:Herc1 UTSW 9 66,415,563 (GRCm39) nonsense probably null
R2338:Herc1 UTSW 9 66,336,251 (GRCm39) missense possibly damaging 0.69
R3035:Herc1 UTSW 9 66,391,217 (GRCm39) missense possibly damaging 0.89
R3732:Herc1 UTSW 9 66,352,922 (GRCm39) missense probably damaging 1.00
R3732:Herc1 UTSW 9 66,352,922 (GRCm39) missense probably damaging 1.00
R3733:Herc1 UTSW 9 66,352,922 (GRCm39) missense probably damaging 1.00
R3917:Herc1 UTSW 9 66,341,748 (GRCm39) missense possibly damaging 0.94
R3953:Herc1 UTSW 9 66,341,075 (GRCm39) nonsense probably null
R4073:Herc1 UTSW 9 66,325,774 (GRCm39) missense probably benign 0.12
R4075:Herc1 UTSW 9 66,325,774 (GRCm39) missense probably benign 0.12
R4241:Herc1 UTSW 9 66,355,630 (GRCm39) frame shift probably null
R4260:Herc1 UTSW 9 66,355,630 (GRCm39) frame shift probably null
R4261:Herc1 UTSW 9 66,355,630 (GRCm39) frame shift probably null
R4300:Herc1 UTSW 9 66,396,688 (GRCm39) missense probably damaging 1.00
R4398:Herc1 UTSW 9 66,386,735 (GRCm39) missense probably benign 0.13
R4426:Herc1 UTSW 9 66,403,287 (GRCm39) missense probably damaging 1.00
R4427:Herc1 UTSW 9 66,403,287 (GRCm39) missense probably damaging 1.00
R4590:Herc1 UTSW 9 66,344,946 (GRCm39) missense probably damaging 0.97
R4630:Herc1 UTSW 9 66,340,996 (GRCm39) splice site probably null
R4656:Herc1 UTSW 9 66,301,993 (GRCm39) missense probably damaging 0.97
R4658:Herc1 UTSW 9 66,386,773 (GRCm39) missense possibly damaging 0.50
R4663:Herc1 UTSW 9 66,340,660 (GRCm39) missense probably damaging 0.98
R4675:Herc1 UTSW 9 66,298,740 (GRCm39) missense probably damaging 1.00
R4678:Herc1 UTSW 9 66,323,551 (GRCm39) missense probably benign 0.00
R4754:Herc1 UTSW 9 66,408,488 (GRCm39) missense probably benign 0.00
R4766:Herc1 UTSW 9 66,349,211 (GRCm39) missense probably benign 0.00
R4828:Herc1 UTSW 9 66,404,625 (GRCm39) splice site probably null
R4832:Herc1 UTSW 9 66,403,253 (GRCm39) missense probably benign 0.11
R4879:Herc1 UTSW 9 66,370,119 (GRCm39) nonsense probably null
R4948:Herc1 UTSW 9 66,392,184 (GRCm39) missense probably benign
R5021:Herc1 UTSW 9 66,377,608 (GRCm39) missense possibly damaging 0.48
R5022:Herc1 UTSW 9 66,377,608 (GRCm39) missense possibly damaging 0.48
R5023:Herc1 UTSW 9 66,377,608 (GRCm39) missense possibly damaging 0.48
R5024:Herc1 UTSW 9 66,377,608 (GRCm39) missense possibly damaging 0.48
R5025:Herc1 UTSW 9 66,377,608 (GRCm39) missense possibly damaging 0.48
R5026:Herc1 UTSW 9 66,393,408 (GRCm39) missense probably benign 0.03
R5027:Herc1 UTSW 9 66,380,811 (GRCm39) missense probably benign 0.01
R5027:Herc1 UTSW 9 66,411,900 (GRCm39) missense probably damaging 0.98
R5038:Herc1 UTSW 9 66,383,742 (GRCm39) intron probably benign
R5041:Herc1 UTSW 9 66,336,327 (GRCm39) missense possibly damaging 0.86
R5053:Herc1 UTSW 9 66,377,608 (GRCm39) missense possibly damaging 0.48
R5137:Herc1 UTSW 9 66,355,505 (GRCm39) missense probably benign
R5197:Herc1 UTSW 9 66,355,786 (GRCm39) missense probably damaging 0.99
R5207:Herc1 UTSW 9 66,307,151 (GRCm39) nonsense probably null
R5247:Herc1 UTSW 9 66,341,833 (GRCm39) missense probably benign 0.01
R5267:Herc1 UTSW 9 66,369,091 (GRCm39) missense probably damaging 1.00
R5274:Herc1 UTSW 9 66,306,691 (GRCm39) missense probably benign
R5375:Herc1 UTSW 9 66,375,169 (GRCm39) missense probably damaging 0.99
R5401:Herc1 UTSW 9 66,409,338 (GRCm39) missense probably damaging 1.00
R5560:Herc1 UTSW 9 66,358,401 (GRCm39) missense probably benign 0.02
R5566:Herc1 UTSW 9 66,372,819 (GRCm39) missense possibly damaging 0.95
R5577:Herc1 UTSW 9 66,389,263 (GRCm39) missense probably damaging 0.99
R5596:Herc1 UTSW 9 66,341,345 (GRCm39) critical splice acceptor site probably benign
R5665:Herc1 UTSW 9 66,372,717 (GRCm39) missense probably damaging 1.00
R5744:Herc1 UTSW 9 66,415,475 (GRCm39) missense probably damaging 1.00
R5802:Herc1 UTSW 9 66,370,160 (GRCm39) missense probably damaging 1.00
R5822:Herc1 UTSW 9 66,352,894 (GRCm39) missense probably benign 0.00
R5954:Herc1 UTSW 9 66,358,774 (GRCm39) splice site probably benign
R5977:Herc1 UTSW 9 66,340,604 (GRCm39) missense possibly damaging 0.77
R6022:Herc1 UTSW 9 66,390,967 (GRCm39) missense probably damaging 1.00
R6043:Herc1 UTSW 9 66,315,436 (GRCm39) missense probably benign
R6046:Herc1 UTSW 9 66,352,831 (GRCm39) missense probably damaging 0.99
R6089:Herc1 UTSW 9 66,352,814 (GRCm39) missense probably damaging 1.00
R6123:Herc1 UTSW 9 66,404,532 (GRCm39) missense probably damaging 0.97
R6155:Herc1 UTSW 9 66,340,705 (GRCm39) missense possibly damaging 0.95
R6190:Herc1 UTSW 9 66,283,663 (GRCm39) missense possibly damaging 0.56
R6220:Herc1 UTSW 9 66,341,070 (GRCm39) missense probably damaging 1.00
R6265:Herc1 UTSW 9 66,279,298 (GRCm39) missense probably benign 0.05
R6348:Herc1 UTSW 9 66,395,258 (GRCm39) missense possibly damaging 0.77
R6362:Herc1 UTSW 9 66,379,190 (GRCm39) missense probably damaging 1.00
R6394:Herc1 UTSW 9 66,302,341 (GRCm39) missense probably damaging 0.99
R6434:Herc1 UTSW 9 66,393,464 (GRCm39) missense probably damaging 0.99
R6483:Herc1 UTSW 9 66,355,811 (GRCm39) missense possibly damaging 0.64
R6607:Herc1 UTSW 9 66,325,849 (GRCm39) missense probably benign 0.02
R6633:Herc1 UTSW 9 66,346,534 (GRCm39) nonsense probably null
R6634:Herc1 UTSW 9 66,345,026 (GRCm39) missense probably benign
R6693:Herc1 UTSW 9 66,386,258 (GRCm39) missense probably damaging 0.99
R6695:Herc1 UTSW 9 66,391,148 (GRCm39) splice site probably null
R6748:Herc1 UTSW 9 66,408,470 (GRCm39) frame shift probably null
R6750:Herc1 UTSW 9 66,408,470 (GRCm39) frame shift probably null
R6751:Herc1 UTSW 9 66,408,470 (GRCm39) frame shift probably null
R6774:Herc1 UTSW 9 66,408,470 (GRCm39) frame shift probably null
R6785:Herc1 UTSW 9 66,408,470 (GRCm39) frame shift probably null
R6786:Herc1 UTSW 9 66,408,470 (GRCm39) frame shift probably null
R6856:Herc1 UTSW 9 66,305,180 (GRCm39) missense probably benign 0.05
R6966:Herc1 UTSW 9 66,318,347 (GRCm39) missense probably benign 0.07
R7020:Herc1 UTSW 9 66,393,360 (GRCm39) missense probably benign 0.07
R7109:Herc1 UTSW 9 66,389,171 (GRCm39) missense probably benign 0.03
R7122:Herc1 UTSW 9 66,307,056 (GRCm39) missense possibly damaging 0.69
R7209:Herc1 UTSW 9 66,292,314 (GRCm39) missense possibly damaging 0.95
R7222:Herc1 UTSW 9 66,374,781 (GRCm39) missense probably damaging 0.98
R7303:Herc1 UTSW 9 66,358,098 (GRCm39) missense possibly damaging 0.93
R7305:Herc1 UTSW 9 66,369,150 (GRCm39) missense
R7438:Herc1 UTSW 9 66,302,038 (GRCm39) missense probably benign 0.00
R7535:Herc1 UTSW 9 66,382,135 (GRCm39) missense probably damaging 1.00
R7585:Herc1 UTSW 9 66,352,829 (GRCm39) missense probably damaging 1.00
R7603:Herc1 UTSW 9 66,358,665 (GRCm39) nonsense probably null
R7670:Herc1 UTSW 9 66,323,629 (GRCm39) missense probably damaging 0.99
R7705:Herc1 UTSW 9 66,347,116 (GRCm39) missense possibly damaging 0.86
R7723:Herc1 UTSW 9 66,279,158 (GRCm39) missense probably benign 0.24
R7730:Herc1 UTSW 9 66,400,472 (GRCm39) small deletion probably benign
R7880:Herc1 UTSW 9 66,415,506 (GRCm39) missense probably damaging 0.99
R7958:Herc1 UTSW 9 66,393,475 (GRCm39) missense probably damaging 1.00
R7976:Herc1 UTSW 9 66,341,552 (GRCm39) missense possibly damaging 0.94
R8006:Herc1 UTSW 9 66,352,842 (GRCm39) nonsense probably null
R8084:Herc1 UTSW 9 66,383,217 (GRCm39) missense probably benign 0.45
R8094:Herc1 UTSW 9 66,400,462 (GRCm39) missense probably damaging 0.98
R8099:Herc1 UTSW 9 66,279,422 (GRCm39) missense probably damaging 1.00
R8151:Herc1 UTSW 9 66,341,073 (GRCm39) missense probably damaging 0.98
R8159:Herc1 UTSW 9 66,369,003 (GRCm39) missense probably null
R8190:Herc1 UTSW 9 66,325,733 (GRCm39) missense probably benign 0.00
R8213:Herc1 UTSW 9 66,358,170 (GRCm39) missense probably damaging 0.99
R8230:Herc1 UTSW 9 66,377,598 (GRCm39) missense probably damaging 0.99
R8265:Herc1 UTSW 9 66,293,986 (GRCm39) nonsense probably null
R8270:Herc1 UTSW 9 66,395,232 (GRCm39) missense probably damaging 1.00
R8353:Herc1 UTSW 9 66,415,571 (GRCm39) missense possibly damaging 0.88
R8423:Herc1 UTSW 9 66,415,442 (GRCm39) missense probably damaging 0.99
R8506:Herc1 UTSW 9 66,380,863 (GRCm39) missense possibly damaging 0.52
R8523:Herc1 UTSW 9 66,358,224 (GRCm39) missense probably benign
R8530:Herc1 UTSW 9 66,325,910 (GRCm39) missense probably benign
R8545:Herc1 UTSW 9 66,279,257 (GRCm39) nonsense probably null
R8682:Herc1 UTSW 9 66,370,130 (GRCm39) missense
R8720:Herc1 UTSW 9 66,389,105 (GRCm39) missense probably benign 0.38
R8792:Herc1 UTSW 9 66,372,768 (GRCm39) missense probably damaging 1.00
R8915:Herc1 UTSW 9 66,318,456 (GRCm39) missense probably damaging 1.00
R8964:Herc1 UTSW 9 66,352,872 (GRCm39) missense probably damaging 1.00
R9056:Herc1 UTSW 9 66,380,782 (GRCm39) missense probably benign 0.10
R9158:Herc1 UTSW 9 66,376,400 (GRCm39) missense probably benign 0.00
R9167:Herc1 UTSW 9 66,411,900 (GRCm39) missense possibly damaging 0.75
R9192:Herc1 UTSW 9 66,321,413 (GRCm39) missense probably benign 0.35
R9252:Herc1 UTSW 9 66,309,834 (GRCm39) missense probably damaging 1.00
R9260:Herc1 UTSW 9 66,325,691 (GRCm39) nonsense probably null
R9261:Herc1 UTSW 9 66,412,129 (GRCm39) missense probably damaging 0.98
R9430:Herc1 UTSW 9 66,325,785 (GRCm39) nonsense probably null
R9519:Herc1 UTSW 9 66,307,356 (GRCm39) missense probably damaging 0.97
R9563:Herc1 UTSW 9 66,294,193 (GRCm39) critical splice donor site probably null
R9589:Herc1 UTSW 9 66,372,840 (GRCm39) missense possibly damaging 0.95
R9600:Herc1 UTSW 9 66,304,594 (GRCm39) missense possibly damaging 0.95
R9659:Herc1 UTSW 9 66,307,185 (GRCm39) missense probably benign 0.03
R9740:Herc1 UTSW 9 66,355,796 (GRCm39) missense probably damaging 1.00
R9774:Herc1 UTSW 9 66,372,032 (GRCm39) missense probably null
R9781:Herc1 UTSW 9 66,280,004 (GRCm39) missense probably benign
R9788:Herc1 UTSW 9 66,307,185 (GRCm39) missense probably benign 0.03
RF023:Herc1 UTSW 9 66,365,616 (GRCm39) missense
X0011:Herc1 UTSW 9 66,307,441 (GRCm39) missense probably benign 0.28
X0067:Herc1 UTSW 9 66,355,806 (GRCm39) missense probably benign 0.03
Z1176:Herc1 UTSW 9 66,341,858 (GRCm39) missense probably benign
Z1177:Herc1 UTSW 9 66,379,193 (GRCm39) missense probably damaging 0.99
Z1177:Herc1 UTSW 9 66,365,707 (GRCm39) missense probably null
Predicted Primers PCR Primer
(F):5'- TGGGTAGAGGAATAGATATCTCTGTAG -3'
(R):5'- GAATTACAGCTGGTGACCTCTCC -3'

Sequencing Primer
(F):5'- CAAGTGCCTCTGTGCTT -3'
(R):5'- AGCTGGTGACCTCTCCCTAAC -3'
Posted On 2016-02-04